Graham Packham

Affiliations

Cancer Research UK Centre, Cancer Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK.

ORCID: 0000-0002-9232-5691

Publications (12)

Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.

Brain pathology (Zurich, Switzerland)

Avec: Christina E Toomey , Wendy Heywood , Bridget C Benson , Georgia Packham , Kevin Mills , Tammaryn Lashley

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors.

Exploration of targeted anti-tumor therapy

Avec: Rachael Arthur , Beatriz Valle-Argos , Andrew J Steele , Graham Packham

Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.

Cellular and molecular life sciences : CMLS

Avec: Sarah Wilmore , Karly-Rai Rogers-Broadway , Joe Taylor , Elizabeth Lemm , Rachel Fell , Freda K Stevenson , Francesco Forconi , Andrew J Steele , Mark Coldwell , Graham Packham , Alison Yeomans

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.

Journal of medicinal chemistry

Avec: Ruxandra Moraru , Beatriz Valle-Argos , Annabel Minton , Lara Buermann , Suyin Pan , Thomas E Wales , Raji E Joseph , Amy H Andreotti , Jonathan C Strefford , Graham Packham , Matthias G J Baud

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation.

European journal of nutrition

Avec: Natasa S Giallourou , Ian R Rowland , Steve D Rothwell , Graham Packham , Daniel M Commane , Jonathan R Swann

Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment.

Blood

Avec: Zhenghao Chen , Helga Simon-Molas , Gaspard Cretenet , Beatriz Valle-Argos , Lindsay D Smith , Francesco Forconi , Bauke V Schomakers , Michel van Weeghel , Dean J Bryant , Jaco A C van Bruggen , Fleur S Peters , Jeffrey C Rathmell , Gerritje J W van der Windt , Arnon P Kater , Graham Packham , Eric Eldering

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL.

Leukemia

Avec: Dean Bryant , Lindsay Smith , Karly Rai Rogers-Broadway , Laura Karydis , Jeongmin Woo , Matthew D Blunt , Francesco Forconi , Freda K Stevenson , Christopher Goodnow , Amanda Russell , Peter Humburg , Graham Packham , Andrew J Steele , Jonathan C Strefford

Upregulation of epithelial metallothioneins by metal-rich ultrafine particulate matter from an underground railway.

Metallomics : integrated biometal science

Avec: Matthew Loxham , Jeongmin Woo , Akul Singhania , Natalie P Smithers , Alison Yeomans , Graham Packham , Alina M Crainic , Richard B Cook , Flemming R Cassee , Christopher H Woelk , Donna E Davies

Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.

Leukemia

Avec: Francesca Arruga , Valeria Bracciamà , Nicoletta Vitale , Tiziana Vaisitti , Katiuscia Gizzi , Alison Yeomans , Marta Coscia , Giovanni D'Arena , Gianluca Gaidano , John N Allan , Richard R Furman , Graham Packham , Francesco Forconi , Silvia Deaglio

Correction: Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.

Leukemia

Avec: Francesca Arruga , Valeria Bracciamà , Nicoletta Vitale , Tiziana Vaisitti , Katiuscia Gizzi , Alison Yeomans , Marta Coscia , Giovanni D'Arena , Gianluca Gaidano , John N Allan , Richard R Furman , Graham Packham , Francesco Forconi , Silvia Deaglio

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells.

Exploration of targeted anti-tumor therapy

Avec: Annabel R Minton , Lindsay D Smith , Dean J Bryant , Jonathan C Strefford , Francesco Forconi , Freda K Stevenson , David A Tumbarello , Edd James , Geir Åge Løset , Ludvig A Munthe , Andrew J Steele , Graham Packham

BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression.

Blood advances

Avec: Thomas E C Cummin , Kerry L Cox , Tom D Murray , Anna H Turaj , Lisa Dunning , Vikki L English , Rachel Fell , Graham Packham , Yan Ma , Ben Powell , Peter W M Johnson , Mark S Cragg , Matthew J Carter

Réseau de co-auteurs

Francesco Forconi 6 collaborations

Andrew J Steele 4 collaborations

Alison Yeomans 4 collaborations

Beatriz Valle-Argos 3 collaborations

Freda K Stevenson 3 collaborations

Jonathan C Strefford 3 collaborations

Rachel Fell 2 collaborations

Lindsay D Smith 2 collaborations

Dean J Bryant 2 collaborations

Jeongmin Woo 2 collaborations

Francesca Arruga 2 collaborations

Valeria Bracciamà 2 collaborations

Nicoletta Vitale 2 collaborations

Tiziana Vaisitti 2 collaborations

Katiuscia Gizzi 2 collaborations

Marta Coscia 2 collaborations

Giovanni D'Arena 2 collaborations

Gianluca Gaidano 2 collaborations

John N Allan 2 collaborations

Richard R Furman 2 collaborations

Silvia Deaglio 2 collaborations

Christina E Toomey 1 collaboration

Wendy Heywood 1 collaboration

Bridget C Benson 1 collaboration

Georgia Packham 1 collaboration

Kevin Mills 1 collaboration

Tammaryn Lashley 1 collaboration

Rachael Arthur 1 collaboration

Sarah Wilmore 1 collaboration

Karly-Rai Rogers-Broadway 1 collaboration

Joe Taylor 1 collaboration

Elizabeth Lemm 1 collaboration

Mark Coldwell 1 collaboration

Ruxandra Moraru 1 collaboration

Annabel Minton 1 collaboration

Lara Buermann 1 collaboration

Suyin Pan 1 collaboration

Thomas E Wales 1 collaboration

Raji E Joseph 1 collaboration

Amy H Andreotti 1 collaboration

Matthias G J Baud 1 collaboration

Natasa S Giallourou 1 collaboration

Ian R Rowland 1 collaboration

Steve D Rothwell 1 collaboration

Daniel M Commane 1 collaboration

Jonathan R Swann 1 collaboration

Zhenghao Chen 1 collaboration

Helga Simon-Molas 1 collaboration

Gaspard Cretenet 1 collaboration

Bauke V Schomakers 1 collaboration

Michel van Weeghel 1 collaboration

Jaco A C van Bruggen 1 collaboration

Fleur S Peters 1 collaboration

Jeffrey C Rathmell 1 collaboration

Gerritje J W van der Windt 1 collaboration

Arnon P Kater 1 collaboration

Eric Eldering 1 collaboration

Dean Bryant 1 collaboration

Lindsay Smith 1 collaboration

Karly Rai Rogers-Broadway 1 collaboration

Laura Karydis 1 collaboration

Matthew D Blunt 1 collaboration

Christopher Goodnow 1 collaboration

Amanda Russell 1 collaboration

Peter Humburg 1 collaboration

Matthew Loxham 1 collaboration

Akul Singhania 1 collaboration

Natalie P Smithers 1 collaboration

Alina M Crainic 1 collaboration

Richard B Cook 1 collaboration

Flemming R Cassee 1 collaboration

Christopher H Woelk 1 collaboration

Donna E Davies 1 collaboration

Annabel R Minton 1 collaboration

David A Tumbarello 1 collaboration

Edd James 1 collaboration

Geir Åge Løset 1 collaboration

Ludvig A Munthe 1 collaboration

Thomas E C Cummin 1 collaboration

Kerry L Cox 1 collaboration

Tom D Murray 1 collaboration

Anna H Turaj 1 collaboration

Lisa Dunning 1 collaboration

Vikki L English 1 collaboration

Yan Ma 1 collaboration

Ben Powell 1 collaboration

Peter W M Johnson 1 collaboration

Mark S Cragg 1 collaboration

Matthew J Carter 1 collaboration