Brian Topp

Affiliations

Merck & Co., Inc., Kenilworth, New Jersey, USA.

Publications (4)

Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response.

CPT: pharmacometrics & systems pharmacology

Avec: Rukmini Kumar , Kannan Thiagarajan , Lakshmanan Jagannathan , Liming Liu , Kapil Mayawala , Dinesh de Alwis , Brian Topp

Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1.

British journal of cancer

Avec: Sara Zalba , Virginia Belsúe , Brian Topp , Dinesh de Alwis , Maite Alvarez , Iñaki F Trocóniz , Pedro Berraondo , María J Garrido

Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.

CPT: pharmacometrics & systems pharmacology

Avec: Erica L Bradshaw , Mary E Spilker , Richard Zang , Loveleena Bansal , Handan He , Rhys D O Jones , Kha Le , Mark Penney , Edgar Schuck , Brian Topp , Alice Tsai , Christine Xu , Marjoleen J M A Nijsen , Jason R Chan

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.

Cancers

Avec: Aymara Sancho-Araiz , Sara Zalba , María J Garrido , Pedro Berraondo , Brian Topp , Dinesh de Alwis , Zinnia P Parra-Guillen , Víctor Mangas-Sanjuan , Iñaki F Trocóniz

Réseau de co-auteurs

Dinesh de Alwis 3 collaborations

Sara Zalba 2 collaborations

Iñaki F Trocóniz 2 collaborations

Pedro Berraondo 2 collaborations

María J Garrido 2 collaborations

Rukmini Kumar 1 collaboration

Kannan Thiagarajan 1 collaboration

Lakshmanan Jagannathan 1 collaboration

Liming Liu 1 collaboration

Kapil Mayawala 1 collaboration

Virginia Belsúe 1 collaboration

Maite Alvarez 1 collaboration

Erica L Bradshaw 1 collaboration

Mary E Spilker 1 collaboration

Richard Zang 1 collaboration

Loveleena Bansal 1 collaboration

Handan He 1 collaboration

Rhys D O Jones 1 collaboration

Kha Le 1 collaboration

Mark Penney 1 collaboration

Edgar Schuck 1 collaboration

Alice Tsai 1 collaboration

Christine Xu 1 collaboration

Marjoleen J M A Nijsen 1 collaboration

Jason R Chan 1 collaboration

Aymara Sancho-Araiz 1 collaboration

Zinnia P Parra-Guillen 1 collaboration

Víctor Mangas-Sanjuan 1 collaboration