Anne Paccaly

Affiliations

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.

Publications (17)

Immunogenicity of Sarilumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Inadequate Responders or Intolerant to Disease-Modifying Antirheumatic Drugs.

Rheumatology and therapy

Avec: Alvin F Wells , Janie Parrino , Erin K Mangan , Anne Paccaly , Yong Lin , Christine Xu , Chunpeng Fan , Neil M H Graham , Hubert van Hoogstraten , Albert Torri

Phase I Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced Melanoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Avec: Omid Hamid , Karl D Lewis , Amy Weise , Meredith McKean , Kyriakos P Papadopoulos , John Crown , Tae Min Kim , Dae Ho Lee , Sajeve S Thomas , Janice Mehnert , John Kaczmar , Nehal J Lakhani , Kevin B Kim , Mark R Middleton , Guilherme Rabinowits , Alexander I Spira , Melinda Yushak , Inderjit Mehmi , Fang Fang , Shuquan Chen , Jayakumar Mani , Vladimir Jankovic , Fang Wang , Nathalie Fiaschi , Laura Brennan , Anne Paccaly , Sheila Masinde , Mark Salvati , Matthew G Fury , Glenn Kroog , Israel Lowy , Giuseppe Gullo

Subcutaneous Administration of Monoclonal Antibodies: Pharmacology, Delivery, Immunogenicity, and Learnings From Applications to Clinical Development.

Clinical pharmacology and therapeutics

Avec: John D Davis , Marçal Bravo Padros , Daniela J Conrado , Samit Ganguly , Xiaowen Guan , Hazem E Hassan , Anasuya Hazra , Susan C Irvin , Priya Jayachandran , Matthew P Kosloski , Kuan-Ju Lin , Kamalika Mukherjee , Anne Paccaly , Apostolos Papachristos , Michael A Partridge , Saileta Prabhu , Jennifer Visich , Erik S Welf , Xiaoying Xu , An Zhao , Min Zhu

Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis.

CPT: pharmacometrics & systems pharmacology

Avec: Pavel Kovalenko , Anne Paccaly , Anita Boyapati , Christine Xu , Gregory St John , Michael C Nivens , John D Davis , Ronda Rippley , A Thomas DiCioccio

Differential Binding of Sarilumab and Tocilizumab to IL-6Rα and Effects of Receptor Occupancy on Clinical Parameters.

Journal of clinical pharmacology

Avec: Christine Xu , Ashique Rafique , Terra Potocky , Anne Paccaly , Patrick Nolain , Qiang Lu , Melitza Iglesias-Rodriguez , Gregory St John , Michael C Nivens , Vanaja Kanamaluru , Jeanette Fairhurst , Tomonori Ishii , Rafael Maldonado , Ernest Choy , Paul Emery

Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial.

Nature medicine

Avec: Miranda Gogishvili , Tamar Melkadze , Tamta Makharadze , Davit Giorgadze , Mikhail Dvorkin , Konstantin Penkov , Konstantin Laktionov , Gia Nemsadze , Marina Nechaeva , Irina Rozhkova , Ewa Kalinka , Christian Gessner , Brizio Moreno-Jaime , Rodolfo Passalacqua , Siyu Li , Kristina McGuire , Manika Kaul , Anne Paccaly , Ruben G W Quek , Bo Gao , Frank Seebach , David M Weinreich , George D Yancopoulos , Israel Lowy , Giuseppe Gullo , Petra Rietschel

Population Pharmacokinetics of Sarilumab in Patients with Rheumatoid Arthritis.

Clinical pharmacokinetics

Avec: Christine Xu , Yaming Su , Anne Paccaly , Vanaja Kanamaluru

Bioanalytical Challenges due to Prior Checkpoint Inhibitor Exposure: Interference and Mitigation in Drug Concentration and Immunogenicity Assays.

The AAPS journal

Avec: Andrew F Dengler , Rachel Weiss , Tiffany Truong , Susan C Irvin , Nidhi Gadhia , Mohamed Hassanein , Camille Georgaros , Jessica-Ann Taylor , Anne Paccaly , Giane Sumner , Matthew D Andisik , Albert Torri , Michael A Partridge

Population pharmacokinetics modeling and exposure-response analyses of cemiplimab in patients with recurrent or metastatic cervical cancer.

CPT: pharmacometrics & systems pharmacology

Avec: Jenny-Hoa Nguyen , Daniel Epling , Nancy Dolphin , Anne Paccaly , Daniela Conrado , John D Davis , Nidal Al-Huniti

Immunogenicity of Cemiplimab: Low Incidence of Antidrug Antibodies and Cut-Point Suitability Across Tumor Types.

Journal of clinical pharmacology

Avec: Jenny L Valentine , Andrew Dengler , An Zhao , Tiffany Truong , Sean McAfee , Mohamed Hassanein , Susan C Irvin , Jihua Chen , Xiao Meng , Hong Yan , Albert Torri , Giane Sumner , Matthew D Andisik , Anne Paccaly , Michael A Partridge

Cemiplimab monotherapy in Japanese patients with recurrent or metastatic cervical cancer.

Cancer medicine

Avec: Kosei Hasegawa , Shunji Takahashi , Kimio Ushijima , Masao Okadome , Kan Yonemori , Harushige Yokota , Ignace Vergote , Bradley J Monk , Krishnansu S Tewari , Keiichi Fujiwara , Jingjin Li , Shaheda Jamil , Anne Paccaly , Kazuhiro Takehara , Tomoka Usami , Yoichi Aoki , Nao Suzuki , Yoichi Kobayashi , Yoshio Yoshida , Hidemichi Watari , Frank Seebach , Israel Lowy , Melissa Mathias , Matthew G Fury , Ana Oaknin

Safety and tolerability of subcutaneous sarilumab and intravenous tocilizumab in patients with rheumatoid arthritis.

Rheumatology (Oxford, England)

Avec: Paul Emery , Juan Rondon , Janie Parrino , Yong Lin , Claudia Pena-Rossi , Hubert van Hoogstraten , Neil M H Graham , Nancy Liu , Anne Paccaly , Richard Wu , Alberto Spindler

Population Pharmacokinetic-Pharmacodynamic Relationships of Sarilumab Using Disease Activity Score 28-Joint C-Reactive Protein and Absolute Neutrophil Counts in Patients with Rheumatoid Arthritis.

Clinical pharmacokinetics

Avec: Lei Ma , Christine Xu , Anne Paccaly , Vanaja Kanamaluru

First-In-Human Study of Cemiplimab Alone or In Combination with Radiotherapy and/or Low-dose Cyclophosphamide in Patients with Advanced Malignancies.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Kyriakos P Papadopoulos , Melissa L Johnson , Albert C Lockhart , Kathleen Moore , Gerald S Falchook , Silvia C Formenti , Aung Naing , Richard D Carvajal , Lee S Rosen , Glen J Weiss , Rom S Leidner , Jingjin Li , Anne Paccaly , Minjie Feng , Elizabeth Stankevich , Israel Lowy , Matthew G Fury , Marka R Crittenden

Dose exploration results from Phase 1 study of cemiplimab, a human monoclonal programmed death (PD)-1 antibody, in Japanese patients with advanced malignancies.

Cancer chemotherapy and pharmacology

Avec: Shigehisa Kitano , Toshio Shimizu , Takafumi Koyama , Takahiro Ebata , Satoru Iwasa , Shunsuke Kondo , Akihiko Shimomura , Yutaka Fujiwara , Noboru Yamamoto , Anne Paccaly , Siyu Li , Petra Rietschel , Tasha Sims

Safety and Immune Responses Following Anti-PD-1 Monoclonal Antibody Infusions in Healthy Persons With Human Immunodeficiency Virus on Antiretroviral Therapy.

Open forum infectious diseases

Avec: Cynthia L Gay , Ronald J Bosch , Ashley McKhann , Raymond Cha , Gene D Morse , Chanelle L Wimbish , Danielle M Campbell , Kendall F Moseley , Steven Hendrickx , Michael Messer , Constance A Benson , Edgar T Overton , Anne Paccaly , Vladimir Jankovic , Elizabeth Miller , Randall Tressler , Jonathan Z Li , Daniel R Kuritzkes , Bernard J C Macatangay , Joseph J Eron , W David Hardy , Auteur inconnu

First-In-Human Dose-Escalation Study of Fianlimab, an Anti-Lymphocyte Activation Gene-3 Antibody, with Cemiplimab in patients with advanced malignancies.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Nehal J Lakhani , Kyriakos P Papadopoulos , Melissa Lynne Johnson , Haeseong Park , Ding Wang , Timothy A Yap , Afshin Dowlati , Robert G Maki , Susanna Ulahannan , Filipa Lynce , Karen Kelly , Stephen Williamson , Jyoti Malhotra , Shuquan Chen , Ana Gonzalez Ortiz , Vladimir Jankovic , Anne Paccaly , Sheila Masinde , Jayakumar Mani , Israel Lowy , Giuseppe Gullo , Tasha Sims , Glenn Kroog

Réseau de co-auteurs

Christine Xu 5 collaborations

Israel Lowy 5 collaborations

Albert Torri 3 collaborations

Kyriakos P Papadopoulos 3 collaborations

Vladimir Jankovic 3 collaborations

Matthew G Fury 3 collaborations

Giuseppe Gullo 3 collaborations

John D Davis 3 collaborations

Susan C Irvin 3 collaborations

Michael A Partridge 3 collaborations

Vanaja Kanamaluru 3 collaborations

Janie Parrino 2 collaborations

Yong Lin 2 collaborations

Neil M H Graham 2 collaborations

Hubert van Hoogstraten 2 collaborations

Nehal J Lakhani 2 collaborations

Shuquan Chen 2 collaborations

Jayakumar Mani 2 collaborations

Sheila Masinde 2 collaborations

Glenn Kroog 2 collaborations

An Zhao 2 collaborations

Gregory St John 2 collaborations

Michael C Nivens 2 collaborations

Paul Emery 2 collaborations

Siyu Li 2 collaborations

Frank Seebach 2 collaborations

Petra Rietschel 2 collaborations

Tiffany Truong 2 collaborations

Mohamed Hassanein 2 collaborations

Giane Sumner 2 collaborations

Matthew D Andisik 2 collaborations

Jingjin Li 2 collaborations

Tasha Sims 2 collaborations

Alvin F Wells 1 collaboration

Erin K Mangan 1 collaboration

Chunpeng Fan 1 collaboration

Omid Hamid 1 collaboration

Karl D Lewis 1 collaboration

Amy Weise 1 collaboration

Meredith McKean 1 collaboration

John Crown 1 collaboration

Tae Min Kim 1 collaboration

Dae Ho Lee 1 collaboration

Sajeve S Thomas 1 collaboration

Janice Mehnert 1 collaboration

John Kaczmar 1 collaboration

Kevin B Kim 1 collaboration

Mark R Middleton 1 collaboration

Guilherme Rabinowits 1 collaboration

Alexander I Spira 1 collaboration

Melinda Yushak 1 collaboration

Inderjit Mehmi 1 collaboration

Fang Fang 1 collaboration

Fang Wang 1 collaboration

Nathalie Fiaschi 1 collaboration

Laura Brennan 1 collaboration

Mark Salvati 1 collaboration

Marçal Bravo Padros 1 collaboration

Daniela J Conrado 1 collaboration

Samit Ganguly 1 collaboration

Xiaowen Guan 1 collaboration

Hazem E Hassan 1 collaboration

Anasuya Hazra 1 collaboration

Priya Jayachandran 1 collaboration

Matthew P Kosloski 1 collaboration

Kuan-Ju Lin 1 collaboration

Kamalika Mukherjee 1 collaboration

Apostolos Papachristos 1 collaboration

Saileta Prabhu 1 collaboration

Jennifer Visich 1 collaboration

Erik S Welf 1 collaboration

Xiaoying Xu 1 collaboration

Min Zhu 1 collaboration

Pavel Kovalenko 1 collaboration

Anita Boyapati 1 collaboration

Ronda Rippley 1 collaboration

A Thomas DiCioccio 1 collaboration

Ashique Rafique 1 collaboration

Terra Potocky 1 collaboration

Patrick Nolain 1 collaboration

Qiang Lu 1 collaboration

Melitza Iglesias-Rodriguez 1 collaboration

Jeanette Fairhurst 1 collaboration

Tomonori Ishii 1 collaboration

Rafael Maldonado 1 collaboration

Ernest Choy 1 collaboration

Miranda Gogishvili 1 collaboration

Tamar Melkadze 1 collaboration

Tamta Makharadze 1 collaboration

Davit Giorgadze 1 collaboration

Mikhail Dvorkin 1 collaboration

Konstantin Penkov 1 collaboration

Konstantin Laktionov 1 collaboration

Gia Nemsadze 1 collaboration

Marina Nechaeva 1 collaboration

Irina Rozhkova 1 collaboration

Ewa Kalinka 1 collaboration

Christian Gessner 1 collaboration

Brizio Moreno-Jaime 1 collaboration

Rodolfo Passalacqua 1 collaboration

Kristina McGuire 1 collaboration

Manika Kaul 1 collaboration

Ruben G W Quek 1 collaboration

Bo Gao 1 collaboration

David M Weinreich 1 collaboration

George D Yancopoulos 1 collaboration

Yaming Su 1 collaboration

Andrew F Dengler 1 collaboration

Rachel Weiss 1 collaboration

Nidhi Gadhia 1 collaboration

Camille Georgaros 1 collaboration

Jessica-Ann Taylor 1 collaboration

Jenny-Hoa Nguyen 1 collaboration

Daniel Epling 1 collaboration

Nancy Dolphin 1 collaboration

Daniela Conrado 1 collaboration

Nidal Al-Huniti 1 collaboration

Jenny L Valentine 1 collaboration

Andrew Dengler 1 collaboration

Sean McAfee 1 collaboration

Jihua Chen 1 collaboration

Xiao Meng 1 collaboration

Hong Yan 1 collaboration

Kosei Hasegawa 1 collaboration

Shunji Takahashi 1 collaboration

Kimio Ushijima 1 collaboration

Masao Okadome 1 collaboration

Kan Yonemori 1 collaboration

Harushige Yokota 1 collaboration

Ignace Vergote 1 collaboration

Bradley J Monk 1 collaboration

Krishnansu S Tewari 1 collaboration

Keiichi Fujiwara 1 collaboration

Shaheda Jamil 1 collaboration

Kazuhiro Takehara 1 collaboration

Tomoka Usami 1 collaboration

Yoichi Aoki 1 collaboration

Nao Suzuki 1 collaboration

Yoichi Kobayashi 1 collaboration

Yoshio Yoshida 1 collaboration

Hidemichi Watari 1 collaboration

Melissa Mathias 1 collaboration

Ana Oaknin 1 collaboration

Juan Rondon 1 collaboration

Claudia Pena-Rossi 1 collaboration

Nancy Liu 1 collaboration

Richard Wu 1 collaboration

Alberto Spindler 1 collaboration

Lei Ma 1 collaboration

Melissa L Johnson 1 collaboration

Albert C Lockhart 1 collaboration

Kathleen Moore 1 collaboration

Gerald S Falchook 1 collaboration

Silvia C Formenti 1 collaboration

Aung Naing 1 collaboration

Richard D Carvajal 1 collaboration

Lee S Rosen 1 collaboration

Glen J Weiss 1 collaboration

Rom S Leidner 1 collaboration

Minjie Feng 1 collaboration

Elizabeth Stankevich 1 collaboration

Marka R Crittenden 1 collaboration

Shigehisa Kitano 1 collaboration

Toshio Shimizu 1 collaboration

Takafumi Koyama 1 collaboration

Takahiro Ebata 1 collaboration

Satoru Iwasa 1 collaboration

Shunsuke Kondo 1 collaboration

Akihiko Shimomura 1 collaboration

Yutaka Fujiwara 1 collaboration

Noboru Yamamoto 1 collaboration

Cynthia L Gay 1 collaboration

Ronald J Bosch 1 collaboration

Ashley McKhann 1 collaboration

Raymond Cha 1 collaboration

Gene D Morse 1 collaboration

Chanelle L Wimbish 1 collaboration

Danielle M Campbell 1 collaboration

Kendall F Moseley 1 collaboration

Steven Hendrickx 1 collaboration

Michael Messer 1 collaboration

Constance A Benson 1 collaboration

Edgar T Overton 1 collaboration

Elizabeth Miller 1 collaboration

Randall Tressler 1 collaboration

Jonathan Z Li 1 collaboration

Daniel R Kuritzkes 1 collaboration

Bernard J C Macatangay 1 collaboration

Joseph J Eron 1 collaboration

W David Hardy 1 collaboration

None None 1 collaboration

Melissa Lynne Johnson 1 collaboration

Haeseong Park 1 collaboration

Ding Wang 1 collaboration

Timothy A Yap 1 collaboration

Afshin Dowlati 1 collaboration

Robert G Maki 1 collaboration

Susanna Ulahannan 1 collaboration

Filipa Lynce 1 collaboration

Karen Kelly 1 collaboration

Stephen Williamson 1 collaboration

Jyoti Malhotra 1 collaboration

Ana Gonzalez Ortiz 1 collaboration