Aaron T Alpar

Affiliations

Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

Publications (20)

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics.

Cell reports. Medicine

Avec: Rachel P Wallace , Kirsten C Refvik , Jennifer T Antane , Kym Brünggel , Andrew C Tremain , Michal R Raczy , Aaron T Alpar , Mindy Nguyen , Ani Solanki , Anna J Slezak , Elyse A Watkins , Abigail L Lauterbach , Shijie Cao , D Scott Wilson , Jeffrey A Hubbell

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity.

bioRxiv : the preprint server for biology

Avec: Lisa R Volpatti , Rachel P Wallace , Shijie Cao , Michal M Raczy , Ruyi Wang , Laura T Gray , Aaron T Alpar , Priscilla S Briquez , Nikolaos Mitrousis , Tiffany M Marchell , Maria Stella Sasso , Mindy Nguyen , Aslan Mansurov , Erica Budina , Ani Solanki , Elyse A Watkins , Mathew R Schnorenberg , Andrew C Tremain , Joseph W Reda , Vlad Nicolaescu , Kevin Furlong , Steve Dvorkin , Shann S Yu , Balaji Manicassamy , James L LaBelle , Matthew V Tirrell , Glenn Randall , Marcin Kwissa , Melody A Swartz , Jeffrey A Hubbell

Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity.

ACS central science

Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.

Nature biomedical engineering

Avec: Aslan Mansurov , Peyman Hosseinchi , Kevin Chang , Abigail L Lauterbach , Laura T Gray , Aaron T Alpar , Erica Budina , Anna J Slezak , Seounghun Kang , Shijie Cao , Ani Solanki , Suzana Gomes , John-Michael Williford , Melody A Swartz , Juan L Mendoza , Jun Ishihara , Jeffrey A Hubbell

Tumor Cell-Surface Binding of Immune Stimulating Polymeric Glyco-Adjuvant via Cysteine-Reactive Pyridyl Disulfide Promotes Antitumor Immunity.

ACS central science

Avec: Anna J Slezak , Aslan Mansurov , Michal M Raczy , Kevin Chang , Aaron T Alpar , Abigail L Lauterbach , Rachel P Wallace , Rachel K Weathered , Jorge E G Medellin , Claudia Battistella , Laura T Gray , Tiffany M Marchell , Suzana Gomes , Melody A Swartz , Jeffrey A Hubbell

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics.

bioRxiv : the preprint server for biology

Engineering Targeting Materials for Therapeutic Cancer Vaccines.

Frontiers in bioengineering and biotechnology

Avec: Priscilla S Briquez , Sylvie Hauert , Alexandre de Titta , Laura T Gray , Aaron T Alpar , Melody A Swartz , Jeffrey A Hubbell

Publisher Correction: Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.

Nature biomedical engineering

Avec: Ako Ishihara , Jun Ishihara , Elyse A Watkins , Andrew C Tremain , Mindy Nguyen , Ani Solanki , Kiyomitsu Katsumata , Aslan Mansurov , Erica Budina , Aaron T Alpar , Peyman Hosseinchi , Lea Maillat , Joseph W Reda , Takahiro Kageyama , Melody A Swartz , Eiji Yuba , Jeffrey A Hubbell

Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Eiji Yuba , Erica Budina , Kiyomitsu Katsumata , Ako Ishihara , Aslan Mansurov , Aaron T Alpar , Elyse A Watkins , Peyman Hosseinchi , Joseph W Reda , Abigail L Lauterbach , Mindy Nguyen , Ani Solanki , Takahiro Kageyama , Melody A Swartz , Jun Ishihara , Jeffrey A Hubbell

A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice.

Nature biomedical engineering

Avec: Shijie Cao , Erica Budina , Michal M Raczy , Ani Solanki , Mindy Nguyen , Taryn N Beckman , Joseph W Reda , Kevin Hultgren , Phillip S Ang , Anna J Slezak , Lauren A Hesser , Aaron T Alpar , Kirsten C Refvik , Lucas S Shores , Ishita Pillai , Rachel P Wallace , Arjun Dhar , Elyse A Watkins , Jeffrey A Hubbell

Cysteine-binding adjuvant enhances survival and promotes immune function in a murine model of acute myeloid leukemia.

Blood advances

Avec: Anna J Slezak , Kevin Chang , Taryn N Beckman , Kirsten C Refvik , Aaron T Alpar , Abigail L Lauterbach , Ani Solanki , Jung Woo Kwon , Suzana Gomes , Aslan Mansurov , Jeffrey A Hubbell

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant.

Biomaterials

Avec: Laura T Gray , Michal M Raczy , Priscilla S Briquez , Tiffany M Marchell , Aaron T Alpar , Rachel P Wallace , Lisa R Volpatti , Maria Stella Sasso , Shijie Cao , Mindy Nguyen , Aslan Mansurov , Erica Budina , Elyse A Watkins , Ani Solanki , Nikolaos Mitrousis , Joseph W Reda , Shann S Yu , Andrew C Tremain , Ruyi Wang , Vlad Nicolaescu , Kevin Furlong , Steve Dvorkin , Balaji Manicassamy , Glenn Randall , D Scott Wilson , Marcin Kwissa , Melody A Swartz , Jeffrey A Hubbell

Immunoengineering approaches for cytokine therapy.

American journal of physiology. Cell physiology

Avec: Aslan Mansurov , Abigail Lauterbach , Erica Budina , Aaron T Alpar , Jeffrey A Hubbell , Jun Ishihara

Membrane-localized neoantigens predict the efficacy of cancer immunotherapy.

Cell reports. Medicine

Avec: Zoe Goldberger , Sylvie Hauert , Kevin Chang , Trevin Kurtanich , Aaron T Alpar , Grégoire Repond , Yue Wang , Suzana Gomes , Raga Krishnakumar , Prabha Siddarth , Melody A Swartz , Jeffrey A Hubbell , Priscilla S Briquez

Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses.

Nature biomedical engineering

Avec: Andrew C Tremain , Rachel P Wallace , Kristen M Lorentz , Thomas B Thornley , Jennifer T Antane , Michal R Raczy , Joseph W Reda , Aaron T Alpar , Anna J Slezak , Elyse A Watkins , Chitavi D Maulloo , Erica Budina , Ani Solanki , Mindy Nguyen , David J Bischoff , Jamie L Harrington , Rabinarayan Mishra , Gregory P Conley , Romain Marlin , Nathalie Dereuddre-Bosquet , Anne-Sophie Gallouët , Roger LeGrand , D Scott Wilson , Stephan Kontos , Jeffrey A Hubbell

Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis.

Scientific reports

Avec: Michael J V White , Melis Ozkan , Jorge Emiliano Gomez-Medellin , Michal M Rączy , Kyle M Koss , Ani Solanki , Zheng Jenny Zhang , Aaron T Alpar , Bilal A Naved , Jason Wertheim , Jeffrey A Hubbell

Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours.

Nature biomedical engineering

Avec: Aslan Mansurov , Jun Ishihara , Peyman Hosseinchi , Lambert Potin , Tiffany M Marchell , Ako Ishihara , John-Michael Williford , Aaron T Alpar , Michal M Raczy , Laura T Gray , Melody A Swartz , Jeffrey A Hubbell

Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.

Nature biomedical engineering

Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds.

NPJ Regenerative medicine

Avec: Abigail L Lauterbach , Rachel P Wallace , Aaron T Alpar , Kirsten C Refvik , Joseph W Reda , Ako Ishihara , Taryn N Beckman , Anna J Slezak , Yukari Mizukami , Aslan Mansurov , Suzana Gomes , Jun Ishihara , Jeffrey A Hubbell

Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity.

Science advances

Avec: Seounghun Kang , Aslan Mansurov , Trevin Kurtanich , Hye Rin Chun , Anna J Slezak , Lisa R Volpatti , Kevin Chang , Thomas Wang , Aaron T Alpar , Kirsten C Refvik , O Isabella Hansen , Gustavo J Borjas , Ha-Na Shim , Kevin T Hultgren , Suzana Gomes , Ani Solanki , Jun Ishihara , Melody A Swartz , Jeffrey A Hubbell

Réseau de co-auteurs

Jeffrey A Hubbell 20 collaborations

Ani Solanki 14 collaborations

Aslan Mansurov 13 collaborations

Melody A Swartz 12 collaborations

Mindy Nguyen 10 collaborations

Elyse A Watkins 10 collaborations

Erica Budina 10 collaborations

Rachel P Wallace 9 collaborations

Anna J Slezak 9 collaborations

Joseph W Reda 9 collaborations

Andrew C Tremain 8 collaborations

Jun Ishihara 8 collaborations

Abigail L Lauterbach 7 collaborations

Shijie Cao 7 collaborations

Laura T Gray 7 collaborations

Kirsten C Refvik 6 collaborations

Michal M Raczy 6 collaborations

Suzana Gomes 6 collaborations

Priscilla S Briquez 5 collaborations

Tiffany M Marchell 5 collaborations

Peyman Hosseinchi 5 collaborations

Kevin Chang 5 collaborations

Ako Ishihara 5 collaborations

D Scott Wilson 4 collaborations

Lisa R Volpatti 4 collaborations

Jennifer T Antane 3 collaborations

Michal R Raczy 3 collaborations

Ruyi Wang 3 collaborations

Nikolaos Mitrousis 3 collaborations

Maria Stella Sasso 3 collaborations

Vlad Nicolaescu 3 collaborations

Kevin Furlong 3 collaborations

Steve Dvorkin 3 collaborations

Shann S Yu 3 collaborations

Balaji Manicassamy 3 collaborations

Glenn Randall 3 collaborations

Marcin Kwissa 3 collaborations

Kiyomitsu Katsumata 3 collaborations

Takahiro Kageyama 3 collaborations

Eiji Yuba 3 collaborations

Taryn N Beckman 3 collaborations

Kym Brünggel 2 collaborations

Mathew R Schnorenberg 2 collaborations

James L LaBelle 2 collaborations

Matthew V Tirrell 2 collaborations

Seounghun Kang 2 collaborations

John-Michael Williford 2 collaborations

Sylvie Hauert 2 collaborations

Lea Maillat 2 collaborations

Trevin Kurtanich 2 collaborations

Juan L Mendoza 1 collaboration

Rachel K Weathered 1 collaboration

Jorge E G Medellin 1 collaboration

Claudia Battistella 1 collaboration

Alexandre de Titta 1 collaboration

Kevin Hultgren 1 collaboration

Phillip S Ang 1 collaboration

Lauren A Hesser 1 collaboration

Lucas S Shores 1 collaboration

Ishita Pillai 1 collaboration

Arjun Dhar 1 collaboration

Jung Woo Kwon 1 collaboration

Abigail Lauterbach 1 collaboration

Zoe Goldberger 1 collaboration

Grégoire Repond 1 collaboration

Yue Wang 1 collaboration

Raga Krishnakumar 1 collaboration

Prabha Siddarth 1 collaboration

Kristen M Lorentz 1 collaboration

Thomas B Thornley 1 collaboration

Chitavi D Maulloo 1 collaboration

David J Bischoff 1 collaboration

Jamie L Harrington 1 collaboration

Rabinarayan Mishra 1 collaboration

Gregory P Conley 1 collaboration

Romain Marlin 1 collaboration

Nathalie Dereuddre-Bosquet 1 collaboration

Anne-Sophie Gallouët 1 collaboration

Roger LeGrand 1 collaboration

Stephan Kontos 1 collaboration

Michael J V White 1 collaboration

Melis Ozkan 1 collaboration

Jorge Emiliano Gomez-Medellin 1 collaboration

Michal M Rączy 1 collaboration

Kyle M Koss 1 collaboration

Zheng Jenny Zhang 1 collaboration

Bilal A Naved 1 collaboration

Jason Wertheim 1 collaboration

Lambert Potin 1 collaboration

Yukari Mizukami 1 collaboration

Hye Rin Chun 1 collaboration

Thomas Wang 1 collaboration

O Isabella Hansen 1 collaboration

Gustavo J Borjas 1 collaboration

Ha-Na Shim 1 collaboration

Kevin T Hultgren 1 collaboration