David M MacAlpine

Affiliations
  • Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA.

Publications (13)

Linking the dynamics of chromatin occupancy and transcription with predictive models.

Genome research
Avec: Trung Q Tran , Heather K MacAlpine , Vinay Tripuraneni , Sneha Mitra , David M MacAlpine , Alexander J Hartemink

Stochastic initiation of DNA replication across the human genome.

Molecular cell
Avec: David M MacAlpine

Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation.

bioRxiv : the preprint server for biology
Avec: Kevin Moyung , Yulong Li , Alexander J Hartemink , David M MacAlpine

Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork.

Genome research
Avec: Mónica P Gutiérrez , Heather K MacAlpine , David M MacAlpine

Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase.

bioRxiv : the preprint server for biology
Avec: Boning Chen , Heather K MacAlpine , Alexander J Hartemink , David M MacAlpine

Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication.

Genome research
Avec: Vinay Tripuraneni , Gonen Memisoglu , Heather K MacAlpine , Trung Q Tran , Wei Zhu , Alexander J Hartemink , James E Haber , David M MacAlpine

RoboCOP: Multivariate State Space Model Integrating Epigenomic Accessibility Data to Elucidate Genome-Wide Chromatin Occupancy.

Research in computational molecular biology : ... Annual International Conference, RECOMB ... : proceedings. RECOMB (Conference : 2005- )
Avec: Sneha Mitra , Jianling Zhong , David M MacAlpine , Alexander J Hartemink

Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase.

Genome research
Avec: Boning Chen , Heather K MacAlpine , Alexander J Hartemink , David M MacAlpine

RoboCOP: jointly computing chromatin occupancy profiles for numerous factors from chromatin accessibility data.

Nucleic acids research
Avec: Sneha Mitra , Jianling Zhong , Trung Q Tran , David M MacAlpine , Alexander J Hartemink

Capturing the primordial Kras mutation initiating urethane carcinogenesis.

Nature communications
Avec: Siqi Li , David M MacAlpine , Christopher M Counter

Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats.

PLoS genetics
Avec: Eric J Foss , Tonibelle Gatbonton-Schwager , Adam H Thiesen , Erin Taylor , Rafael Soriano , Uyen Lao , David M MacAlpine , Antonio Bedalov

Cell-Cycle-Dependent Chromatin Dynamics at Replication Origins.

Genes
Avec: Yulong Li , Alexander J Hartemink , David M MacAlpine

Disruption of origin chromatin structure by helicase activation in the absence of DNA replication.

Genes & development
Avec: Rachel A Hoffman , Heather K MacAlpine , David M MacAlpine

Réseau de co-auteurs

Alexander J Hartemink 8 collaborations
Heather K MacAlpine 6 collaborations
Trung Q Tran 3 collaborations
Sneha Mitra 3 collaborations
Vinay Tripuraneni 2 collaborations
Yulong Li 2 collaborations
Boning Chen 2 collaborations
Jianling Zhong 2 collaborations
Kevin Moyung 1 collaboration
Mónica P Gutiérrez 1 collaboration
Gonen Memisoglu 1 collaboration
Wei Zhu 1 collaboration
James E Haber 1 collaboration
Siqi Li 1 collaboration
Christopher M Counter 1 collaboration
Eric J Foss 1 collaboration
Tonibelle Gatbonton-Schwager 1 collaboration
Adam H Thiesen 1 collaboration
Erin Taylor 1 collaboration
Rafael Soriano 1 collaboration
Uyen Lao 1 collaboration
Antonio Bedalov 1 collaboration
Rachel A Hoffman 1 collaboration