Filip Liebsch

Affiliations

Integrated Program in Neuroscience, McGill University, Montreal, QC, H3G 0B1, Canada.
Department of Chemistry, Institute of Biochemistry, University of Cologne, 50674, Cologne, Germany.

Publications (6)

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis.

Scientific reports

Avec: Irem Ulku , Filip Liebsch , S Can Akerman , Jana F Schulz , Luka Kulic , Christoph Hock , Claus Pietrzik , Alessandro Di Spiezio , Gopal Thinakaran , Paul Saftig , Gerhard Multhaup

Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants.

eNeuro

Avec: Filip Liebsch , Fynn R Eggersmann , Yvonne Merkler , Peter Kloppenburg , Günter Schwarz

Biallelic gephyrin variants lead to impaired GABAergic inhibition in a patient with developmental and epileptic encephalopathy.

Human molecular genetics

Avec: Arthur Macha , Filip Liebsch , Steffen Fricke , Florian Hetsch , Franziska Neuser , Lena Johannes , Vanessa Kress , Tania Djémié , Jose A Santamaria-Araujo , Catheline Vilain , Alec Aeby , Patrick Van Bogaert , Borislav Dejanovic , Sarah Weckhuysen , Jochen C Meier , Guenter Schwarz

The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease.

Acta neuropathologica communications

Avec: Tunahan Kirabali , Serena Rigotti , Alessandro Siccoli , Filip Liebsch , Adeola Shobo , Christoph Hock , Roger M Nitsch , Gerhard Multhaup , Luka Kulic

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.

Nature communications

Avec: Filip Liebsch , Luka Kulic , Charlotte Teunissen , Adeola Shobo , Irem Ulku , Vivienne Engelschalt , Mark A Hancock , Wiesje M van der Flier , Peter Kunach , Pedro Rosa-Neto , Philip Scheltens , Judes Poirier , Paul Saftig , Randall J Bateman , John Breitner , Christoph Hock , Gerhard Multhaup

Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high level BACE1 expression.

The Journal of biological chemistry

Avec: Irem Ulku , Rocher Leung , Fritz Herre , Lina Walther , Adeola Shobo , Paul Saftig , Mark A Hancock , Filip Liebsch , Gerd Multhaup

Réseau de co-auteurs

Irem Ulku 3 collaborations

Luka Kulic 3 collaborations

Christoph Hock 3 collaborations

Paul Saftig 3 collaborations

Gerhard Multhaup 3 collaborations

Adeola Shobo 3 collaborations

Mark A Hancock 2 collaborations

S Can Akerman 1 collaboration

Jana F Schulz 1 collaboration

Claus Pietrzik 1 collaboration

Alessandro Di Spiezio 1 collaboration

Gopal Thinakaran 1 collaboration

Fynn R Eggersmann 1 collaboration

Yvonne Merkler 1 collaboration

Peter Kloppenburg 1 collaboration

Günter Schwarz 1 collaboration

Arthur Macha 1 collaboration

Steffen Fricke 1 collaboration

Florian Hetsch 1 collaboration

Franziska Neuser 1 collaboration

Lena Johannes 1 collaboration

Vanessa Kress 1 collaboration

Tania Djémié 1 collaboration

Jose A Santamaria-Araujo 1 collaboration

Catheline Vilain 1 collaboration

Alec Aeby 1 collaboration

Patrick Van Bogaert 1 collaboration

Borislav Dejanovic 1 collaboration

Sarah Weckhuysen 1 collaboration

Jochen C Meier 1 collaboration

Guenter Schwarz 1 collaboration

Tunahan Kirabali 1 collaboration

Serena Rigotti 1 collaboration

Alessandro Siccoli 1 collaboration

Roger M Nitsch 1 collaboration

Charlotte Teunissen 1 collaboration

Vivienne Engelschalt 1 collaboration

Wiesje M van der Flier 1 collaboration

Peter Kunach 1 collaboration

Pedro Rosa-Neto 1 collaboration

Philip Scheltens 1 collaboration

Judes Poirier 1 collaboration

Randall J Bateman 1 collaboration

John Breitner 1 collaboration

Rocher Leung 1 collaboration

Fritz Herre 1 collaboration

Lina Walther 1 collaboration

Gerd Multhaup 1 collaboration