Helen Lockstone

Affiliations

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

Publications (14)

High-Throughput Identification of MiR-145 Targets in Human Articular Chondrocytes.

Life (Basel, Switzerland)

Avec: Aida Martinez-Sanchez , Stefano Lazzarano , Eshita Sharma , Helen Lockstone , Christopher L Murphy

Sequencing of human genomes with nanopore technology.

Nature communications

Avec: Rory Bowden , Robert W Davies , Andreas Heger , Alistair T Pagnamenta , Mariateresa de Cesare , Laura E Oikkonen , Duncan Parkes , Colin Freeman , Fatima Dhalla , Smita Y Patel , Niko Popitsch , Camilla L C Ip , Hannah E Roberts , Silvia Salatino , Helen Lockstone , Gerton Lunter , Jenny C Taylor , David Buck , Michael A Simpson , Peter Donnelly

Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs

Frontiers in immunology

Avec: Kamayani Singh , Hai Fang , Graham Davies , Benjamin Wright , Helen Lockstone , Richard O Williams , Daniela Ciháková , Julian C Knight , Shoumo Bhattacharya

Using de novo assembly to identify structural variation of eight complex immune system gene regions.

PLoS computational biology

Avec: Jia-Yuan Zhang , Hannah Roberts , David S C Flores , Antony J Cutler , Andrew C Brown , Justin P Whalley , Olga Mielczarek , David Buck , Helen Lockstone , Barbara Xella , Karen Oliver , Craig Corton , Emma Betteridge , Rachael Bashford-Rogers , Julian C Knight , John A Todd , Gavin Band

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.

Molecular cell

Avec: Florian J Groelly , Rebecca A Dagg , Michalis Petropoulos , Giacomo G Rossetti , Birbal Prasad , Andreas Panagopoulos , Teressa Paulsen , Angeliki Karamichali , Samuel E Jones , Fena Ochs , Vasilis S Dionellis , Emilia Puig Lombardi , Matthieu J Miossec , Helen Lockstone , Gaëlle Legube , Andrew N Blackford , Matthias Altmeyer , Thanos D Halazonetis , Madalena Tarsounas

Identification of cellular retinoic acid binding protein 2 (CRABP2) as downstream target of nuclear factor I/X (NFIX): implications for skeletal dysplasia syndromes.

JBMR plus

Avec: Kreepa G Kooblall , Mark Stevenson , Raphael Heilig , Michelle Stewart , Benjamin Wright , Helen Lockstone , David Buck , Roman Fischer , Sara Wells , Kate E Lines , Lydia Teboul , Raoul C Hennekam , Rajesh V Thakker

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.

Nature communications

Avec: Timo Reisländer , Emilia Puig Lombardi , Florian J Groelly , Ana Miar , Manuela Porru , Serena Di Vito , Benjamin Wright , Helen Lockstone , Annamaria Biroccio , Adrian Harris , Arturo Londoño-Vallejo , Madalena Tarsounas

Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors.

Nature communications

Avec: Karen R Mifsud , Clare L M Kennedy , Silvia Salatino , Eshita Sharma , Emily M Price , Samantha N Haque , Andriana Gialeli , Hannah M Goss , Polina E Panchenko , John Broxholme , Simon Engledow , Helen Lockstone , Oscar Cordero Llana , Johannes M H M Reul

A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells.

Nature communications

Avec: Rebecca A Dagg , Gijs Zonderland , Emilia Puig Lombardi , Giacomo G Rossetti , Florian J Groelly , Sonia Barroso , Eliana M C Tacconi , Benjamin Wright , Helen Lockstone , Andrés Aguilera , Thanos D Halazonetis , Madalena Tarsounas

Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma.

Scientific reports

Avec: Hannah E Roberts , Maria Lopopolo , Alistair T Pagnamenta , Eshita Sharma , Duncan Parkes , Lorne Lonie , Colin Freeman , Samantha J L Knight , Gerton Lunter , Helene Dreau , Helen Lockstone , Jenny C Taylor , Anna Schuh , Rory Bowden , David Buck

RNA-seq analysis of the human surfactant air-liquid interface culture reveals alveolar type II cell-like transcriptome.

Molecular therapy. Methods & clinical development

Avec: Altar M Munis , Benjamin Wright , Frederic Jackson , Helen Lockstone , Stephen C Hyde , Catherine M Green , Deborah R Gill

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.

The Lancet. Digital health

Avec: Christos P Kotanidis , Cheng Xie , Donna Alexander , Jonathan C L Rodrigues , Katie Burnham , Alexander Mentzer , Daniel O'Connor , Julian Knight , Muhammad Siddique , Helen Lockstone , Sheena Thomas , Rafail Kotronias , Evangelos K Oikonomou , Ileana Badi , Maria Lyasheva , Cheerag Shirodaria , Sheila F Lumley , Bede Constantinides , Nicholas Sanderson , Gillian Rodger , Kevin K Chau , Archie Lodge , Maria Tsakok , Fergus Gleeson , David Adlam , Praveen Rao , Das Indrajeet , Aparna Deshpande , Amrita Bajaj , Benjamin J Hudson , Vivek Srivastava , Shakil Farid , George Krasopoulos , Rana Sayeed , Ling-Pei Ho , Stefan Neubauer , David E Newby , Keith M Channon , John Deanfield , Charalambos Antoniades , Auteur inconnu , Auteur inconnu

A Mouse Model with a Frameshift Mutation in the Nuclear Factor I/X (

JBMR plus

Avec: Kreepa G Kooblall , Mark Stevenson , Michelle Stewart , Lachlan Harris , Oressia Zalucki , Hannah Dewhurst , Natalie Butterfield , Houfu Leng , Tertius A Hough , Da Ma , Bernard Siow , Paul Potter , Roger D Cox , Stephen D M Brown , Nicole Horwood , Benjamin Wright , Helen Lockstone , David Buck , Tonia L Vincent , Fadil M Hannan , J H Duncan Bassett , Graham R Williams , Kate E Lines , Michael Piper , Sara Wells , Lydia Teboul , Raoul C Hennekam , Rajesh V Thakker

Metabolic profiling of aortic stenosis and hypertrophic cardiomyopathy identifies mechanistic contrasts in substrate utilization.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Nikhil Pal , Animesh Acharjee , Zsuzsanna Ament , Tim Dent , Arash Yavari , Masliza Mahmod , Rina Ariga , James West , Violetta Steeples , Mark Cassar , Neil J Howell , Helen Lockstone , Kate Elliott , Parisa Yavari , William Briggs , Michael Frenneaux , Bernard Prendergast , Jeremy S Dwight , Rajesh Kharbanda , Hugh Watkins , Houman Ashrafian , Julian L Griffin

Réseau de co-auteurs

Benjamin Wright 6 collaborations

David Buck 5 collaborations

Eshita Sharma 3 collaborations

Florian J Groelly 3 collaborations

Emilia Puig Lombardi 3 collaborations

Madalena Tarsounas 3 collaborations

Rory Bowden 2 collaborations

Alistair T Pagnamenta 2 collaborations

Duncan Parkes 2 collaborations

Colin Freeman 2 collaborations

Hannah E Roberts 2 collaborations

Silvia Salatino 2 collaborations

Gerton Lunter 2 collaborations

Jenny C Taylor 2 collaborations

Julian C Knight 2 collaborations

Rebecca A Dagg 2 collaborations

Giacomo G Rossetti 2 collaborations

Thanos D Halazonetis 2 collaborations

Kreepa G Kooblall 2 collaborations

Mark Stevenson 2 collaborations

Michelle Stewart 2 collaborations

Sara Wells 2 collaborations

Kate E Lines 2 collaborations

Lydia Teboul 2 collaborations

Raoul C Hennekam 2 collaborations

Rajesh V Thakker 2 collaborations

None None 2 collaborations

Aida Martinez-Sanchez 1 collaboration

Stefano Lazzarano 1 collaboration

Christopher L Murphy 1 collaboration

Robert W Davies 1 collaboration

Andreas Heger 1 collaboration

Mariateresa de Cesare 1 collaboration

Laura E Oikkonen 1 collaboration

Fatima Dhalla 1 collaboration

Smita Y Patel 1 collaboration

Niko Popitsch 1 collaboration

Camilla L C Ip 1 collaboration

Michael A Simpson 1 collaboration

Peter Donnelly 1 collaboration

Kamayani Singh 1 collaboration

Hai Fang 1 collaboration

Graham Davies 1 collaboration

Richard O Williams 1 collaboration

Daniela Ciháková 1 collaboration

Shoumo Bhattacharya 1 collaboration

Jia-Yuan Zhang 1 collaboration

Hannah Roberts 1 collaboration

David S C Flores 1 collaboration

Antony J Cutler 1 collaboration

Andrew C Brown 1 collaboration

Justin P Whalley 1 collaboration

Olga Mielczarek 1 collaboration

Barbara Xella 1 collaboration

Karen Oliver 1 collaboration

Craig Corton 1 collaboration

Emma Betteridge 1 collaboration

Rachael Bashford-Rogers 1 collaboration

John A Todd 1 collaboration

Gavin Band 1 collaboration

Michalis Petropoulos 1 collaboration

Birbal Prasad 1 collaboration

Andreas Panagopoulos 1 collaboration

Teressa Paulsen 1 collaboration

Angeliki Karamichali 1 collaboration

Samuel E Jones 1 collaboration

Fena Ochs 1 collaboration

Vasilis S Dionellis 1 collaboration

Matthieu J Miossec 1 collaboration

Gaëlle Legube 1 collaboration

Andrew N Blackford 1 collaboration

Matthias Altmeyer 1 collaboration

Raphael Heilig 1 collaboration

Roman Fischer 1 collaboration

Timo Reisländer 1 collaboration

Ana Miar 1 collaboration

Manuela Porru 1 collaboration

Serena Di Vito 1 collaboration

Annamaria Biroccio 1 collaboration

Adrian Harris 1 collaboration

Arturo Londoño-Vallejo 1 collaboration

Karen R Mifsud 1 collaboration

Clare L M Kennedy 1 collaboration

Emily M Price 1 collaboration

Samantha N Haque 1 collaboration

Andriana Gialeli 1 collaboration

Hannah M Goss 1 collaboration

Polina E Panchenko 1 collaboration

John Broxholme 1 collaboration

Simon Engledow 1 collaboration

Oscar Cordero Llana 1 collaboration

Johannes M H M Reul 1 collaboration

Gijs Zonderland 1 collaboration

Sonia Barroso 1 collaboration

Eliana M C Tacconi 1 collaboration

Andrés Aguilera 1 collaboration

Maria Lopopolo 1 collaboration

Lorne Lonie 1 collaboration

Samantha J L Knight 1 collaboration

Helene Dreau 1 collaboration

Anna Schuh 1 collaboration

Altar M Munis 1 collaboration

Frederic Jackson 1 collaboration

Stephen C Hyde 1 collaboration

Catherine M Green 1 collaboration

Deborah R Gill 1 collaboration

Christos P Kotanidis 1 collaboration

Cheng Xie 1 collaboration

Donna Alexander 1 collaboration

Jonathan C L Rodrigues 1 collaboration

Katie Burnham 1 collaboration

Alexander Mentzer 1 collaboration

Daniel O'Connor 1 collaboration

Julian Knight 1 collaboration

Muhammad Siddique 1 collaboration

Sheena Thomas 1 collaboration

Rafail Kotronias 1 collaboration

Evangelos K Oikonomou 1 collaboration

Ileana Badi 1 collaboration

Maria Lyasheva 1 collaboration

Cheerag Shirodaria 1 collaboration

Sheila F Lumley 1 collaboration

Bede Constantinides 1 collaboration

Nicholas Sanderson 1 collaboration

Gillian Rodger 1 collaboration

Kevin K Chau 1 collaboration

Archie Lodge 1 collaboration

Maria Tsakok 1 collaboration

Fergus Gleeson 1 collaboration

David Adlam 1 collaboration

Praveen Rao 1 collaboration

Das Indrajeet 1 collaboration

Aparna Deshpande 1 collaboration

Amrita Bajaj 1 collaboration

Benjamin J Hudson 1 collaboration

Vivek Srivastava 1 collaboration

Shakil Farid 1 collaboration

George Krasopoulos 1 collaboration

Rana Sayeed 1 collaboration

Ling-Pei Ho 1 collaboration

Stefan Neubauer 1 collaboration

David E Newby 1 collaboration

Keith M Channon 1 collaboration

John Deanfield 1 collaboration

Charalambos Antoniades 1 collaboration

Lachlan Harris 1 collaboration

Oressia Zalucki 1 collaboration

Hannah Dewhurst 1 collaboration

Natalie Butterfield 1 collaboration

Houfu Leng 1 collaboration

Tertius A Hough 1 collaboration

Da Ma 1 collaboration

Bernard Siow 1 collaboration

Paul Potter 1 collaboration

Roger D Cox 1 collaboration

Stephen D M Brown 1 collaboration

Nicole Horwood 1 collaboration

Tonia L Vincent 1 collaboration

Fadil M Hannan 1 collaboration

J H Duncan Bassett 1 collaboration

Graham R Williams 1 collaboration

Michael Piper 1 collaboration

Nikhil Pal 1 collaboration

Animesh Acharjee 1 collaboration

Zsuzsanna Ament 1 collaboration

Tim Dent 1 collaboration

Arash Yavari 1 collaboration

Masliza Mahmod 1 collaboration

Rina Ariga 1 collaboration

James West 1 collaboration

Violetta Steeples 1 collaboration

Mark Cassar 1 collaboration

Neil J Howell 1 collaboration

Kate Elliott 1 collaboration

Parisa Yavari 1 collaboration

William Briggs 1 collaboration

Michael Frenneaux 1 collaboration

Bernard Prendergast 1 collaboration

Jeremy S Dwight 1 collaboration

Rajesh Kharbanda 1 collaboration

Hugh Watkins 1 collaboration

Houman Ashrafian 1 collaboration

Julian L Griffin 1 collaboration