Jacob Gadwa

Affiliations

Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.

Publications (23)

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis.

Journal for immunotherapy of cancer

Avec: Michael W Knitz , Thomas E Bickett , Laurel B Darragh , Ayman J Oweida , Shilpa Bhatia , Benjamin Van Court , Shiv Bhuvane , Miles Piper , Jacob Gadwa , Adam C Mueller , Diemmy Nguyen , Varuna Nangia , Douglas G Osborne , Xiyuan Bai , Sarah E Ferrara , Mary-Keara Boss , Andrew Goodspeed , Matthew A Burchill , Beth A Jirón Tamburini , Edward D Chan , Curtis R Pickering , Eric T Clambey , Sana D Karam

Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs.

Med (New York, N.Y.)

Avec: Laurel B Darragh , Alexander Nguyen , Tiffany T Pham , Shaquia Idlett-Ali , Michael W Knitz , Jacob Gadwa , Sanjana Bukkapatnam , Sophia Corbo , Nicholas A Olimpo , Diemmy Nguyen , Benjamin Van Court , Brooke Neupert , Justin Yu , Richard B Ross , Michaele Corbisiero , Khalid N M Abdelazeem , Sean P Maroney , David C Galindo , Laith Mukdad , Anthony Saviola , Molishree Joshi , Ruth White , Yazeed Alhiyari , Von Samedi , Adrie Van Bokhoven , Maie St John , Sana D Karam

IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models.

Cancer immunology, immunotherapy : CII

Avec: Justin Yu , Jacob Gadwa , Richard B Ross , Michael Knitz , Laurel B Darragh , Khalid N M Abdelazeem , Jessica Beynor , Brooke Neupert , Alexander Nguyen , Diemmy Nguyen , Nicholas Olimpo , Sophia Corbo , Benjamin Van Court , Angelo D'Alessandro , Anthony Saviola , Sana D Karam

Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC.

bioRxiv : the preprint server for biology

Avec: Khalid N M Abdelazeem , Diemmy Nguyen , Sophia Corbo , Laurel B Darragh , Mike W Matsumoto , Benjamin Van Court , Brooke Neupert , Justin Yu , Nicholas A Olimpo , Douglas Grant Osborne , Jacob Gadwa , Richard B Ross , Alexander Nguyen , Shilpa Bhatia , Mohit Kapoor , Rachel S Friedman , Jordan Jacobelli , Anthony J Saviola , Michael W Knitz , Elena B Pasquale , Sana D Karam

Frontiers in cellular and infection microbiology

Avec: Xiyuan Bai , Deepshikha Verma , Cindy Garcia , Ariel Musheyev , Kevin Kim , Lorelenn Fornis , David E Griffith , Li Li , Nicholas Whittel , Jacob Gadwa , Tamara Ohanjanyan , Matthew J Eggleston , Manuel Galvan , Brian M Freed , Diane Ordway , Edward D Chan

Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.

Nature communications

Avec: Laurel B Darragh , Jacob Gadwa , Tiffany T Pham , Benjamin Van Court , Brooke Neupert , Nicholas A Olimpo , Khoa Nguyen , Diemmy Nguyen , Michael W Knitz , Maureen Hoen , Sophia Corbo , Molishree Joshi , Yonghua Zhuang , Maria Amann , Xiao-Jing Wang , Steven Dow , Ross M Kedl , Von Samedi , Mary-Keara Boss , Sana D Karam

Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis.

Cancer cell

Avec: Miles Piper , Maureen Hoen , Laurel B Darragh , Michael W Knitz , Diemmy Nguyen , Jacob Gadwa , Greta Durini , Idil Karakoc , Abby Grier , Brooke Neupert , Benjamin Van Court , Khalid N M Abdelazeem , Justin Yu , Nicholas A Olimpo , Sophia Corbo , Richard Blake Ross , Tiffany T Pham , Molishree Joshi , Ross M Kedl , Anthony J Saviola , Maria Amann , Pablo Umaña , Laura Codarri Deak , Christian Klein , Angelo D'Alessandro , Sana D Karam

PPARα Agonism Enhances Immune Response to Radiotherapy while Dietary Oleic Acid Results in Counteraction.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Richard Blake Ross , Jacob Gadwa , Justin Yu , Laurel B Darragh , Michael W Knitz , Diemmy Nguyen , Nicholas A Olimpo , Khalid N M Abdelazeem , Alexander Nguyen , Sophia Corbo , Benjamin Van Court , Jessica Beynor , Brooke Neupert , Anthony J Saviola , Angelo D'Alessandro , Sana D Karam

Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer.

International journal of radiation oncology, biology, physics

Avec: Jacob Gadwa , Sana D Karam

Nanoluciferase Reporter Mycobacteriophage for Sensitive and Rapid Detection of Mycobacterium tuberculosis Drug Susceptibility.

Journal of bacteriology

Avec: Paras Jain , Spencer Garing , Deepshikha Verma , Rajagopalan Saranathan , Nicholas Clute-Reinig , Jacob Gadwa , Chelsea Peterson , Gleda Hermansky , Anna Astashkina Fernandez , Emmanuel Asare , Torin R Weisbrod , Ethan Spencer , Claire V Mulholland , Michael Berney , David Bell , Kevin P Nichols , Anne-Laure M Le Ny , Diane Ordway , William R Jacobs , Akos Somoskovi , Kyle J Minch

Frontiers in microbiology

Avec: Deepshikha Verma , Megan Stapleton , Jake Gadwa , Kridakorn Vongtongsalee , Alan R Schenkel , Edward D Chan , Diane Ordway

Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer.

Journal for immunotherapy of cancer

Avec: Jacob Gadwa , Thomas E Bickett , Laurel B Darragh , Michael William Knitz , Shilpa Bhatia , Miles Piper , Benjamin Van Court , Shiv Bhuvane , Diemmy Nguyen , Varuna Nangia , Emily K Kleczko , Raphael A Nemenoff , Sana D Karam

Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer.

Cancer research

Avec: Adam C Mueller , Miles Piper , Andrew Goodspeed , Shiv Bhuvane , Jason S Williams , Shilpa Bhatia , Andy V Phan , Benjamin Van Court , Kathryn L Zolman , Brisa Peña , Ayman J Oweida , Sara Zakem , Cheryl Meguid , Michael W Knitz , Laurel Darragh , Thomas E Bickett , Jacob Gadwa , Luisa Mestroni , Matthew R G Taylor , Kimberly R Jordan , Peter Dempsey , M Scott Lucia , Martin D McCarter , Marco Del Chiaro , Wells A Messersmith , Richard D Schulick , Karyn A Goodman , Michael J Gough , Casey S Greene , James C Costello , Antonio Galveo Neto , David Lagares , Kirk C Hansen , Adrie Van Bokhoven , Sana D Karam

The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme.

Molecular carcinogenesis

Avec: Shilpa Bhatia , Sanjana Bukkapatnam , Benjamin Van Court , Andy Phan , Ayman Oweida , Jacob Gadwa , Adam C Mueller , Miles Piper , Laurel Darragh , Diemmy Nguyen , Ahmed Gilani , Michael Knitz , Thomas Bickett , Adam Green , Sujatha Venkataraman , Rajeev Vibhakar , Diana Cittelly , Sana D Karam

Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Thomas E Bickett , Michael W Knitz , Miles Piper , Ayman J Oweida , Jacob Gadwa , Laurel B Darragh , Diemmy Nguyen , Shilpa Bhatia , Shiv Bhuvane , Andy V Phan , Benjamin Van Court , Sophia Corbo , Tiffany Pham , Alexander L Dent , Laurel Lenz , Sana D Karam

The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression.

bioRxiv : the preprint server for biology

Avec: Sophia Corbo , Diemmy Nguyen , Shilpa Bhatia , Laurel B Darragh , Khalid N M Abdelazeem , Benjamin Van Court , Nicholas A Olimpo , Jacob Gadwa , Justin Yu , Chloe Hodgson , Von Samedi , Enrique Sanz Garcia , Lillian Siu , Anthony Saviola , Lynn E Heasley , Michael W Knitz , Elena B Pasquale , Sana D Karam

Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC.

Cell reports. Medicine

Avec: Jacob Gadwa , Maria Amann , Thomas E Bickett , Michael W Knitz , Laurel B Darragh , Miles Piper , Benjamin Van Court , Sanjana Bukkapatnam , Tiffany T Pham , Xiao-Jing Wang , Anthony J Saviola , Laura Codarri Deak , Pablo Umaña , Christian Klein , Angelo D'Alessandro , Sana D Karam

Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma.

Cancer immunology, immunotherapy : CII

Avec: Michael W Knitz , Laurel B Darragh , Thomas E Bickett , Shilpa Bhatia , Sanjana Bukkapatnam , Jacob Gadwa , Miles Piper , Sophia Corbo , Diemmy Nguyen , Benjamin Van Court , Ayman Oweida , Sana D Karam

FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Thomas E Bickett , Michael Knitz , Laurel B Darragh , Shilpa Bhatia , Benjamin Van Court , Jacob Gadwa , Shiv Bhuvane , Miles Piper , Diemmy Nguyen , Hua Tu , Laurel Lenz , Eric T Clambey , Kevin Barry , Sana D Karam

Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Miles Piper , Benjamin Van Court , Adam Mueller , Shuichi Watanabe , Thomas Bickett , Shilpa Bhatia , Laurel B Darragh , Max Mayeda , Diemmy Nguyen , Jacob Gadwa , Michael Knitz , Sophia Corbo , Rustain Morgan , Jung-Jae Lee , Alexander Dent , Karyn Goodman , Wells Messersmith , Richard Schulick , Marco Del Chiaro , Yuwen Zhu , Ross M Kedl , Laurel Lenz , Sana D Karam

EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.

Nature communications

Avec: Shilpa Bhatia , Diemmy Nguyen , Laurel B Darragh , Benjamin Van Court , Jaspreet Sharma , Michael W Knitz , Miles Piper , Sanjana Bukkapatnam , Jacob Gadwa , Thomas E Bickett , Shiv Bhuvane , Sophia Corbo , Brian Wu , Yichien Lee , Mayumi Fujita , Molishree Joshi , Lynn E Heasley , Robert L Ferris , Olga Rodriguez , Christopher Albanese , Mohit Kapoor , Elena B Pasquale , Sana D Karam

A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC.

Nature cancer

Avec: Laurel B Darragh , Michael M Knitz , Junxiao Hu , Eric T Clambey , Jennifer Backus , Andrew Dumit , Von Samedi , Andrew Bubak , Casey Greene , Timothy Waxweiler , Sanjana Mehrotra , Shilpa Bhatia , Jacob Gadwa , Thomas Bickett , Miles Piper , Kareem Fakhoury , Arthur Liu , Joshua Petit , Daniel Bowles , Ashesh Thaker , Kimberly Atiyeh , Julie Goddard , Robert Hoyer , Adrie Van Bokhoven , Kimberly Jordan , Antonio Jimeno , Angelo D'Alessandro , David Raben , Jessica D McDermott , Sana D Karam

IL15/IL15Rα complex induces an anti-tumor immune response following radiation therapy only in the absence of Tregs and fails to induce expansion of progenitor TCF1+ CD8 T cells.

bioRxiv : the preprint server for biology

Avec: Miles Piper , Jacob Gadwa , Chloe Hodgson , Michael Knitz , Elliott Yee , Yuwen Zhu , Keira Y Larson , Christian Klein , Maria Amann , Anthony Saviola , Sana D Karam

Réseau de co-auteurs

Sana D Karam 20 collaborations

Benjamin Van Court 17 collaborations

Laurel B Darragh 16 collaborations

Diemmy Nguyen 15 collaborations

Miles Piper 13 collaborations

Michael W Knitz 12 collaborations

Shilpa Bhatia 12 collaborations

Sophia Corbo 11 collaborations

Thomas E Bickett 8 collaborations

Shiv Bhuvane 6 collaborations

Nicholas A Olimpo 6 collaborations

Brooke Neupert 6 collaborations

Justin Yu 6 collaborations

Khalid N M Abdelazeem 6 collaborations

Sanjana Bukkapatnam 5 collaborations

Michael Knitz 5 collaborations

Angelo D'Alessandro 5 collaborations

Alexander Nguyen 4 collaborations

Tiffany T Pham 4 collaborations

Anthony Saviola 4 collaborations

Molishree Joshi 4 collaborations

Von Samedi 4 collaborations

Anthony J Saviola 4 collaborations

Maria Amann 4 collaborations

Ayman J Oweida 3 collaborations

Adam C Mueller 3 collaborations

Edward D Chan 3 collaborations

Eric T Clambey 3 collaborations

Richard B Ross 3 collaborations

Adrie Van Bokhoven 3 collaborations

Elena B Pasquale 3 collaborations

Deepshikha Verma 3 collaborations

Diane Ordway 3 collaborations

Ross M Kedl 3 collaborations

Christian Klein 3 collaborations

Thomas Bickett 3 collaborations

Laurel Lenz 3 collaborations

Varuna Nangia 2 collaborations

Xiyuan Bai 2 collaborations

Mary-Keara Boss 2 collaborations

Andrew Goodspeed 2 collaborations

Jessica Beynor 2 collaborations

Mohit Kapoor 2 collaborations

Maureen Hoen 2 collaborations

Xiao-Jing Wang 2 collaborations

Richard Blake Ross 2 collaborations

Pablo Umaña 2 collaborations

Laura Codarri Deak 2 collaborations

Andy V Phan 2 collaborations

Laurel Darragh 2 collaborations

Marco Del Chiaro 2 collaborations

Ayman Oweida 2 collaborations

Chloe Hodgson 2 collaborations

Lynn E Heasley 2 collaborations

Yuwen Zhu 2 collaborations

Douglas G Osborne 1 collaboration

Sarah E Ferrara 1 collaboration

Matthew A Burchill 1 collaboration

Beth A Jirón Tamburini 1 collaboration

Curtis R Pickering 1 collaboration

Shaquia Idlett-Ali 1 collaboration

Michaele Corbisiero 1 collaboration

Sean P Maroney 1 collaboration

David C Galindo 1 collaboration

Laith Mukdad 1 collaboration

Ruth White 1 collaboration

Yazeed Alhiyari 1 collaboration

Maie St John 1 collaboration

Nicholas Olimpo 1 collaboration

Mike W Matsumoto 1 collaboration

Douglas Grant Osborne 1 collaboration

Rachel S Friedman 1 collaboration

Jordan Jacobelli 1 collaboration

Cindy Garcia 1 collaboration

Ariel Musheyev 1 collaboration

Kevin Kim 1 collaboration

Lorelenn Fornis 1 collaboration

David E Griffith 1 collaboration

Li Li 1 collaboration

Nicholas Whittel 1 collaboration

Tamara Ohanjanyan 1 collaboration

Matthew J Eggleston 1 collaboration

Manuel Galvan 1 collaboration

Brian M Freed 1 collaboration

Khoa Nguyen 1 collaboration

Yonghua Zhuang 1 collaboration

Steven Dow 1 collaboration

Greta Durini 1 collaboration

Idil Karakoc 1 collaboration

Abby Grier 1 collaboration

Paras Jain 1 collaboration

Spencer Garing 1 collaboration

Rajagopalan Saranathan 1 collaboration

Nicholas Clute-Reinig 1 collaboration

Chelsea Peterson 1 collaboration

Gleda Hermansky 1 collaboration

Anna Astashkina Fernandez 1 collaboration

Emmanuel Asare 1 collaboration

Torin R Weisbrod 1 collaboration

Ethan Spencer 1 collaboration

Claire V Mulholland 1 collaboration

Michael Berney 1 collaboration

David Bell 1 collaboration

Kevin P Nichols 1 collaboration

Anne-Laure M Le Ny 1 collaboration

William R Jacobs 1 collaboration

Akos Somoskovi 1 collaboration

Kyle J Minch 1 collaboration

Megan Stapleton 1 collaboration

Jake Gadwa 1 collaboration

Kridakorn Vongtongsalee 1 collaboration

Alan R Schenkel 1 collaboration

Michael William Knitz 1 collaboration

Emily K Kleczko 1 collaboration

Raphael A Nemenoff 1 collaboration

Jason S Williams 1 collaboration

Kathryn L Zolman 1 collaboration

Brisa Peña 1 collaboration

Sara Zakem 1 collaboration

Cheryl Meguid 1 collaboration

Luisa Mestroni 1 collaboration

Matthew R G Taylor 1 collaboration

Kimberly R Jordan 1 collaboration

Peter Dempsey 1 collaboration

M Scott Lucia 1 collaboration

Martin D McCarter 1 collaboration

Wells A Messersmith 1 collaboration

Richard D Schulick 1 collaboration

Karyn A Goodman 1 collaboration

Michael J Gough 1 collaboration

Casey S Greene 1 collaboration

James C Costello 1 collaboration

Antonio Galveo Neto 1 collaboration

David Lagares 1 collaboration

Kirk C Hansen 1 collaboration

Andy Phan 1 collaboration

Ahmed Gilani 1 collaboration

Adam Green 1 collaboration

Sujatha Venkataraman 1 collaboration

Rajeev Vibhakar 1 collaboration

Diana Cittelly 1 collaboration

Tiffany Pham 1 collaboration

Alexander L Dent 1 collaboration

Enrique Sanz Garcia 1 collaboration

Lillian Siu 1 collaboration

Hua Tu 1 collaboration

Kevin Barry 1 collaboration

Adam Mueller 1 collaboration

Shuichi Watanabe 1 collaboration

Max Mayeda 1 collaboration

Rustain Morgan 1 collaboration

Jung-Jae Lee 1 collaboration

Alexander Dent 1 collaboration

Karyn Goodman 1 collaboration

Wells Messersmith 1 collaboration

Richard Schulick 1 collaboration

Jaspreet Sharma 1 collaboration

Brian Wu 1 collaboration

Yichien Lee 1 collaboration

Mayumi Fujita 1 collaboration

Robert L Ferris 1 collaboration

Olga Rodriguez 1 collaboration

Christopher Albanese 1 collaboration

Michael M Knitz 1 collaboration

Junxiao Hu 1 collaboration

Jennifer Backus 1 collaboration

Andrew Dumit 1 collaboration

Andrew Bubak 1 collaboration

Casey Greene 1 collaboration

Timothy Waxweiler 1 collaboration

Sanjana Mehrotra 1 collaboration

Kareem Fakhoury 1 collaboration

Arthur Liu 1 collaboration

Joshua Petit 1 collaboration

Daniel Bowles 1 collaboration

Ashesh Thaker 1 collaboration

Kimberly Atiyeh 1 collaboration

Julie Goddard 1 collaboration

Robert Hoyer 1 collaboration

Kimberly Jordan 1 collaboration

Antonio Jimeno 1 collaboration

David Raben 1 collaboration

Jessica D McDermott 1 collaboration

Elliott Yee 1 collaboration

Keira Y Larson 1 collaboration