Alexandre Hinzpeter

Affiliations

INSERM U1151, Institut Necker Enfants Malades, Université de Paris, 75015, Paris, France.

Publications (25)

New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.

Scientific reports

Avec: Sara Bitam , Ahmad Elbahnsi , Geordie Creste , Iwona Pranke , Benoit Chevalier , Farouk Berhal , Brice Hoffmann , Nathalie Servel , Nesrine Baatalah , Danielle Tondelier , Aurelie Hatton , Christelle Moquereau , Mélanie Faria Da Cunha , Alexandra Pastor , Agathe Lepissier , Alexandre Hinzpeter , Jean-Paul Mornon , Guillaume Prestat , Aleksander Edelman , Isabelle Callebaut , Christine Gravier-Pelletier , Isabelle Sermet-Gaudelus

Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites.

Cellular and molecular life sciences : CMLS

Avec: Kusumika Saha , Benoit Chevalier , Stéphane Doly , Nesrine Baatallah , Thomas Guilbert , Iwona Pranke , Mark G H Scott , Hervé Enslen , Chiara Guerrera , Cérina Chuon , Aleksander Edelman , Isabelle Sermet-Gaudelus , Alexandre Hinzpeter , Stefano Marullo

Exon identity influences splicing induced by exonic variants and in silico prediction efficacy.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Natacha Martin , Anne Bergougnoux , Nesrine Baatallah , Benoit Chevalier , Jessica Varilh , David Baux , Bruno Costes , Pascale Fanen , Caroline Raynal , Isabelle Sermet-Gaudelus , Emmanuelle Girodon , Magali Taulan-Cadars , Alexandre Hinzpeter

Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.

Cellular and molecular life sciences : CMLS

Avec: Nesrine Baatallah , Ahmad Elbahnsi , Jean-Paul Mornon , Benoit Chevalier , Iwona Pranke , Nathalie Servel , Renaud Zelli , Jean-Luc Décout , Aleksander Edelman , Isabelle Sermet-Gaudelus , Isabelle Callebaut , Alexandre Hinzpeter

TLN468 changes the pattern of tRNA used to read through premature termination codons in CFTR.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Sabrina Karri , David Cornu , Claudia Serot , Lynda Biri , Aurélie Hatton , Elise Dréanot , Camille Rullaud , Iwona Pranke , Isabelle Sermet-Gaudelus , Alexandre Hinzpeter , Laure Bidou , Olivier Namy

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

Cellular and molecular life sciences : CMLS

Avec: Iwona Maria Pranke , Benoit Chevalier , Aiswarya Premchandar , Nesrine Baatallah , Kamil F Tomaszewski , Sara Bitam , Danielle Tondelier , Anita Golec , Jan Stolk , Gergely L Lukacs , Pieter S Hiemstra , Michal Dadlez , David A Lomas , James A Irving , Agnes Delaunay-Moisan , Eelco van Anken , Alexandre Hinzpeter , Isabelle Sermet-Gaudelus , Aleksander Edelman

Nonsense mutations accelerate lung disease and decrease survival of cystic fibrosis children.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Annalisa Orenti , Iwona Pranke , Caroline Faucon , Jessica Varilh , Aurelie Hatton , Anita Golec , Clemence Dehillotte , Isabelle Durieu , Philippe Reix , Pierre-Régis Burgel , Dominique Grenet , Céline Tasset , Elsa Gachelin , Caroline Perisson , Agathe Lepissier , Elise Dreano , Danielle Tondelier , Benoit Chevalier , Laurence Weiss , Sébastien Kiefer , Muriel Laurans , Raphael Chiron , Lydie Lemonnier , Christophe Marguet , Andreas Jung , Aleksander Edelman , Bat-Sheva Kerem , Emmanuelle Girodon , Magali Taulan-Cadars , Alexandre Hinzpeter , Eitan Kerem , Lutz Naehrlich , Isabelle Sermet-Gaudelus , Auteur inconnu

Unsolved severe chronic rhinosinusitis elucidated by extensive

Clinical case reports

Avec: Fanny Degrugillier , Stéphanie Simon , Abdel Aissat , Natascha Remus , Chadia Mekki , Xavier Decrouy , Aurélie Hatton , Alexandre Hinzpeter , Brice Hoffmann , Isabelle Sermet-Gaudelus , Isabelle Callebaut , Pascale Fanen , Virginie Prulière-Escabasse

Theratyping cystic fibrosis patients to guide elexacaftor/tezacaftor/ivacaftor out-of-label prescription.

The European respiratory journal

Avec: Elise Dreano , Pierre Régis Burgel , Aurelie Hatton , Naim Bouazza , Benoit Chevalier , Julie Macey , Sylvie Leroy , Isabelle Durieu , Laurence Weiss , Dominique Grenet , Nathalie Stremler , Camille Ohlmann , Philippe Reix , Michele Porzio , Pauline Roux Claude , Natacha Rémus , Benoit Douvry , Sylvie Montcouquiol , Laure Cosson , Julie Mankikian , Jeanne Languepin , Veronique Houdouin , Laurence Le Clainche , Anne Guillaumot , Delphine Pouradier , Adrien Tissot , Pascaline Priou , Laurent Mély , Frederique Chedevergne , Muriel Lebourgeois , Jean Lebihan , Clémence Martin , Flora Zavala , Jennifer Da Silva , Lydie Lemonnier , Mairead Kelly-Aubert , Anita Golec , Pierre Foucaud , Christophe Marguet , Aleksander Edelman , Alexandre Hinzpeter , Paola de Carli , Emmanuelle Girodon , Isabelle Sermet-Gaudelus , Iwona Pranke , Auteur inconnu

Design of Crotoxin-Based Peptides with Potentiator Activity Targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

Journal of molecular biology

Avec: Marc Ravatin , Norbert Odolczyk , Nathalie Servel , J Iñaki Guijarro , Eric Tagat , Benoit Chevalier , Nesrine Baatallah , Pierre-Jean Corringer , Gergely L Lukács , Aleksander Edelman , Piotr Zielenkiewicz , Jean-Marie Chambard , Alexandre Hinzpeter , Grazyna Faure

Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis.

Scientific reports

Avec: Juliette Simonin , Emmanuelle Bille , Gilles Crambert , Sabrina Noel , Elise Dreano , Aurélie Edwards , Aurélie Hatton , Iwona Pranke , Bérengère Villeret , Charles-Henry Cottart , Jean-Patrick Vrel , Valérie Urbach , Nesrine Baatallah , Alexandre Hinzpeter , Anita Golec , Lhousseine Touqui , Xavier Nassif , Luis J V Galietta , Gabrielle Planelles , Jean-Michel Sallenave , Aleksander Edelman , Isabelle Sermet-Gaudelus

Emerging Therapeutic Approaches for Cystic Fibrosis. From Gene Editing to Personalized Medicine.

Frontiers in pharmacology

Avec: Iwona Pranke , Anita Golec , Alexandre Hinzpeter , Aleksander Edelman , Isabelle Sermet-Gaudelus

The influence of CFTR complex alleles on precision therapy of cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Benoit Chevalier , Alexandre Hinzpeter

Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.

European journal of medicinal chemistry

Avec: Lionel Froux , Ahmad Elbahnsi , Benjamin Boucherle , Arnaud Billet , Nesrine Baatallah , Brice Hoffmann , Julien Alliot , Renaud Zelli , Wael Zeinyeh , Romain Haudecoeur , Benoit Chevalier , Antoine Fortuné , Sandra Mirval , Christophe Simard , Pierre Lehn , Jean-Paul Mornon , Alexandre Hinzpeter , Frédéric Becq , Isabelle Callebaut , Jean-Luc Décout

Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice.

Scientific reports

Avec: Mélanie Faria da Cunha , Iwona Pranke , Ali Sassi , Christiane Schreiweis , Stéphanie Moriceau , Dragana Vidovic , Aurélie Hatton , Mariane Sylvia Carlon , Geordie Creste , Farouk Berhal , Guillaume Prestat , Romain Freund , Norbert Odolczyk , Jean Philippe Jais , Christine Gravier-Pelletier , Piotr Zielenkiewicz , Vincent Jullien , Alexandre Hinzpeter , Franck Oury , Aleksander Edelman , Isabelle Sermet-Gaudelus

Reclassifying inconclusive diagnosis after newborn screening for cystic fibrosis. Moving forward.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Aurelie Hatton , Anne Bergougnoux , Katarzyna Zybert , Benoit Chevalier , Myriam Mesbahi , Jean Pierre Altéri , Katarzyna Walicka-Serzysko , Magdalena Postek , Magali Taulan-Cadars , Aleksander Edelman , Alexandre Hinzpeter , Mireille Claustres , Emmanuelle Girodon , Caroline Raynal , Isabelle Sermet-Gaudelus , Dorota Sands

[Therapeutics in cystic fibrosis: Clinical revolution and new challenges].

Medecine sciences : M/S

Avec: Emmanuelle Bardin , Iwona Pranke , Alexandre Hinzpeter , Isabelle Sermet-Gaudelus

Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction.

American journal of respiratory cell and molecular biology

Avec: Hélène Le Ribeuz , Anaïs Saint-Martin Willer , Benoit Chevalier , Maria Sancho , Bastien Masson , Mélanie Eyries , Vincent Jung , Ida Chiara Guerrera , Mary Dutheil , Kristelle El Jekmek , Loann Laubry , Gilles Carpentier , Francisco Perez-Vizcaino , Ly Tu , Christophe Guignabert , Marie-Camille Chaumais , Christine Péchoux , Marc Humbert , Alexandre Hinzpeter , Olaf Mercier , Véronique Capuano , David Montani , Fabrice Antigny

Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants.

International journal of molecular sciences

Avec: Nesrine Baatallah , Ahmad Elbahnsi , Benoit Chevalier , Solène Castanier , Jean-Paul Mornon , Iwona Pranke , Aleksander Edelman , Isabelle Sermet-Gaudelus , Isabelle Callebaut , Alexandre Hinzpeter

Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis.

Scientific reports

Predictive factors for lumacaftor/ivacaftor clinical response.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Alexandra Masson , Elena K Schneider-Futschik , Nesrine Baatallah , Thao Nguyen-Khoa , Emmanuelle Girodon , Aurélie Hatton , Thomas Flament , Muriel Le Bourgeois , Frederique Chedevergne , Céline Bailly , Sylvia Kyrilli , Diane Achimastos , Alexandre Hinzpeter , Aleksander Edelman , Isabelle Sermet-Gaudelus

Correlating genotype with phenotype using CFTR-mediated whole-cell Cl

The Journal of physiology

Avec: Sabrina Noel , Nathalie Servel , Aurélie Hatton , Anita Golec , Mayuree Rodrat , Demi R S Ng , Hongyu Li , Iwona Pranke , Alexandre Hinzpeter , Aleksander Edelman , David N Sheppard , Isabelle Sermet-Gaudelus

Modulators of CFTR. Updates on clinical development and future directions.

European journal of medicinal chemistry

Avec: Emmanuelle Bardin , Alexandra Pastor , Michaela Semeraro , Anita Golec , Kate Hayes , Benoit Chevalier , Farouk Berhal , Guillaume Prestat , Alexandre Hinzpeter , Christine Gravier-Pelletier , Iwona Pranke , Isabelle Sermet-Gaudelus

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.

International journal of molecular sciences

Avec: Benoît Chevalier , Nesrine Baatallah , Matthieu Najm , Solène Castanier , Vincent Jung , Iwona Pranke , Anita Golec , Véronique Stoven , Stefano Marullo , Fabrice Antigny , Ida Chiara Guerrera , Isabelle Sermet-Gaudelus , Aleksander Edelman , Alexandre Hinzpeter

Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation.

Cellular and molecular life sciences : CMLS

Avec: Solène Castanier , Ahmad Elbahnsi , Benoit Chevalier , Nesrine Baatallah , Iwona Pranke , Lynda Berri , Aleksander Edelman , Isabelle Sermet-Gaudelus , Jean-Paul Mornon , Isabelle Callebaut , Alexandre Hinzpeter

Réseau de co-auteurs

Isabelle Sermet-Gaudelus 21 collaborations

Aleksander Edelman 17 collaborations

Iwona Pranke 16 collaborations

Benoit Chevalier 15 collaborations

Nesrine Baatallah 12 collaborations

Anita Golec 9 collaborations

Aurélie Hatton 7 collaborations

Isabelle Callebaut 6 collaborations

Ahmad Elbahnsi 5 collaborations

Jean-Paul Mornon 5 collaborations

Emmanuelle Girodon 5 collaborations

Nathalie Servel 4 collaborations

Aurelie Hatton 4 collaborations

Elise Dreano 4 collaborations

Farouk Berhal 3 collaborations

Brice Hoffmann 3 collaborations

Danielle Tondelier 3 collaborations

Guillaume Prestat 3 collaborations

Christine Gravier-Pelletier 3 collaborations

Magali Taulan-Cadars 3 collaborations

Sabrina Noel 3 collaborations

Solène Castanier 3 collaborations

Sara Bitam 2 collaborations

Geordie Creste 2 collaborations

Alexandra Pastor 2 collaborations

Agathe Lepissier 2 collaborations

Stefano Marullo 2 collaborations

Anne Bergougnoux 2 collaborations

Jessica Varilh 2 collaborations

Pascale Fanen 2 collaborations

Caroline Raynal 2 collaborations

Renaud Zelli 2 collaborations

Jean-Luc Décout 2 collaborations

Isabelle Durieu 2 collaborations

Philippe Reix 2 collaborations

Dominique Grenet 2 collaborations

Laurence Weiss 2 collaborations

Lydie Lemonnier 2 collaborations

Christophe Marguet 2 collaborations

None None 2 collaborations

Frederique Chedevergne 2 collaborations

Norbert Odolczyk 2 collaborations

Piotr Zielenkiewicz 2 collaborations

Juliette Simonin 2 collaborations

Emmanuelle Bille 2 collaborations

Gilles Crambert 2 collaborations

Aurélie Edwards 2 collaborations

Bérengère Villeret 2 collaborations

Charles-Henry Cottart 2 collaborations

Jean-Patrick Vrel 2 collaborations

Valérie Urbach 2 collaborations

Lhousseine Touqui 2 collaborations

Xavier Nassif 2 collaborations

Luis J V Galietta 2 collaborations

Gabrielle Planelles 2 collaborations

Jean-Michel Sallenave 2 collaborations

Emmanuelle Bardin 2 collaborations

Vincent Jung 2 collaborations

Ida Chiara Guerrera 2 collaborations

Fabrice Antigny 2 collaborations

Nesrine Baatalah 1 collaboration

Christelle Moquereau 1 collaboration

Mélanie Faria Da Cunha 1 collaboration

Kusumika Saha 1 collaboration

Stéphane Doly 1 collaboration

Thomas Guilbert 1 collaboration

Mark G H Scott 1 collaboration

Hervé Enslen 1 collaboration

Chiara Guerrera 1 collaboration

Cérina Chuon 1 collaboration

Natacha Martin 1 collaboration

David Baux 1 collaboration

Bruno Costes 1 collaboration

Sabrina Karri 1 collaboration

David Cornu 1 collaboration

Claudia Serot 1 collaboration

Lynda Biri 1 collaboration

Elise Dréanot 1 collaboration

Camille Rullaud 1 collaboration

Laure Bidou 1 collaboration

Olivier Namy 1 collaboration

Iwona Maria Pranke 1 collaboration

Aiswarya Premchandar 1 collaboration

Kamil F Tomaszewski 1 collaboration

Jan Stolk 1 collaboration

Gergely L Lukacs 1 collaboration

Pieter S Hiemstra 1 collaboration

Michal Dadlez 1 collaboration

David A Lomas 1 collaboration

James A Irving 1 collaboration

Agnes Delaunay-Moisan 1 collaboration

Eelco van Anken 1 collaboration

Annalisa Orenti 1 collaboration

Caroline Faucon 1 collaboration

Clemence Dehillotte 1 collaboration

Pierre-Régis Burgel 1 collaboration

Céline Tasset 1 collaboration

Elsa Gachelin 1 collaboration

Caroline Perisson 1 collaboration

Sébastien Kiefer 1 collaboration

Muriel Laurans 1 collaboration

Raphael Chiron 1 collaboration

Andreas Jung 1 collaboration

Bat-Sheva Kerem 1 collaboration

Eitan Kerem 1 collaboration

Lutz Naehrlich 1 collaboration

Fanny Degrugillier 1 collaboration

Stéphanie Simon 1 collaboration

Abdel Aissat 1 collaboration

Natascha Remus 1 collaboration

Chadia Mekki 1 collaboration

Xavier Decrouy 1 collaboration

Virginie Prulière-Escabasse 1 collaboration

Pierre Régis Burgel 1 collaboration

Naim Bouazza 1 collaboration

Julie Macey 1 collaboration

Sylvie Leroy 1 collaboration

Nathalie Stremler 1 collaboration

Camille Ohlmann 1 collaboration

Michele Porzio 1 collaboration

Pauline Roux Claude 1 collaboration

Natacha Rémus 1 collaboration

Benoit Douvry 1 collaboration

Sylvie Montcouquiol 1 collaboration

Laure Cosson 1 collaboration

Julie Mankikian 1 collaboration

Jeanne Languepin 1 collaboration

Veronique Houdouin 1 collaboration

Laurence Le Clainche 1 collaboration

Anne Guillaumot 1 collaboration

Delphine Pouradier 1 collaboration

Adrien Tissot 1 collaboration

Pascaline Priou 1 collaboration

Laurent Mély 1 collaboration

Muriel Lebourgeois 1 collaboration

Jean Lebihan 1 collaboration

Clémence Martin 1 collaboration

Flora Zavala 1 collaboration

Jennifer Da Silva 1 collaboration

Mairead Kelly-Aubert 1 collaboration

Pierre Foucaud 1 collaboration

Paola de Carli 1 collaboration

Marc Ravatin 1 collaboration

J Iñaki Guijarro 1 collaboration

Eric Tagat 1 collaboration

Pierre-Jean Corringer 1 collaboration

Gergely L Lukács 1 collaboration

Jean-Marie Chambard 1 collaboration

Grazyna Faure 1 collaboration

Lionel Froux 1 collaboration

Benjamin Boucherle 1 collaboration

Arnaud Billet 1 collaboration

Julien Alliot 1 collaboration

Wael Zeinyeh 1 collaboration

Romain Haudecoeur 1 collaboration

Antoine Fortuné 1 collaboration

Sandra Mirval 1 collaboration

Christophe Simard 1 collaboration

Pierre Lehn 1 collaboration

Frédéric Becq 1 collaboration

Mélanie Faria da Cunha 1 collaboration

Ali Sassi 1 collaboration

Christiane Schreiweis 1 collaboration

Stéphanie Moriceau 1 collaboration

Dragana Vidovic 1 collaboration

Mariane Sylvia Carlon 1 collaboration

Romain Freund 1 collaboration

Jean Philippe Jais 1 collaboration

Vincent Jullien 1 collaboration

Franck Oury 1 collaboration

Katarzyna Zybert 1 collaboration

Myriam Mesbahi 1 collaboration

Jean Pierre Altéri 1 collaboration

Katarzyna Walicka-Serzysko 1 collaboration

Magdalena Postek 1 collaboration

Mireille Claustres 1 collaboration

Dorota Sands 1 collaboration

Hélène Le Ribeuz 1 collaboration

Anaïs Saint-Martin Willer 1 collaboration

Maria Sancho 1 collaboration

Bastien Masson 1 collaboration

Mélanie Eyries 1 collaboration

Mary Dutheil 1 collaboration

Kristelle El Jekmek 1 collaboration

Loann Laubry 1 collaboration

Gilles Carpentier 1 collaboration

Francisco Perez-Vizcaino 1 collaboration

Ly Tu 1 collaboration

Christophe Guignabert 1 collaboration

Marie-Camille Chaumais 1 collaboration

Christine Péchoux 1 collaboration

Marc Humbert 1 collaboration

Olaf Mercier 1 collaboration

Véronique Capuano 1 collaboration

David Montani 1 collaboration

Alexandra Masson 1 collaboration

Elena K Schneider-Futschik 1 collaboration

Thao Nguyen-Khoa 1 collaboration

Thomas Flament 1 collaboration

Muriel Le Bourgeois 1 collaboration

Céline Bailly 1 collaboration

Sylvia Kyrilli 1 collaboration

Diane Achimastos 1 collaboration

Mayuree Rodrat 1 collaboration

Demi R S Ng 1 collaboration

Hongyu Li 1 collaboration

David N Sheppard 1 collaboration

Michaela Semeraro 1 collaboration

Kate Hayes 1 collaboration

Benoît Chevalier 1 collaboration

Matthieu Najm 1 collaboration

Véronique Stoven 1 collaboration

Lynda Berri 1 collaboration