Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing.

Antitubercular Agents / pharmacology Bacteriophages / genetics Drug Resistance, Bacterial / drug effects Extensively Drug-Resistant Tuberculosis / drug therapy Flow Cytometry / methods Green Fluorescent Proteins / genetics Humans Microbial Sensitivity Tests Mycobacterium tuberculosis / drug effects Polymorphism, Single Nucleotide Rifampin / pharmacology Sputum / microbiology Tuberculosis, Pulmonary / drug therapy Whole Genome Sequencing
South Africa extensively drug-resistant tuberculosis heteroresistance phage tuberculosis whole-genome sequencing

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
04 2019
Historique:
received: 28 08 2018
accepted: 14 12 2018
pubmed: 24 1 2019
medline: 11 3 2020
entrez: 24 1 2019
Statut: epublish

Résumé

A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency

Identifiants

DOI: 10.1128/AAC.01834-18 PMID: 30670422 PMC: PMC6437479
pubmed: 30670422
pii: AAC.01834-18
doi: 10.1128/AAC.01834-18
pmc: PMC6437479
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Green Fluorescent Proteins 147336-22-9
Rifampin VJT6J7R4TR

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI098479
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114900
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007061
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2019 American Society for Microbiology.

Références

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Auteurs

Max R O'Donnell (MR)

Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA mo2130@columbia.edu.
Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA.
Centre for AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.

Michelle H Larsen (MH)

Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Tyler S Brown (TS)

Infectious Diseases Division, Massachusetts General Hospital, Boston, Massachusetts, USA.

Paras Jain (P)

Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Vanisha Munsamy (V)

Africa Health Research Institute (AHRI), Durban, South Africa.

Allison Wolf (A)

Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.

Lorenzo Uccellini (L)

Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.

Farina Karim (F)

Africa Health Research Institute (AHRI), Durban, South Africa.

Tulio de Oliveira (T)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Barun Mathema (B)

Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA.

William R Jacobs (WR)

Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Alexander Pym (A)

Africa Health Research Institute (AHRI), Durban, South Africa.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Early Detection of Emergent Extensively...
questionsmedicales.fr › Virus › Bactériophages › Early Detection of Emergent Extensively...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Early Detection of Emergent Extensively...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Tuberculose multirésistante › Tuberculose ultrarésistante aux médicaments › Early Detection of Emergent Extensively...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Early Detection of Emergent Extensively...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines luminescentes › Protéines à fluorescence verte › Early Detection of Emergent Extensively...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early Detection of Emergent Extensively...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Early Detection of Emergent Extensively...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Early Detection of Emergent Extensively...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Early Detection of Emergent Extensively...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Lactames macrocycliques › Rifamycine › Rifampicine › Early Detection of Emergent Extensively...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Expectoration › Early Detection of Emergent Extensively...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Tuberculose pulmonaire › Early Detection of Emergent Extensively...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Early Detection of Emergent Extensively...