Gerald P Linette

Affiliations

Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Publications (21)

RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma.

Journal of neuro-oncology

Avec: Stephen J Bagley , Wei-Ting Hwang , Steven Brem , Gerald P Linette , Donald M O'Rourke , Arati S Desai

Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Gerald P Linette , Michelle Becker-Hapak , Zachary L Skidmore , Miren Lorea Baroja , Chong Xu , Jasreet Hundal , David H Spencer , Weixuan Fu , Casey Cummins , Maya Robnett , Saghar Kaabinejadian , William H Hildebrand , Vincent Magrini , Ryan Demeter , Alexander S Krupnick , Obi L Griffith , Malachi Griffith , Elaine R Mardis , Beatriz M Carreno

On the Twentieth Anniversary of Dendritic Cell Vaccines - Riding the Next Wave.

Cancer research

Avec: Gerald P Linette , Beatriz M Carreno

A Phase I Study of Apolizumab, an Anti-HLA-DR ß-chain Monoclonal Antibody, in Patients With Solid Tumor Malignancies.

American journal of clinical oncology

Avec: Paula M Fracasso , Sherry A Goodner , Jonathan D Wildi , Michael J Naughton , Gerald P Linette , Ramaswamy Govindan , Benjamin R Tan , Kristie A Blum , Gary J Jones , Tillman E Pearce , Daniel J Levitt , Gerald H Clamon

Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy.

Blood cancer discovery

Avec: Alfred L Garfall , Adam D Cohen , Sandra P Susanibar-Adaniya , Wei-Ting Hwang , Dan T Vogl , Adam J Waxman , Simon F Lacey , Vanessa E Gonzalez , Joseph A Fraietta , Minnal Gupta , Irina Kulikovskaya , Lifeng Tian , Fang Chen , Natalka Koterba , Robert L Bartoszek , Margaret Patchin , Rong Xu , Gabriela Plesa , Don L Siegel , Andrea Brennan , Anne Marie Nelson , Regina Ferthio , Angela Cosey , Kim-Marie Shea , Rachel Leskowitz , Megan Four , Wesley V Wilson , Fei Miao , Eric Lancaster , Beatriz M Carreno , Gerald P Linette , Elizabeth O Hexner , Regina M Young , Dexiu Bu , Keith G Mansfield , Jennifer L Brogdon , Carl H June , Michael C Milone , Edward A Stadtmauer

Expression of inducible factors reprograms CAR-T cells for enhanced function and safety.

Cancer cell

Avec: Anže Smole , Alexander Benton , Mathilde A Poussin , Monika A Eiva , Claudia Mezzanotte , Barbara Camisa , Beatrice Greco , Prannda Sharma , Nicholas G Minutolo , Falon Gray , Adham S Bear , Miren L Baroja , Casey Cummins , Chong Xu , Francesca Sanvito , Andrea Lang Goldgewicht , Tatiana Blanchard , Alba Rodriguez-Garcia , Michael Klichinsky , Chiara Bonini , Carl H June , Avery D Posey , Gerald P Linette , Beatriz M Carreno , Monica Casucci , Daniel J Powell

CD5 deletion enhances the antitumor activity of adoptive T cell therapies.

Science immunology

Avec: Ruchi P Patel , Guido Ghilardi , Yunlin Zhang , Yi-Hao Chiang , Wei Xie , Puneeth Guruprasad , Ki Hyun Kim , Inkook Chun , Mathew G Angelos , Raymone Pajarillo , Seok Jae Hong , Yong Gu Lee , Olga Shestova , Carolyn Shaw , Ivan Cohen , Aasha Gupta , Trang Vu , Dean Qian , Steven Yang , Aditya Nimmagadda , Adam E Snook , Nicholas Siciliano , Antonia Rotolo , Arati Inamdar , Jaryse Harris , Ositadimma Ugwuanyi , Michael Wang , Alberto Carturan , Luca Paruzzo , Linhui Chen , Hatcher J Ballard , Tatiana Blanchard , Chong Xu , Mohamed Abdel-Mohsen , Khatuna Gabunia , Maria Wysocka , Gerald P Linette , Beatriz Carreno , David M Barrett , David T Teachey , Avery D Posey , Daniel J Powell , C Tor Sauter , Stefano Pileri , Vinodh Pillai , John Scholler , Alain H Rook , Stephen J Schuster , Stefan K Barta , Patrizia Porazzi , Marco Ruella

Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.

Clinical & translational immunology

Avec: Gautam N Shenoy , Christopher J Greene , Maulasri Bhatta , Miren L Baroja , Jenni L Loyall , Sathy V Balu-Iyer , Raymond J Kelleher , Beatriz M Carreno , Gerald P Linette , Leonard D Shultz , Richard B Bankert

Tumor-Infiltrating Lymphocytes in the Checkpoint Inhibitor Era.

Current hematologic malignancy reports

Avec: Gerald P Linette , Beatriz M Carreno

Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma.

Cancer research communications

Avec: Payal D Shah , Alexander C Huang , Xiaowei Xu , Robert Orlowski , Ravi K Amaravadi , Lynn M Schuchter , Paul Zhang , Julia Tchou , Tina Matlawski , Amanda Cervini , Joanne Shea , Joan Gilmore , Lester Lledo , Karen Dengel , Amy Marshall , E John Wherry , Gerald P Linette , Andrea Brennan , Vanessa Gonzalez , Irina Kulikovskaya , Simon F Lacey , Gabriela Plesa , Carl H June , Robert H Vonderheide , Tara C Mitchell

Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors.

The Journal of clinical investigation

Avec: Adham S Bear , Rebecca B Nadler , Mark H O'Hara , Kelsey L Stanton , Chong Xu , Robert J Saporito , Andrew J Rech , Miren L Baroja , Tatiana Blanchard , Maxwell H Elliott , Michael J Ford , Richard C Jones , Shivang Patel , Andrea L Brennan , Zachary O'Neil , Daniel J Powell , Robert H Vonderheide , Gerald P Linette , Beatriz M Carreno

Primary Bone Tumors: Challenges and Opportunities for CAR-T Therapies.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Avec: Ian W Folkert , Samir Devalaraja , Gerald P Linette , Kristy Weber , Malay Haldar

A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma.

Nature medicine

Avec: Alexander C Huang , Robert J Orlowski , Xiaowei Xu , Rosemarie Mick , Sangeeth M George , Patrick K Yan , Sasikanth Manne , Adam A Kraya , Bradley Wubbenhorst , Liza Dorfman , Kurt D'Andrea , Brandon M Wenz , Shujing Liu , Lakshmi Chilukuri , Andrew Kozlov , Mary Carberry , Lydia Giles , Melanie W Kier , Felix Quagliarello , Suzanne McGettigan , Kristin Kreider , Lakshmanan Annamalai , Qing Zhao , Robin Mogg , Wei Xu , Wendy M Blumenschein , Jennifer H Yearley , Gerald P Linette , Ravi K Amaravadi , Lynn M Schuchter , Ramin S Herati , Bertram Bengsch , Katherine L Nathanson , Michael D Farwell , Giorgos C Karakousis , E John Wherry , Tara C Mitchell

Avelumab in patients with previously treated metastatic Merkel cell carcinoma (JAVELIN Merkel 200): updated overall survival data after >5 years of follow-up.

ESMO open

Avec: S P D'Angelo , S Bhatia , A S Brohl , O Hamid , J M Mehnert , P Terheyden , K C Shih , I Brownell , C Lebbé , K D Lewis , G P Linette , M Milella , H Xiong , G Guezel , P T Nghiem

A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Iris K Lee , Nitika Sharma , Estela Noguera-Ortega , Maria Liousia , Miren L Baroja , Jean M Etersque , Jonathan Pham , Swarbhanu Sarkar , Beatriz M Carreno , Gerald P Linette , Ellen Puré , Steven M Albelda , Mark A Sellmyer

Facts and hopes in immunotherapy strategies targeting antigens derived from KRAS mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Gerald P Linette , Adham S Bear , Beatriz M Carreno

Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma.

Cancer immunology, immunotherapy : CII

Avec: Sandra P D'Angelo , Matthias Hunger , Andrew S Brohl , Paul Nghiem , Shailender Bhatia , Omid Hamid , Janice M Mehnert , Patrick Terheyden , Kent C Shih , Isaac Brownell , Céleste Lebbé , Karl D Lewis , Gerald P Linette , Michele Milella , Michael Schlichting , Meliessa H Hennessy , Murtuza Bharmal

Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial.

Journal for immunotherapy of cancer

Avec: Sandra P D'Angelo , Shailender Bhatia , Andrew S Brohl , Omid Hamid , Janice M Mehnert , Patrick Terheyden , Kent C Shih , Isaac Brownell , Celeste Lebbé , Karl D Lewis , Gerald P Linette , Michele Milella , Sara Georges , Parantu Shah , Barbara Ellers-Lenz , Marcis Bajars , Gülseren Güzel , Paul T Nghiem

Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting.

Nature communications

Avec: Adham S Bear , Tatiana Blanchard , Joseph Cesare , Michael J Ford , Lee P Richman , Chong Xu , Miren L Baroja , Sarah McCuaig , Christina Costeas , Khatuna Gabunia , John Scholler , Avery D Posey , Mark H O'Hara , Anze Smole , Daniel J Powell , Benjamin A Garcia , Robert H Vonderheide , Gerald P Linette , Beatriz M Carreno

BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Janice M Mehnert , Tara C Mitchell , Alexander C Huang , Tomas S Aleman , Benjamin J Kim , Lynn M Schuchter , Gerald P Linette , Giorgos C Karakousis , Sheryl Mitnick , Lydia Giles , Mary Carberry , Noelle Frey , Andrew Kossenkov , Roman Groisberg , Leonel F Hernandez-Aya , George Ansstas , Ann W Silk , Sunandana Chandra , Jeffrey A Sosman , Phyllis A Gimotty , Rosemarie Mick , Ravi K Amaravadi

Identification of core techniques that enhance genome editing of human T cells expressing synthetic antigen receptors.

Cancer immunology research

Avec: Ju-Fang Chang , Nils Wellhausen , Nils Wolfgang Engel , Jack H Landmann , Caitlin R Hopkins , January Salas-McKee , Adham S Bear , Mehmet Emrah Selli , Sangya Agarwal , Julie Jadlowsky , Gerald P Linette , Saar Gill , Carl H June , Joseph A Fraietta , Nathan Singh

Réseau de co-auteurs

Beatriz M Carreno 10 collaborations

Chong Xu 5 collaborations

Adham S Bear 5 collaborations

Miren L Baroja 5 collaborations

Carl H June 4 collaborations

Tatiana Blanchard 4 collaborations

Daniel J Powell 4 collaborations

Avery D Posey 3 collaborations

Alexander C Huang 3 collaborations

Ravi K Amaravadi 3 collaborations

Lynn M Schuchter 3 collaborations

Robert H Vonderheide 3 collaborations

Tara C Mitchell 3 collaborations

Janice M Mehnert 3 collaborations

Wei-Ting Hwang 2 collaborations

Casey Cummins 2 collaborations

Simon F Lacey 2 collaborations

Joseph A Fraietta 2 collaborations

Irina Kulikovskaya 2 collaborations

Gabriela Plesa 2 collaborations

Andrea Brennan 2 collaborations

Khatuna Gabunia 2 collaborations

John Scholler 2 collaborations

Xiaowei Xu 2 collaborations

E John Wherry 2 collaborations

Mark H O'Hara 2 collaborations

Michael J Ford 2 collaborations

Rosemarie Mick 2 collaborations

Mary Carberry 2 collaborations

Lydia Giles 2 collaborations

Giorgos C Karakousis 2 collaborations

Sandra P D'Angelo 2 collaborations

Andrew S Brohl 2 collaborations

Shailender Bhatia 2 collaborations

Omid Hamid 2 collaborations

Patrick Terheyden 2 collaborations

Kent C Shih 2 collaborations

Isaac Brownell 2 collaborations

Karl D Lewis 2 collaborations

Michele Milella 2 collaborations

Stephen J Bagley 1 collaboration

Steven Brem 1 collaboration

Donald M O'Rourke 1 collaboration

Arati S Desai 1 collaboration

Michelle Becker-Hapak 1 collaboration

Zachary L Skidmore 1 collaboration

Miren Lorea Baroja 1 collaboration

Jasreet Hundal 1 collaboration

David H Spencer 1 collaboration

Weixuan Fu 1 collaboration

Maya Robnett 1 collaboration

Saghar Kaabinejadian 1 collaboration

William H Hildebrand 1 collaboration

Vincent Magrini 1 collaboration

Ryan Demeter 1 collaboration

Alexander S Krupnick 1 collaboration

Obi L Griffith 1 collaboration

Malachi Griffith 1 collaboration

Elaine R Mardis 1 collaboration

Paula M Fracasso 1 collaboration

Sherry A Goodner 1 collaboration

Jonathan D Wildi 1 collaboration

Michael J Naughton 1 collaboration

Ramaswamy Govindan 1 collaboration

Benjamin R Tan 1 collaboration

Kristie A Blum 1 collaboration

Gary J Jones 1 collaboration

Tillman E Pearce 1 collaboration

Daniel J Levitt 1 collaboration

Gerald H Clamon 1 collaboration

Alfred L Garfall 1 collaboration

Adam D Cohen 1 collaboration

Sandra P Susanibar-Adaniya 1 collaboration

Dan T Vogl 1 collaboration

Adam J Waxman 1 collaboration

Vanessa E Gonzalez 1 collaboration

Minnal Gupta 1 collaboration

Lifeng Tian 1 collaboration

Fang Chen 1 collaboration

Natalka Koterba 1 collaboration

Robert L Bartoszek 1 collaboration

Margaret Patchin 1 collaboration

Rong Xu 1 collaboration

Don L Siegel 1 collaboration

Anne Marie Nelson 1 collaboration

Regina Ferthio 1 collaboration

Angela Cosey 1 collaboration

Kim-Marie Shea 1 collaboration

Rachel Leskowitz 1 collaboration

Megan Four 1 collaboration

Wesley V Wilson 1 collaboration

Fei Miao 1 collaboration

Eric Lancaster 1 collaboration

Elizabeth O Hexner 1 collaboration

Regina M Young 1 collaboration

Dexiu Bu 1 collaboration

Keith G Mansfield 1 collaboration

Jennifer L Brogdon 1 collaboration

Michael C Milone 1 collaboration

Edward A Stadtmauer 1 collaboration

Anže Smole 1 collaboration

Alexander Benton 1 collaboration

Mathilde A Poussin 1 collaboration

Monika A Eiva 1 collaboration

Claudia Mezzanotte 1 collaboration

Barbara Camisa 1 collaboration

Beatrice Greco 1 collaboration

Prannda Sharma 1 collaboration

Nicholas G Minutolo 1 collaboration

Falon Gray 1 collaboration

Francesca Sanvito 1 collaboration

Andrea Lang Goldgewicht 1 collaboration

Alba Rodriguez-Garcia 1 collaboration

Michael Klichinsky 1 collaboration

Chiara Bonini 1 collaboration

Monica Casucci 1 collaboration

Ruchi P Patel 1 collaboration

Guido Ghilardi 1 collaboration

Yunlin Zhang 1 collaboration

Yi-Hao Chiang 1 collaboration

Wei Xie 1 collaboration

Puneeth Guruprasad 1 collaboration

Ki Hyun Kim 1 collaboration

Inkook Chun 1 collaboration

Mathew G Angelos 1 collaboration

Raymone Pajarillo 1 collaboration

Seok Jae Hong 1 collaboration

Yong Gu Lee 1 collaboration

Olga Shestova 1 collaboration

Carolyn Shaw 1 collaboration

Ivan Cohen 1 collaboration

Aasha Gupta 1 collaboration

Trang Vu 1 collaboration

Dean Qian 1 collaboration

Steven Yang 1 collaboration

Aditya Nimmagadda 1 collaboration

Adam E Snook 1 collaboration

Nicholas Siciliano 1 collaboration

Antonia Rotolo 1 collaboration

Arati Inamdar 1 collaboration

Jaryse Harris 1 collaboration

Ositadimma Ugwuanyi 1 collaboration

Michael Wang 1 collaboration

Alberto Carturan 1 collaboration

Luca Paruzzo 1 collaboration

Linhui Chen 1 collaboration

Hatcher J Ballard 1 collaboration

Mohamed Abdel-Mohsen 1 collaboration

Maria Wysocka 1 collaboration

Beatriz Carreno 1 collaboration

David M Barrett 1 collaboration

David T Teachey 1 collaboration

C Tor Sauter 1 collaboration

Stefano Pileri 1 collaboration

Vinodh Pillai 1 collaboration

Alain H Rook 1 collaboration

Stephen J Schuster 1 collaboration

Stefan K Barta 1 collaboration

Patrizia Porazzi 1 collaboration

Marco Ruella 1 collaboration

Gautam N Shenoy 1 collaboration

Christopher J Greene 1 collaboration

Maulasri Bhatta 1 collaboration

Jenni L Loyall 1 collaboration

Sathy V Balu-Iyer 1 collaboration

Raymond J Kelleher 1 collaboration

Leonard D Shultz 1 collaboration

Richard B Bankert 1 collaboration

Payal D Shah 1 collaboration

Robert Orlowski 1 collaboration

Paul Zhang 1 collaboration

Julia Tchou 1 collaboration

Tina Matlawski 1 collaboration

Amanda Cervini 1 collaboration

Joanne Shea 1 collaboration

Joan Gilmore 1 collaboration

Lester Lledo 1 collaboration

Karen Dengel 1 collaboration

Amy Marshall 1 collaboration

Vanessa Gonzalez 1 collaboration

Rebecca B Nadler 1 collaboration

Kelsey L Stanton 1 collaboration

Robert J Saporito 1 collaboration

Andrew J Rech 1 collaboration

Maxwell H Elliott 1 collaboration

Richard C Jones 1 collaboration

Shivang Patel 1 collaboration

Andrea L Brennan 1 collaboration

Zachary O'Neil 1 collaboration

Ian W Folkert 1 collaboration

Samir Devalaraja 1 collaboration

Kristy Weber 1 collaboration

Malay Haldar 1 collaboration

Robert J Orlowski 1 collaboration

Sangeeth M George 1 collaboration

Patrick K Yan 1 collaboration

Sasikanth Manne 1 collaboration

Adam A Kraya 1 collaboration

Bradley Wubbenhorst 1 collaboration

Liza Dorfman 1 collaboration

Kurt D'Andrea 1 collaboration

Brandon M Wenz 1 collaboration

Shujing Liu 1 collaboration

Lakshmi Chilukuri 1 collaboration

Andrew Kozlov 1 collaboration

Melanie W Kier 1 collaboration

Felix Quagliarello 1 collaboration

Suzanne McGettigan 1 collaboration

Kristin Kreider 1 collaboration

Lakshmanan Annamalai 1 collaboration

Qing Zhao 1 collaboration

Robin Mogg 1 collaboration

Wei Xu 1 collaboration

Wendy M Blumenschein 1 collaboration

Jennifer H Yearley 1 collaboration

Ramin S Herati 1 collaboration

Bertram Bengsch 1 collaboration

Katherine L Nathanson 1 collaboration

Michael D Farwell 1 collaboration

S P D'Angelo 1 collaboration

S Bhatia 1 collaboration

A S Brohl 1 collaboration

O Hamid 1 collaboration

J M Mehnert 1 collaboration

P Terheyden 1 collaboration

K C Shih 1 collaboration

I Brownell 1 collaboration

C Lebbé 1 collaboration

K D Lewis 1 collaboration

G P Linette 1 collaboration

M Milella 1 collaboration

H Xiong 1 collaboration

G Guezel 1 collaboration

P T Nghiem 1 collaboration

Iris K Lee 1 collaboration

Nitika Sharma 1 collaboration

Estela Noguera-Ortega 1 collaboration

Maria Liousia 1 collaboration

Jean M Etersque 1 collaboration

Jonathan Pham 1 collaboration

Swarbhanu Sarkar 1 collaboration

Ellen Puré 1 collaboration

Steven M Albelda 1 collaboration

Mark A Sellmyer 1 collaboration

Matthias Hunger 1 collaboration

Paul Nghiem 1 collaboration

Céleste Lebbé 1 collaboration

Michael Schlichting 1 collaboration

Meliessa H Hennessy 1 collaboration

Murtuza Bharmal 1 collaboration

Celeste Lebbé 1 collaboration

Sara Georges 1 collaboration

Parantu Shah 1 collaboration

Barbara Ellers-Lenz 1 collaboration

Marcis Bajars 1 collaboration

Gülseren Güzel 1 collaboration

Paul T Nghiem 1 collaboration

Joseph Cesare 1 collaboration

Lee P Richman 1 collaboration

Sarah McCuaig 1 collaboration

Christina Costeas 1 collaboration

Anze Smole 1 collaboration

Benjamin A Garcia 1 collaboration

Tomas S Aleman 1 collaboration

Benjamin J Kim 1 collaboration

Sheryl Mitnick 1 collaboration

Noelle Frey 1 collaboration

Andrew Kossenkov 1 collaboration

Roman Groisberg 1 collaboration

Leonel F Hernandez-Aya 1 collaboration

George Ansstas 1 collaboration

Ann W Silk 1 collaboration

Sunandana Chandra 1 collaboration

Jeffrey A Sosman 1 collaboration

Phyllis A Gimotty 1 collaboration

Ju-Fang Chang 1 collaboration

Nils Wellhausen 1 collaboration

Nils Wolfgang Engel 1 collaboration

Jack H Landmann 1 collaboration

Caitlin R Hopkins 1 collaboration

January Salas-McKee 1 collaboration

Mehmet Emrah Selli 1 collaboration

Sangya Agarwal 1 collaboration

Julie Jadlowsky 1 collaboration

Saar Gill 1 collaboration

Nathan Singh 1 collaboration