Fran Humby

Affiliations

Centre for Experimental Medicine and Rheumatology, Barts and the London School of Medicine and Dentistry, London, UK.

Publications (18)

B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: F Rivellese , F Humby , S Bugatti , L Fossati-Jimack , H Rizvi , D Lucchesi , G Lliso-Ribera , A Nerviani , R E Hands , G Giorli , B Frias , G Thorborn , E Jaworska , C John , K Goldmann , M J Lewis , A Manzo , M Bombardieri , C Pitzalis , Auteur inconnu

Factors associated with physical activity engagement among adults with rheumatoid arthritis: A cross-sectional study.

Musculoskeletal care

Avec: Xiang Li Tan , Gemma Pugh , Frances Humby , Dylan Morrissey

Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials.

The Lancet. Rheumatology

Avec: Felice Rivellese , Alessandra Nerviani , Giovanni Giorli , Louise Warren , Edyta Jaworska , Michele Bombardieri , Myles J Lewis , Frances Humby , Arthur G Pratt , Andrew Filer , Nagui Gendi , Alberto Cauli , Ernest Choy , Iain McInnes , Patrick Durez , Christopher J Edwards , Maya H Buch , Elisa Gremese , Peter C Taylor , Nora Ng , Juan D Cañete , Sabrina Raizada , Neil D McKay , Deepak Jadon , Pier Paolo Sainaghi , Richard Stratton , Michael R Ehrenstein , Pauline Ho , Joaquim P Pereira , Bhaskar Dasgupta , Claire Gorman , James Galloway , Hector Chinoy , Désirée van der Heijde , Peter Sasieni , Anne Barton , Costantino Pitzalis , Auteur inconnu

Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC).

Annals of the rheumatic diseases

Avec: Gloria Lliso-Ribera , Frances Humby , Myles Lewis , Alessandra Nerviani , Daniele Mauro , Felice Rivellese , Stephen Kelly , Rebecca Hands , Fabiola Bene , Nandhini Ramamoorthi , Jason A Hackney , Alberto Cauli , Ernest H Choy , Andrew Filer , Peter C Taylor , Iain McInnes , Michael J Townsend , Costantino Pitzalis

Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial.

Nature medicine

Avec: Felice Rivellese , Anna E A Surace , Katriona Goldmann , Elisabetta Sciacca , Cankut Çubuk , Giovanni Giorli , Christopher R John , Alessandra Nerviani , Liliane Fossati-Jimack , Georgina Thorborn , Manzoor Ahmed , Edoardo Prediletto , Sarah E Church , Briana M Hudson , Sarah E Warren , Paul M McKeigue , Frances Humby , Michele Bombardieri , Michael R Barnes , Myles J Lewis , Costantino Pitzalis , Auteur inconnu

Six-month prospective trial in early and long-standing rheumatoid arthritis: evaluating disease activity in the wrist through sequential synovial histopathological analysis, RAMRIS magnetic resonance score and EULAR-OMERACT ultrasound score.

RMD open

Avec: Søren Andreas Just , Christian Nielsen , Jens Christian Werlinrud , Pia Veldt Larsen , Camilla Schufri Klinkby , Henrik Daa Schrøder , Fran Humby , Trine Torfing , Hanne Lindegaard

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4

Cell metabolism

Avec: Valentina Pucino , Michelangelo Certo , Vinay Bulusu , Danilo Cucchi , Katriona Goldmann , Elena Pontarini , Robert Haas , Joanne Smith , Sarah E Headland , Kevin Blighe , Massimiliano Ruscica , Frances Humby , Myles J Lewis , Jurre J Kamphorst , Michele Bombardieri , Costantino Pitzalis , Claudio Mauro

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes.

Cell reports

Avec: Myles J Lewis , Michael R Barnes , Kevin Blighe , Katriona Goldmann , Sharmila Rana , Jason A Hackney , Nandhini Ramamoorthi , Christopher R John , David S Watson , Sarah K Kummerfeld , Rebecca Hands , Sudeh Riahi , Vidalba Rocher-Ros , Felice Rivellese , Frances Humby , Stephen Kelly , Michele Bombardieri , Nora Ng , Maria DiCicco , Désirée van der Heijde , Robert Landewé , Annette van der Helm-van Mil , Alberto Cauli , Iain B McInnes , Christopher D Buckley , Ernest Choy , Peter C Taylor , Michael J Townsend , Costantino Pitzalis

Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study.

Seminars in arthritis and rheumatism

Avec: Vasco C Romão , Frances Humby , Stephen Kelly , Maria Di Cicco , Arti Mahto , Ilias Lazarou , Rebecca Hands , Vidalba Rocher-Ros , Désirée van der Heijde , João Eurico Fonseca , Costantino Pitzalis

Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.

Nature communications

Avec: Alessandra Nerviani , Marie-Astrid Boutet , Giulia Maria Ghirardi , Katriona Goldmann , Elisabetta Sciacca , Felice Rivellese , Elena Pontarini , Edoardo Prediletto , Federico Abatecola , Mattia Caliste , Sara Pagani , Daniele Mauro , Mattia Bellan , Cankut Cubuk , Rachel Lau , Sarah E Church , Briana M Hudson , Frances Humby , Michele Bombardieri , Myles J Lewis , Costantino Pitzalis

Attitudes towards technology supported rheumatoid arthritis care: investigating patient- and clinician-perceived opportunities and barriers.

Rheumatology advances in practice

Avec: Amy MacBrayne , Paul Curzon , Hamit Soyel , William Marsh , Norman Fenton , Costantino Pitzalis , Frances Humby

Fibrocytes in early and long-standing rheumatoid arthritis: a 6-month trial with repeated synovial biopsy, imaging and lung function test.

RMD open

Avec: Søren Andreas Just , Christian Nielsen , Jens Christian Werlinrud , Pia Veldt Larsen , Eva Kildall Hejbøl , Helene Broch Tenstad , Henrik Daa Schrøder , Torben Barington , Trine Torfing , Frances Humby , Hanne Lindegaard

From Personalised Predictions to Targeted Advice: Improving Self-Management in Rheumatoid Arthritis.

Studies in health technology and informatics

Avec: Ali Fahmi , Hamit Soyel , William Marsh , Paul Curzon , Amy MacBrayne , Frances Humby

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial.

Lancet (London, England)

Avec: Frances Humby , Patrick Durez , Maya H Buch , Myles J Lewis , Hasan Rizvi , Felice Rivellese , Alessandra Nerviani , Giovanni Giorli , Arti Mahto , Carlomaurizio Montecucco , Bernard Lauwerys , Nora Ng , Pauline Ho , Michele Bombardieri , Vasco C Romão , Patrick Verschueren , Stephen Kelly , Pier Paolo Sainaghi , Nagui Gendi , Bhaskar Dasgupta , Alberto Cauli , Piero Reynolds , Juan D Cañete , Robert Moots , Peter C Taylor , Christopher J Edwards , John Isaacs , Peter Sasieni , Ernest Choy , Costantino Pitzalis , Auteur inconnu

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis.

Annals of the rheumatic diseases

Avec: Javier Rodríguez-Ubreva , Carlos de la Calle-Fabregat , Tianlu Li , Laura Ciudad , Maria L Ballestar , Francesc Català-Moll , Octavio Morante-Palacios , Antonio Garcia-Gomez , Raquel Celis , Frances Humby , Alessandra Nerviani , Javier Martin , Costantino Pitzalis , Juan D Cañete , Esteban Ballestar

Efficacy, Safety, and Sample Quality of Ultrasound-Guided Synovial Needle Biopsy in Clinical Practice and Research: A Prospective Observational Study.

Arthritis care & research

Avec: Vasco C Romão , Joaquim Polido-Pereira , Rita Barros , Rita Luís , Bruno Vidal , Elsa Vieira-Sousa , Emília Vitorino , Frances Humby , Stephen Kelly , Costantino Pitzalis , Fernando Saraiva , João Eurico Fonseca

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients.

Annals of the rheumatic diseases

Avec: Frances Humby , Myles Lewis , Nandhini Ramamoorthi , Jason A Hackney , Michael R Barnes , Michele Bombardieri , A Francesca Setiadi , Stephen Kelly , Fabiola Bene , Maria DiCicco , Sudeh Riahi , Vidalba Rocher , Nora Ng , Ilias Lazarou , Rebecca Hands , Désirée van der Heijde , Robert B M Landewé , Annette van der Helm-van Mil , Alberto Cauli , Iain McInnes , Christopher Dominic Buckley , Ernest H Choy , Peter C Taylor , Michael J Townsend , Costantino Pitzalis

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.

Science advances

Avec: Mattias N D Svensson , Martina Zoccheddu , Shen Yang , Gyrid Nygaard , Christian Secchi , Karen M Doody , Kamil Slowikowski , Fumitaka Mizoguchi , Frances Humby , Rebecca Hands , Eugenio Santelli , Cristiano Sacchetti , Kuninobu Wakabayashi , Dennis J Wu , Christopher Barback , Rizi Ai , Wei Wang , Gary P Sims , Piotr Mydel , Tsuyoshi Kasama , David L Boyle , Francesco Galimi , David Vera , Michel L Tremblay , Soumya Raychaudhuri , Michael B Brenner , Gary S Firestein , Costantino Pitzalis , Anna-Karin H Ekwall , Stephanie M Stanford , Nunzio Bottini

Réseau de co-auteurs

Frances Humby 16 collaborations

Costantino Pitzalis 13 collaborations

Michele Bombardieri 7 collaborations

Felice Rivellese 6 collaborations

Alessandra Nerviani 6 collaborations

Myles J Lewis 6 collaborations

Stephen Kelly 6 collaborations

Alberto Cauli 5 collaborations

Peter C Taylor 5 collaborations

Rebecca Hands 5 collaborations

None None 4 collaborations

Nora Ng 4 collaborations

Désirée van der Heijde 4 collaborations

Katriona Goldmann 4 collaborations

Giovanni Giorli 3 collaborations

Ernest Choy 3 collaborations

Iain McInnes 3 collaborations

Juan D Cañete 3 collaborations

Nandhini Ramamoorthi 3 collaborations

Jason A Hackney 3 collaborations

Michael J Townsend 3 collaborations

Michael R Barnes 3 collaborations

Vasco C Romão 3 collaborations

Andrew Filer 2 collaborations

Nagui Gendi 2 collaborations

Patrick Durez 2 collaborations

Christopher J Edwards 2 collaborations

Maya H Buch 2 collaborations

Pier Paolo Sainaghi 2 collaborations

Pauline Ho 2 collaborations

Bhaskar Dasgupta 2 collaborations

Peter Sasieni 2 collaborations

Myles Lewis 2 collaborations

Daniele Mauro 2 collaborations

Fabiola Bene 2 collaborations

Ernest H Choy 2 collaborations

Elisabetta Sciacca 2 collaborations

Christopher R John 2 collaborations

Edoardo Prediletto 2 collaborations

Sarah E Church 2 collaborations

Briana M Hudson 2 collaborations

Søren Andreas Just 2 collaborations

Christian Nielsen 2 collaborations

Jens Christian Werlinrud 2 collaborations

Pia Veldt Larsen 2 collaborations

Henrik Daa Schrøder 2 collaborations

Trine Torfing 2 collaborations

Hanne Lindegaard 2 collaborations

Elena Pontarini 2 collaborations

Kevin Blighe 2 collaborations

Sudeh Riahi 2 collaborations

Vidalba Rocher-Ros 2 collaborations

Maria DiCicco 2 collaborations

Annette van der Helm-van Mil 2 collaborations

Arti Mahto 2 collaborations

Ilias Lazarou 2 collaborations

João Eurico Fonseca 2 collaborations

Amy MacBrayne 2 collaborations

Paul Curzon 2 collaborations

Hamit Soyel 2 collaborations

William Marsh 2 collaborations

F Rivellese 1 collaboration

F Humby 1 collaboration

S Bugatti 1 collaboration

L Fossati-Jimack 1 collaboration

H Rizvi 1 collaboration

D Lucchesi 1 collaboration

G Lliso-Ribera 1 collaboration

A Nerviani 1 collaboration

R E Hands 1 collaboration

G Giorli 1 collaboration

B Frias 1 collaboration

G Thorborn 1 collaboration

E Jaworska 1 collaboration

C John 1 collaboration

K Goldmann 1 collaboration

M J Lewis 1 collaboration

A Manzo 1 collaboration

M Bombardieri 1 collaboration

C Pitzalis 1 collaboration

Xiang Li Tan 1 collaboration

Gemma Pugh 1 collaboration

Dylan Morrissey 1 collaboration

Louise Warren 1 collaboration

Edyta Jaworska 1 collaboration

Arthur G Pratt 1 collaboration

Elisa Gremese 1 collaboration

Sabrina Raizada 1 collaboration

Neil D McKay 1 collaboration

Deepak Jadon 1 collaboration

Richard Stratton 1 collaboration

Michael R Ehrenstein 1 collaboration

Joaquim P Pereira 1 collaboration

Claire Gorman 1 collaboration

James Galloway 1 collaboration

Hector Chinoy 1 collaboration

Anne Barton 1 collaboration

Gloria Lliso-Ribera 1 collaboration

Anna E A Surace 1 collaboration

Cankut Çubuk 1 collaboration

Liliane Fossati-Jimack 1 collaboration

Georgina Thorborn 1 collaboration

Manzoor Ahmed 1 collaboration

Sarah E Warren 1 collaboration

Paul M McKeigue 1 collaboration

Camilla Schufri Klinkby 1 collaboration

Valentina Pucino 1 collaboration

Michelangelo Certo 1 collaboration

Vinay Bulusu 1 collaboration

Danilo Cucchi 1 collaboration

Robert Haas 1 collaboration

Joanne Smith 1 collaboration

Sarah E Headland 1 collaboration

Massimiliano Ruscica 1 collaboration

Jurre J Kamphorst 1 collaboration

Claudio Mauro 1 collaboration

Sharmila Rana 1 collaboration

David S Watson 1 collaboration

Sarah K Kummerfeld 1 collaboration

Robert Landewé 1 collaboration

Iain B McInnes 1 collaboration

Christopher D Buckley 1 collaboration

Maria Di Cicco 1 collaboration

Marie-Astrid Boutet 1 collaboration

Giulia Maria Ghirardi 1 collaboration

Federico Abatecola 1 collaboration

Mattia Caliste 1 collaboration

Sara Pagani 1 collaboration

Mattia Bellan 1 collaboration

Cankut Cubuk 1 collaboration

Rachel Lau 1 collaboration

Norman Fenton 1 collaboration

Eva Kildall Hejbøl 1 collaboration

Helene Broch Tenstad 1 collaboration

Torben Barington 1 collaboration

Ali Fahmi 1 collaboration

Hasan Rizvi 1 collaboration

Carlomaurizio Montecucco 1 collaboration

Bernard Lauwerys 1 collaboration

Patrick Verschueren 1 collaboration

Piero Reynolds 1 collaboration

Robert Moots 1 collaboration

John Isaacs 1 collaboration

Javier Rodríguez-Ubreva 1 collaboration

Carlos de la Calle-Fabregat 1 collaboration

Tianlu Li 1 collaboration

Laura Ciudad 1 collaboration

Maria L Ballestar 1 collaboration

Francesc Català-Moll 1 collaboration

Octavio Morante-Palacios 1 collaboration

Antonio Garcia-Gomez 1 collaboration

Raquel Celis 1 collaboration

Javier Martin 1 collaboration

Esteban Ballestar 1 collaboration

Joaquim Polido-Pereira 1 collaboration

Rita Barros 1 collaboration

Rita Luís 1 collaboration

Bruno Vidal 1 collaboration

Elsa Vieira-Sousa 1 collaboration

Emília Vitorino 1 collaboration

Fernando Saraiva 1 collaboration

A Francesca Setiadi 1 collaboration

Vidalba Rocher 1 collaboration

Robert B M Landewé 1 collaboration

Christopher Dominic Buckley 1 collaboration

Mattias N D Svensson 1 collaboration

Martina Zoccheddu 1 collaboration

Shen Yang 1 collaboration

Gyrid Nygaard 1 collaboration

Christian Secchi 1 collaboration

Karen M Doody 1 collaboration

Kamil Slowikowski 1 collaboration

Fumitaka Mizoguchi 1 collaboration

Eugenio Santelli 1 collaboration

Cristiano Sacchetti 1 collaboration

Kuninobu Wakabayashi 1 collaboration

Dennis J Wu 1 collaboration

Christopher Barback 1 collaboration

Rizi Ai 1 collaboration

Wei Wang 1 collaboration

Gary P Sims 1 collaboration

Piotr Mydel 1 collaboration

Tsuyoshi Kasama 1 collaboration

David L Boyle 1 collaboration

Francesco Galimi 1 collaboration

David Vera 1 collaboration

Michel L Tremblay 1 collaboration

Soumya Raychaudhuri 1 collaboration

Michael B Brenner 1 collaboration

Gary S Firestein 1 collaboration

Anna-Karin H Ekwall 1 collaboration

Stephanie M Stanford 1 collaboration

Nunzio Bottini 1 collaboration