Benjamin Orris

Affiliations

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, United States.

Publications (6)

Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2.

DNA repair

Avec: Gaddiel Rodriguez , Benjamin Orris , Ananya Majumdar , Shridhar Bhat , James T Stivers

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies.

bioRxiv : the preprint server for biology

Avec: Benjamin Orris , Min Woo Sung , Shridhar Bhat , Yingrong Xu , Kevin W Huynh , Seungil Han , Darren C Johnson , Benedikt Bosbach , David J Shields , James T Stivers

Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.

ACS chemical biology

Avec: Matthew Egleston , Linghao Dong , A Hasan Howlader , Shridhar Bhat , Benjamin Orris , Mario A Bianchet , Marc M Greenberg , James T Stivers

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics.

Nucleic acids research

Avec: Benjamin Orris , Kevin W Huynh , Mark Ammirati , Seungil Han , Ben Bolaños , Jason Carmody , Matthew D Petroski , Benedikt Bosbach , David J Shields , James T Stivers

Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.

Nucleic acids research

Avec: Benjamin Orris , Min Woo Sung , Shridhar Bhat , Yingrong Xu , Kevin W Huynh , Seungil Han , Darren C Johnson , Benedikt Bosbach , David J Shields , James T Stivers

Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.

Molecular pharmacology

Avec: Eric S Christenson , Anthony Gizzi , Junru Cui , Matthew Egleston , Kyle J Seamon , Michael DePasquale , Benjamin Orris , Ben H Park , James T Stivers

Réseau de co-auteurs

James T Stivers 6 collaborations

Shridhar Bhat 4 collaborations

Kevin W Huynh 3 collaborations

Seungil Han 3 collaborations

Benedikt Bosbach 3 collaborations

David J Shields 3 collaborations

Min Woo Sung 2 collaborations

Yingrong Xu 2 collaborations

Darren C Johnson 2 collaborations

Matthew Egleston 2 collaborations

Gaddiel Rodriguez 1 collaboration

Ananya Majumdar 1 collaboration

Linghao Dong 1 collaboration

A Hasan Howlader 1 collaboration

Mario A Bianchet 1 collaboration

Marc M Greenberg 1 collaboration

Mark Ammirati 1 collaboration

Ben Bolaños 1 collaboration

Jason Carmody 1 collaboration

Matthew D Petroski 1 collaboration

Eric S Christenson 1 collaboration

Anthony Gizzi 1 collaboration

Junru Cui 1 collaboration

Kyle J Seamon 1 collaboration

Michael DePasquale 1 collaboration

Ben H Park 1 collaboration