F Manders

Affiliations

Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CSUtrecht, the Netherlands.
Oncode, Utrecht, the Netherlands.

Publications (14)

Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes.

Blood cancer discovery

Avec: Arianne M Brandsma , Eline J M Bertrums , Markus J van Roosmalen , Damon A Hofman , Rurika Oka , Mark Verheul , Freek Manders , Joske Ubels , Mirjam E Belderbos , Ruben van Boxtel

MutationalPatterns: the one stop shop for the analysis of mutational processes.

BMC genomics

Avec: Freek Manders , Arianne M Brandsma , Jurrian de Kanter , Mark Verheul , Rurika Oka , Markus J van Roosmalen , Bastiaan van der Roest , Arne van Hoeck , Edwin Cuppen , Ruben van Boxtel

A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs.

BMC genomics

Avec: Yun Yu , Freek Manders , Guy C M Grinwis , Martien A M Groenen , Richard P M A Crooijmans

Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis.

Scientific reports

Avec: Karlijn A L Hasaart , Freek Manders , Marie-Louise van der Hoorn , Mark Verheul , Tomasz Poplonski , Ewart Kuijk , Susana M Chuva de Sousa Lopes , Ruben van Boxtel

Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells

iScience

Avec: Karlijn A L Hasaart , Freek Manders , Joske Ubels , Mark Verheul , Markus J van Roosmalen , Niels M Groenen , Rurika Oka , Ewart Kuijk , Susana M Chuva de Sousa Lopes , Ruben van Boxtel

The Dynamics of Somatic Mutagenesis During Life in Humans.

Frontiers in aging

Avec: Freek Manders , Ruben van Boxtel , Sjors Middelkamp

Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox.

Cell genomics

Avec: Sjors Middelkamp , Freek Manders , Flavia Peci , Markus J van Roosmalen , Diego Montiel González , Eline J M Bertrums , Inge van der Werf , Lucca L M Derks , Niels M Groenen , Mark Verheul , Laurianne Trabut , Cayetano Pleguezuelos-Manzano , Arianne M Brandsma , Evangelia Antoniou , Dirk Reinhardt , Marc Bierings , Mirjam E Belderbos , Ruben van Boxtel

Characterizing Mutational Load and Clonal Composition of Human Blood.

Journal of visualized experiments : JoVE

Avec: Axel Rosendahl Huber , Freek Manders , Rurika Oka , Ruben van Boxtel

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes.

EMBO molecular medicine

Avec: Michael T Meister , Marian J A Groot Koerkamp , Terezinha de Souza , Willemijn B Breunis , Ewa Frazer-Mendelewska , Mariël Brok , Jeff DeMartino , Freek Manders , Camilla Calandrini , Hinri H D Kerstens , Alex Janse , M Emmy M Dolman , Selma Eising , Karin P S Langenberg , Marc van Tuil , Rutger R G Knops , Sheila Terwisscha van Scheltinga , Laura S Hiemcke-Jiwa , Uta Flucke , Johannes H M Merks , Max M van Noesel , Bastiaan B J Tops , Jayne Y Hehir-Kwa , Patrick Kemmeren , Jan J Molenaar , Marc van de Wetering , Ruben van Boxtel , Jarno Drost , Frank C P Holstege

Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells.

iScience

Avec: Freek Manders , Jip van Dinter , Ruben van Boxtel

DNA mismatch repair controls the mutagenicity of Polymerase ζ-dependent translesion synthesis at methylated guanines.

DNA repair

Avec: Anastasia Tsaalbi-Shtylik , Cécile Mingard , Michael Räz , Rurika Oka , Freek Manders , Ruben Van Boxtel , Niels De Wind , Shana J Sturla

Mutational signature in colorectal cancer caused by genotoxic pks

Nature

Avec: Cayetano Pleguezuelos-Manzano , Jens Puschhof , Axel Rosendahl Huber , Arne van Hoeck , Henry M Wood , Jason Nomburg , Carino Gurjao , Freek Manders , Guillaume Dalmasso , Paul B Stege , Fernanda L Paganelli , Maarten H Geurts , Joep Beumer , Tomohiro Mizutani , Yi Miao , Reinier van der Linden , Stefan van der Elst , Auteur inconnu , K Christopher Garcia , Janetta Top , Rob J L Willems , Marios Giannakis , Richard Bonnet , Phil Quirke , Matthew Meyerson , Edwin Cuppen , Ruben van Boxtel , Hans Clevers

Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients.

Cell stem cell

Avec: Jurrian K de Kanter , Flavia Peci , Eline Bertrums , Axel Rosendahl Huber , Anaïs van Leeuwen , Markus J van Roosmalen , Freek Manders , Mark Verheul , Rurika Oka , Arianne M Brandsma , Marc Bierings , Mirjam Belderbos , Ruben van Boxtel

Increased risk of leukaemia in children with Down syndrome: a somatic evolutionary view.

Expert reviews in molecular medicine

Avec: K A L Hasaart , E J M Bertrums , F Manders , B F Goemans , R van Boxtel

Réseau de co-auteurs

Freek Manders 13 collaborations

Ruben van Boxtel 11 collaborations

Rurika Oka 6 collaborations

Mark Verheul 6 collaborations

Markus J van Roosmalen 5 collaborations

Arianne M Brandsma 4 collaborations

Axel Rosendahl Huber 3 collaborations

Eline J M Bertrums 2 collaborations

Joske Ubels 2 collaborations

Mirjam E Belderbos 2 collaborations

Arne van Hoeck 2 collaborations

Edwin Cuppen 2 collaborations

Karlijn A L Hasaart 2 collaborations

Ewart Kuijk 2 collaborations

Susana M Chuva de Sousa Lopes 2 collaborations

Niels M Groenen 2 collaborations

Sjors Middelkamp 2 collaborations

Flavia Peci 2 collaborations

Cayetano Pleguezuelos-Manzano 2 collaborations

Marc Bierings 2 collaborations

Damon A Hofman 1 collaboration

Jurrian de Kanter 1 collaboration

Bastiaan van der Roest 1 collaboration

Yun Yu 1 collaboration

Guy C M Grinwis 1 collaboration

Martien A M Groenen 1 collaboration

Richard P M A Crooijmans 1 collaboration

Marie-Louise van der Hoorn 1 collaboration

Tomasz Poplonski 1 collaboration

Diego Montiel González 1 collaboration

Inge van der Werf 1 collaboration

Lucca L M Derks 1 collaboration

Laurianne Trabut 1 collaboration

Evangelia Antoniou 1 collaboration

Dirk Reinhardt 1 collaboration

Michael T Meister 1 collaboration

Marian J A Groot Koerkamp 1 collaboration

Terezinha de Souza 1 collaboration

Willemijn B Breunis 1 collaboration

Ewa Frazer-Mendelewska 1 collaboration

Mariël Brok 1 collaboration

Jeff DeMartino 1 collaboration

Camilla Calandrini 1 collaboration

Hinri H D Kerstens 1 collaboration

Alex Janse 1 collaboration

M Emmy M Dolman 1 collaboration

Selma Eising 1 collaboration

Karin P S Langenberg 1 collaboration

Marc van Tuil 1 collaboration

Rutger R G Knops 1 collaboration

Sheila Terwisscha van Scheltinga 1 collaboration

Laura S Hiemcke-Jiwa 1 collaboration

Uta Flucke 1 collaboration

Johannes H M Merks 1 collaboration

Max M van Noesel 1 collaboration

Bastiaan B J Tops 1 collaboration

Jayne Y Hehir-Kwa 1 collaboration

Patrick Kemmeren 1 collaboration

Jan J Molenaar 1 collaboration

Marc van de Wetering 1 collaboration

Jarno Drost 1 collaboration

Frank C P Holstege 1 collaboration

Jip van Dinter 1 collaboration

Anastasia Tsaalbi-Shtylik 1 collaboration

Cécile Mingard 1 collaboration

Michael Räz 1 collaboration

Ruben Van Boxtel 1 collaboration

Niels De Wind 1 collaboration

Shana J Sturla 1 collaboration

Jens Puschhof 1 collaboration

Henry M Wood 1 collaboration

Jason Nomburg 1 collaboration

Carino Gurjao 1 collaboration

Guillaume Dalmasso 1 collaboration

Paul B Stege 1 collaboration

Fernanda L Paganelli 1 collaboration

Maarten H Geurts 1 collaboration

Joep Beumer 1 collaboration

Tomohiro Mizutani 1 collaboration

Yi Miao 1 collaboration

Reinier van der Linden 1 collaboration

Stefan van der Elst 1 collaboration

None None 1 collaboration

K Christopher Garcia 1 collaboration

Janetta Top 1 collaboration

Rob J L Willems 1 collaboration

Marios Giannakis 1 collaboration

Richard Bonnet 1 collaboration

Phil Quirke 1 collaboration

Matthew Meyerson 1 collaboration

Hans Clevers 1 collaboration

Jurrian K de Kanter 1 collaboration

Eline Bertrums 1 collaboration

Anaïs van Leeuwen 1 collaboration

Mirjam Belderbos 1 collaboration

K A L Hasaart 1 collaboration

E J M Bertrums 1 collaboration

B F Goemans 1 collaboration

R van Boxtel 1 collaboration