From the Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter (C.F.W.), the Wellcome Sanger Institute (P.C., R.Y.E., D.P., S.B., P.D., E.J.G., V.K.C., S.J.L., K.A., J.H., J.K., K.E.S., J.F., R.J.H., H.C.M., M.E.H., H.V.F.), European Molecular Biology Laboratory, European Bioinformatics Institute (D.P., S.B., J.F.), and Wellcome Connecting Science (A.M.), Wellcome Genome Campus, and Cambridge University Hospitals Foundation Trust, Addenbrooke's Hospital (P.C., H.V.F.), Cambridge, the Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh (S.A., D.R.F.), and the Wellcome Centre for Ethics and Humanities, Ethox Centre, Oxford Population Health, Big Data Institute, University of Oxford, Oxford (M.J.P.) - all in the United Kingdom.