Andreas Machl

Affiliations

EMD Serono, Billerica, Massachusetts, USA.

Publications (8)

Tumor growth inhibition modeling in patients with second line biliary tract cancer and first line non-small cell lung cancer based on bintrafusp alfa trials.

CPT: pharmacometrics & systems pharmacology

Avec: Ana-Marija Milenković-Grišić , Nadia Terranova , Diane R Mould , Yulia Vugmeyster , Thomas Mrowiec , Andreas Machl , Pascal Girard , Karthik Venkatakrishnan , Akash Khandelwal

Bintrafusp Alfa: A Bifunctional Fusion Protein Targeting PD-L1 and TGF-β, in Patients with Pretreated Colorectal Cancer: Results from a Phase I Trial.

The oncologist

Avec: Alexander Spira , Michael S Wertheim , Edward J Kim , Benjamin Tan , Heinz-Josef Lenz , Petros Nikolinakos , Patricia L Rich , Genevieve Jehl , Andreas Machl , Rena Ito , James L Gulley , Scott Kopetz

Bintrafusp Alfa Versus Pembrolizumab in Patients With Treatment-Naive, Programmed Death-Ligand 1-High Advanced NSCLC: A Randomized, Open-Label, Phase 3 Trial.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Byoung Chul Cho , Jong Seok Lee , Yi-Long Wu , Irfan Cicin , Manuel Cobo Dols , Myung-Ju Ahn , Kristof Cuppens , Rémi Veillon , Ernest Nadal , Josiane Mourão Dias , Claudio Martin , Martin Reck , Edward B Garon , Enriqueta Felip , Luis Paz-Ares , Francoise Mornex , Everett E Vokes , Alex A Adjei , Clifford Robinson , Masashi Sato , Yulia Vugmeyster , Andreas Machl , Francois Audhuy , Surendra Chaudhary , Fabrice Barlesi

Efficacy, safety, and biomarker analyses of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with advanced non-small cell lung cancer.

Journal for immunotherapy of cancer

Avec: Arun Rajan , Houssein Abdul Sater , Osama Rahma , Richy Agajanian , Wiem Lassoued , Jennifer L Marté , Yo-Ting Tsai , Renee N Donahue , Elizabeth Lamping , Shania Bailey , Andrew Weisman , Beatriz Walter-Rodriguez , Rena Ito , Yulia Vugmeyster , Masashi Sato , Andreas Machl , Jeffrey Schlom , James L Gulley

Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.

Journal of medicinal chemistry

Avec: Lizbeth DeSelm , Bayard Huck , Ruoxi Lan , Constantin Neagu , Justin Potnick , Yufang Xiao , Xiaoling Chen , Reinaldo Jones , Thomas E Richardson , Brian H Heasley , Thomas Haxell , Joseph Moore , Hui Tian , Katrin Georgi , Felix Rohdich , Amanda Sutton , Theresa Johnson , Igor Mochalkin , Jennifer Jackson , Jing Lin , Lindsey Crowley , Andreas Machl , Anderson Clark , Erik Wilker , Brian Sherer , Andreas Goutopoulos

Phase I study of peposertib and avelumab with or without palliative radiotherapy in patients with advanced solid tumors.

ESMO open

Avec: B Perez , R Aljumaily , T U Marron , M R Shafique , H Burris , W T Iams , S J Chmura , J J Luke , W Edenfield , D Sohal , X Liao , C Boesler , A Machl , J Seebeck , A Becker , B Guenther , A Rodriguez-Gutierrez , S J Antonia

Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.

Bioorganic & medicinal chemistry letters

Avec: Yufang Xiao , Bayard R Huck , Ruoxi Lan , Lizbeth DeSelm , Xiaoling Chen , Hui Qiu , Constantin Neagu , Theresa Johnson , Igor Mochalkin , Anna Gardberg , Xuliang Jiang , Hui Tian , Vikram Dutt , Dusica Santos , Jared Head , Jennifer Jackson , Sakeena Syed , Jing Lin , Erik Wilker , Jianguo Ma , Anderson Clark , Andreas Machl , Donald Bankston , Christopher C V Jones , Andreas Goutopoulos , Brian Sherer

Phase 2 trial of bintrafusp alfa as second-line therapy for patients with locally advanced/metastatic biliary tract cancers.

Hepatology (Baltimore, Md.)

Avec: Changhoon Yoo , Milind M Javle , Helena Verdaguer Mata , Filippo de Braud , Jörg Trojan , Jean-Luc Raoul , Jin Won Kim , Makoto Ueno , Choong-Kun Lee , Susumu Hijioka , Antonio Cubillo , Junji Furuse , Nilofer Azad , Masashi Sato , Yulia Vugmeyster , Andreas Machl , Marcis Bajars , John Bridgewater , Do-Youn Oh , Mitesh J Borad

Réseau de co-auteurs

Yulia Vugmeyster 4 collaborations

Masashi Sato 3 collaborations

Rena Ito 2 collaborations

James L Gulley 2 collaborations

Lizbeth DeSelm 2 collaborations

Ruoxi Lan 2 collaborations

Constantin Neagu 2 collaborations

Yufang Xiao 2 collaborations

Xiaoling Chen 2 collaborations

Hui Tian 2 collaborations

Theresa Johnson 2 collaborations

Igor Mochalkin 2 collaborations

Jennifer Jackson 2 collaborations

Jing Lin 2 collaborations

Anderson Clark 2 collaborations

Erik Wilker 2 collaborations

Brian Sherer 2 collaborations

Andreas Goutopoulos 2 collaborations

Ana-Marija Milenković-Grišić 1 collaboration

Nadia Terranova 1 collaboration

Diane R Mould 1 collaboration

Thomas Mrowiec 1 collaboration

Pascal Girard 1 collaboration

Karthik Venkatakrishnan 1 collaboration

Akash Khandelwal 1 collaboration

Alexander Spira 1 collaboration

Michael S Wertheim 1 collaboration

Edward J Kim 1 collaboration

Benjamin Tan 1 collaboration

Heinz-Josef Lenz 1 collaboration

Petros Nikolinakos 1 collaboration

Patricia L Rich 1 collaboration

Genevieve Jehl 1 collaboration

Scott Kopetz 1 collaboration

Byoung Chul Cho 1 collaboration

Jong Seok Lee 1 collaboration

Yi-Long Wu 1 collaboration

Irfan Cicin 1 collaboration

Manuel Cobo Dols 1 collaboration

Myung-Ju Ahn 1 collaboration

Kristof Cuppens 1 collaboration

Rémi Veillon 1 collaboration

Ernest Nadal 1 collaboration

Josiane Mourão Dias 1 collaboration

Claudio Martin 1 collaboration

Martin Reck 1 collaboration

Edward B Garon 1 collaboration

Enriqueta Felip 1 collaboration

Luis Paz-Ares 1 collaboration

Francoise Mornex 1 collaboration

Everett E Vokes 1 collaboration

Alex A Adjei 1 collaboration

Clifford Robinson 1 collaboration

Francois Audhuy 1 collaboration

Surendra Chaudhary 1 collaboration

Fabrice Barlesi 1 collaboration

Arun Rajan 1 collaboration

Houssein Abdul Sater 1 collaboration

Osama Rahma 1 collaboration

Richy Agajanian 1 collaboration

Wiem Lassoued 1 collaboration

Jennifer L Marté 1 collaboration

Yo-Ting Tsai 1 collaboration

Renee N Donahue 1 collaboration

Elizabeth Lamping 1 collaboration

Shania Bailey 1 collaboration

Andrew Weisman 1 collaboration

Beatriz Walter-Rodriguez 1 collaboration

Jeffrey Schlom 1 collaboration

Bayard Huck 1 collaboration

Justin Potnick 1 collaboration

Reinaldo Jones 1 collaboration

Thomas E Richardson 1 collaboration

Brian H Heasley 1 collaboration

Thomas Haxell 1 collaboration

Joseph Moore 1 collaboration

Katrin Georgi 1 collaboration

Felix Rohdich 1 collaboration

Amanda Sutton 1 collaboration

Lindsey Crowley 1 collaboration

B Perez 1 collaboration

R Aljumaily 1 collaboration

T U Marron 1 collaboration

M R Shafique 1 collaboration

H Burris 1 collaboration

W T Iams 1 collaboration

S J Chmura 1 collaboration

J J Luke 1 collaboration

W Edenfield 1 collaboration

D Sohal 1 collaboration

X Liao 1 collaboration

C Boesler 1 collaboration

A Machl 1 collaboration

J Seebeck 1 collaboration

A Becker 1 collaboration

B Guenther 1 collaboration

A Rodriguez-Gutierrez 1 collaboration

S J Antonia 1 collaboration

Bayard R Huck 1 collaboration

Hui Qiu 1 collaboration

Anna Gardberg 1 collaboration

Xuliang Jiang 1 collaboration

Vikram Dutt 1 collaboration

Dusica Santos 1 collaboration

Jared Head 1 collaboration

Sakeena Syed 1 collaboration

Jianguo Ma 1 collaboration

Donald Bankston 1 collaboration

Christopher C V Jones 1 collaboration

Changhoon Yoo 1 collaboration

Milind M Javle 1 collaboration

Helena Verdaguer Mata 1 collaboration

Filippo de Braud 1 collaboration

Jörg Trojan 1 collaboration

Jean-Luc Raoul 1 collaboration

Jin Won Kim 1 collaboration

Makoto Ueno 1 collaboration

Choong-Kun Lee 1 collaboration

Susumu Hijioka 1 collaboration

Antonio Cubillo 1 collaboration

Junji Furuse 1 collaboration

Nilofer Azad 1 collaboration

Marcis Bajars 1 collaboration

John Bridgewater 1 collaboration

Do-Youn Oh 1 collaboration

Mitesh J Borad 1 collaboration