Jonathan Zalevsky

Affiliations

Nektar Therapeutics, 455 Mission Bay Boulevard South, San Francisco, CA, 94158, USA.

Publications (17)

NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases.

Journal of translational autoimmunity

Avec: Neha Dixit , Christie Fanton , John L Langowski , Yolanda Kirksey , Peter Kirk , Thomas Chang , Janet Cetz , Vidula Dixit , Grace Kim , Peiwen Kuo , Mekhala Maiti , Yinyan Tang , Laurie A VanderVeen , Ping Zhang , Myong Lee , Jerome Ritz , Yusuke Kamihara , Chunmei Ji , Werner Rubas , Theresa D Sweeney , Stephen K Doberstein , Jonathan Zalevsky

Bempegaldesleukin (BEMPEG; NKTR-214) efficacy as a single agent and in combination with checkpoint-inhibitor therapy in mouse models of osteosarcoma.

International journal of cancer

Avec: Marlene Hennessy , Andrew Wahba , Kumar Felix , Mariella Cabrera , Maria Gabriela Segura , Vikas Kundra , Murali K Ravoori , John Stewart , Eugenie S Kleinerman , Vanessa Behrana Jensen , Vidya Gopalakrishnan , Rhoneil Pena , Phi Quach , Grace Kim , Saul Kivimäe , Loui Madakamutil , Willem W Overwijk , Jonathan Zalevsky , Nancy Gordon

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.

Nature communications

Avec: Meenu Sharma , Hiep Khong , Faisal Fa'ak , Salah-Eddine Bentebibel , Louise M E Janssen , Brent C Chesson , Caitlin A Creasy , Marie-Andrée Forget , Laura Maria S Kahn , Barbara Pazdrak , Binisha Karki , Yared Hailemichael , Manisha Singh , Christina Vianden , Srinivas Vennam , Uddalak Bharadwaj , David J Tweardy , Cara Haymaker , Chantale Bernatchez , Shixia Huang , Kimal Rajapakshe , Cristian Coarfa , Michael E Hurwitz , Mario Sznol , Patrick Hwu , Ute Hoch , Murali Addepalli , Deborah H Charych , Jonathan Zalevsky , Adi Diab , Willem W Overwijk

Phase I study protocol: NKTR-255 as monotherapy or combined with daratumumab or rituximab in hematologic malignancies.

Future oncology (London, England)

Avec: Nina Shah , Miguel-Angel Perales , Cameron J Turtle , Mitchell S Cairo , Andrew J Cowan , Hayder Saeed , Lihua E Budde , Alan Tan , Zachary Lee , Kazuharu Kai , Mario Q Marcondes , Jonathan Zalevsky , Mary A Tagliaferri , Krina K Patel

Selective expansion of regulatory T cells by NKTR-358 in healthy volunteers and patients with systemic lupus erythematosus.

Journal of translational autoimmunity

Avec: Christie Fanton , Richard Furie , Vishala Chindalore , Robert Levin , Isam Diab , Neha Dixit , Cat Haglund , Jacqueline Gibbons , Nathan Hanan , Daniel Dickerson , Jonathan Zalevsky , Brian L Kotzin

A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors.

Cancer discovery

Avec: Salah-Eddine Bentebibel , Michael E Hurwitz , Chantale Bernatchez , Cara Haymaker , Courtney W Hudgens , Harriet M Kluger , Michael T Tetzlaff , Mary A Tagliaferri , Jonathan Zalevsky , Ute Hoch , Christie Fanton , Sandra Aung , Patrick Hwu , Brendan D Curti , Nizar M Tannir , Mario Sznol , Adi Diab

Engineering IL-2 to Give New Life to T Cell Immunotherapy.

Annual review of medicine

Avec: Willem W Overwijk , Mary A Tagliaferri , Jonathan Zalevsky

NKTR-255 is a polymer-conjugated IL-15 with unique mechanisms of action on T and natural killer cells.

The Journal of clinical investigation

Avec: Tanya O Robinson , Shweta M Hegde , Allison Chang , Achintyan Gangadharan , Sarai Rivas , Loui Madakamutil , Jonathan Zalevsky , Takahiro Miyazaki , Kimberly S Schluns

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist.

Nature communications

Avec: Giulia Parisi , Justin D Saco , Felix B Salazar , Jennifer Tsoi , Paige Krystofinski , Cristina Puig-Saus , Ruixue Zhang , Jing Zhou , Gardenia C Cheung-Lau , Alejandro J Garcia , Catherine S Grasso , Richard Tavaré , Siwen Hu-Lieskovan , Sean Mackay , Jonathan Zalevsky , Chantale Bernatchez , Adi Diab , Anna M Wu , Begoña Comin-Anduix , Deborah Charych , Antoni Ribas

Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02).

Cancer discovery

Avec: Adi Diab , Nizar M Tannir , Salah-Eddine Bentebibel , Patrick Hwu , Vassiliki Papadimitrakopoulou , Cara Haymaker , Harriet M Kluger , Scott N Gettinger , Mario Sznol , Scott S Tykodi , Brendan D Curti , Mary A Tagliaferri , Jonathan Zalevsky , Alison L Hannah , Ute Hoch , Sandra Aung , Christie Fanton , Ahsan Rizwan , Ernesto Iacucci , Yijie Liao , Chantale Bernatchez , Michael E Hurwitz , Daniel C Cho

Bempegaldesleukin plus nivolumab in first-line advanced/metastatic urothelial carcinoma: Results from a phase II single-arm study (PIVOT-10).

Urologic oncology

Avec: Arlene O Siefker-Radtke , Robert A Huddart , Mehmet A Bilen , Arjun Balar , Daniel Castellano , Srikala S Sridhar , Ugo De Giorgi , Konstantin Penkov , Aleksandr Vasiliev , Avivit Peer , Riikka Järvinen , Hakan Harputluoğlu , Vadim S Koshkin , Shermeen Poushnejad , Tianhua Wang , Anila Qureshi , Mary A Tagliaferri , Jonathan Zalevsky , Yohann Loriot

Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents.

Cellular and molecular neurobiology

Avec: Caroline M Kopruszinski , Juliana Swiokla , Yeon Sun Lee , Edita Navratilova , Laurie VanderVeen , Miao Yang , Yi Liu , Takahiro Miyazaki , William K Schmidt , Jonathan Zalevsky , Frank Porreca

A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys.

The Journal of pharmacology and experimental therapeutics

Avec: Wouter Korver , Mary Carsillo , Josh Yuan , Neeraja Idamakanti , Matthew Wagoner , Pu Shi , Cindy Q Xia , Glennda Smithson , Lachy McLean , Jonathan Zalevsky , Eric R Fedyk

NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy.

Journal for immunotherapy of cancer

Avec: Takahiro Miyazaki , Mekhala Maiti , Marlene Hennessy , Thomas Chang , Peiwen Kuo , Murali Addepalli , Palakshi Obalapur , Sara Sheibani , Joanna Wilczek , Rhoneil Pena , Phi Quach , Janet Cetz , Andrew Moffett , Yinyan Tang , Peter Kirk , Jicai Huang , Dawei Sheng , Ping Zhang , Werner Rubas , Loui Madakamutil , Saul Kivimäe , Jonathan Zalevsky

Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion.

Journal for immunotherapy of cancer

Avec: Anna Morena D'Alise , Guido Leoni , Maria De Lucia , Francesca Langone , Linda Nocchi , Fabio Giovanni Tucci , Elisa Micarelli , Gabriella Cotugno , Fulvia Troise , Irene Garzia , Rosa Vitale , Veronica Bignone , Elena Di Matteo , Rosa Bartolomeo , Deborah H Charych , Armin Lahm , Jonathan Zalevsky , Alfredo Nicosia , Elisa Scarselli

Bempegaldesleukin plus nivolumab in first-line renal cell carcinoma: results from the PIVOT-02 study.

Journal for immunotherapy of cancer

Avec: Nizar M Tannir , Daniel C Cho , Adi Diab , Mario Sznol , Mehmet A Bilen , Arjun V Balar , Giovanni Grignani , Erika Puente , Lily Tang , David Chien , Ute Hoch , Arkopal Choudhury , Danni Yu , Sue L Currie , Mary A Tagliaferri , Jonathan Zalevsky , Arlene O Siefker-Radtke , Michael E Hurwitz

Frontiers in pain research (Lausanne, Switzerland)

Avec: Alex S Lee , Suchi Tiwari , Isabel Bishop , Vartan Matossian , Nicole Romaneschi , Takahiro Miyazaki , Laurie VanderVeen , Jonathan Zalevsky , Kathryn DeFea , Catherine M Cahill , Wendy M Walwyn

Réseau de co-auteurs

Mary A Tagliaferri 6 collaborations

Adi Diab 5 collaborations

Christie Fanton 4 collaborations

Chantale Bernatchez 4 collaborations

Michael E Hurwitz 4 collaborations

Mario Sznol 4 collaborations

Ute Hoch 4 collaborations

Takahiro Miyazaki 4 collaborations

Loui Madakamutil 3 collaborations

Willem W Overwijk 3 collaborations

Salah-Eddine Bentebibel 3 collaborations

Cara Haymaker 3 collaborations

Patrick Hwu 3 collaborations

Nizar M Tannir 3 collaborations

Neha Dixit 2 collaborations

Peter Kirk 2 collaborations

Thomas Chang 2 collaborations

Janet Cetz 2 collaborations

Grace Kim 2 collaborations

Peiwen Kuo 2 collaborations

Mekhala Maiti 2 collaborations

Yinyan Tang 2 collaborations

Ping Zhang 2 collaborations

Werner Rubas 2 collaborations

Marlene Hennessy 2 collaborations

Rhoneil Pena 2 collaborations

Phi Quach 2 collaborations

Saul Kivimäe 2 collaborations

Murali Addepalli 2 collaborations

Deborah H Charych 2 collaborations

Harriet M Kluger 2 collaborations

Sandra Aung 2 collaborations

Brendan D Curti 2 collaborations

Daniel C Cho 2 collaborations

Arlene O Siefker-Radtke 2 collaborations

Mehmet A Bilen 2 collaborations

Laurie VanderVeen 2 collaborations

John L Langowski 1 collaboration

Yolanda Kirksey 1 collaboration

Vidula Dixit 1 collaboration

Laurie A VanderVeen 1 collaboration

Myong Lee 1 collaboration

Jerome Ritz 1 collaboration

Yusuke Kamihara 1 collaboration

Chunmei Ji 1 collaboration

Theresa D Sweeney 1 collaboration

Stephen K Doberstein 1 collaboration

Andrew Wahba 1 collaboration

Kumar Felix 1 collaboration

Mariella Cabrera 1 collaboration

Maria Gabriela Segura 1 collaboration

Vikas Kundra 1 collaboration

Murali K Ravoori 1 collaboration

John Stewart 1 collaboration

Eugenie S Kleinerman 1 collaboration

Vanessa Behrana Jensen 1 collaboration

Vidya Gopalakrishnan 1 collaboration

Nancy Gordon 1 collaboration

Meenu Sharma 1 collaboration

Hiep Khong 1 collaboration

Faisal Fa'ak 1 collaboration

Louise M E Janssen 1 collaboration

Brent C Chesson 1 collaboration

Caitlin A Creasy 1 collaboration

Marie-Andrée Forget 1 collaboration

Laura Maria S Kahn 1 collaboration

Barbara Pazdrak 1 collaboration

Binisha Karki 1 collaboration

Yared Hailemichael 1 collaboration

Manisha Singh 1 collaboration

Christina Vianden 1 collaboration

Srinivas Vennam 1 collaboration

Uddalak Bharadwaj 1 collaboration

David J Tweardy 1 collaboration

Shixia Huang 1 collaboration

Kimal Rajapakshe 1 collaboration

Cristian Coarfa 1 collaboration

Nina Shah 1 collaboration

Miguel-Angel Perales 1 collaboration

Cameron J Turtle 1 collaboration

Mitchell S Cairo 1 collaboration

Andrew J Cowan 1 collaboration

Hayder Saeed 1 collaboration

Lihua E Budde 1 collaboration

Alan Tan 1 collaboration

Zachary Lee 1 collaboration

Kazuharu Kai 1 collaboration

Mario Q Marcondes 1 collaboration

Krina K Patel 1 collaboration

Richard Furie 1 collaboration

Vishala Chindalore 1 collaboration

Robert Levin 1 collaboration

Isam Diab 1 collaboration

Cat Haglund 1 collaboration

Jacqueline Gibbons 1 collaboration

Nathan Hanan 1 collaboration

Daniel Dickerson 1 collaboration

Brian L Kotzin 1 collaboration

Courtney W Hudgens 1 collaboration

Michael T Tetzlaff 1 collaboration

Tanya O Robinson 1 collaboration

Shweta M Hegde 1 collaboration

Allison Chang 1 collaboration

Achintyan Gangadharan 1 collaboration

Sarai Rivas 1 collaboration

Kimberly S Schluns 1 collaboration

Giulia Parisi 1 collaboration

Justin D Saco 1 collaboration

Felix B Salazar 1 collaboration

Jennifer Tsoi 1 collaboration

Paige Krystofinski 1 collaboration

Cristina Puig-Saus 1 collaboration

Ruixue Zhang 1 collaboration

Jing Zhou 1 collaboration

Gardenia C Cheung-Lau 1 collaboration

Alejandro J Garcia 1 collaboration

Catherine S Grasso 1 collaboration

Richard Tavaré 1 collaboration

Siwen Hu-Lieskovan 1 collaboration

Sean Mackay 1 collaboration

Anna M Wu 1 collaboration

Begoña Comin-Anduix 1 collaboration

Deborah Charych 1 collaboration

Antoni Ribas 1 collaboration

Vassiliki Papadimitrakopoulou 1 collaboration

Scott N Gettinger 1 collaboration

Scott S Tykodi 1 collaboration

Alison L Hannah 1 collaboration

Ahsan Rizwan 1 collaboration

Ernesto Iacucci 1 collaboration

Yijie Liao 1 collaboration

Robert A Huddart 1 collaboration

Arjun Balar 1 collaboration

Daniel Castellano 1 collaboration

Srikala S Sridhar 1 collaboration

Ugo De Giorgi 1 collaboration

Konstantin Penkov 1 collaboration

Aleksandr Vasiliev 1 collaboration

Avivit Peer 1 collaboration

Riikka Järvinen 1 collaboration

Hakan Harputluoğlu 1 collaboration

Vadim S Koshkin 1 collaboration

Shermeen Poushnejad 1 collaboration

Tianhua Wang 1 collaboration

Anila Qureshi 1 collaboration

Yohann Loriot 1 collaboration

Caroline M Kopruszinski 1 collaboration

Juliana Swiokla 1 collaboration

Yeon Sun Lee 1 collaboration

Edita Navratilova 1 collaboration

Miao Yang 1 collaboration

Yi Liu 1 collaboration

William K Schmidt 1 collaboration

Frank Porreca 1 collaboration

Wouter Korver 1 collaboration

Mary Carsillo 1 collaboration

Josh Yuan 1 collaboration

Neeraja Idamakanti 1 collaboration

Matthew Wagoner 1 collaboration

Pu Shi 1 collaboration

Cindy Q Xia 1 collaboration

Glennda Smithson 1 collaboration

Lachy McLean 1 collaboration

Eric R Fedyk 1 collaboration

Palakshi Obalapur 1 collaboration

Sara Sheibani 1 collaboration

Joanna Wilczek 1 collaboration

Andrew Moffett 1 collaboration

Jicai Huang 1 collaboration

Dawei Sheng 1 collaboration

Anna Morena D'Alise 1 collaboration

Guido Leoni 1 collaboration

Maria De Lucia 1 collaboration

Francesca Langone 1 collaboration

Linda Nocchi 1 collaboration

Fabio Giovanni Tucci 1 collaboration

Elisa Micarelli 1 collaboration

Gabriella Cotugno 1 collaboration

Fulvia Troise 1 collaboration

Irene Garzia 1 collaboration

Rosa Vitale 1 collaboration

Veronica Bignone 1 collaboration

Elena Di Matteo 1 collaboration

Rosa Bartolomeo 1 collaboration

Armin Lahm 1 collaboration

Alfredo Nicosia 1 collaboration

Elisa Scarselli 1 collaboration

Arjun V Balar 1 collaboration

Giovanni Grignani 1 collaboration

Erika Puente 1 collaboration

Lily Tang 1 collaboration

David Chien 1 collaboration

Arkopal Choudhury 1 collaboration

Danni Yu 1 collaboration

Sue L Currie 1 collaboration

Alex S Lee 1 collaboration

Suchi Tiwari 1 collaboration

Isabel Bishop 1 collaboration

Vartan Matossian 1 collaboration

Nicole Romaneschi 1 collaboration

Kathryn DeFea 1 collaboration

Catherine M Cahill 1 collaboration

Wendy M Walwyn 1 collaboration