From the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.