Christopher Secker

Affiliations

Neuroproteomics, Max Delbrück Centre for Molecular Medicine, Berlin, Germany.

Publications (10)

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.

Cell systems

Avec: Todd M Greco , Christopher Secker , Eduardo Silva Ramos , Joel D Federspiel , Jeh-Ping Liu , Alma M Perez , Ismael Al-Ramahi , Jeffrey P Cantle , Jeffrey B Carroll , Juan Botas , Scott O Zeitlin , Erich E Wanker , Ileana M Cristea

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.

bioRxiv : the preprint server for biology

Avec: Philipp Trepte , Christopher Secker , Simona Kostova , Sibusiso B Maseko , Soon Gang Choi , Jeremy Blavier , Igor Minia , Eduardo Silva Ramos , Patricia Cassonnet , Sabrina Golusik , Martina Zenkner , Stephanie Beetz , Mara J Liebich , Nadine Scharek , Anja Schütz , Marcel Sperling , Michael Lisurek , Yang Wang , Kerstin Spirohn , Tong Hao , Michael A Calderwood , David E Hill , Markus Landthaler , Julien Olivet , Jean-Claude Twizere , Marc Vidal , Erich E Wanker

A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.

The Journal of experimental medicine

Avec: David Brenner , Kirsten Sieverding , Jahnavi Srinidhi , Susanne Zellner , Christopher Secker , Rüstem Yilmaz , Julia Dyckow , Shady Amr , Anna Ponomarenko , Esra Tunaboylu , Yasmin Douahem , Joana S Schlag , Lucía Rodríguez Martínez , Georg Kislinger , Cornelia Niemann , Karsten Nalbach , Wolfgang P Ruf , Jonathan Uhl , Johanna Hollenbeck , Lucas Schirmer , Alberto Catanese , Christian S Lobsiger , Karin M Danzer , Deniz Yilmazer-Hanke , Christian Münch , Philipp Koch , Axel Freischmidt , Martina Fetting , Christian Behrends , Rosanna Parlato , Jochen H Weishaupt

The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.

Journal of neurochemistry

Avec: Christopher Secker , Angelika Y Motzny , Simona Kostova , Alexander Buntru , Lucas Helmecke , Laura Reus , Robert Steinfort , Lydia Brusendorf , Annett Boeddrich , Nancy Neuendorf , Lisa Diez , Peter Schmieder , Aline Schulz , Constantin Czekelius , Erich E Wanker

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.

Structure (London, England : 1993)

Avec: Matthew G Alteen , Justin C Deme , Claudia P Alvarez , Peter Loppnau , Ashley Hutchinson , Alma Seitova , Renu Chandrasekaran , Eduardo Silva Ramos , Christopher Secker , Mona Alqazzaz , Erich E Wanker , Susan M Lea , Cheryl H Arrowsmith , Rachel J Harding

CellFIE: CRISPR- and Cell Fusion-based Two-hybrid Interaction Mapping of Endogenous Proteins.

Journal of molecular biology

Avec: Christopher Secker , Simona Kostova , Hannah Niederlechner , Stephanie Beetz , Ina Wendland , Mara J Liebich , Oliver Polzer , Mirjam Groh , Sigrid Schnoegl , Philipp Trepte , Erich E Wanker

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.

Nature communications

Avec: Gizem Inak , Agnieszka Rybak-Wolf , Pawel Lisowski , Tancredi M Pentimalli , René Jüttner , Petar Glažar , Karan Uppal , Emanuela Bottani , Dario Brunetti , Christopher Secker , Annika Zink , David Meierhofer , Marie-Thérèse Henke , Monishita Dey , Ummi Ciptasari , Barbara Mlody , Tobias Hahn , Maria Berruezo-Llacuna , Nikos Karaiskos , Michela Di Virgilio , Johannes A Mayr , Saskia B Wortmann , Josef Priller , Michael Gotthardt , Dean P Jones , Ertan Mayatepek , Werner Stenzel , Sebastian Diecke , Ralf Kühn , Erich E Wanker , Nikolaus Rajewsky , Markus Schuelke , Alessandro Prigione

Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists.

Journal of cheminformatics

Avec: Christopher Secker , Konstantin Fackeldey , Marcus Weber , Sourav Ray , Christoph Gorgulla , Christof Schütte

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.

Molecular systems biology

Avec: Philipp Trepte , Christopher Secker , Julien Olivet , Jeremy Blavier , Simona Kostova , Sibusiso B Maseko , Igor Minia , Eduardo Silva Ramos , Patricia Cassonnet , Sabrina Golusik , Martina Zenkner , Stephanie Beetz , Mara J Liebich , Nadine Scharek , Anja Schütz , Marcel Sperling , Michael Lisurek , Yang Wang , Kerstin Spirohn , Tong Hao , Michael A Calderwood , David E Hill , Markus Landthaler , Soon Gang Choi , Jean-Claude Twizere , Marc Vidal , Erich E Wanker

N-methyl-D-aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit.

Annals of neurology

Avec: Nina Kerstin Wenke , Jakob Kreye , Ewa Andrzejak , Adriana van Casteren , Jonas Leubner , Manuela S Murgueitio , S Momsen Reincke , Christopher Secker , Lars Schmidl , Christian Geis , Frauke Ackermann , Marc Nikolaus , Craig C Garner , Hedda Wardemann , Gerhard Wolber , Harald Prüss

Réseau de co-auteurs

Erich E Wanker 7 collaborations

Eduardo Silva Ramos 4 collaborations

Simona Kostova 4 collaborations

Philipp Trepte 3 collaborations

Stephanie Beetz 3 collaborations

Mara J Liebich 3 collaborations

Sibusiso B Maseko 2 collaborations

Soon Gang Choi 2 collaborations

Jeremy Blavier 2 collaborations

Igor Minia 2 collaborations

Patricia Cassonnet 2 collaborations

Sabrina Golusik 2 collaborations

Martina Zenkner 2 collaborations

Nadine Scharek 2 collaborations

Anja Schütz 2 collaborations

Marcel Sperling 2 collaborations

Michael Lisurek 2 collaborations

Yang Wang 2 collaborations

Kerstin Spirohn 2 collaborations

Tong Hao 2 collaborations

Michael A Calderwood 2 collaborations

David E Hill 2 collaborations

Markus Landthaler 2 collaborations

Julien Olivet 2 collaborations

Jean-Claude Twizere 2 collaborations

Marc Vidal 2 collaborations

Todd M Greco 1 collaboration

Joel D Federspiel 1 collaboration

Jeh-Ping Liu 1 collaboration

Alma M Perez 1 collaboration

Ismael Al-Ramahi 1 collaboration

Jeffrey P Cantle 1 collaboration

Jeffrey B Carroll 1 collaboration

Juan Botas 1 collaboration

Scott O Zeitlin 1 collaboration

Ileana M Cristea 1 collaboration

David Brenner 1 collaboration

Kirsten Sieverding 1 collaboration

Jahnavi Srinidhi 1 collaboration

Susanne Zellner 1 collaboration

Rüstem Yilmaz 1 collaboration

Julia Dyckow 1 collaboration

Shady Amr 1 collaboration

Anna Ponomarenko 1 collaboration

Esra Tunaboylu 1 collaboration

Yasmin Douahem 1 collaboration

Joana S Schlag 1 collaboration

Lucía Rodríguez Martínez 1 collaboration

Georg Kislinger 1 collaboration

Cornelia Niemann 1 collaboration

Karsten Nalbach 1 collaboration

Wolfgang P Ruf 1 collaboration

Jonathan Uhl 1 collaboration

Johanna Hollenbeck 1 collaboration

Lucas Schirmer 1 collaboration

Alberto Catanese 1 collaboration

Christian S Lobsiger 1 collaboration

Karin M Danzer 1 collaboration

Deniz Yilmazer-Hanke 1 collaboration

Christian Münch 1 collaboration

Philipp Koch 1 collaboration

Axel Freischmidt 1 collaboration

Martina Fetting 1 collaboration

Christian Behrends 1 collaboration

Rosanna Parlato 1 collaboration

Jochen H Weishaupt 1 collaboration

Angelika Y Motzny 1 collaboration

Alexander Buntru 1 collaboration

Lucas Helmecke 1 collaboration

Laura Reus 1 collaboration

Robert Steinfort 1 collaboration

Lydia Brusendorf 1 collaboration

Annett Boeddrich 1 collaboration

Nancy Neuendorf 1 collaboration

Lisa Diez 1 collaboration

Peter Schmieder 1 collaboration

Aline Schulz 1 collaboration

Constantin Czekelius 1 collaboration

Matthew G Alteen 1 collaboration

Justin C Deme 1 collaboration

Claudia P Alvarez 1 collaboration

Peter Loppnau 1 collaboration

Ashley Hutchinson 1 collaboration

Alma Seitova 1 collaboration

Renu Chandrasekaran 1 collaboration

Mona Alqazzaz 1 collaboration

Susan M Lea 1 collaboration

Cheryl H Arrowsmith 1 collaboration

Rachel J Harding 1 collaboration

Hannah Niederlechner 1 collaboration

Ina Wendland 1 collaboration

Oliver Polzer 1 collaboration

Mirjam Groh 1 collaboration

Sigrid Schnoegl 1 collaboration

Gizem Inak 1 collaboration

Agnieszka Rybak-Wolf 1 collaboration

Pawel Lisowski 1 collaboration

Tancredi M Pentimalli 1 collaboration

René Jüttner 1 collaboration

Petar Glažar 1 collaboration

Karan Uppal 1 collaboration

Emanuela Bottani 1 collaboration

Dario Brunetti 1 collaboration

Annika Zink 1 collaboration

David Meierhofer 1 collaboration

Marie-Thérèse Henke 1 collaboration

Monishita Dey 1 collaboration

Ummi Ciptasari 1 collaboration

Barbara Mlody 1 collaboration

Tobias Hahn 1 collaboration

Maria Berruezo-Llacuna 1 collaboration

Nikos Karaiskos 1 collaboration

Michela Di Virgilio 1 collaboration

Johannes A Mayr 1 collaboration

Saskia B Wortmann 1 collaboration

Josef Priller 1 collaboration

Michael Gotthardt 1 collaboration

Dean P Jones 1 collaboration

Ertan Mayatepek 1 collaboration

Werner Stenzel 1 collaboration

Sebastian Diecke 1 collaboration

Ralf Kühn 1 collaboration

Nikolaus Rajewsky 1 collaboration

Markus Schuelke 1 collaboration

Alessandro Prigione 1 collaboration

Konstantin Fackeldey 1 collaboration

Marcus Weber 1 collaboration

Sourav Ray 1 collaboration

Christoph Gorgulla 1 collaboration

Christof Schütte 1 collaboration

Nina Kerstin Wenke 1 collaboration

Jakob Kreye 1 collaboration

Ewa Andrzejak 1 collaboration

Adriana van Casteren 1 collaboration

Jonas Leubner 1 collaboration

Manuela S Murgueitio 1 collaboration

S Momsen Reincke 1 collaboration

Lars Schmidl 1 collaboration

Christian Geis 1 collaboration

Frauke Ackermann 1 collaboration

Marc Nikolaus 1 collaboration

Craig C Garner 1 collaboration

Hedda Wardemann 1 collaboration

Gerhard Wolber 1 collaboration

Harald Prüss 1 collaboration