SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.
Animals
Diabetes Mellitus, Type 2
/ genetics
Disease Models, Animal
Humans
Insulin Resistance
/ genetics
Mice
Polymorphism, Single Nucleotide
Prospective Studies
Pulmonary Arterial Hypertension
/ genetics
Severity of Illness Index
Sirtuin 3
/ genetics
Treatment Outcome
Uncoupling Protein 2
/ genetics
insulin resistance
mitochondria
plexogenic arteriopathy
pulmonary arterial hypertension
vascular disease
vascular remodeling
vascular smooth muscle cells
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
07 12 2021
07 12 2021
Historique:
pubmed:
2
11
2021
medline:
24
3
2022
entrez:
1
11
2021
Statut:
ppublish
Résumé
Background Isolated loss-of-function single nucleotide polymorphisms (SNPs) for
Identifiants
pubmed: 34719264
doi: 10.1161/JAHA.120.020451
pmc: PMC9075406
doi:
Substances chimiques
Uncoupling Protein 2
0
Sirtuin 3
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e020451Subventions
Organisme : CIHR
Pays : Canada
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
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