Josbert M Metselaar

Affiliations

Enceladus Pharmaceuticals, Naarden, The Netherlands.
Rheinisch-Westfälische Technische Hochschule Aachen University Clinic, Aachen, Germany.

Publications (17)

A pilot study on the use of prednisolone-encapsulated liposomes for the treatment of moderate-to-severe Graves' orbitopathy with reduced systemic steroid exposure.

Acta ophthalmologica

Avec: Sanne E Detiger , Tessa M Kremer , Virgil A S H Dalm , Ronald O B de Keizer , Rene J Wubbels , J M Metselaar , P Martin van Hagen , Robin P Peeters , Dion Paridaens

An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer.

Pharmacology research & perspectives

Avec: Josephina P M Vrouwe , Ingrid M C Kamerling , Michiel J van Esdonk , Josbert M Metselaar , Frederik E Stuurman , Gabri van der Pluijm , Jacobus Burggraaf , Susanne Osanto

Tunable polymeric micelles for taxane and corticosteroid co-delivery.

Drug delivery and translational research

Avec: Armin Azadkhah Shalmani , Alec Wang , Zaheer Ahmed , Maryam Sheybanifard , Rahaf Mihyar , Eva Miriam Buhl , Michael Pohl , Wim E Hennink , Fabian Kiessling , Josbert M Metselaar , Yang Shi , Twan Lammers , Quim Peña

Nanobody-liposomes as novel cancer vaccine platform to efficiently stimulate T cell immunity.

International journal of pharmaceutics

Avec: R G Bouma , M K Nijen Twilhaar , H Brink , A J Affandi , B S Mesquita , K Olesek , J M A van Dommelen , R Heukers , A M de Haas , H Kalay , M Ambrosini , J M Metselaar , A van Rooijen , G Storm , S Oliveira , Y van Kooyk , J M M den Haan

Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer.

Biomaterials

Avec: Chenghua Liang , Xiangyang Bai , Cuiling Qi , Qingxue Sun , Xiaoyan Han , Tianyun Lan , Haibo Zhang , Xiaoming Zheng , Rongpu Liang , Ju Jiao , Zongheng Zheng , Jiafeng Fang , Purun Lei , Yan Wang , Diana Möckel , Josbert M Metselaar , Gert Storm , Wim E Hennink , Fabian Kiessling , Hongbo Wei , Twan Lammers , Yang Shi , Bo Wei

Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Tamás Fülöp , Gergely T Kozma , Ildikó Vashegyi , Tamás Mészáros , László Rosivall , Rudolf Urbanics , Gert Storm , Josbert M Metselaar , János Szebeni

Scale-Up of the Manufacturing Process To Produce Docetaxel-Loaded mPEG-

Organic process research & development

Avec: Jaleesa Bresseleers , Mahsa Bagheri , Gert Storm , Josbert M Metselaar , Wim E Hennink , Silvie A Meeuwissen , Jan C M van Hest

Effect of Radical Polymerization Method on Pharmaceutical Properties of Π Electron-Stabilized HPMA-Based Polymeric Micelles.

Biomacromolecules

Avec: Armin Azadkhah Shalmani , Zaheer Ahmed , Maryam Sheybanifard , Alec Wang , Marek Weiler , Eva Miriam Buhl , Geir Klinkenberg , Ruth Schmid , Wim Hennink , Fabian Kiessling , Josbert M Metselaar , Twan Lammers , Quim Peña , Yang Shi

Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection.

Transplantation

Avec: Carla M A van Alem , Martina Schmidbauer , Song Rong , Katja Derlin , Jessica Schmitz , Jan H Bräsen , Anja Thorenz , Rongjun Chen , Jurjen M Ruben , Elizabeth M Winter , Maaike Schilperoort , Sander Kooijman , Reshma A Lalai , Josbert M Metselaar , Christian Klemann , Martin Meier , Cees van Kooten , Faikah Gueler , Joris I Rotmans

Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Anil K Deshantri , Marcel H Fens , Ruud W J Ruiter , Josbert M Metselaar , Gert Storm , Louis van Bloois , Aida Varela-Moreira , Sanjay N Mandhane , Tuna Mutis , Anton C M Martens , Richard W J Groen , Raymond M Schiffelers

Systematic evaluation of design features enables efficient selection of Π electron-stabilized polymeric micelles.

International journal of pharmaceutics

Avec: Maryam Sheybanifard , Nataliia Beztsinna , Mahsa Bagheri , Eva Miriam Buhl , Jaleesa Bresseleers , Aida Varela-Moreira , Yang Shi , Cornelus F van Nostrum , Gabri van der Pluijm , Gert Storm , Wim E Hennink , Twan Lammers , Josbert M Metselaar

A Doxorubicin-Glucuronide Prodrug Released from Nanogels Activated by High-Intensity Focused Ultrasound Liberated β-Glucuronidase.

Pharmaceutics

Avec: Helena C Besse , Yinan Chen , Hans W Scheeren , Josbert M Metselaar , Twan Lammers , Chrit T W Moonen , Wim E Hennink , Roel Deckers

ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer.

Science advances

Avec: Praneeth R Kuninty , Ruchi Bansal , Susanna W L De Geus , Deby F Mardhian , Jonas Schnittert , Joop van Baarlen , Gert Storm , Maarten F Bijlsma , Hanneke W van Laarhoven , Josbert M Metselaar , Peter J K Kuppen , Alexander L Vahrmeijer , Arne Östman , Cornelis F M Sier , Jai Prakash

Development and characterization of liposomal formulation of bortezomib.

International journal of pharmaceutics: X

Avec: Anil K Deshantri , Josbert M Metselaar , Stavroula Zagkou , Gert Storm , Sanjay N Mandhane , Marcel H A M Fens , Raymond M Schiffelers

Challenges in nanomedicine clinical translation.

Drug delivery and translational research

Avec: Josbert M Metselaar , Twan Lammers

Recent Advances in Liposomal-Based Anti-Inflammatory Therapy.

Pharmaceutics

Avec: Carla M A van Alem , Josbert M Metselaar , Cees van Kooten , Joris I Rotmans

Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment.

Pharmaceutics

Avec: Margarida Ferreira-Silva , Catarina Faria-Silva , Manuela C Carvalheiro , Sandra Simões , H Susana Marinho , Paulo Marcelino , Maria Celeste Campos , Josbert M Metselaar , Eduarda Fernandes , Pedro V Baptista , Alexandra R Fernandes , Maria Luísa Corvo

Réseau de co-auteurs

Gert Storm 7 collaborations

Twan Lammers 6 collaborations

Wim E Hennink 5 collaborations

Yang Shi 4 collaborations

Maryam Sheybanifard 3 collaborations

Eva Miriam Buhl 3 collaborations

Fabian Kiessling 3 collaborations

J M Metselaar 2 collaborations

Gabri van der Pluijm 2 collaborations

Armin Azadkhah Shalmani 2 collaborations

Alec Wang 2 collaborations

Zaheer Ahmed 2 collaborations

Quim Peña 2 collaborations

Jaleesa Bresseleers 2 collaborations

Mahsa Bagheri 2 collaborations

Carla M A van Alem 2 collaborations

Cees van Kooten 2 collaborations

Joris I Rotmans 2 collaborations

Anil K Deshantri 2 collaborations

Aida Varela-Moreira 2 collaborations

Sanjay N Mandhane 2 collaborations

Raymond M Schiffelers 2 collaborations

Sanne E Detiger 1 collaboration

Tessa M Kremer 1 collaboration

Virgil A S H Dalm 1 collaboration

Ronald O B de Keizer 1 collaboration

Rene J Wubbels 1 collaboration

P Martin van Hagen 1 collaboration

Robin P Peeters 1 collaboration

Dion Paridaens 1 collaboration

Josephina P M Vrouwe 1 collaboration

Ingrid M C Kamerling 1 collaboration

Michiel J van Esdonk 1 collaboration

Frederik E Stuurman 1 collaboration

Jacobus Burggraaf 1 collaboration

Susanne Osanto 1 collaboration

Rahaf Mihyar 1 collaboration

Michael Pohl 1 collaboration

R G Bouma 1 collaboration

M K Nijen Twilhaar 1 collaboration

H Brink 1 collaboration

A J Affandi 1 collaboration

B S Mesquita 1 collaboration

K Olesek 1 collaboration

J M A van Dommelen 1 collaboration

R Heukers 1 collaboration

A M de Haas 1 collaboration

H Kalay 1 collaboration

M Ambrosini 1 collaboration

A van Rooijen 1 collaboration

G Storm 1 collaboration

S Oliveira 1 collaboration

Y van Kooyk 1 collaboration

J M M den Haan 1 collaboration

Chenghua Liang 1 collaboration

Xiangyang Bai 1 collaboration

Cuiling Qi 1 collaboration

Qingxue Sun 1 collaboration

Xiaoyan Han 1 collaboration

Tianyun Lan 1 collaboration

Haibo Zhang 1 collaboration

Xiaoming Zheng 1 collaboration

Rongpu Liang 1 collaboration

Ju Jiao 1 collaboration

Zongheng Zheng 1 collaboration

Jiafeng Fang 1 collaboration

Purun Lei 1 collaboration

Yan Wang 1 collaboration

Diana Möckel 1 collaboration

Hongbo Wei 1 collaboration

Bo Wei 1 collaboration

Tamás Fülöp 1 collaboration

Gergely T Kozma 1 collaboration

Ildikó Vashegyi 1 collaboration

Tamás Mészáros 1 collaboration

László Rosivall 1 collaboration

Rudolf Urbanics 1 collaboration

János Szebeni 1 collaboration

Silvie A Meeuwissen 1 collaboration

Jan C M van Hest 1 collaboration

Marek Weiler 1 collaboration

Geir Klinkenberg 1 collaboration

Ruth Schmid 1 collaboration

Wim Hennink 1 collaboration

Martina Schmidbauer 1 collaboration

Song Rong 1 collaboration

Katja Derlin 1 collaboration

Jessica Schmitz 1 collaboration

Jan H Bräsen 1 collaboration

Anja Thorenz 1 collaboration

Rongjun Chen 1 collaboration

Jurjen M Ruben 1 collaboration

Elizabeth M Winter 1 collaboration

Maaike Schilperoort 1 collaboration

Sander Kooijman 1 collaboration

Reshma A Lalai 1 collaboration

Christian Klemann 1 collaboration

Martin Meier 1 collaboration

Faikah Gueler 1 collaboration

Marcel H Fens 1 collaboration

Ruud W J Ruiter 1 collaboration

Louis van Bloois 1 collaboration

Tuna Mutis 1 collaboration

Anton C M Martens 1 collaboration

Richard W J Groen 1 collaboration

Nataliia Beztsinna 1 collaboration

Cornelus F van Nostrum 1 collaboration

Helena C Besse 1 collaboration

Yinan Chen 1 collaboration

Hans W Scheeren 1 collaboration

Chrit T W Moonen 1 collaboration

Roel Deckers 1 collaboration

Praneeth R Kuninty 1 collaboration

Ruchi Bansal 1 collaboration

Susanna W L De Geus 1 collaboration

Deby F Mardhian 1 collaboration

Jonas Schnittert 1 collaboration

Joop van Baarlen 1 collaboration

Maarten F Bijlsma 1 collaboration

Hanneke W van Laarhoven 1 collaboration

Peter J K Kuppen 1 collaboration

Alexander L Vahrmeijer 1 collaboration

Arne Östman 1 collaboration

Cornelis F M Sier 1 collaboration

Jai Prakash 1 collaboration

Stavroula Zagkou 1 collaboration

Marcel H A M Fens 1 collaboration

Margarida Ferreira-Silva 1 collaboration

Catarina Faria-Silva 1 collaboration

Manuela C Carvalheiro 1 collaboration

Sandra Simões 1 collaboration

H Susana Marinho 1 collaboration

Paulo Marcelino 1 collaboration

Maria Celeste Campos 1 collaboration

Eduarda Fernandes 1 collaboration

Pedro V Baptista 1 collaboration

Alexandra R Fernandes 1 collaboration

Maria Luísa Corvo 1 collaboration