Line Ledsgaard

Affiliations

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

Publications (16)

Synthetic antibodies block receptor binding and current-inhibiting effects of α-cobratoxin from Naja kaouthia.

Protein science : a publication of the Protein Society

Avec: Shane Miersch , Guillermo de la Rosa , Rasmus Friis , Line Ledsgaard , Kim Boddum , Andreas H Laustsen , Sachdev S Sidhu

Advances in antibody phage display technology.

Drug discovery today

Avec: Line Ledsgaard , Anne Ljungars , Charlotte Rimbault , Christoffer V Sørensen , Tulika Tulika , Jack Wade , Yessica Wouters , John McCafferty , Andreas H Laustsen

Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling.

Structure (London, England : 1993)

Avec: Tulika Tulika , Fulgencio Ruso-Julve , Shirin Ahmadi , Anne Ljungars , Esperanza Rivera-de-Torre , Jack Wade , Monica L Fernández-Quintero , Timothy P Jenkins , Selma B Belfakir , Georgina M S Ross , Lars Boyens-Thiele , Alexander K Buell , Siri A Sakya , Christoffer V Sørensen , Markus-Frederik Bohn , Line Ledsgaard , Bjørn G Voldborg , Chiara Francavilla , Tilman Schlothauer , Bruno Lomonte , Jan Terje Andersen , Andreas H Laustsen

Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes.

Bioconjugate chemistry

Avec: Jack Wade , Charlotte Rimbault , Hanif Ali , Line Ledsgaard , Esperanza Rivera-de-Torre , Maher Abou Hachem , Kim Boddum , Nadia Mirza , Markus-Frederik Bohn , Siri A Sakya , Fulgencio Ruso-Julve , Jan Terje Andersen , Andreas H Laustsen

Cross-reactivity trends when selecting scFv antibodies against snake toxins using a phage display-based cross-panning strategy.

Scientific reports

Avec: Christoffer V Sørensen , Line Ledsgaard , Helen H K Wildenauer , Camilla H Dahl , Tasja W Ebersole , Markus-Frederik Bohn , Anne Ljungars , Timothy P Jenkins , Andreas H Laustsen

Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library.

Protein science : a publication of the Protein Society

Avec: Tulika Tulika , Rasmus W Pedersen , Charlotte Rimbault , Shirin Ahmadi , Esperanza Rivera-de-Torre , Monica L Fernández-Quintero , Johannes R Loeffler , Markus-Frederik Bohn , Anne Ljungars , Line Ledsgaard , Bjørn G Voldborg , Fulgencio Ruso-Julve , Jan Terje Andersen , Andreas H Laustsen

Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A

Frontiers in pharmacology

Avec: Manuela B Pucca , Shirin Ahmadi , Felipe A Cerni , Line Ledsgaard , Christoffer V Sørensen , Farrell T S McGeoghan , Trenton Stewart , Erwin Schoof , Bruno Lomonte , Ulrich Auf dem Keller , Eliane C Arantes , Figen Çalışkan , Andreas H Laustsen

An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies.

Scientific reports

Avec: Shirin Ahmadi , Manuela B Pucca , Jonas A Jürgensen , Rahel Janke , Line Ledsgaard , Erwin M Schoof , Christoffer V Sørensen , Figen Çalışkan , Andreas H Laustsen

Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.

Frontiers in immunology

Avec: Georgia Bullen , Jacob D Galson , Gareth Hall , Pedro Villar , Lien Moreels , Line Ledsgaard , Giada Mattiuzzo , Emma M Bentley , Edward W Masters , David Tang , Sophie Millett , Danielle Tongue , Richard Brown , Ioannis Diamantopoulos , Kothai Parthiban , Claire Tebbutt , Rachael Leah , Krishna Chaitanya , Sandra Ergueta-Carballo , Deividas Pazeraitis , Sachin B Surade , Omodele Ashiru , Lucia Crippa , Richard Cowan , Matthew W Bowler , Jamie I Campbell , Wing-Yiu Jason Lee , Mark D Carr , David Matthews , Paul Pfeffer , Simon E Hufton , Kovilen Sawmynaden , Jane Osbourn , John McCafferty , Aneesh Karatt-Vellatt

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules.

Biochemical pharmacology

Avec: Rohit N Patel , Rachel H Clare , Line Ledsgaard , Mieke Nys , Jeroen Kool , Andreas H Laustsen , Chris Ulens , Nicholas R Casewell

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes.

Nature communications

Avec: Line Ledsgaard , Jack Wade , Timothy P Jenkins , Kim Boddum , Irina Oganesyan , Julian A Harrison , Pedro Villar , Rachael A Leah , Renato Zenobi , Sanne Schoffelen , Bjørn Voldborg , Anne Ljungars , John McCafferty , Bruno Lomonte , José M Gutiérrez , Andreas H Laustsen , Aneesh Karatt-Vellatt

History of Envenoming Therapy and Current Perspectives.

Frontiers in immunology

Avec: Manuela B Pucca , Felipe A Cerni , Rahel Janke , Erick Bermúdez-Méndez , Line Ledsgaard , José E Barbosa , Andreas H Laustsen

Engineering and design considerations for next-generation snakebite antivenoms.

Toxicon : official journal of the International Society on Toxinology

Avec: Cecilie Knudsen , Line Ledsgaard , Rasmus Ibsen Dehli , Shirin Ahmadi , Christoffer Vinther Sørensen , Andreas Hougaard Laustsen

Discovery of a Recombinant Human Monoclonal Immunoglobulin G Antibody Against α-Latrotoxin From the Mediterranean Black Widow Spider (

Frontiers in immunology

Avec: Sofie Føns , Line Ledsgaard , Maxim V Nikolaev , Alexander A Vassilevski , Christoffer V Sørensen , Manon K Chevalier , Michael Fiebig , Andreas H Laustsen

Orally active bivalent V

iScience

Avec: Berthe Katrine Fiil , Sandra Wingaard Thrane , Michael Pichler , Tiia Kittilä , Line Ledsgaard , Shirin Ahmadi , Grith Miriam Maigaard Hermansen , Lars Jelsbak , Charlotte Lauridsen , Susanne Brix , Andreas Hougaard Laustsen

Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper.

Nature communications

Avec: Christoffer V Sørensen , Julián Fernández , Anna Christina Adams , Helen H K Wildenauer , Sanne Schoffelen , Line Ledsgaard , Manuela B Pucca , Michael Fiebig , Felipe A Cerni , Tulika Tulika , Bjørn G Voldborg , Aneesh Karatt-Vellatt , J Preben Morth , Anne Ljungars , Lise M Grav , Bruno Lomonte , Andreas H Laustsen

Réseau de co-auteurs

Andreas H Laustsen 13 collaborations

Christoffer V Sørensen 7 collaborations

Anne Ljungars 6 collaborations

Shirin Ahmadi 6 collaborations

Tulika Tulika 4 collaborations

Jack Wade 4 collaborations

Markus-Frederik Bohn 4 collaborations

Bruno Lomonte 4 collaborations

Manuela B Pucca 4 collaborations

Kim Boddum 3 collaborations

Charlotte Rimbault 3 collaborations

John McCafferty 3 collaborations

Fulgencio Ruso-Julve 3 collaborations

Esperanza Rivera-de-Torre 3 collaborations

Timothy P Jenkins 3 collaborations

Bjørn G Voldborg 3 collaborations

Jan Terje Andersen 3 collaborations

Felipe A Cerni 3 collaborations

Aneesh Karatt-Vellatt 3 collaborations

Monica L Fernández-Quintero 2 collaborations

Siri A Sakya 2 collaborations

Helen H K Wildenauer 2 collaborations

Figen Çalışkan 2 collaborations

Rahel Janke 2 collaborations

Pedro Villar 2 collaborations

Sanne Schoffelen 2 collaborations

Andreas Hougaard Laustsen 2 collaborations

Michael Fiebig 2 collaborations

Shane Miersch 1 collaboration

Guillermo de la Rosa 1 collaboration

Rasmus Friis 1 collaboration

Sachdev S Sidhu 1 collaboration

Yessica Wouters 1 collaboration

Selma B Belfakir 1 collaboration

Georgina M S Ross 1 collaboration

Lars Boyens-Thiele 1 collaboration

Alexander K Buell 1 collaboration

Chiara Francavilla 1 collaboration

Tilman Schlothauer 1 collaboration

Hanif Ali 1 collaboration

Maher Abou Hachem 1 collaboration

Nadia Mirza 1 collaboration

Camilla H Dahl 1 collaboration

Tasja W Ebersole 1 collaboration

Rasmus W Pedersen 1 collaboration

Johannes R Loeffler 1 collaboration

Farrell T S McGeoghan 1 collaboration

Trenton Stewart 1 collaboration

Erwin Schoof 1 collaboration

Ulrich Auf dem Keller 1 collaboration

Eliane C Arantes 1 collaboration

Jonas A Jürgensen 1 collaboration

Erwin M Schoof 1 collaboration

Georgia Bullen 1 collaboration

Jacob D Galson 1 collaboration

Gareth Hall 1 collaboration

Lien Moreels 1 collaboration

Giada Mattiuzzo 1 collaboration

Emma M Bentley 1 collaboration

Edward W Masters 1 collaboration

David Tang 1 collaboration

Sophie Millett 1 collaboration

Danielle Tongue 1 collaboration

Richard Brown 1 collaboration

Ioannis Diamantopoulos 1 collaboration

Kothai Parthiban 1 collaboration

Claire Tebbutt 1 collaboration

Rachael Leah 1 collaboration

Krishna Chaitanya 1 collaboration

Sandra Ergueta-Carballo 1 collaboration

Deividas Pazeraitis 1 collaboration

Sachin B Surade 1 collaboration

Omodele Ashiru 1 collaboration

Lucia Crippa 1 collaboration

Richard Cowan 1 collaboration

Matthew W Bowler 1 collaboration

Jamie I Campbell 1 collaboration

Wing-Yiu Jason Lee 1 collaboration

Mark D Carr 1 collaboration

David Matthews 1 collaboration

Paul Pfeffer 1 collaboration

Simon E Hufton 1 collaboration

Kovilen Sawmynaden 1 collaboration

Jane Osbourn 1 collaboration

Rohit N Patel 1 collaboration

Rachel H Clare 1 collaboration

Mieke Nys 1 collaboration

Jeroen Kool 1 collaboration

Chris Ulens 1 collaboration

Nicholas R Casewell 1 collaboration

Irina Oganesyan 1 collaboration

Julian A Harrison 1 collaboration

Rachael A Leah 1 collaboration

Renato Zenobi 1 collaboration

Bjørn Voldborg 1 collaboration

José M Gutiérrez 1 collaboration

Erick Bermúdez-Méndez 1 collaboration

José E Barbosa 1 collaboration

Cecilie Knudsen 1 collaboration

Rasmus Ibsen Dehli 1 collaboration

Christoffer Vinther Sørensen 1 collaboration

Sofie Føns 1 collaboration

Maxim V Nikolaev 1 collaboration

Alexander A Vassilevski 1 collaboration

Manon K Chevalier 1 collaboration

Berthe Katrine Fiil 1 collaboration

Sandra Wingaard Thrane 1 collaboration

Michael Pichler 1 collaboration

Tiia Kittilä 1 collaboration

Grith Miriam Maigaard Hermansen 1 collaboration

Lars Jelsbak 1 collaboration

Charlotte Lauridsen 1 collaboration

Susanne Brix 1 collaboration

Julián Fernández 1 collaboration

Anna Christina Adams 1 collaboration

J Preben Morth 1 collaboration

Lise M Grav 1 collaboration