Alejandro A Pezzulo

Affiliations

Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.

Publications (28)

TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin.

American journal of physiology. Cell physiology

Avec: Tayyab Rehman , Ian M Thornell , Alejandro A Pezzulo , Andrew L Thurman , Guillermo S Romano Ibarra , Philip H Karp , Ping Tan , Michael E Duffey , Michael J Welsh

Vitamin D-mediated effects on airway innate immunity in vitro.

PloS one

Avec: Emma M Stapleton , Kathy Keck , Robert Windisch , Mallory R Stroik , Andrew L Thurman , Joseph Zabner , Ian M Thornell , Alejandro A Pezzulo , Julia Klesney-Tait , Alejandro P Comellas

Eosinophil expression of Triggering receptor expressed on myeloid cells-1 (TREM-1) restricts type 2 lung inflammation.

Journal of leukocyte biology

Avec: Jayden L Bowen , Kathy Keck , Sankar Baruah , Kathy H Nguyen , Andrew L Thurman , Alejandro A Pezzulo , Julia Klesney-Tait

FXYD3 facilitates Na

American journal of physiology. Cell physiology

Avec: Camilo Cano Portillo , Raul Villacreses , Andrew L Thurman , Alejandro A Pezzulo , Joseph Zabner , Ian M Thornell

Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model.

Laboratory investigation; a journal of technical methods and pathology

Avec: Keyan Zarei , Mallory R Stroik , Nick D Gansemer , Andrew L Thurman , Lynda S Ostedgaard , Sarah E Ernst , Ian M Thornell , Linda S Powers , Alejandro A Pezzulo , David K Meyerholz , David A Stoltz

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract.

bioRxiv : the preprint server for biology

Avec: Miguel E Ortiz Bezara , Andrew Thurman , Alejandro A Pezzulo , Mariah R Leidinger , Julia A Klesney-Tait , Philip H Karp , Ping Tan , Christine Wohlford-Lenane , Paul B McCray , David K Meyerholz

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract.

EBioMedicine

Avec: Miguel E Ortiz , Andrew Thurman , Alejandro A Pezzulo , Mariah R Leidinger , Julia A Klesney-Tait , Philip H Karp , Ping Tan , Christine Wohlford-Lenane , Paul B McCray , David K Meyerholz

Performance of a scalable RNA extraction-free transcriptome profiling method for adherent cultured human cells.

Scientific reports

Avec: Shreya Ghimire , Carley G Stewart , Andrew L Thurman , Alejandro A Pezzulo

Lentiviral vectors transduce lung stem cells without disrupting plasticity.

Molecular therapy. Nucleic acids

Avec: Ashley L Cooney , Andrew L Thurman , Paul B McCray , Alejandro A Pezzulo , Patrick L Sinn

A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis.

American journal of respiratory cell and molecular biology

Avec: Andrew L Thurman , Xiaopeng Li , Raul Villacreses , Wenjie Yu , Huiyu Gong , Steven E Mather , Guillermo S Romano-Ibarra , David K Meyerholz , David A Stoltz , Michael J Welsh , Ian M Thornell , Joseph Zabner , Alejandro A Pezzulo

Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection.

Radiology

Avec: Josalyn L Cho , Raul Villacreses , Prashant Nagpal , Junfeng Guo , Alejandro A Pezzulo , Andrew L Thurman , Nabeel Y Hamzeh , Robert J Blount , Spyridon Fortis , Eric A Hoffman , Joseph Zabner , Alejandro P Comellas

WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.

American journal of respiratory cell and molecular biology

Avec: Tayyab Rehman , Philip H Karp , Andrew L Thurman , Steven E Mather , Akansha Jain , Ashley L Cooney , Patrick L Sinn , Alejandro A Pezzulo , Michael E Duffey , Michael J Welsh

Polarized AAVR expression determines infectivity by AAV gene therapy vectors.

Gene therapy

Avec: Bradley A Hamilton , Xiaopeng Li , Alejandro A Pezzulo , Mahmoud H Abou Alaiwa , Joseph Zabner

Inflammatory cytokines TNF-α and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.

The Journal of clinical investigation

Avec: Tayyab Rehman , Philip H Karp , Ping Tan , Brian J Goodell , Alejandro A Pezzulo , Andrew L Thurman , Ian M Thornell , Samantha L Durfey , Michael E Duffey , David A Stoltz , Edward F McKone , Pradeep K Singh , Michael J Welsh

MRSA strains with distinct accessory genes predominate at different ages in cystic fibrosis.

Pediatric pulmonology

Avec: Harry S Porterfield , Lucas J Maakestad , Mason M LaMarche , Andrew L Thurman , Zoe E Kienenberger , Nicholas J Pitcher , Alexis R Hansen , Christian F Zirbes , Linda Boyken , Bethany L Muyskens , Alejandro A Pezzulo , Sachinkumar B Singh , Erik Twait , Bradley Ford , Daniel J Diekema , Valérie Reeb , Anthony J Fischer

A predominately pulmonary activation of complement in a mouse model of severe COVID-19.

bioRxiv : the preprint server for biology

Avec: Peter J Szachowicz , Christine Wohlford-Lenane , Cobey J Heinen , Shreya Ghimire , Biyun Xue , Timothy J Boly , Abhishek Verma , Leila MašinoviĆ , Jennifer R Bermick , Stanley Perlman , David K Meyerholz , Alejandro A Pezzulo , Yuzhou Zhang , Richard J H Smith , Paul B McCray

Il-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption.

The Journal of clinical investigation

Avec: Guillermo S Romano Ibarra , Lei Lei , Wenjie Yu , Andrew L Thurman , Nicholas D Gansemer , David K Meyerholz , Alejandro A Pezzulo , Paul B McCray , Ian M Thornell , David A Stoltz

HSP90 inhibitor geldanamycin reverts IL-13- and IL-17-induced airway goblet cell metaplasia.

The Journal of clinical investigation

Avec: Alejandro A Pezzulo , Rosarie A Tudas , Carley G Stewart , Luis G Vargas Buonfiglio , Brian D Lindsay , Peter J Taft , Nicholas D Gansemer , Joseph Zabner

Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH.

The Journal of physiology

Avec: Ian M Thornell , Tayyab Rehman , Alejandro A Pezzulo , Michael J Welsh

Translating in vitro CFTR rescue into small molecule correctors for cystic fibrosis using the Library of Integrated Network-based Cellular Signatures drug discovery platform.

CPT: pharmacometrics & systems pharmacology

Avec: Matthew D Strub , Shyam Ramachandran , Dmitri Y Boudko , Ella A Meleshkevitch , Alejandro A Pezzulo , Aravind Subramanian , Arthur Liberzon , Robert J Bridges , Paul B McCray

Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Wenjie Yu , Thomas O Moninger , Andrew L Thurman , Yuliang Xie , Akansha Jain , Keyan Zarei , Linda S Powers , Alejandro A Pezzulo , David A Stoltz , Michael J Welsh

Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.

Nature

Avec: Lok-Yin Roy Wong , Jian Zheng , Kevin Wilhelmsen , Kun Li , Miguel E Ortiz , Nicholas J Schnicker , Andrew Thurman , Alejandro A Pezzulo , Peter J Szachowicz , Pengfei Li , Ruangang Pan , Klaus Klumpp , Fred Aswad , Justin Rebo , Shuh Narumiya , Makoto Murakami , Sonia Zuniga , Isabel Sola , Luis Enjuanes , David K Meyerholz , Kristen Fortney , Paul B McCray , Stanley Perlman

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo.

bioRxiv : the preprint server for biology

Avec: Shreya Ghimire , Biyun Xue , Kun Li , Ryan M Gannon , Christine L Wohlford-Lenane , Andrew L Thurman , Huiyu Gong , Grace C Necker , Jian Zheng , David K Meyerholz , Stanley Perlman , Paul B McCray , Alejandro A Pezzulo

Differential gene expression analysis for multi-subject single-cell RNA-sequencing studies with aggregateBioVar.

Bioinformatics (Oxford, England)

Avec: Andrew L Thurman , Jason A Ratcliff , Michael S Chimenti , Alejandro A Pezzulo

Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19.

bioRxiv : the preprint server for biology

Avec: Lok-Yin Roy Wong , Jian Zheng , Kevin Wilhelmsen , Kun Li , Miguel E Ortiz , Nicholas J Schnicker , Alejandro A Pezzulo , Peter J Szachowicz , Klaus Klumpp , Fred Aswad , Justin Rebo , Shuh Narumiya , Makoto Murakami , David K Meyerholz , Kristen Fortney , Paul B McCray , Stanley Perlman

Measles virus exits human airway epithelia within dislodged metabolically active infectious centers.

PLoS pathogens

Avec: Camilla E Hippee , Brajesh K Singh , Andrew L Thurman , Ashley L Cooney , Alejandro A Pezzulo , Roberto Cattaneo , Patrick L Sinn

Increased ENaC-mediated liquid absorption across vitamin-D deficient human airway epithelia.

American journal of physiology. Cell physiology

Avec: Emma M Stapleton , Andrew L Thurman , Alejandro Antonio Pezzulo , Alejandro P Comellas , Ian M Thornell

IL-13 induced inflammation increases DPP4 abundance but does not enhance MERS-CoV replication in airway epithelia.

The Journal of infectious diseases

Avec: Kun Li , Jennifer A Bartlett , Christine L Wohlford-Lenane , Biyun Xue , Andrew L Thurman , Thomas M Gallagher , Alejandro A Pezzulo , Paul B McCray

Réseau de co-auteurs

Andrew L Thurman 19 collaborations

Paul B McCray 10 collaborations

Ian M Thornell 9 collaborations

David K Meyerholz 9 collaborations

Michael J Welsh 6 collaborations

Joseph Zabner 6 collaborations

Philip H Karp 5 collaborations

David A Stoltz 5 collaborations

Tayyab Rehman 4 collaborations

Ping Tan 4 collaborations

Stanley Perlman 4 collaborations

Kun Li 4 collaborations

Michael E Duffey 3 collaborations

Alejandro P Comellas 3 collaborations

Raul Villacreses 3 collaborations

Andrew Thurman 3 collaborations

Christine Wohlford-Lenane 3 collaborations

Miguel E Ortiz 3 collaborations

Shreya Ghimire 3 collaborations

Ashley L Cooney 3 collaborations

Patrick L Sinn 3 collaborations

Wenjie Yu 3 collaborations

Peter J Szachowicz 3 collaborations

Biyun Xue 3 collaborations

Jian Zheng 3 collaborations

Guillermo S Romano Ibarra 2 collaborations

Emma M Stapleton 2 collaborations

Kathy Keck 2 collaborations

Mallory R Stroik 2 collaborations

Julia Klesney-Tait 2 collaborations

Keyan Zarei 2 collaborations

Linda S Powers 2 collaborations

Mariah R Leidinger 2 collaborations

Julia A Klesney-Tait 2 collaborations

Carley G Stewart 2 collaborations

Xiaopeng Li 2 collaborations

Huiyu Gong 2 collaborations

Steven E Mather 2 collaborations

Akansha Jain 2 collaborations

Nicholas D Gansemer 2 collaborations

Lok-Yin Roy Wong 2 collaborations

Kevin Wilhelmsen 2 collaborations

Nicholas J Schnicker 2 collaborations

Klaus Klumpp 2 collaborations

Fred Aswad 2 collaborations

Justin Rebo 2 collaborations

Shuh Narumiya 2 collaborations

Makoto Murakami 2 collaborations

Kristen Fortney 2 collaborations

Christine L Wohlford-Lenane 2 collaborations

Robert Windisch 1 collaboration

Jayden L Bowen 1 collaboration

Sankar Baruah 1 collaboration

Kathy H Nguyen 1 collaboration

Camilo Cano Portillo 1 collaboration

Nick D Gansemer 1 collaboration

Lynda S Ostedgaard 1 collaboration

Sarah E Ernst 1 collaboration

Miguel E Ortiz Bezara 1 collaboration

Guillermo S Romano-Ibarra 1 collaboration

Josalyn L Cho 1 collaboration

Prashant Nagpal 1 collaboration

Junfeng Guo 1 collaboration

Nabeel Y Hamzeh 1 collaboration

Robert J Blount 1 collaboration

Spyridon Fortis 1 collaboration

Eric A Hoffman 1 collaboration

Bradley A Hamilton 1 collaboration

Mahmoud H Abou Alaiwa 1 collaboration

Brian J Goodell 1 collaboration

Samantha L Durfey 1 collaboration

Edward F McKone 1 collaboration

Pradeep K Singh 1 collaboration

Harry S Porterfield 1 collaboration

Lucas J Maakestad 1 collaboration

Mason M LaMarche 1 collaboration

Zoe E Kienenberger 1 collaboration

Nicholas J Pitcher 1 collaboration

Alexis R Hansen 1 collaboration

Christian F Zirbes 1 collaboration

Linda Boyken 1 collaboration

Bethany L Muyskens 1 collaboration

Sachinkumar B Singh 1 collaboration

Erik Twait 1 collaboration

Bradley Ford 1 collaboration

Daniel J Diekema 1 collaboration

Valérie Reeb 1 collaboration

Anthony J Fischer 1 collaboration

Cobey J Heinen 1 collaboration

Timothy J Boly 1 collaboration

Abhishek Verma 1 collaboration

Leila MašinoviĆ 1 collaboration

Jennifer R Bermick 1 collaboration

Yuzhou Zhang 1 collaboration

Richard J H Smith 1 collaboration

Lei Lei 1 collaboration

Rosarie A Tudas 1 collaboration

Luis G Vargas Buonfiglio 1 collaboration

Brian D Lindsay 1 collaboration

Peter J Taft 1 collaboration

Matthew D Strub 1 collaboration

Shyam Ramachandran 1 collaboration

Dmitri Y Boudko 1 collaboration

Ella A Meleshkevitch 1 collaboration

Aravind Subramanian 1 collaboration

Arthur Liberzon 1 collaboration

Robert J Bridges 1 collaboration

Thomas O Moninger 1 collaboration

Yuliang Xie 1 collaboration

Pengfei Li 1 collaboration

Ruangang Pan 1 collaboration

Sonia Zuniga 1 collaboration

Isabel Sola 1 collaboration

Luis Enjuanes 1 collaboration

Ryan M Gannon 1 collaboration

Grace C Necker 1 collaboration

Jason A Ratcliff 1 collaboration

Michael S Chimenti 1 collaboration

Camilla E Hippee 1 collaboration

Brajesh K Singh 1 collaboration

Roberto Cattaneo 1 collaboration

Alejandro Antonio Pezzulo 1 collaboration

Jennifer A Bartlett 1 collaboration

Thomas M Gallagher 1 collaboration