Systematic evaluation of design features enables efficient selection of Π electron-stabilized polymeric micelles.
Antineoplastic Agents, Phytogenic
/ administration & dosage
Benzene
/ chemistry
Chemistry, Pharmaceutical
Drug Carriers
/ administration & dosage
Drug Liberation
Drug Stability
Electrons
Hep G2 Cells
Humans
Methacrylates
/ chemistry
Micelles
Paclitaxel
/ administration & dosage
Particle Size
Polyethylene Glycols
/ chemistry
3D cell culture
In vitro release kinetics
Paclitaxel
Polymeric micelles
Storage stability
π-π stacking interactions
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Jun 2020
30 Jun 2020
Historique:
received:
29
02
2020
revised:
03
05
2020
accepted:
04
05
2020
pubmed:
12
5
2020
medline:
4
3
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
Polymeric micelles (PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) loaded with paclitaxel (PTX-PM) have shown promising results in overcoming the suboptimal efficacy/toxicity profile of paclitaxel. To get insight into the stability of PTX-PM formulations upon storage and to optimize their in vivo tumor-targeted drug delivery properties, we set out to identify a lead PTX-PM formulation with the optimal polymer composition. To this end, PM based on four different mPEG
Identifiants
pubmed: 32389790
pii: S0378-5173(20)30393-8
doi: 10.1016/j.ijpharm.2020.119409
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Drug Carriers
0
Methacrylates
0
Micelles
0
Polyethylene Glycols
3WJQ0SDW1A
Benzene
J64922108F
Paclitaxel
P88XT4IS4D
hydroxypropyl methacrylate
UKW89XAX2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119409Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.