Falk Hertwig

Affiliations

Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Publications (10)

Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.

Nature genetics

Avec: Carolina Rosswog , Christoph Bartenhagen , Anne Welte , Yvonne Kahlert , Nadine Hemstedt , Witali Lorenz , Maria Cartolano , Sandra Ackermann , Sven Perner , Wenzel Vogel , Janine Altmüller , Peter Nürnberg , Falk Hertwig , Gudrun Göhring , Esther Lilienweiss , Adrian M Stütz , Jan O Korbel , Roman K Thomas , Martin Peifer , Matthias Fischer

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.

Nature communications

Avec: Steffen Fuchs , Clara Danßmann , Filippos Klironomos , Annika Winkler , Jörg Fallmann , Louisa-Marie Kruetzfeldt , Annabell Szymansky , Julian Naderi , Stephan H Bernhart , Laura Grunewald , Konstantin Helmsauer , Elias Rodriguez-Fos , Marieluise Kirchner , Philipp Mertins , Kathy Astrahantseff , Christin Suenkel , Joern Toedling , Fabienne Meggetto , Marc Remke , Peter F Stadler , Patrick Hundsdoerfer , Hedwig E Deubzer , Annette Künkele , Peter Lang , Jörg Fuchs , Anton G Henssen , Angelika Eggert , Nikolaus Rajewsky , Falk Hertwig , Johannes H Schulte

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.

PLoS computational biology

Avec: Mathurin Dorel , Bertram Klinger , Tommaso Mari , Joern Toedling , Eric Blanc , Clemens Messerschmidt , Michal Nadler-Holly , Matthias Ziehm , Anja Sieber , Falk Hertwig , Dieter Beule , Angelika Eggert , Johannes H Schulte , Matthias Selbach , Nils Blüthgen

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.

Nature communications

Avec: Konstantin Helmsauer , Maria E Valieva , Salaheddine Ali , Rocío Chamorro González , Robert Schöpflin , Claudia Röefzaad , Yi Bei , Heathcliff Dorado Garcia , Elias Rodriguez-Fos , Montserrat Puiggròs , Katharina Kasack , Kerstin Haase , Csilla Keskeny , Celine Y Chen , Luis P Kuschel , Philipp Euskirchen , Verena Heinrich , Michael I Robson , Carolina Rosswog , Joern Toedling , Annabell Szymansky , Falk Hertwig , Matthias Fischer , David Torrents , Angelika Eggert , Johannes H Schulte , Stefan Mundlos , Anton G Henssen , Richard P Koche

Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing.

Journal of personalized medicine

Avec: Annabell Szymansky , Louisa-Marie Kruetzfeldt , Lukas C Heukamp , Falk Hertwig , Jessica Theissen , Hedwig E Deubzer , Eva-Maria Willing , Roopika Menon , Steffen Fuchs , Theresa Thole , Stefanie Schulte , Karin Schmelz , Annette Künkele , Peter Lang , Jörg Fuchs , Angelika Eggert , Cornelia Eckert , Matthias Fischer , Anton G Henssen , Elias Rodriguez-Fos , Johannes H Schulte

Mutational topography reflects clinical neuroblastoma heterogeneity.

Cell genomics

Avec: Elias Rodriguez-Fos , Mercè Planas-Fèlix , Martin Burkert , Montserrat Puiggròs , Joern Toedling , Nina Thiessen , Eric Blanc , Annabell Szymansky , Falk Hertwig , Naveed Ishaque , Dieter Beule , David Torrents , Angelika Eggert , Richard P Koche , Roland F Schwarz , Kerstin Haase , Johannes H Schulte , Anton G Henssen

Publisher Correction: Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Nature genetics

Avec: Richard P Koche , Elias Rodriguez-Fos , Konstantin Helmsauer , Martin Burkert , Ian C MacArthur , Jesper Maag , Rocio Chamorro , Natalia Munoz-Perez , Montserrat Puiggròs , Heathcliff Dorado Garcia , Yi Bei , Claudia Röefzaad , Victor Bardinet , Annabell Szymansky , Annika Winkler , Theresa Thole , Natalie Timme , Katharina Kasack , Steffen Fuchs , Filippos Klironomos , Nina Thiessen , Eric Blanc , Karin Schmelz , Annette Künkele , Patrick Hundsdörfer , Carolina Rosswog , Jessica Theissen , Dieter Beule , Hedwig Deubzer , Sascha Sauer , Joern Toedling , Matthias Fischer , Falk Hertwig , Roland F Schwarz , Angelika Eggert , David Torrents , Johannes H Schulte , Anton G Henssen

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.

Cell

Avec: Ron D Jachimowicz , Filippo Beleggia , Jörg Isensee , Bhagya Bhavana Velpula , Jonas Goergens , Matias A Bustos , Markus A Doll , Anjana Shenoy , Cintia Checa-Rodriguez , Janica Lea Wiederstein , Keren Baranes-Bachar , Christoph Bartenhagen , Falk Hertwig , Nizan Teper , Tomohiko Nishi , Anna Schmitt , Felix Distelmaier , Hermann-Josef Lüdecke , Beate Albrecht , Marcus Krüger , Björn Schumacher , Tamar Geiger , Dave S B Hoon , Pablo Huertas , Matthias Fischer , Tim Hucho , Martin Peifer , Yael Ziv , H Christian Reinhardt , Dagmar Wieczorek , Yosef Shiloh

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.

Molecular cancer

Avec: Mareike Berlak , Elizabeth Tucker , Mathurin Dorel , Annika Winkler , Aleixandria McGearey , Elias Rodriguez-Fos , Barbara Martins da Costa , Karen Barker , Elicia Fyle , Elizabeth Calton , Selma Eising , Kim Ober , Deborah Hughes , Eleni Koutroumanidou , Paul Carter , Reda Stankunaite , Paula Proszek , Neha Jain , Carolina Rosswog , Heathcliff Dorado-Garcia , Jan Jasper Molenaar , Mike Hubank , Giuseppe Barone , John Anderson , Peter Lang , Hedwig Elisabeth Deubzer , Annette Künkele , Matthias Fischer , Angelika Eggert , Charlotte Kloft , Anton George Henssen , Michael Boettcher , Falk Hertwig , Nils Blüthgen , Louis Chesler , Johannes Hubertus Schulte

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Nature genetics

Avec: Richard P Koche , Elias Rodriguez-Fos , Konstantin Helmsauer , Martin Burkert , Ian C MacArthur , Jesper Maag , Rocio Chamorro , Natalia Munoz-Perez , Montserrat Puiggròs , Heathcliff Dorado Garcia , Yi Bei , Claudia Röefzaad , Victor Bardinet , Annabell Szymansky , Annika Winkler , Theresa Thole , Natalie Timme , Katharina Kasack , Steffen Fuchs , Filippos Klironomos , Nina Thiessen , Eric Blanc , Karin Schmelz , Annette Künkele , Patrick Hundsdörfer , Carolina Rosswog , Jessica Theissen , Dieter Beule , Hedwig Deubzer , Sascha Sauer , Joern Toedling , Matthias Fischer , Falk Hertwig , Roland F Schwarz , Angelika Eggert , David Torrents , Johannes H Schulte , Anton G Henssen

Réseau de co-auteurs

Angelika Eggert 8 collaborations

Matthias Fischer 7 collaborations

Elias Rodriguez-Fos 7 collaborations

Johannes H Schulte 7 collaborations

Annabell Szymansky 6 collaborations

Joern Toedling 6 collaborations

Anton G Henssen 6 collaborations

Carolina Rosswog 5 collaborations

Annette Künkele 5 collaborations

Steffen Fuchs 4 collaborations

Annika Winkler 4 collaborations

Konstantin Helmsauer 4 collaborations

Eric Blanc 4 collaborations

Dieter Beule 4 collaborations

Montserrat Puiggròs 4 collaborations

David Torrents 4 collaborations

Richard P Koche 4 collaborations

Filippos Klironomos 3 collaborations

Peter Lang 3 collaborations

Claudia Röefzaad 3 collaborations

Yi Bei 3 collaborations

Heathcliff Dorado Garcia 3 collaborations

Katharina Kasack 3 collaborations

Jessica Theissen 3 collaborations

Theresa Thole 3 collaborations

Karin Schmelz 3 collaborations

Martin Burkert 3 collaborations

Nina Thiessen 3 collaborations

Roland F Schwarz 3 collaborations

Christoph Bartenhagen 2 collaborations

Martin Peifer 2 collaborations

Louisa-Marie Kruetzfeldt 2 collaborations

Hedwig E Deubzer 2 collaborations

Jörg Fuchs 2 collaborations

Mathurin Dorel 2 collaborations

Nils Blüthgen 2 collaborations

Kerstin Haase 2 collaborations

Ian C MacArthur 2 collaborations

Jesper Maag 2 collaborations

Rocio Chamorro 2 collaborations

Natalia Munoz-Perez 2 collaborations

Victor Bardinet 2 collaborations

Natalie Timme 2 collaborations

Patrick Hundsdörfer 2 collaborations

Hedwig Deubzer 2 collaborations

Sascha Sauer 2 collaborations

Anne Welte 1 collaboration

Yvonne Kahlert 1 collaboration

Nadine Hemstedt 1 collaboration

Witali Lorenz 1 collaboration

Maria Cartolano 1 collaboration

Sandra Ackermann 1 collaboration

Sven Perner 1 collaboration

Wenzel Vogel 1 collaboration

Janine Altmüller 1 collaboration

Peter Nürnberg 1 collaboration

Gudrun Göhring 1 collaboration

Esther Lilienweiss 1 collaboration

Adrian M Stütz 1 collaboration

Jan O Korbel 1 collaboration

Roman K Thomas 1 collaboration

Clara Danßmann 1 collaboration

Jörg Fallmann 1 collaboration

Julian Naderi 1 collaboration

Stephan H Bernhart 1 collaboration

Laura Grunewald 1 collaboration

Marieluise Kirchner 1 collaboration

Philipp Mertins 1 collaboration

Kathy Astrahantseff 1 collaboration

Christin Suenkel 1 collaboration

Fabienne Meggetto 1 collaboration

Marc Remke 1 collaboration

Peter F Stadler 1 collaboration

Patrick Hundsdoerfer 1 collaboration

Nikolaus Rajewsky 1 collaboration

Bertram Klinger 1 collaboration

Tommaso Mari 1 collaboration

Clemens Messerschmidt 1 collaboration

Michal Nadler-Holly 1 collaboration

Matthias Ziehm 1 collaboration

Anja Sieber 1 collaboration

Matthias Selbach 1 collaboration

Maria E Valieva 1 collaboration

Salaheddine Ali 1 collaboration

Rocío Chamorro González 1 collaboration

Robert Schöpflin 1 collaboration

Csilla Keskeny 1 collaboration

Celine Y Chen 1 collaboration

Luis P Kuschel 1 collaboration

Philipp Euskirchen 1 collaboration

Verena Heinrich 1 collaboration

Michael I Robson 1 collaboration

Stefan Mundlos 1 collaboration

Lukas C Heukamp 1 collaboration

Eva-Maria Willing 1 collaboration

Roopika Menon 1 collaboration

Stefanie Schulte 1 collaboration

Cornelia Eckert 1 collaboration

Mercè Planas-Fèlix 1 collaboration

Naveed Ishaque 1 collaboration

Ron D Jachimowicz 1 collaboration

Filippo Beleggia 1 collaboration

Jörg Isensee 1 collaboration

Bhagya Bhavana Velpula 1 collaboration

Jonas Goergens 1 collaboration

Matias A Bustos 1 collaboration

Markus A Doll 1 collaboration

Anjana Shenoy 1 collaboration

Cintia Checa-Rodriguez 1 collaboration

Janica Lea Wiederstein 1 collaboration

Keren Baranes-Bachar 1 collaboration

Nizan Teper 1 collaboration

Tomohiko Nishi 1 collaboration

Anna Schmitt 1 collaboration

Felix Distelmaier 1 collaboration

Hermann-Josef Lüdecke 1 collaboration

Beate Albrecht 1 collaboration

Marcus Krüger 1 collaboration

Björn Schumacher 1 collaboration

Tamar Geiger 1 collaboration

Dave S B Hoon 1 collaboration

Pablo Huertas 1 collaboration

Tim Hucho 1 collaboration

Yael Ziv 1 collaboration

H Christian Reinhardt 1 collaboration

Dagmar Wieczorek 1 collaboration

Yosef Shiloh 1 collaboration

Mareike Berlak 1 collaboration

Elizabeth Tucker 1 collaboration

Aleixandria McGearey 1 collaboration

Barbara Martins da Costa 1 collaboration

Karen Barker 1 collaboration

Elicia Fyle 1 collaboration

Elizabeth Calton 1 collaboration

Selma Eising 1 collaboration

Kim Ober 1 collaboration

Deborah Hughes 1 collaboration

Eleni Koutroumanidou 1 collaboration

Paul Carter 1 collaboration

Reda Stankunaite 1 collaboration

Paula Proszek 1 collaboration

Neha Jain 1 collaboration

Heathcliff Dorado-Garcia 1 collaboration

Jan Jasper Molenaar 1 collaboration

Mike Hubank 1 collaboration

Giuseppe Barone 1 collaboration

John Anderson 1 collaboration

Hedwig Elisabeth Deubzer 1 collaboration

Charlotte Kloft 1 collaboration

Anton George Henssen 1 collaboration

Michael Boettcher 1 collaboration

Louis Chesler 1 collaboration

Johannes Hubertus Schulte 1 collaboration