Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 Dec 2023
22 Dec 2023
Historique:
received:
04
05
2023
accepted:
06
10
2023
medline:
25
12
2023
pubmed:
23
12
2023
entrez:
22
12
2023
Statut:
epublish
Résumé
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely.
Identifiants
pubmed: 38135686
doi: 10.1038/s41467-023-42320-4
pii: 10.1038/s41467-023-42320-4
pmc: PMC10746705
doi:
Substances chimiques
Cytokines
0
Autoantibodies
0
Inflammation Mediators
0
Biomarkers
0
Glial Fibrillary Acidic Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8487Subventions
Organisme : Wellcome Trust
ID : 206330/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T023791/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19059
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S032304/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Investigateurs
J Kenneth Baillie
(JK)
Peter J Openshaw
(PJ)
Malcolm G Semple
(MG)
Beatrice Alex
(B)
Petros Andrikopoulos
(P)
Benjamin Bach
(B)
Wendy S Barclay
(WS)
Debby Bogaert
(D)
Meera Chand
(M)
Kanta Chechi
(K)
Graham S Cooke
(GS)
Ana da Silva
(A)
Thushan de Silva
(T)
Annemarie B Docherty
(AB)
Gonçalo Dos Santos
(G)
Marc-Emmanuel Dumas
(ME)
Jake Dunning
(J)
Tom Fletcher
(T)
Christoper A Green
(CA)
William Greenhalf
(W)
Julian L Griffin
(JL)
Rishi K Gupta
(RK)
Ewen M Harrison
(EM)
Antonia Y Wai
(AY)
Karl Holden
(K)
Peter W Horby
(PW)
Samreen Ijaz
(S)
Saye Khoo
(S)
Paul Klenerman
(P)
Andrew Law
(A)
Matthew R Lewis
(MR)
Sonia Liggi
(S)
Wei S Lim
(WS)
Lynn Maslen
(L)
Alexander J Mentzer
(AJ)
Laura Merson
(L)
Alison M Meynert
(AM)
Shona C Moore
(SC)
Mahdad Noursadeghi
(M)
Michael Olanipekun
(M)
Anthonia Osagie
(A)
Massimo Palmarini
(M)
Carlo Palmieri
(C)
William A Paxton
(WA)
Georgios Pollakis
(G)
Nicholas Price
(N)
Andrew Rambaut
(A)
David L Robertson
(DL)
Clark D Russell
(CD)
Vanessa Sancho-Shimizu
(V)
Caroline J Sands
(CJ)
Janet T Scott
(JT)
Louise Sigfrid
(L)
Tom Solomon
(T)
Shiranee Sriskandan
(S)
David Stuart
(D)
Charlotte Summers
(C)
Olivia V Swann
(OV)
Zoltan Takats
(Z)
Panteleimon Takis
(P)
Richard S Tedder
(RS)
A A R Thompson
(AAR)
Emma C Thomson
(EC)
Ryan S Thwaites
(RS)
Lance C Turtle
(LC)
Maria Zambon
(M)
Thomas M Drake
(TM)
Cameron J Fairfield
(CJ)
Stephen R Knight
(SR)
Kenneth A Mclean
(KA)
Derek Murphy
(D)
Lisa Norman
(L)
Riinu Pius
(R)
Catherine A Shaw
(CA)
Marie Connor
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Jo Dalton
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Carrol Gamble
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Michelle Girvan
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Emma Thomson
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Eugene Duff
(E)
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(EM)
Ewan Harrison
(E)
Fernando Zelaya
(F)
Gabriella Lewis
(G)
Gavin McDonnell
(G)
Gerome Breen
(G)
Greta K Wood
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C Hannah
(C)
Henry C Rogers
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Jacqueline Smith
(J)
Jade D Harris
(JD)
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(JB)
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(J)
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(JP)
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(JR)
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(J)
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(JR)
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(J)
Judith Breuer
(J)
Julian Hiscox
(J)
Karla Miller
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Katherine C Dodd
(KC)
Kiran Glen
(K)
Laura Benjamin
(L)
Leonie Taams
(L)
Lily George
(L)
Marc Hardwick
(M)
Mark R Baker
(MR)
Masud Husain
(M)
Matthew Butler
(M)
Matthew Hotopf
(M)
Matthew R Broome
(MR)
Merna Samuel
(M)
Michael Griffiths
(M)
Michael P Lunn
(MP)
Michael S Zandi
(MS)
Monika Hartmann
(M)
Nadine Cossette
(N)
Naomi Martin
(N)
Nathalie Nicholas
(N)
Neil A Harrison
(NA)
Neil Basu
(N)
Neil Harrison
(N)
Nicholas Davies
(N)
Nicholas Wood
(N)
Nikos Evangelou
(N)
Pamela J Shaw
(PJ)
Parisa Mansoori
(P)
Paul J Harrison
(PJ)
Peter Jezzard
(P)
Peter M Fernandes
(PM)
Rachel Upthegrove
(R)
Rahul Batra
(R)
Rebecca Gregory
(R)
Rhys H Thomas
(RH)
Richard Bethlehem
(R)
Richard Francis
(R)
Ronan O'Malley
(R)
Rustam A Salman
(RA)
Ryan McIlwaine
(R)
Sandar Kyaw
(S)
Sarosh Irani
(S)
Savini Gunatilake
(S)
Scott Semple
(S)
Shahd H Hamid
(SH)
Sharon Peacock
(S)
Silvia Rota
(S)
Simon Keller
(S)
Sophie Pendered
(S)
Suzanne Barrett
(S)
Stella Hughes
(S)
Stella-Maria Paddick
(SM)
Stephen J Sawcer
(SJ)
Stephen Smith
(S)
Steven Williams
(S)
Sui H Wong
(SH)
Sylviane Defres
(S)
Thomas Jackson
(T)
Thomas M Jenkins
(TM)
Thomas Pollak
(T)
Timothy Nicholson
(T)
Tonny Veenith
(T)
Victoria Grimbly
(V)
Virginia Newcombe
(V)
Informations de copyright
© 2023. The Author(s).
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