Laura M Heiser

Affiliations

Dept. of Biomedical Engineering, Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA.

Publications (19)

Variational Autoencoding Tissue Response to Microenvironment Perturbation.

Proceedings of SPIE--the International Society for Optical Engineering

Avec: Geoffrey F Schau , Guillaume Thibault , Mark A Dane , Joe W Gray , Laura M Heiser , Young Hwan Chang

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines.

Cell systems

Avec: Mario Niepel , Marc Hafner , Caitlin E Mills , Kartik Subramanian , Elizabeth H Williams , Mirra Chung , Benjamin Gaudio , Anne Marie Barrette , Alan D Stern , Bin Hu , James E Korkola , Auteur inconnu , Joe W Gray , Marc R Birtwistle , Laura M Heiser , Peter K Sorger

Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers.

Cancer cell

Avec: Laura M Heiser , Gordon B Mills , Joe W Gray

Cabozantinib and dasatinib synergize to induce tumor regression in non-clear cell renal cell carcinoma.

Cell reports. Medicine

Avec: Hui-Wen Lue , Daniel S Derrick , Soumya Rao , Ahna Van Gaest , Larry Cheng , Jennifer Podolak , Samantha Lawson , Changhui Xue , Devin Garg , Ralph White , Christopher W Ryan , Justin M Drake , Anna Ritz , Laura M Heiser , George V Thomas

Automatic Transformation and Integration to Improve Visualization and Discovery of Latent Effects in Imaging Data.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America

Avec: Gregory J Hunt , Mark A Dane , James E Korkola , Laura M Heiser , Johann A Gagnon-Bartsch

An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer.

Cell reports. Medicine

Avec: Brett E Johnson , Allison L Creason , Jayne M Stommel , Jamie M Keck , Swapnil Parmar , Courtney B Betts , Aurora Blucher , Christopher Boniface , Elmar Bucher , Erik Burlingame , Todd Camp , Koei Chin , Jennifer Eng , Joseph Estabrook , Heidi S Feiler , Michael B Heskett , Zhi Hu , Annette Kolodzie , Ben L Kong , Marilyne Labrie , Jinho Lee , Patrick Leyshock , Souraya Mitri , Janice Patterson , Jessica L Riesterer , Shamilene Sivagnanam , Julia Somers , Damir Sudar , Guillaume Thibault , Benjamin R Weeder , Christina Zheng , Xiaolin Nan , Reid F Thompson , Laura M Heiser , Paul T Spellman , George Thomas , Emek Demir , Young Hwan Chang , Lisa M Coussens , Alexander R Guimaraes , Christopher Corless , Jeremy Goecks , Raymond Bergan , Zahi Mitri , Gordon B Mills , Joe W Gray

Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects.

Nature communications

Avec: Sean M Gross , Farnaz Mohammadi , Crystal Sanchez-Aguila , Paulina J Zhan , Tiera A Liby , Mark A Dane , Aaron S Meyer , Laura M Heiser

Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival.

bioRxiv : the preprint server for biology

Avec: Adam M Tuttle , Lauren N Miller , Lindsey J Royer , Hua Wen , Jimmy J Kelly , Nicholas L Calistri , Laura M Heiser , Alex V Nechiporuk

RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration.

Development (Cambridge, England)

Avec: Hannah M Olson , Amanda Maxfield , Nicholas L Calistri , Laura M Heiser , Weiyi Qian , Holger Knaut , Alex V Nechiporuk

Annot: a Django-based sample, reagent, and experiment metadata tracking system.

BMC bioinformatics

Avec: Elmar Bucher , Cheryl J Claunch , Derrick Hee , Rebecca L Smith , Kaylyn Devlin , Wallace Thompson , James E Korkola , Laura M Heiser

Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state change.

bioRxiv : the preprint server for biology

Avec: Jeremy Copperman , Ian C Mclean , Sean M Gross , Young Hwan Chang , Daniel M Zuckerman , Laura M Heiser

MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.

Nature communications

Avec: Zinab O Doha , Xiaoyan Wang , Nicholas L Calistri , Jennifer Eng , Colin J Daniel , Luke Ternes , Eun Na Kim , Carl Pelz , Michael Munks , Courtney Betts , Sunjong Kwon , Elmar Bucher , Xi Li , Trent Waugh , Zuzana Tatarova , Dylan Blumberg , Aaron Ko , Nell Kirchberger , Jennifer A Pietenpol , Melinda E Sanders , Ellen M Langer , Mu-Shui Dai , Gordon Mills , Koei Chin , Young Hwan Chang , Lisa M Coussens , Joe W Gray , Laura M Heiser , Rosalie C Sears

Functional delineation of the luminal epithelial microenvironment in breast using cell-based screening in combinatorial microenvironments.

Cellular signalling

Avec: Tiina A Jokela , Mark A Dane , Rebecca L Smith , Kaylyn L Devlin , Sundus Shalabi , Jennifer C Lopez , Masaru Miyano , Martha R Stampfer , James E Korkola , Joe W Gray , Laura M Heiser , Mark A LaBarge

A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs.

Nature biotechnology

Avec: Zuzana Tatarova , Dylan C Blumberg , James E Korkola , Laura M Heiser , John L Muschler , Pepper J Schedin , Sebastian W Ahn , Gordon B Mills , Lisa M Coussens , Oliver Jonas , Joe W Gray

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses.

Communications biology

Avec: Sean M Gross , Mark A Dane , Rebecca L Smith , Kaylyn L Devlin , Ian C McLean , Daniel S Derrick , Caitlin E Mills , Kartik Subramanian , Alexandra B London , Denis Torre , John Erol Evangelista , Daniel J B Clarke , Zhuorui Xie , Cemal Erdem , Nicholas Lyons , Ted Natoli , Sarah Pessa , Xiaodong Lu , James Mullahoo , Jonathan Li , Miriam Adam , Brook Wassie , Moqing Liu , David F Kilburn , Tiera A Liby , Elmar Bucher , Crystal Sanchez-Aguila , Kenneth Daily , Larsson Omberg , Yunguan Wang , Connor Jacobson , Clarence Yapp , Mirra Chung , Dusica Vidovic , Yiling Lu , Stephan Schurer , Albert Lee , Ajay Pillai , Aravind Subramanian , Malvina Papanastasiou , Ernest Fraenkel , Heidi S Feiler , Gordon B Mills , Jake D Jaffe , Avi Ma'ayan , Marc R Birtwistle , Peter K Sorger , James E Korkola , Joe W Gray , Laura M Heiser

RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration.

bioRxiv : the preprint server for biology

Avec: Hannah M Olson , Amanda Maxfield , Nicholas L Calistri , Laura M Heiser , Alex V Nechiporuk

Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: Adam M Tuttle , Lauren N Miller , Lindsey J Royer , Hua Wen , Jimmy J Kelly , Nicholas L Calistri , Laura M Heiser , Alex V Nechiporuk

Systems biology approaches to measure and model phenotypic heterogeneity in cancer.

Current opinion in systems biology

Avec: Aaron S Meyer , Laura M Heiser

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer.

Scientific reports

Avec: Daniel J Coleman , Lina Gao , Jacob Schwartzman , James E Korkola , David Sampson , Daniel S Derrick , Joshua Urrutia , Ariel Balter , Julja Burchard , Carly J King , Kami E Chiotti , Laura M Heiser , Joshi J Alumkal

Réseau de co-auteurs

Joe W Gray 8 collaborations

James E Korkola 7 collaborations

Mark A Dane 5 collaborations

Nicholas L Calistri 5 collaborations

Young Hwan Chang 4 collaborations

Gordon B Mills 4 collaborations

Elmar Bucher 4 collaborations

Alex V Nechiporuk 4 collaborations

Daniel S Derrick 3 collaborations

Lisa M Coussens 3 collaborations

Sean M Gross 3 collaborations

Rebecca L Smith 3 collaborations

Guillaume Thibault 2 collaborations

Caitlin E Mills 2 collaborations

Kartik Subramanian 2 collaborations

Mirra Chung 2 collaborations

Marc R Birtwistle 2 collaborations

Peter K Sorger 2 collaborations

Koei Chin 2 collaborations

Jennifer Eng 2 collaborations

Heidi S Feiler 2 collaborations

Crystal Sanchez-Aguila 2 collaborations

Tiera A Liby 2 collaborations

Aaron S Meyer 2 collaborations

Adam M Tuttle 2 collaborations

Lauren N Miller 2 collaborations

Lindsey J Royer 2 collaborations

Hua Wen 2 collaborations

Jimmy J Kelly 2 collaborations

Hannah M Olson 2 collaborations

Amanda Maxfield 2 collaborations

Zuzana Tatarova 2 collaborations

Kaylyn L Devlin 2 collaborations

Geoffrey F Schau 1 collaboration

Mario Niepel 1 collaboration

Marc Hafner 1 collaboration

Elizabeth H Williams 1 collaboration

Benjamin Gaudio 1 collaboration

Anne Marie Barrette 1 collaboration

Alan D Stern 1 collaboration

Bin Hu 1 collaboration

None None 1 collaboration

Hui-Wen Lue 1 collaboration

Soumya Rao 1 collaboration

Ahna Van Gaest 1 collaboration

Larry Cheng 1 collaboration

Jennifer Podolak 1 collaboration

Samantha Lawson 1 collaboration

Changhui Xue 1 collaboration

Devin Garg 1 collaboration

Ralph White 1 collaboration

Christopher W Ryan 1 collaboration

Justin M Drake 1 collaboration

Anna Ritz 1 collaboration

George V Thomas 1 collaboration

Gregory J Hunt 1 collaboration

Johann A Gagnon-Bartsch 1 collaboration

Brett E Johnson 1 collaboration

Allison L Creason 1 collaboration

Jayne M Stommel 1 collaboration

Jamie M Keck 1 collaboration

Swapnil Parmar 1 collaboration

Courtney B Betts 1 collaboration

Aurora Blucher 1 collaboration

Christopher Boniface 1 collaboration

Erik Burlingame 1 collaboration

Todd Camp 1 collaboration

Joseph Estabrook 1 collaboration

Michael B Heskett 1 collaboration

Zhi Hu 1 collaboration

Annette Kolodzie 1 collaboration

Ben L Kong 1 collaboration

Marilyne Labrie 1 collaboration

Jinho Lee 1 collaboration

Patrick Leyshock 1 collaboration

Souraya Mitri 1 collaboration

Janice Patterson 1 collaboration

Jessica L Riesterer 1 collaboration

Shamilene Sivagnanam 1 collaboration

Julia Somers 1 collaboration

Damir Sudar 1 collaboration

Benjamin R Weeder 1 collaboration

Christina Zheng 1 collaboration

Xiaolin Nan 1 collaboration

Reid F Thompson 1 collaboration

Paul T Spellman 1 collaboration

George Thomas 1 collaboration

Emek Demir 1 collaboration

Alexander R Guimaraes 1 collaboration

Christopher Corless 1 collaboration

Jeremy Goecks 1 collaboration

Raymond Bergan 1 collaboration

Zahi Mitri 1 collaboration

Farnaz Mohammadi 1 collaboration

Paulina J Zhan 1 collaboration

Weiyi Qian 1 collaboration

Holger Knaut 1 collaboration

Cheryl J Claunch 1 collaboration

Derrick Hee 1 collaboration

Kaylyn Devlin 1 collaboration

Wallace Thompson 1 collaboration

Jeremy Copperman 1 collaboration

Ian C Mclean 1 collaboration

Daniel M Zuckerman 1 collaboration

Zinab O Doha 1 collaboration

Xiaoyan Wang 1 collaboration

Colin J Daniel 1 collaboration

Luke Ternes 1 collaboration

Eun Na Kim 1 collaboration

Carl Pelz 1 collaboration

Michael Munks 1 collaboration

Courtney Betts 1 collaboration

Sunjong Kwon 1 collaboration

Xi Li 1 collaboration

Trent Waugh 1 collaboration

Dylan Blumberg 1 collaboration

Aaron Ko 1 collaboration

Nell Kirchberger 1 collaboration

Jennifer A Pietenpol 1 collaboration

Melinda E Sanders 1 collaboration

Ellen M Langer 1 collaboration

Mu-Shui Dai 1 collaboration

Gordon Mills 1 collaboration

Rosalie C Sears 1 collaboration

Tiina A Jokela 1 collaboration

Sundus Shalabi 1 collaboration

Jennifer C Lopez 1 collaboration

Masaru Miyano 1 collaboration

Martha R Stampfer 1 collaboration

Mark A LaBarge 1 collaboration

Dylan C Blumberg 1 collaboration

John L Muschler 1 collaboration

Pepper J Schedin 1 collaboration

Sebastian W Ahn 1 collaboration

Oliver Jonas 1 collaboration

Ian C McLean 1 collaboration

Alexandra B London 1 collaboration

Denis Torre 1 collaboration

John Erol Evangelista 1 collaboration

Daniel J B Clarke 1 collaboration

Zhuorui Xie 1 collaboration

Cemal Erdem 1 collaboration

Nicholas Lyons 1 collaboration

Ted Natoli 1 collaboration

Sarah Pessa 1 collaboration

Xiaodong Lu 1 collaboration

James Mullahoo 1 collaboration

Jonathan Li 1 collaboration

Miriam Adam 1 collaboration

Brook Wassie 1 collaboration

Moqing Liu 1 collaboration

David F Kilburn 1 collaboration

Kenneth Daily 1 collaboration

Larsson Omberg 1 collaboration

Yunguan Wang 1 collaboration

Connor Jacobson 1 collaboration

Clarence Yapp 1 collaboration

Dusica Vidovic 1 collaboration

Yiling Lu 1 collaboration

Stephan Schurer 1 collaboration

Albert Lee 1 collaboration

Ajay Pillai 1 collaboration

Aravind Subramanian 1 collaboration

Malvina Papanastasiou 1 collaboration

Ernest Fraenkel 1 collaboration

Jake D Jaffe 1 collaboration

Avi Ma'ayan 1 collaboration

Daniel J Coleman 1 collaboration

Lina Gao 1 collaboration

Jacob Schwartzman 1 collaboration

David Sampson 1 collaboration

Joshua Urrutia 1 collaboration

Ariel Balter 1 collaboration

Julja Burchard 1 collaboration

Carly J King 1 collaboration

Kami E Chiotti 1 collaboration

Joshi J Alumkal 1 collaboration