Helen Tomkinson

Affiliations

Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Cambridge, UK.

Publications (10)

Food Effect Study Design With Oral Drugs: Lessons Learned From Recently Approved Drugs in Oncology.

Journal of clinical pharmacology

Avec: Mark Farha , Eric Masson , Helen Tomkinson , Ganesh Mugundu

Population pharmacokinetics and exposure-response of selumetinib and its N-desmethyl metabolite in pediatric patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas.

Cancer chemotherapy and pharmacology

Avec: Stein Schalkwijk , Li Zhou , Sarit Cohen-Rabbie , Lokesh Jain , Tomoko Freshwater , Karen So , Zhongqing He , Ioanna Gioni , Helen Tomkinson , Karthick Vishwanathan , Diansong Zhou

Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation-Positive, MET-Amplified Non-Small Cell Lung Cancer Model.

Molecular cancer therapeutics

Avec: Rhys D O Jones , Klas Petersson , Areya Tabatabai , Larry Bao , Helen Tomkinson , Alwin G Schuller

Exposure-response analysis of acalabrutinib and its active metabolite, ACP-5862, in patients with B-cell malignancies.

British journal of clinical pharmacology

Avec: Helena Edlund , Núria Buil-Bruna , Karthick Vishwanathan , Helen Wei , Rakesh Raman , Miné de Kock , Zhongqing He , Huan Liu , Marshall Baek , Joseph Ware , Priti Patel , Helen Tomkinson , Shringi Sharma

Efficacy and Safety Exposure-Response Analyses of Olaparib Capsule and Tablet Formulations in Oncology Patients.

Clinical pharmacology and therapeutics

Avec: Diansong Zhou , Jianguo Li , Maria Learoyd , Khanh Bui , Alienor Berges , Tsveta Milenkova , Nidal Al-Huniti , Helen Tomkinson , Hongmei Xu

Population Pharmacokinetic and Exposure-Response Analysis of Selumetinib and Its N-desmethyl Metabolite in Patients With Non-Small Cell Lung Cancer.

Journal of clinical pharmacology

Avec: Xiao Tong , Hongmei Xu , David J Carlile , Helen Tomkinson , Nidal Al-Huniti , Diansong Zhou

Concentration-QT modelling in early clinical oncology settings: Simulation evaluation of performance.

British journal of clinical pharmacology

Avec: Gael Cantet , Alienor Berges , Rhianna O'Sullivan , Sarit Cohen-Rabbie , Corina Dota , Vincent Dubois , Guillemette E Benoist , Helen Tomkinson , Dinko Rekić , Joanna Parkinson , Stein Schalkwijk

In vitro PK/PD modeling of tyrosine kinase inhibitors in non-small cell lung cancer cell lines.

Clinical and translational science

Avec: Linda Wanika , Neil D Evans , Martin Johnson , Helen Tomkinson , Michael J Chappell

Bridging Olaparib Capsule and Tablet Formulations Using Population Pharmacokinetic Meta-analysis in Oncology Patients.

Clinical pharmacokinetics

Avec: Diansong Zhou , Jianguo Li , Khanh Bui , Maria Learoyd , Alienor Berges , Tsveta Milenkova , Nidal Al-Huniti , Helen Tomkinson , Hongmei Xu

Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer.

Cancer chemotherapy and pharmacology

Avec: Toshio Kawata , Mitsuo Higashimori , Yohji Itoh , Helen Tomkinson , Martin G Johnson , Weifeng Tang , Fredrik Nyberg , Haiyi Jiang , Yusuke Tanigawara

Réseau de co-auteurs

Diansong Zhou 4 collaborations

Alienor Berges 3 collaborations

Nidal Al-Huniti 3 collaborations

Hongmei Xu 3 collaborations

Stein Schalkwijk 2 collaborations

Sarit Cohen-Rabbie 2 collaborations

Zhongqing He 2 collaborations

Karthick Vishwanathan 2 collaborations

Jianguo Li 2 collaborations

Maria Learoyd 2 collaborations

Khanh Bui 2 collaborations

Tsveta Milenkova 2 collaborations

Mark Farha 1 collaboration

Eric Masson 1 collaboration

Ganesh Mugundu 1 collaboration

Li Zhou 1 collaboration

Lokesh Jain 1 collaboration

Tomoko Freshwater 1 collaboration

Karen So 1 collaboration

Ioanna Gioni 1 collaboration

Rhys D O Jones 1 collaboration

Klas Petersson 1 collaboration

Areya Tabatabai 1 collaboration

Larry Bao 1 collaboration

Alwin G Schuller 1 collaboration

Helena Edlund 1 collaboration

Núria Buil-Bruna 1 collaboration

Helen Wei 1 collaboration

Rakesh Raman 1 collaboration

Miné de Kock 1 collaboration

Huan Liu 1 collaboration

Marshall Baek 1 collaboration

Joseph Ware 1 collaboration

Priti Patel 1 collaboration

Shringi Sharma 1 collaboration

Xiao Tong 1 collaboration

David J Carlile 1 collaboration

Gael Cantet 1 collaboration

Rhianna O'Sullivan 1 collaboration

Corina Dota 1 collaboration

Vincent Dubois 1 collaboration

Guillemette E Benoist 1 collaboration

Dinko Rekić 1 collaboration

Joanna Parkinson 1 collaboration

Linda Wanika 1 collaboration

Neil D Evans 1 collaboration

Martin Johnson 1 collaboration

Michael J Chappell 1 collaboration

Toshio Kawata 1 collaboration

Mitsuo Higashimori 1 collaboration

Yohji Itoh 1 collaboration

Martin G Johnson 1 collaboration

Weifeng Tang 1 collaboration

Fredrik Nyberg 1 collaboration

Haiyi Jiang 1 collaboration

Yusuke Tanigawara 1 collaboration