Bruno Saleme

Affiliations

Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.

ORCID: 0000-0003-4488-9545

Publications (11)

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

Science translational medicine

Avec: Bruno Saleme , Vikram Gurtu , Yongneng Zhang , Adam Kinnaird , Aristeidis E Boukouris , Keshav Gopal , John R Ussher , Gopinath Sutendra

The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Avec: Xiao Qi , Sanaz Hatami , Sabin Bozso , Xiuhua Wang , Bruno Saleme , Jayan Nagendran , Evangelos Michelakis , Gopinath Sutendra , Darren H Freed

TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.

Science translational medicine

Avec: Maria Areli Lorenzana-Carrillo , Keshav Gopal , Nikole J Byrne , Saymon Tejay , Bruno Saleme , Subhash K Das , Yongneng Zhang , Alois Haromy , Farah Eaton , Michelle Mendiola Pla , Dawn E Bowles , Jason R B Dyck , John R Ussher , Evangelos D Michelakis , Gopinath Sutendra

The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activity.

JCI insight

Avec: Rami Al Batran , Keshav Gopal , Hanin Aburasayn , Amina Eshreif , Malak Almutairi , Amanda A Greenwell , Scott A Campbell , Bruno Saleme , Emily A Court , Farah Eaton , Peter E Light , Gopinath Sutendra , John R Ussher

A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.

Cell reports

Avec: Aristeidis E Boukouris , Yongneng Zhang , Bruno Saleme , Adam Kinnaird , Yuan Yuan Zhao , Yongsheng Liu , Sotirios D Zervopoulos , Subhash K Das , Rohan D Mittal , Alois Haromy , Maria Areli Lorenzana-Carrillo , Amanda R Krysler , Christopher R Cromwell , Basil P Hubbard , Gopinath Sutendra , Evangelos D Michelakis

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation.

Cell metabolism

Avec: Rami Al Batran , Keshav Gopal , Megan E Capozzi , Jadin J Chahade , Bruno Saleme , S Amirhossein Tabatabaei-Dakhili , Amanda A Greenwell , Jingjing Niu , Malak Almutairi , Nikole J Byrne , Grant Masson , Ryekjang Kim , Farah Eaton , Erin E Mulvihill , Léa Garneau , Andrea R Masters , Zeruesenay Desta , Carlos A Velázquez-Martínez , Céline Aguer , Peter A Crawford , Gopinath Sutendra , Jonathan E Campbell , Jason R B Dyck , John R Ussher

Interaction with p53 explains a pro-proliferative function for VHL in cancer.

Journal of molecular medicine (Berlin, Germany)

Avec: Adam Kinnaird , Aristeidis E Boukouris , Bruno Saleme , Peter Dromparis , Sotirios D Zervopoulos , Vikram Gurtu , Gopinath Sutendra , Evangelos D Michelakis

SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.

Journal of the American Heart Association

Avec: Yongneng Zhang , Sotirios D Zervopoulos , Aristeidis E Boukouris , Maria Areli Lorenzana-Carrillo , Bruno Saleme , Linda Webster , Yongsheng Liu , Alois Haromy , Seyed Amirhossein Tabatabaei Dakhili , John R Ussher , Gopinath Sutendra , Evangelos D Michelakis

MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex.

Molecular cell

Avec: Sotirios D Zervopoulos , Aristeidis E Boukouris , Bruno Saleme , Alois Haromy , Saymon Tejay , Gopinath Sutendra , Evangelos D Michelakis

Loss of the fructose transporter SLC2A5 inhibits cancer cell migration.

Frontiers in cell and developmental biology

Avec: Jody Groenendyk , Konstantin Stoletov , Tautvydas Paskevicius , Wenjuan Li , Ning Dai , Myriam Pujol , Erin Busaan , Hoi Hei Ng , Aristeidis E Boukouris , Bruno Saleme , Alois Haromy , Kaisa Cui , Miao Hu , Yanan Yan , Rui Zhang , Evangelos Michelakis , Xing-Zhen Chen , John D Lewis , Jingfeng Tang , Luis B Agellon , Marek Michalak

The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Avec: Xiao Qi , Sanaz Hatami , Sabin Bozso , Xiuhua Wang , Bruno Saleme , Jayan Nagendran , Evangelos Michelakis , Gopinath Sutendra , Darren H Freed

Réseau de co-auteurs

Gopinath Sutendra 10 collaborations

Aristeidis E Boukouris 6 collaborations

John R Ussher 5 collaborations

Alois Haromy 5 collaborations

Evangelos D Michelakis 5 collaborations

Yongneng Zhang 4 collaborations

Keshav Gopal 4 collaborations

Sotirios D Zervopoulos 4 collaborations

Adam Kinnaird 3 collaborations

Evangelos Michelakis 3 collaborations

Maria Areli Lorenzana-Carrillo 3 collaborations

Farah Eaton 3 collaborations

Vikram Gurtu 2 collaborations

Xiao Qi 2 collaborations

Sanaz Hatami 2 collaborations

Sabin Bozso 2 collaborations

Xiuhua Wang 2 collaborations

Jayan Nagendran 2 collaborations

Darren H Freed 2 collaborations

Nikole J Byrne 2 collaborations

Saymon Tejay 2 collaborations

Subhash K Das 2 collaborations

Jason R B Dyck 2 collaborations

Rami Al Batran 2 collaborations

Malak Almutairi 2 collaborations

Amanda A Greenwell 2 collaborations

Yongsheng Liu 2 collaborations

Michelle Mendiola Pla 1 collaboration

Dawn E Bowles 1 collaboration

Hanin Aburasayn 1 collaboration

Amina Eshreif 1 collaboration

Scott A Campbell 1 collaboration

Emily A Court 1 collaboration

Peter E Light 1 collaboration

Yuan Yuan Zhao 1 collaboration

Rohan D Mittal 1 collaboration

Amanda R Krysler 1 collaboration

Christopher R Cromwell 1 collaboration

Basil P Hubbard 1 collaboration

Megan E Capozzi 1 collaboration

Jadin J Chahade 1 collaboration

S Amirhossein Tabatabaei-Dakhili 1 collaboration

Jingjing Niu 1 collaboration

Grant Masson 1 collaboration

Ryekjang Kim 1 collaboration

Erin E Mulvihill 1 collaboration

Léa Garneau 1 collaboration

Andrea R Masters 1 collaboration

Zeruesenay Desta 1 collaboration

Carlos A Velázquez-Martínez 1 collaboration

Céline Aguer 1 collaboration

Peter A Crawford 1 collaboration

Jonathan E Campbell 1 collaboration

Peter Dromparis 1 collaboration

Linda Webster 1 collaboration

Seyed Amirhossein Tabatabaei Dakhili 1 collaboration

Jody Groenendyk 1 collaboration

Konstantin Stoletov 1 collaboration

Tautvydas Paskevicius 1 collaboration

Wenjuan Li 1 collaboration

Ning Dai 1 collaboration

Myriam Pujol 1 collaboration

Erin Busaan 1 collaboration

Hoi Hei Ng 1 collaboration

Kaisa Cui 1 collaboration

Miao Hu 1 collaboration

Yanan Yan 1 collaboration

Rui Zhang 1 collaboration

Xing-Zhen Chen 1 collaboration

John D Lewis 1 collaboration

Jingfeng Tang 1 collaboration

Luis B Agellon 1 collaboration

Marek Michalak 1 collaboration