Hans Guehring

Affiliations

Merck KGaA, Global Patient Safety, Frankfurter Strasse 250, 64293, Darmstadt, Germany.

Publications (18)

Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis.

Scientific reports

Avec: Anne-Christine Bay-Jensen , Asger Bihlet , Inger Byrjalsen , Jeppe Ragnar Andersen , Bente Juhl Riis , Claus Christiansen , Martin Michaelis , Hans Guehring , Christoph Ladel , Morten A Karsdal

Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials.

The Lancet. Neurology

Avec: Xavier Montalban , Patrick Vermersch , Douglas L Arnold , Amit Bar-Or , Bruce A C Cree , Anne H Cross , Eva Kubala Havrdova , Ludwig Kappos , Olaf Stuve , Heinz Wiendl , Jerry S Wolinsky , Frank Dahlke , Claire Le Bolay , Li Shen Loo , Sathej Gopalakrishnan , Yann Hyvert , Andrija Javor , Hans Guehring , Nadia Tenenbaum , Davorka Tomic , Auteur inconnu

Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.

JAMA

Avec: Marc C Hochberg , Ali Guermazi , Hans Guehring , Aida Aydemir , Stephen Wax , Patricia Fleuranceau-Morel , Asger Reinstrup Bihlet , Inger Byrjalsen , Jeppe Ragnar Andersen , Felix Eckstein

The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial.

Seminars in arthritis and rheumatism

Avec: Hans Guehring , Flavie Moreau , Benjamin Daelken , Christoph Ladel , Oliver Guenther , Asger Reinstrup Bihlet , Wolfgang Wirth , Felix Eckstein , Marc Hochberg , Philip G Conaghan

Automated MRI assessment confirms cartilage thickness modification in patients with knee osteoarthritis: post-hoc analysis from a phase II sprifermin study.

Osteoarthritis and cartilage

Avec: A Brett , M A Bowes , P G Conaghan , C Ladel , H Guehring , F Moreau , F Eckstein

Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study.

Annals of the rheumatic diseases

Avec: Felix Eckstein , Marc C Hochberg , Hans Guehring , Flavie Moreau , Victor Ona , Asger Reinstrup Bihlet , Inger Byrjalsen , Jeppe Ragnar Andersen , Benjamin Daelken , Oliver Guenther , Christoph Ladel , Martin Michaelis , Philip G Conaghan

Relationship between motion, using the GaitSmartTM system, and radiographic knee osteoarthritis: an explorative analysis in the IMI-APPROACH cohort.

Rheumatology (Oxford, England)

Avec: Eefje M van Helvoort , Diana Hodgins , Simon C Mastbergen , Anne Karien Marijnissen , Hans Guehring , Marieke Loef , Margreet Kloppenburg , Francisco Blanco , Ida K Haugen , Francis Berenbaum , Floris P J G Lafeber , Paco M J Welsing

Scientific reports

Avec: Arnaud Briat , Claire Jacques , Mélodie Malige , Laure Sudre , Geoffroy Nourissat , Philippe Auzeloux , Hans Guehring , Florent Cachin , Francis Berenbaum , Elisabeth Miot-Noirault

Tissue distribution of sprifermin (recombinant human fibroblast growth factor 18) in the rat following intravenous and intra-articular injection.

Osteoarthritis and cartilage open

Avec: C H Ladel , L Barbero , S Riva , H Guehring

Recombinant fibroblast growth factor-18 (sprifermin) enhances microfracture-induced cartilage healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Avec: Honey Hendesi , Suzanne Stewart , Michelle L Gibison , Hans Guehring , Dean W Richardson , George R Dodge

Efficacy and safety results after >3.5 years of treatment with the Bruton's tyrosine kinase inhibitor evobrutinib in relapsing multiple sclerosis: Long-term follow-up of a Phase II randomised clinical trial with a cerebrospinal fluid sub-study.

Multiple sclerosis (Houndmills, Basingstoke, England)

Avec: Xavier Montalban , Karolina Piasecka-Stryczynska , Jens Kuhle , Pascal Benkert , Douglas L Arnold , Martin S Weber , Andrea Seitzinger , Hans Guehring , Jamie Shaw , Davorka Tomic , Yann Hyvert , Danielle E Harlow , Martin Dyroff , Jerry S Wolinsky

A plain language summary of what clinical studies can tell us about the safety of evobrutinib - a potential treatment for multiple sclerosis.

Neurodegenerative disease management

Avec: Xavier Montalban , Daniel Wallace , Mark C Genovese , Davorka Tomic , Dana Parsons-Rich , Claire Le Bolay , Amy H Kao , Hans Guehring

Recombinant human FGF18 preserves depth-dependent mechanical inhomogeneity in articular cartilage.

European cells & materials

Avec: G R Meloni , A Farran , B Mohanraj , H Guehring , R Cocca , E Rabut , R L Mauck , G R Dodge

Predicting knee replacement in participants eligible for disease-modifying osteoarthritis drug treatment with structural endpoints.

Osteoarthritis and cartilage

Avec: C K Kwoh , H Guehring , A Aydemir , M J Hannon , F Eckstein , M C Hochberg

Low levels of type II collagen formation (PRO-C2) are associated with response to sprifermin: a pre-defined, exploratory biomarker analysis from the FORWARD study.

Osteoarthritis and cartilage

Avec: A C Bay-Jensen , A A Manginelli , M Karsdal , Y Luo , Y He , M Michaelis , H Guehring , C Ladel

Safety, Tolerability, and Pharmacodynamics of the ADAMTS-5 Nanobody M6495: Two Phase 1, Single-Center, Double-Blind, Randomized, Placebo-Controlled Studies in Healthy Subjects and Patients With Osteoarthritis.

ACR open rheumatology

Avec: Asger Reinstrup Bihlet , Torben Balchen , Kosalaram Goteti , Jesper Sonne , Christoph Ladel , Morten Asser Karsdal , Victor Ona , Flavie Moreau , Roseann Waterhouse , Anne-Christine Bay-Jensen , Hans Guehring

Characterisation of the safety profile of evobrutinib in over 1000 patients from phase II clinical trials in multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus: an integrated safety analysis.

Journal of neurology, neurosurgery, and psychiatry

Avec: Xavier Montalban , Daniel Wallace , Mark C Genovese , Davorka Tomic , Dana Parsons-Rich , Claire Le Bolay , Amy H Kao , Hans Guehring

Efficacy and Safety of the Bruton's Tyrosine Kinase Inhibitor Evobrutinib in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Trial.

ACR open rheumatology

Avec: Daniel J Wallace , Thomas Dörner , David S Pisetsky , Jorge Sanchez-Guerrero , Anand C Patel , Dana Parsons-Rich , Claire Le Bolay , Elise E Drouin , Amy H Kao , Hans Guehring , Maria Dall'Era

Réseau de co-auteurs

H Guehring 5 collaborations

Christoph Ladel 4 collaborations

Xavier Montalban 4 collaborations

Claire Le Bolay 4 collaborations

Davorka Tomic 4 collaborations

Asger Reinstrup Bihlet 4 collaborations

Inger Byrjalsen 3 collaborations

Jeppe Ragnar Andersen 3 collaborations

Felix Eckstein 3 collaborations

Flavie Moreau 3 collaborations

Dana Parsons-Rich 3 collaborations

Amy H Kao 3 collaborations

Anne-Christine Bay-Jensen 2 collaborations

Martin Michaelis 2 collaborations

Douglas L Arnold 2 collaborations

Jerry S Wolinsky 2 collaborations

Yann Hyvert 2 collaborations

Marc C Hochberg 2 collaborations

Benjamin Daelken 2 collaborations

Oliver Guenther 2 collaborations

Philip G Conaghan 2 collaborations

C Ladel 2 collaborations

F Eckstein 2 collaborations

Victor Ona 2 collaborations

Francis Berenbaum 2 collaborations

Daniel Wallace 2 collaborations

Mark C Genovese 2 collaborations

Asger Bihlet 1 collaboration

Bente Juhl Riis 1 collaboration

Claus Christiansen 1 collaboration

Morten A Karsdal 1 collaboration

Patrick Vermersch 1 collaboration

Amit Bar-Or 1 collaboration

Bruce A C Cree 1 collaboration

Anne H Cross 1 collaboration

Eva Kubala Havrdova 1 collaboration

Ludwig Kappos 1 collaboration

Olaf Stuve 1 collaboration

Heinz Wiendl 1 collaboration

Frank Dahlke 1 collaboration

Li Shen Loo 1 collaboration

Sathej Gopalakrishnan 1 collaboration

Andrija Javor 1 collaboration

Nadia Tenenbaum 1 collaboration

None None 1 collaboration

Ali Guermazi 1 collaboration

Aida Aydemir 1 collaboration

Stephen Wax 1 collaboration

Patricia Fleuranceau-Morel 1 collaboration

Wolfgang Wirth 1 collaboration

Marc Hochberg 1 collaboration

A Brett 1 collaboration

M A Bowes 1 collaboration

P G Conaghan 1 collaboration

F Moreau 1 collaboration

Eefje M van Helvoort 1 collaboration

Diana Hodgins 1 collaboration

Simon C Mastbergen 1 collaboration

Anne Karien Marijnissen 1 collaboration

Marieke Loef 1 collaboration

Margreet Kloppenburg 1 collaboration

Francisco Blanco 1 collaboration

Ida K Haugen 1 collaboration

Floris P J G Lafeber 1 collaboration

Paco M J Welsing 1 collaboration

Arnaud Briat 1 collaboration

Claire Jacques 1 collaboration

Mélodie Malige 1 collaboration

Laure Sudre 1 collaboration

Geoffroy Nourissat 1 collaboration

Philippe Auzeloux 1 collaboration

Florent Cachin 1 collaboration

Elisabeth Miot-Noirault 1 collaboration

C H Ladel 1 collaboration

L Barbero 1 collaboration

S Riva 1 collaboration

Honey Hendesi 1 collaboration

Suzanne Stewart 1 collaboration

Michelle L Gibison 1 collaboration

Dean W Richardson 1 collaboration

George R Dodge 1 collaboration

Karolina Piasecka-Stryczynska 1 collaboration

Jens Kuhle 1 collaboration

Pascal Benkert 1 collaboration

Martin S Weber 1 collaboration

Andrea Seitzinger 1 collaboration

Jamie Shaw 1 collaboration

Danielle E Harlow 1 collaboration

Martin Dyroff 1 collaboration

G R Meloni 1 collaboration

A Farran 1 collaboration

B Mohanraj 1 collaboration

R Cocca 1 collaboration

E Rabut 1 collaboration

R L Mauck 1 collaboration

G R Dodge 1 collaboration

C K Kwoh 1 collaboration

A Aydemir 1 collaboration

M J Hannon 1 collaboration

M C Hochberg 1 collaboration

A C Bay-Jensen 1 collaboration

A A Manginelli 1 collaboration

M Karsdal 1 collaboration

Y Luo 1 collaboration

Y He 1 collaboration

M Michaelis 1 collaboration

Torben Balchen 1 collaboration

Kosalaram Goteti 1 collaboration

Jesper Sonne 1 collaboration

Morten Asser Karsdal 1 collaboration

Roseann Waterhouse 1 collaboration

Daniel J Wallace 1 collaboration

Thomas Dörner 1 collaboration

David S Pisetsky 1 collaboration

Jorge Sanchez-Guerrero 1 collaboration

Anand C Patel 1 collaboration

Elise E Drouin 1 collaboration

Maria Dall'Era 1 collaboration