Hugues Lortat-Jacob

Affiliations

Institut de Biologie Structurale, UMR 5075, University Grenoble Alpes, Centre National de la Recherche Scientifique, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Grenoble, France.

ORCID: http://orcid.org/0000-0002-9772-0762

Publications (12)

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.

Nature immunology

Avec: Josephine Kemna , Evelyne Gout , Leon Daniau , Jessica Lao , Kristoffer Weißert , Sandra Ammann , Ralf Kühn , Matthias Richter , Christine Molenda , Anje Sporbert , Dario Zocholl , Robert Klopfleisch , Anja Schütz , Hugues Lortat-Jacob , Peter Aichele , Thomas Kammertoens , Thomas Blankenstein

Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling.

Nature communications

Avec: Ana Boulanger , Camille Thinat , Stephan Züchner , Lee G Fradkin , Hugues Lortat-Jacob , Jean-Maurice Dura

Surface plasmon resonance imaging coupled to on-chip mass spectrometry: a new tool to probe protein-GAG interactions.

Analytical and bioanalytical chemistry

Avec: Cédric Przybylski , Florence Gonnet , Els Saesen , Hugues Lortat-Jacob , Régis Daniel

Expression and purification of recombinant extracellular sulfatase HSulf-2 allows deciphering of enzyme sub-domain coordinated role for the binding and 6-O-desulfation of heparan sulfate.

Cellular and molecular life sciences : CMLS

Avec: Amal Seffouh , Rana El Masri , Olga Makshakova , Evelyne Gout , Zahra El Oula Hassoun , Jean-Pierre Andrieu , Hugues Lortat-Jacob , Romain R Vivès

Discrimination of deletion to point cytokine mutants based on an array of cross-reactive receptors mimicking protein recognition by heparan sulfate.

Analytical and bioanalytical chemistry

Avec: Maria Genua , Laurie-Amandine Garçon , Yulia N Sergeeva , Els Saesen , Benjamin Musnier , Arnaud Buhot , Martial Billon , Evelyne Gout , Rabia Sadir , Hugues Lortat-Jacob , Christine Le Narvor , David Bonnaffé , Thierry Livache , Yanxia Hou

Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity.

Cell reports

Avec: Rana El Masri , Amal Seffouh , Caroline Roelants , Ilham Seffouh , Evelyne Gout , Julien Pérard , Fabien Dalonneau , Kazuchika Nishitsuji , Fredrik Noborn , Mahnaz Nikpour , Göran Larson , Yoann Crétinon , Mélanie Friedel-Arboleas , Kenji Uchimura , Régis Daniel , Hugues Lortat-Jacob , Odile Filhol , Romain R Vivès

Structure of the human heparan sulfate polymerase complex EXT1-EXT2.

Nature communications

Avec: Francisco Leisico , Juneina Omeiri , Christine Le Narvor , Joël Beaudouin , Michael Hons , Daphna Fenel , Guy Schoehn , Yohann Couté , David Bonnaffé , Rabia Sadir , Hugues Lortat-Jacob , Rebekka Wild

Deciphering the structural attributes of protein-heparan sulfate interactions using chemo-enzymatic approaches and NMR spectroscopy.

Glycobiology

Avec: Aurélie Préchoux , Jean-Pierre Simorre , Hugues Lortat-Jacob , Cédric Laguri

Preparation and Characterization of Heparan Sulfate-Derived Oligosaccharides to Investigate Protein-GAG Interaction and HS Biosynthesis Enzyme Activity.

Methods in molecular biology (Clifton, N.J.)

Avec: Cédric Laguri , Rabia Sadir , Evelyne Gout , Romain R Vivès , Hugues Lortat-Jacob

Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Claire Debarnot , Yoan R Monneau , Véronique Roig-Zamboni , Vincent Delauzun , Christine Le Narvor , Emeline Richard , Jérôme Hénault , Adeline Goulet , Firas Fadel , Romain R Vivès , Bernard Priem , David Bonnaffé , Hugues Lortat-Jacob , Yves Bourne

A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis.

Annals of neurology

Avec: Laurie Baert , Mahdia Benkhoucha , Natalia Popa , Mashal C Ahmed , Benoit Manfroi , Jean Boutonnat , Nathalie Sturm , Gilda Raguenez , Marine Tessier , Olivier Casez , Romain Marignier , Mitra Ahmadi , Alexis Broisat , Catherine Ghezzi , Cyril Rivat , Corinne Sonrier , Michael Hahne , Dominique Baeten , Romain R Vives , Hugues Lortat-Jacob , Patrice N Marche , Pascal Schneider , Hans P Lassmann , Jose Boucraut , Patrice H Lalive , Bertrand Huard

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity.

Molecules (Basel, Switzerland)

Avec: Thibault Annaval , Rebekka Wild , Yoann Crétinon , Rabia Sadir , Romain R Vivès , Hugues Lortat-Jacob

Réseau de co-auteurs

Evelyne Gout 5 collaborations

Romain R Vivès 5 collaborations

Rabia Sadir 4 collaborations

Christine Le Narvor 3 collaborations

David Bonnaffé 3 collaborations

Els Saesen 2 collaborations

Régis Daniel 2 collaborations

Amal Seffouh 2 collaborations

Rana El Masri 2 collaborations

Yoann Crétinon 2 collaborations

Rebekka Wild 2 collaborations

Cédric Laguri 2 collaborations

Josephine Kemna 1 collaboration

Leon Daniau 1 collaboration

Jessica Lao 1 collaboration

Kristoffer Weißert 1 collaboration

Sandra Ammann 1 collaboration

Ralf Kühn 1 collaboration

Matthias Richter 1 collaboration

Christine Molenda 1 collaboration

Anje Sporbert 1 collaboration

Dario Zocholl 1 collaboration

Robert Klopfleisch 1 collaboration

Anja Schütz 1 collaboration

Peter Aichele 1 collaboration

Thomas Kammertoens 1 collaboration

Thomas Blankenstein 1 collaboration

Ana Boulanger 1 collaboration

Camille Thinat 1 collaboration

Stephan Züchner 1 collaboration

Lee G Fradkin 1 collaboration

Jean-Maurice Dura 1 collaboration

Cédric Przybylski 1 collaboration

Florence Gonnet 1 collaboration

Olga Makshakova 1 collaboration

Zahra El Oula Hassoun 1 collaboration

Jean-Pierre Andrieu 1 collaboration

Maria Genua 1 collaboration

Laurie-Amandine Garçon 1 collaboration

Yulia N Sergeeva 1 collaboration

Benjamin Musnier 1 collaboration

Arnaud Buhot 1 collaboration

Martial Billon 1 collaboration

Thierry Livache 1 collaboration

Yanxia Hou 1 collaboration

Caroline Roelants 1 collaboration

Ilham Seffouh 1 collaboration

Julien Pérard 1 collaboration

Fabien Dalonneau 1 collaboration

Kazuchika Nishitsuji 1 collaboration

Fredrik Noborn 1 collaboration

Mahnaz Nikpour 1 collaboration

Göran Larson 1 collaboration

Mélanie Friedel-Arboleas 1 collaboration

Kenji Uchimura 1 collaboration

Odile Filhol 1 collaboration

Francisco Leisico 1 collaboration

Juneina Omeiri 1 collaboration

Joël Beaudouin 1 collaboration

Michael Hons 1 collaboration

Daphna Fenel 1 collaboration

Guy Schoehn 1 collaboration

Yohann Couté 1 collaboration

Aurélie Préchoux 1 collaboration

Jean-Pierre Simorre 1 collaboration

Claire Debarnot 1 collaboration

Yoan R Monneau 1 collaboration

Véronique Roig-Zamboni 1 collaboration

Vincent Delauzun 1 collaboration

Emeline Richard 1 collaboration

Jérôme Hénault 1 collaboration

Adeline Goulet 1 collaboration

Firas Fadel 1 collaboration

Bernard Priem 1 collaboration

Yves Bourne 1 collaboration

Laurie Baert 1 collaboration

Mahdia Benkhoucha 1 collaboration

Natalia Popa 1 collaboration

Mashal C Ahmed 1 collaboration

Benoit Manfroi 1 collaboration

Jean Boutonnat 1 collaboration

Nathalie Sturm 1 collaboration

Gilda Raguenez 1 collaboration

Marine Tessier 1 collaboration

Olivier Casez 1 collaboration

Romain Marignier 1 collaboration

Mitra Ahmadi 1 collaboration

Alexis Broisat 1 collaboration

Catherine Ghezzi 1 collaboration

Cyril Rivat 1 collaboration

Corinne Sonrier 1 collaboration

Michael Hahne 1 collaboration

Dominique Baeten 1 collaboration

Romain R Vives 1 collaboration

Patrice N Marche 1 collaboration

Pascal Schneider 1 collaboration

Hans P Lassmann 1 collaboration

Jose Boucraut 1 collaboration

Patrice H Lalive 1 collaboration

Bertrand Huard 1 collaboration

Thibault Annaval 1 collaboration