Freek Manders

Affiliations

Princess Máxima Center for Pediatric Oncology and Oncode Institute, Utrecht, the Netherlands.

ORCID: 0000-0001-6197-347X

Publications (14)

Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes.

Blood cancer discovery

Avec: Arianne M Brandsma , Eline J M Bertrums , Markus J van Roosmalen , Damon A Hofman , Rurika Oka , Mark Verheul , Freek Manders , Joske Ubels , Mirjam E Belderbos , Ruben van Boxtel

MutationalPatterns: the one stop shop for the analysis of mutational processes.

BMC genomics

Avec: Freek Manders , Arianne M Brandsma , Jurrian de Kanter , Mark Verheul , Rurika Oka , Markus J van Roosmalen , Bastiaan van der Roest , Arne van Hoeck , Edwin Cuppen , Ruben van Boxtel

A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs.

BMC genomics

Avec: Yun Yu , Freek Manders , Guy C M Grinwis , Martien A M Groenen , Richard P M A Crooijmans

Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis.

Scientific reports

Avec: Karlijn A L Hasaart , Freek Manders , Marie-Louise van der Hoorn , Mark Verheul , Tomasz Poplonski , Ewart Kuijk , Susana M Chuva de Sousa Lopes , Ruben van Boxtel

Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells

iScience

Avec: Karlijn A L Hasaart , Freek Manders , Joske Ubels , Mark Verheul , Markus J van Roosmalen , Niels M Groenen , Rurika Oka , Ewart Kuijk , Susana M Chuva de Sousa Lopes , Ruben van Boxtel

The Dynamics of Somatic Mutagenesis During Life in Humans.

Frontiers in aging

Avec: Freek Manders , Ruben van Boxtel , Sjors Middelkamp

Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox.

Cell genomics

Avec: Sjors Middelkamp , Freek Manders , Flavia Peci , Markus J van Roosmalen , Diego Montiel González , Eline J M Bertrums , Inge van der Werf , Lucca L M Derks , Niels M Groenen , Mark Verheul , Laurianne Trabut , Cayetano Pleguezuelos-Manzano , Arianne M Brandsma , Evangelia Antoniou , Dirk Reinhardt , Marc Bierings , Mirjam E Belderbos , Ruben van Boxtel

Characterizing Mutational Load and Clonal Composition of Human Blood.

Journal of visualized experiments : JoVE

Avec: Axel Rosendahl Huber , Freek Manders , Rurika Oka , Ruben van Boxtel

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes.

EMBO molecular medicine

Avec: Michael T Meister , Marian J A Groot Koerkamp , Terezinha de Souza , Willemijn B Breunis , Ewa Frazer-Mendelewska , Mariël Brok , Jeff DeMartino , Freek Manders , Camilla Calandrini , Hinri H D Kerstens , Alex Janse , M Emmy M Dolman , Selma Eising , Karin P S Langenberg , Marc van Tuil , Rutger R G Knops , Sheila Terwisscha van Scheltinga , Laura S Hiemcke-Jiwa , Uta Flucke , Johannes H M Merks , Max M van Noesel , Bastiaan B J Tops , Jayne Y Hehir-Kwa , Patrick Kemmeren , Jan J Molenaar , Marc van de Wetering , Ruben van Boxtel , Jarno Drost , Frank C P Holstege

Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells.

iScience

Avec: Freek Manders , Jip van Dinter , Ruben van Boxtel

DNA mismatch repair controls the mutagenicity of Polymerase ζ-dependent translesion synthesis at methylated guanines.

DNA repair

Avec: Anastasia Tsaalbi-Shtylik , Cécile Mingard , Michael Räz , Rurika Oka , Freek Manders , Ruben Van Boxtel , Niels De Wind , Shana J Sturla

Mutational signature in colorectal cancer caused by genotoxic pks

Nature

Avec: Cayetano Pleguezuelos-Manzano , Jens Puschhof , Axel Rosendahl Huber , Arne van Hoeck , Henry M Wood , Jason Nomburg , Carino Gurjao , Freek Manders , Guillaume Dalmasso , Paul B Stege , Fernanda L Paganelli , Maarten H Geurts , Joep Beumer , Tomohiro Mizutani , Yi Miao , Reinier van der Linden , Stefan van der Elst , Auteur inconnu , K Christopher Garcia , Janetta Top , Rob J L Willems , Marios Giannakis , Richard Bonnet , Phil Quirke , Matthew Meyerson , Edwin Cuppen , Ruben van Boxtel , Hans Clevers

Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients.

Cell stem cell

Avec: Jurrian K de Kanter , Flavia Peci , Eline Bertrums , Axel Rosendahl Huber , Anaïs van Leeuwen , Markus J van Roosmalen , Freek Manders , Mark Verheul , Rurika Oka , Arianne M Brandsma , Marc Bierings , Mirjam Belderbos , Ruben van Boxtel

Increased risk of leukaemia in children with Down syndrome: a somatic evolutionary view.

Expert reviews in molecular medicine

Avec: K A L Hasaart , E J M Bertrums , F Manders , B F Goemans , R van Boxtel

Réseau de co-auteurs

Ruben van Boxtel 11 collaborations

Rurika Oka 6 collaborations

Mark Verheul 6 collaborations

Markus J van Roosmalen 5 collaborations

Arianne M Brandsma 4 collaborations

Axel Rosendahl Huber 3 collaborations

Eline J M Bertrums 2 collaborations

Joske Ubels 2 collaborations

Mirjam E Belderbos 2 collaborations

Arne van Hoeck 2 collaborations

Edwin Cuppen 2 collaborations

Karlijn A L Hasaart 2 collaborations

Ewart Kuijk 2 collaborations

Susana M Chuva de Sousa Lopes 2 collaborations

Niels M Groenen 2 collaborations

Sjors Middelkamp 2 collaborations

Flavia Peci 2 collaborations

Cayetano Pleguezuelos-Manzano 2 collaborations

Marc Bierings 2 collaborations

Damon A Hofman 1 collaboration

Jurrian de Kanter 1 collaboration

Bastiaan van der Roest 1 collaboration

Yun Yu 1 collaboration

Guy C M Grinwis 1 collaboration

Martien A M Groenen 1 collaboration

Richard P M A Crooijmans 1 collaboration

Marie-Louise van der Hoorn 1 collaboration

Tomasz Poplonski 1 collaboration

Diego Montiel González 1 collaboration

Inge van der Werf 1 collaboration

Lucca L M Derks 1 collaboration

Laurianne Trabut 1 collaboration

Evangelia Antoniou 1 collaboration

Dirk Reinhardt 1 collaboration

Michael T Meister 1 collaboration

Marian J A Groot Koerkamp 1 collaboration

Terezinha de Souza 1 collaboration

Willemijn B Breunis 1 collaboration

Ewa Frazer-Mendelewska 1 collaboration

Mariël Brok 1 collaboration

Jeff DeMartino 1 collaboration

Camilla Calandrini 1 collaboration

Hinri H D Kerstens 1 collaboration

Alex Janse 1 collaboration

M Emmy M Dolman 1 collaboration

Selma Eising 1 collaboration

Karin P S Langenberg 1 collaboration

Marc van Tuil 1 collaboration

Rutger R G Knops 1 collaboration

Sheila Terwisscha van Scheltinga 1 collaboration

Laura S Hiemcke-Jiwa 1 collaboration

Uta Flucke 1 collaboration

Johannes H M Merks 1 collaboration

Max M van Noesel 1 collaboration

Bastiaan B J Tops 1 collaboration

Jayne Y Hehir-Kwa 1 collaboration

Patrick Kemmeren 1 collaboration

Jan J Molenaar 1 collaboration

Marc van de Wetering 1 collaboration

Jarno Drost 1 collaboration

Frank C P Holstege 1 collaboration

Jip van Dinter 1 collaboration

Anastasia Tsaalbi-Shtylik 1 collaboration

Cécile Mingard 1 collaboration

Michael Räz 1 collaboration

Ruben Van Boxtel 1 collaboration

Niels De Wind 1 collaboration

Shana J Sturla 1 collaboration

Jens Puschhof 1 collaboration

Henry M Wood 1 collaboration

Jason Nomburg 1 collaboration

Carino Gurjao 1 collaboration

Guillaume Dalmasso 1 collaboration

Paul B Stege 1 collaboration

Fernanda L Paganelli 1 collaboration

Maarten H Geurts 1 collaboration

Joep Beumer 1 collaboration

Tomohiro Mizutani 1 collaboration

Yi Miao 1 collaboration

Reinier van der Linden 1 collaboration

Stefan van der Elst 1 collaboration

None None 1 collaboration

K Christopher Garcia 1 collaboration

Janetta Top 1 collaboration

Rob J L Willems 1 collaboration

Marios Giannakis 1 collaboration

Richard Bonnet 1 collaboration

Phil Quirke 1 collaboration

Matthew Meyerson 1 collaboration

Hans Clevers 1 collaboration

Jurrian K de Kanter 1 collaboration

Eline Bertrums 1 collaboration

Anaïs van Leeuwen 1 collaboration

Mirjam Belderbos 1 collaboration

K A L Hasaart 1 collaboration

E J M Bertrums 1 collaboration

F Manders 1 collaboration

B F Goemans 1 collaboration

R van Boxtel 1 collaboration