Gene Colice

Affiliations

Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.

Publications (30)

Baseline type 2 biomarker levels and response to tezepelumab in severe asthma.

Allergy

Avec: Jonathan Corren , Tuyet-Hang Pham , Esther Garcia Gil , Kinga Sałapa , Pin Ren , Jane R Parnes , Gene Colice , Janet M Griffiths

Tezepelumab Reduces Exacerbations Across All Seasons in Patients with Severe, Uncontrolled Asthma: A Post Hoc Analysis of the PATHWAY Phase 2b Study.

Journal of asthma and allergy

Avec: Jonathan Corren , Martin Karpefors , Åsa Hellqvist , Jane R Parnes , Gene Colice

Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma: The NAVIGATOR study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

Avec: Andrew Menzies-Gow , Arnaud Bourdin , Geoffrey Chupp , Elliot Israel , Åsa Hellqvist , Gillian Hunter , Stephanie L Roseti , Christopher S Ambrose , Jean-Pierre Llanos , Bill Cook , Jonathan Corren , Gene Colice

SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma.

Respiratory research

Avec: Michael E Wechsler , Gene Colice , Janet M Griffiths , Gun Almqvist , Tor Skärby , Teresa Piechowiak , Primal Kaur , Karin Bowen , Åsa Hellqvist , May Mo , Esther Garcia Gil

NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma.

Respiratory research

Avec: Andrew Menzies-Gow , Gene Colice , Janet M Griffiths , Gun Almqvist , Sandhia Ponnarambil , Primal Kaur , Gennaro Ruberto , Karin Bowen , Åsa Hellqvist , May Mo , Esther Garcia Gil

Patient characteristics, biomarkers and exacerbation risk in severe, uncontrolled asthma.

The European respiratory journal

Avec: Monica Kraft , Guy Brusselle , J Mark FitzGerald , Ian D Pavord , Matthew Keith , Malin Fagerås , Esther Garcia Gil , Ian Hirsch , Mitchell Goldman , Gene Colice

Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial.

The Lancet. Respiratory medicine

Avec: Sarah Diver , Latifa Khalfaoui , Claire Emson , Sally E Wenzel , Andrew Menzies-Gow , Michael E Wechsler , James Johnston , Nestor Molfino , Jane R Parnes , Ayman Megally , Gene Colice , Christopher E Brightling , Auteur inconnu

Evaluation of the oral corticosteroid-sparing effect of tezepelumab in adults with oral corticosteroid-dependent asthma (SOURCE): a randomised, placebo-controlled, phase 3 study.

The Lancet. Respiratory medicine

Avec: Michael E Wechsler , Andrew Menzies-Gow , Christopher E Brightling , Piotr Kuna , Stephanie Korn , Tobias Welte , Janet M Griffiths , Kinga Sałapa , Åsa Hellqvist , Gun Almqvist , Harbans Lal , Primal Kaur , Tor Skärby , Gene Colice , Auteur inconnu

Tralokinumab did not demonstrate oral corticosteroid-sparing effects in severe asthma.

The European respiratory journal

Avec: William W Busse , Guy G Brusselle , Stephanie Korn , Piotr Kuna , Antoine Magnan , David Cohen , Karin Bowen , Teresa Piechowiak , Millie M Wang , Gene Colice

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma.

Respiratory research

Avec: Claire Emson , Sarah Diver , Latifa Chachi , Ayman Megally , Cherrie Small , John Downie , Jane R Parnes , Karin Bowen , Gene Colice , Chris E Brightling

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma and Perennial Allergy.

The journal of allergy and clinical immunology. In practice

Avec: Jonathan Corren , Christopher S Ambrose , Kinga Sałapa , Stephanie L Roseti , Janet M Griffiths , Jane R Parnes , Gene Colice

Targeting TSLP in Asthma.

Journal of asthma and allergy

Avec: Jane R Parnes , Nestor A Molfino , Gene Colice , Ubaldo Martin , Jonathan Corren , Andrew Menzies-Gow

Tezepelumab for the treatment of severe asthma: a plain language summary of the PATHWAY and NAVIGATOR studies.

Immunotherapy

Avec: Jonathan Corren , Andrew Menzies-Gow , Johan Bimmel , Anthony McGuinness , Gun Almqvist , Karin Bowen , Janet M Griffiths , Sandhia Ponnarambil , Arnaud Bourdin , Elliot Israel , Gene Colice , Christopher E Brightling , Michael E Wechsler , Auteur inconnu

Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma.

NEJM evidence

Avec: Lars H Nordenmark , Åsa Hellqvist , Claire Emson , Sarah Diver , Celeste Porsbjerg , Janet M Griffiths , John D Newell , Samuel Peterson , Beata Pawlikowska , Jane R Parnes , Ayman Megally , Gene Colice , Christopher E Brightling

Tezepelumab Pharmacokinetics, Safety, and Tolerability After Administration via Vial-and-syringe, Accessorized Prefilled Syringe, or Autoinjector: A Randomized Trial in Healthy Volunteers.

Clinical therapeutics

Avec: Yanan Zheng , Lubna Abuqayyas , Ayman Megally , Rainard Fuhr , Kinga Sałapa , John Downie , Gene Colice

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.

The New England journal of medicine

Avec: Andrew Menzies-Gow , Jonathan Corren , Arnaud Bourdin , Geoffrey Chupp , Elliot Israel , Michael E Wechsler , Christopher E Brightling , Janet M Griffiths , Åsa Hellqvist , Karin Bowen , Primal Kaur , Gun Almqvist , Sandhia Ponnarambil , Gene Colice

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with and without Nasal Polyposis: A

Journal of asthma and allergy

Avec: Claire Emson , Jonathan Corren , Kinga Sałapa , Åsa Hellqvist , Jane R Parnes , Gene Colice

Effect of Tezepelumab on Lung Function in Patients With Severe, Uncontrolled Asthma in the Phase 3 NAVIGATOR Study.

Advances in therapy

Avec: Andrew Menzies-Gow , Christopher S Ambrose , Gene Colice , Gillian Hunter , Bill Cook , Nestor A Molfino , Jean-Pierre Llanos , Elliot Israel

Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR).

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

Avec: Ian D Pavord , Flavia C L Hoyte , Andrew W Lindsley , Christopher S Ambrose , Joseph D Spahn , Stephanie L Roseti , Bill Cook , Janet M Griffiths , Åsa Hellqvist , Nicole Martin , Jean-Pierre Llanos , Neil Martin , Gene Colice , Jonathan Corren

Effect of Tezepelumab on the Humoral Immune Response to Seasonal Quadrivalent Influenza Vaccination in Patients with Moderate to Severe Asthma: The Phase 3b VECTOR Study.

Pulmonary therapy

Avec: Jeremy Cole , Iwona Cąpała-Szczurko , Stephanie Roseti , Claudia Chen , Scott Caveney , Anastasia A Aksyuk , Katie Streicher , Sandhia Ponnarambil , Gene Colice

Population Pharmacokinetic Modeling and Exposure-Efficacy and Body Weight-Response Analyses for Tezepelumab in Patients With Severe, Uncontrolled Asthma.

Journal of clinical pharmacology

Avec: Yanan Zheng , Lubna Abuqayyas , Angelica Quartino , Ye Guan , Yuying Gao , Lu Liu , Åsa Hellqvist , Gene Colice , Alexander MacDonald

Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma.

BMC pulmonary medicine

Avec: Mattis Gottlow , David J Svensson , Ilya Lipkovich , Monika Huhn , Karin Bowen , Peter Wessman , Gene Colice

Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma.

Drug safety

Avec: Mats Carlsson , Martin Braddock , Yuling Li , Jihong Wang , Weichen Xu , Nicholas White , Ayman Megally , Gillian Hunter , Gene Colice

Functionality and Performance of an Accessorized Pre-Filled Syringe and an Autoinjector for At-Home Administration of Tezepelumab in Patients with Severe, Uncontrolled Asthma.

Journal of asthma and allergy

Avec: Sady Alpizar , Ayman Megally , Claudia Chen , Abhi Raj , John Downie , Gene Colice

DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma.

Respiratory research

Avec: Andrew Menzies-Gow , Sandhia Ponnarambil , John Downie , Karin Bowen , Åsa Hellqvist , Gene Colice

Feno differentiates epithelial gene expression clusters: Exploratory analysis from the MESOS randomized controlled trial.

The Journal of allergy and clinical immunology

Avec: Sarah Diver , Sriram Sridhar , Latifa C Khalfaoui , Richard J Russell , Claire Emson , Janet M Griffiths , Melissa de Los Reyes , Da Yin , Gene Colice , Christopher E Brightling

One-year safety and tolerability of tezepelumab in Japanese patients with severe uncontrolled asthma: results of the NOZOMI study.

The Journal of asthma : official journal of the Association for the Care of Asthma

Avec: Masaharu Shinkai , Motohiro Ebisawa , Yasushi Fukushima , Satomi Takeuchi , Hiroshi Okada , Tatsuro Tokiyo , Nobuya Hayashi , Mami Takikawa , Gene Colice , Gun Almqvist

Efficacy and safety of tezepelumab in patients recruited in Japan who participated in the phase 3 NAVIGATOR study.

Allergology international : official journal of the Japanese Society of Allergology

Avec: Tamotsu Ishizuka , Andrew Menzies-Gow , Hiroshi Okada , Yasushi Fukushima , Nobuya Hayashi , Gene Colice , Sandhia Ponnarambil , Gillian Hunter , Hiroshi Odajima , Motohiro Ebisawa

Efficacy of tezepelumab in patients with evidence of severe allergic asthma: Results from the phase 3 NAVIGATOR study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Avec: Jonathan Corren , Christopher S Ambrose , Janet M Griffiths , Åsa Hellqvist , Andrew W Lindsley , Jean-Pierre Llanos , Gene Colice , Andrew Menzies-Gow

Long-term safety and efficacy of tezepelumab in people with severe, uncontrolled asthma (DESTINATION): a randomised, placebo-controlled extension study.

The Lancet. Respiratory medicine

Avec: Andrew Menzies-Gow , Michael E Wechsler , Christopher E Brightling , Stephanie Korn , Jonathan Corren , Elliot Israel , Geoffrey Chupp , Artur Bednarczyk , Sandhia Ponnarambil , Scott Caveney , Gun Almqvist , Monika Gołąbek , Linda Simonsson , Kaitlyn Lawson , Karin Bowen , Gene Colice , Auteur inconnu

Réseau de co-auteurs

Åsa Hellqvist 12 collaborations

Andrew Menzies-Gow 12 collaborations

Jonathan Corren 11 collaborations

Janet M Griffiths 11 collaborations

Karin Bowen 9 collaborations

Jane R Parnes 8 collaborations

Gun Almqvist 7 collaborations

Sandhia Ponnarambil 7 collaborations

Christopher E Brightling 7 collaborations

Michael E Wechsler 6 collaborations

Ayman Megally 6 collaborations

Kinga Sałapa 5 collaborations

Elliot Israel 5 collaborations

Christopher S Ambrose 5 collaborations

Claire Emson 5 collaborations

Esther Garcia Gil 4 collaborations

Gillian Hunter 4 collaborations

Jean-Pierre Llanos 4 collaborations

Primal Kaur 4 collaborations

Sarah Diver 4 collaborations

None None 4 collaborations

John Downie 4 collaborations

Arnaud Bourdin 3 collaborations

Geoffrey Chupp 3 collaborations

Stephanie L Roseti 3 collaborations

Bill Cook 3 collaborations

Stephanie Korn 3 collaborations

Tor Skärby 2 collaborations

Teresa Piechowiak 2 collaborations

May Mo 2 collaborations

Ian D Pavord 2 collaborations

Piotr Kuna 2 collaborations

Nestor A Molfino 2 collaborations

Yanan Zheng 2 collaborations

Lubna Abuqayyas 2 collaborations

Andrew W Lindsley 2 collaborations

Claudia Chen 2 collaborations

Scott Caveney 2 collaborations

Motohiro Ebisawa 2 collaborations

Yasushi Fukushima 2 collaborations

Hiroshi Okada 2 collaborations

Nobuya Hayashi 2 collaborations

Tuyet-Hang Pham 1 collaboration

Pin Ren 1 collaboration

Martin Karpefors 1 collaboration

Gennaro Ruberto 1 collaboration

Monica Kraft 1 collaboration

Guy Brusselle 1 collaboration

J Mark FitzGerald 1 collaboration

Matthew Keith 1 collaboration

Malin Fagerås 1 collaboration

Ian Hirsch 1 collaboration

Mitchell Goldman 1 collaboration

Latifa Khalfaoui 1 collaboration

Sally E Wenzel 1 collaboration

James Johnston 1 collaboration

Nestor Molfino 1 collaboration

Tobias Welte 1 collaboration

Harbans Lal 1 collaboration

William W Busse 1 collaboration

Guy G Brusselle 1 collaboration

Antoine Magnan 1 collaboration

David Cohen 1 collaboration

Millie M Wang 1 collaboration

Latifa Chachi 1 collaboration

Cherrie Small 1 collaboration

Chris E Brightling 1 collaboration

Ubaldo Martin 1 collaboration

Johan Bimmel 1 collaboration

Anthony McGuinness 1 collaboration

Lars H Nordenmark 1 collaboration

Celeste Porsbjerg 1 collaboration

John D Newell 1 collaboration

Samuel Peterson 1 collaboration

Beata Pawlikowska 1 collaboration

Rainard Fuhr 1 collaboration

Flavia C L Hoyte 1 collaboration

Joseph D Spahn 1 collaboration

Nicole Martin 1 collaboration

Neil Martin 1 collaboration

Jeremy Cole 1 collaboration

Iwona Cąpała-Szczurko 1 collaboration

Stephanie Roseti 1 collaboration

Anastasia A Aksyuk 1 collaboration

Katie Streicher 1 collaboration

Angelica Quartino 1 collaboration

Ye Guan 1 collaboration

Yuying Gao 1 collaboration

Lu Liu 1 collaboration

Alexander MacDonald 1 collaboration

Mattis Gottlow 1 collaboration

David J Svensson 1 collaboration

Ilya Lipkovich 1 collaboration

Monika Huhn 1 collaboration

Peter Wessman 1 collaboration

Mats Carlsson 1 collaboration

Martin Braddock 1 collaboration

Yuling Li 1 collaboration

Jihong Wang 1 collaboration

Weichen Xu 1 collaboration

Nicholas White 1 collaboration

Sady Alpizar 1 collaboration

Abhi Raj 1 collaboration

Sriram Sridhar 1 collaboration

Latifa C Khalfaoui 1 collaboration

Richard J Russell 1 collaboration

Melissa de Los Reyes 1 collaboration

Da Yin 1 collaboration

Masaharu Shinkai 1 collaboration

Satomi Takeuchi 1 collaboration

Tatsuro Tokiyo 1 collaboration

Mami Takikawa 1 collaboration

Tamotsu Ishizuka 1 collaboration

Hiroshi Odajima 1 collaboration

Artur Bednarczyk 1 collaboration

Monika Gołąbek 1 collaboration

Linda Simonsson 1 collaboration

Kaitlyn Lawson 1 collaboration