Alex Pym

Affiliations

South African Medical Research Council, Africa Health Research Institute, and Durban, South Africa.

Publications (20)

Space-time clustering of recently-diagnosed tuberculosis and impact of ART scale-up: Evidence from an HIV hyper-endemic rural South African population.

Scientific reports

Avec: Andrew Tomita , Catherine M Smith , Richard J Lessells , Alexander Pym , Alison D Grant , Tulio de Oliveira , Frank Tanser

A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, Plutella xylostella.

Insect biochemistry and molecular biology

Avec: Mark Mallott , Sarah Hamm , Bartlomiej J Troczka , Emma Randall , Adam Pym , Charles Grant , Simon Baxter , Heiko Vogel , Anthony M Shelton , Linda M Field , Martin S Williamson , Mark Paine , Christoph T Zimmer , Russell Slater , Jan Elias , Chris Bass

Transmission of drug-resistant tuberculosis in HIV-endemic settings.

The Lancet. Infectious diseases

Avec: Palwasha Y Khan , Tom A Yates , Muhammad Osman , Robin M Warren , Yuri van der Heijden , Nesri Padayatchi , Edward A Nardell , David Moore , Barun Mathema , Neel Gandhi , Vegard Eldholm , Keertan Dheda , Anneke C Hesseling , Valerie Mizrahi , Roxana Rustomjee , Alexander Pym

Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis.

The Journal of infectious diseases

Avec: N F Walker , F Karim , M Y S Moosa , S Moodley , M Mazibuko , K Khan , T R Sterling , Y F van der Heijden , A D Grant , P T Elkington , A Pym , A Leslie

The role of the Bemisia tabaci and Trialeurodes vaporariorum cytochrome-P450 clade CYP6DPx in resistance to nicotine and neonicotinoids.

Pesticide biochemistry and physiology

Avec: Adam Pym , Bartlomiej J Troczka , Angela Hayward , Bin Zeng , Cong-Fen Gao , Jan Elias , Russell Slater , Christoph T Zimmer , Chris Bass

Spirotetramat resistance in Myzus persicae (Sulzer) (Hemiptera: Aphididae) and its association with the presence of the A2666V mutation.

Pest management science

Avec: Paul A Umina , Chris Bass , Anthony van Rooyen , Evatt Chirgwin , Aston L Arthur , Adam Pym , Jo Mackisack , Andrew Mathews , Lisa Kirkland

Host plant adaptation in the polyphagous whitefly, Trialeurodes vaporariorum, is associated with transcriptional plasticity and altered sensitivity to insecticides.

BMC genomics

Avec: Adam Pym , Kumar Saurabh Singh , Åsa Nordgren , T G Emyr Davies , Christoph T Zimmer , Jan Elias , Russell Slater , Chris Bass

Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing.

Antimicrobial agents and chemotherapy

Avec: Max R O'Donnell , Michelle H Larsen , Tyler S Brown , Paras Jain , Vanisha Munsamy , Allison Wolf , Lorenzo Uccellini , Farina Karim , Tulio de Oliveira , Barun Mathema , William R Jacobs , Alexander Pym

Overexpression of UDP-glucuronosyltransferase and cytochrome P450 enzymes confers resistance to sulfoxaflor in field populations of the aphid, Myzus persicae.

Insect biochemistry and molecular biology

Avec: Adam Pym , Paul A Umina , Jenny Reidy-Crofts , Bartlomiej J Troczka , Andrew Matthews , James Gardner , Benjamin J Hunt , Anthony R van Rooyen , Owain R Edwards , Chris Bass

Overexpression of the UDP-glycosyltransferase UGT34A23 confers resistance to the diamide insecticide chlorantraniliprole in the tomato leafminer, Tuta absoluta.

Insect biochemistry and molecular biology

Avec: Charles Grant , Kumar Saurabh Singh , Angela Hayward , Benjamin J Hunt , Bartlomiej J Troczka , Adam Pym , Seung-Joon Ahn , Bin Zeng , Cong-Fen Gao , Alicia Leroux , Eve Daum , Philip Süess , Dariane Souza , Jan Elias , Richard H Ffrench-Constant , John Vontas , Emmanouil Roditakis , Pablo Bielza , Christoph T Zimmer , Chris Bass

Aberrant splicing of a nicotinic acetylcholine receptor alpha 6 subunit is associated with spinosad tolerance in the thrips predator Orius laevigatus.

Pesticide biochemistry and physiology

Avec: Bin Zeng , Benjamin J Hunt , Adam Pym , Virginia Balanza , Chris Bass , Pablo Bielza , Bartlomiej J Troczka

Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis.

The Lancet. Global health

Avec: Gian Luca Di Tanna , Ali Raza Khaki , Grant Theron , Kerrigan McCarthy , Helen Cox , Lucy Mupfumi , Anete Trajman , Lynn Sodai Zijenah , Peter Mason , Tsitsi Bandason , Betina Durovni , Wilbert Bara , Michael Hoelscher , Petra Clowes , Chacha Mangu , Duncan Chanda , Alexander Pym , Peter Mwaba , Frank Cobelens , Mark P Nicol , Keertan Dheda , Gavin Churchyard , Katherine Fielding , John Z Metcalfe

Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation.

The Lancet. Global health

Avec: Anil Pooran , Grant Theron , Lynn Zijenah , Duncan Chanda , Petra Clowes , Lawrence Mwenge , Farirai Mutenherwa , Paul Lecesse , John Metcalfe , Hojoon Sohn , Michael Hoelscher , Alex Pym , Jonny Peter , David Dowdy , Keertan Dheda

Fly-Tox: A panel of transgenic flies expressing pest and pollinator cytochrome P450s.

Pesticide biochemistry and physiology

Avec: Amy McLeman , Bartlomiej J Troczka , Rafael A Homem , Ana Duarte , Christoph Zimmer , William T Garrood , Adam Pym , Katherine Beadle , Rebecca J Reid , Vassilis Douris , John Vontas , T G Emyr Davies , Richard Ffrench Constant , Ralf Nauen , Chris Bass

Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae.

Communications biology

Avec: Kumar Saurabh Singh , Erick M G Cordeiro , Bartlomiej J Troczka , Adam Pym , Joanna Mackisack , Thomas C Mathers , Ana Duarte , Fabrice Legeai , Stéphanie Robin , Pablo Bielza , Hannah J Burrack , Kamel Charaabi , Ian Denholm , Christian C Figueroa , Richard H Ffrench-Constant , Georg Jander , John T Margaritopoulos , Emanuele Mazzoni , Ralf Nauen , Claudio C Ramírez , Guangwei Ren , Ilona Stepanyan , Paul A Umina , Nina V Voronova , John Vontas , Martin S Williamson , Alex C C Wilson , Gao Xi-Wu , Young-Nam Youn , Christoph T Zimmer , Jean-Christophe Simon , Alex Hayward , Chris Bass

P450 gene duplication and divergence led to the evolution of dual novel functions and insecticide cross-resistance in the brown planthopper Nilaparvata lugens.

PLoS genetics

Avec: Ana Duarte , Adam Pym , William T Garrood , Bartlomiej J Troczka , Christoph T Zimmer , T G Emyr Davies , Ralf Nauen , Andrias O O'Reilly , Chris Bass

A cytochrome P450 insecticide detoxification mechanism is not conserved across the Megachilidae family of bees.

Evolutionary applications

Avec: Angela Hayward , Benjamin J Hunt , Julian Haas , Ellie Bushnell-Crowther , Bartlomiej J Troczka , Adam Pym , Katherine Beadle , Jeremy Field , David R Nelson , Ralf Nauen , Chris Bass

A single point mutation in the Bemisia tabaci cytochrome-P450 CYP6CM1 causes enhanced resistance to neonicotinoids.

Insect biochemistry and molecular biology

Avec: Adam Pym , John G M Mina , Bartlomiej J Troczka , Angela Hayward , Eve Daum , Jan Elias , Russell Slater , John Vontas , Chris Bass , Christoph T Zimmer

Transposon accumulation at xenobiotic gene family loci in aphids.

Genome research

Avec: Tobias Baril , Adam Pym , Chris Bass , Alex Hayward

Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis.

Genome medicine

Avec: Camus Nimmo , Arturo Torres Ortiz , Cedric C S Tan , Juanita Pang , Mislav Acman , James Millard , Nesri Padayatchi , Alison D Grant , Max O'Donnell , Alex Pym , Ola B Brynildsrud , Vegard Eldholm , Louis Grandjean , Xavier Didelot , François Balloux , Lucy van Dorp

Réseau de co-auteurs

Adam Pym 13 collaborations

Chris Bass 13 collaborations

Bartlomiej J Troczka 10 collaborations

Christoph T Zimmer 7 collaborations

Jan Elias 5 collaborations

Alexander Pym 4 collaborations

Russell Slater 4 collaborations

Angela Hayward 4 collaborations

Benjamin J Hunt 4 collaborations

John Vontas 4 collaborations

Ralf Nauen 4 collaborations

Keertan Dheda 3 collaborations

Bin Zeng 3 collaborations

Paul A Umina 3 collaborations

Kumar Saurabh Singh 3 collaborations

T G Emyr Davies 3 collaborations

Pablo Bielza 3 collaborations

Ana Duarte 3 collaborations

Alison D Grant 2 collaborations

Tulio de Oliveira 2 collaborations

Charles Grant 2 collaborations

Martin S Williamson 2 collaborations

Nesri Padayatchi 2 collaborations

Barun Mathema 2 collaborations

Vegard Eldholm 2 collaborations

Cong-Fen Gao 2 collaborations

Eve Daum 2 collaborations

Richard H Ffrench-Constant 2 collaborations

Grant Theron 2 collaborations

Michael Hoelscher 2 collaborations

Petra Clowes 2 collaborations

Duncan Chanda 2 collaborations

William T Garrood 2 collaborations

Katherine Beadle 2 collaborations

Alex Hayward 2 collaborations

Andrew Tomita 1 collaboration

Catherine M Smith 1 collaboration

Richard J Lessells 1 collaboration

Frank Tanser 1 collaboration

Mark Mallott 1 collaboration

Sarah Hamm 1 collaboration

Emma Randall 1 collaboration

Simon Baxter 1 collaboration

Heiko Vogel 1 collaboration

Anthony M Shelton 1 collaboration

Linda M Field 1 collaboration

Mark Paine 1 collaboration

Palwasha Y Khan 1 collaboration

Tom A Yates 1 collaboration

Muhammad Osman 1 collaboration

Robin M Warren 1 collaboration

Yuri van der Heijden 1 collaboration

Edward A Nardell 1 collaboration

David Moore 1 collaboration

Neel Gandhi 1 collaboration

Anneke C Hesseling 1 collaboration

Valerie Mizrahi 1 collaboration

Roxana Rustomjee 1 collaboration

N F Walker 1 collaboration

F Karim 1 collaboration

M Y S Moosa 1 collaboration

S Moodley 1 collaboration

M Mazibuko 1 collaboration

K Khan 1 collaboration

T R Sterling 1 collaboration

Y F van der Heijden 1 collaboration

A D Grant 1 collaboration

P T Elkington 1 collaboration

A Pym 1 collaboration

A Leslie 1 collaboration

Anthony van Rooyen 1 collaboration

Evatt Chirgwin 1 collaboration

Aston L Arthur 1 collaboration

Jo Mackisack 1 collaboration

Andrew Mathews 1 collaboration

Lisa Kirkland 1 collaboration

Åsa Nordgren 1 collaboration

Max R O'Donnell 1 collaboration

Michelle H Larsen 1 collaboration

Tyler S Brown 1 collaboration

Paras Jain 1 collaboration

Vanisha Munsamy 1 collaboration

Allison Wolf 1 collaboration

Lorenzo Uccellini 1 collaboration

Farina Karim 1 collaboration

William R Jacobs 1 collaboration

Jenny Reidy-Crofts 1 collaboration

Andrew Matthews 1 collaboration

James Gardner 1 collaboration

Anthony R van Rooyen 1 collaboration

Owain R Edwards 1 collaboration

Seung-Joon Ahn 1 collaboration

Alicia Leroux 1 collaboration

Philip Süess 1 collaboration

Dariane Souza 1 collaboration

Emmanouil Roditakis 1 collaboration

Virginia Balanza 1 collaboration

Gian Luca Di Tanna 1 collaboration

Ali Raza Khaki 1 collaboration

Kerrigan McCarthy 1 collaboration

Helen Cox 1 collaboration

Lucy Mupfumi 1 collaboration

Anete Trajman 1 collaboration

Lynn Sodai Zijenah 1 collaboration

Peter Mason 1 collaboration

Tsitsi Bandason 1 collaboration

Betina Durovni 1 collaboration

Wilbert Bara 1 collaboration

Chacha Mangu 1 collaboration

Peter Mwaba 1 collaboration

Frank Cobelens 1 collaboration

Mark P Nicol 1 collaboration

Gavin Churchyard 1 collaboration

Katherine Fielding 1 collaboration

John Z Metcalfe 1 collaboration

Anil Pooran 1 collaboration

Lynn Zijenah 1 collaboration

Lawrence Mwenge 1 collaboration

Farirai Mutenherwa 1 collaboration

Paul Lecesse 1 collaboration

John Metcalfe 1 collaboration

Hojoon Sohn 1 collaboration

Jonny Peter 1 collaboration

David Dowdy 1 collaboration

Amy McLeman 1 collaboration

Rafael A Homem 1 collaboration

Christoph Zimmer 1 collaboration

Rebecca J Reid 1 collaboration

Vassilis Douris 1 collaboration

Richard Ffrench Constant 1 collaboration

Erick M G Cordeiro 1 collaboration

Joanna Mackisack 1 collaboration

Thomas C Mathers 1 collaboration

Fabrice Legeai 1 collaboration

Stéphanie Robin 1 collaboration

Hannah J Burrack 1 collaboration

Kamel Charaabi 1 collaboration

Ian Denholm 1 collaboration

Christian C Figueroa 1 collaboration

Georg Jander 1 collaboration

John T Margaritopoulos 1 collaboration

Emanuele Mazzoni 1 collaboration

Claudio C Ramírez 1 collaboration

Guangwei Ren 1 collaboration

Ilona Stepanyan 1 collaboration

Nina V Voronova 1 collaboration

Alex C C Wilson 1 collaboration

Gao Xi-Wu 1 collaboration

Young-Nam Youn 1 collaboration

Jean-Christophe Simon 1 collaboration

Andrias O O'Reilly 1 collaboration

Julian Haas 1 collaboration

Ellie Bushnell-Crowther 1 collaboration

Jeremy Field 1 collaboration

David R Nelson 1 collaboration

John G M Mina 1 collaboration

Tobias Baril 1 collaboration

Camus Nimmo 1 collaboration

Arturo Torres Ortiz 1 collaboration

Cedric C S Tan 1 collaboration

Juanita Pang 1 collaboration

Mislav Acman 1 collaboration

James Millard 1 collaboration

Max O'Donnell 1 collaboration

Ola B Brynildsrud 1 collaboration

Louis Grandjean 1 collaboration

Xavier Didelot 1 collaboration

François Balloux 1 collaboration

Lucy van Dorp 1 collaboration