Luke Hodson

Affiliations

Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: daniel.rauh@tu-dortmund.de ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Department of Chemistry and Polymer Science , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa.

ORCID: 0000-0001-9779-1133

Publications (14)

Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis.

Physiological reports

Avec: Pippa J Gunn , Camilla Pramfalk , Val Millar , Thomas Cornfield , Matthew Hutchinson , Elspeth M Johnson , Shilpa R Nagarajan , Perla Troncoso-Rey , Richard F Mithen , Katherine E Pinnick , Maria H Traka , Charlotte J Green , Leanne Hodson

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.

Chemical science

Avec: Jonas Lategahn , Marina Keul , Philip Klövekorn , Hannah L Tumbrink , Janina Niggenaber , Matthias P Müller , Luke Hodson , Maren Flaßhoff , Julia Hardick , Tobias Grabe , Julian Engel , Carsten Schultz-Fademrecht , Matthias Baumann , Julia Ketzer , Thomas Mühlenberg , Wolf Hiller , Georgia Günther , Anke Unger , Heiko Müller , Alena Heimsoeth , Christopher Golz , Bernhard Blank-Landeshammer , Laxmikanth Kollipara , René P Zahedi , Carsten Strohmann , Jan G Hengstler , Willem A L van Otterlo , Sebastian Bauer , Daniel Rauh

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.

Metabolism: clinical and experimental

Avec: Nikolaos Nikolaou , Laura L Gathercole , Lea Marchand , Sara Althari , Niall J Dempster , Charlotte J Green , Martijn van de Bunt , Catriona McNeil , Anastasia Arvaniti , Beverly A Hughes , Bruno Sgromo , Richard S Gillies , Hanns-Ulrich Marschall , Trevor M Penning , John Ryan , Wiebke Arlt , Leanne Hodson , Jeremy W Tomlinson

Fasting hepatic de novo lipogenesis is not reliably assessed using circulating fatty acid markers.

The American journal of clinical nutrition

Avec: Fredrik Rosqvist , Catriona A McNeil , Camilla Pramfalk , Sion A Parry , Wee Suan Low , Thomas Cornfield , Barbara A Fielding , Leanne Hodson

Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism.

BMJ open diabetes research & care

Avec: Charlotte J Green , Camilla Pramfalk , Catriona A Charlton , Pippa J Gunn , Thomas Cornfield , Michael Pavlides , Fredrik Karpe , Leanne Hodson

Nonalcoholic Fatty Liver Disease in Adults: Current Concepts in Etiology, Outcomes, and Management.

Endocrine reviews

Avec: Thomas Marjot , Ahmad Moolla , Jeremy F Cobbold , Leanne Hodson , Jeremy W Tomlinson

Adipocyte NR1D1 dictates adipose tissue expansion during obesity.

eLife

Avec: Ann Louise Hunter , Charlotte E Pelekanou , Nichola J Barron , Rebecca C Northeast , Magdalena Grudzien , Antony D Adamson , Polly Downton , Thomas Cornfield , Peter S Cunningham , Jean-Noel Billaud , Leanne Hodson , Andrew Si Loudon , Richard D Unwin , Mudassar Iqbal , David W Ray , David A Bechtold

The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.

Physiological reports

Avec: David J Dearlove , Adrian Soto Mota , David Hauton , Katherine Pinnick , Rhys Evans , Jack Miller , Roman Fischer , James S O Mccullagh , Leanne Hodson , Kieran Clarke , Pete J Cox

Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice.

Journal of internal medicine

Avec: Camilla Pramfalk , Osman Ahmed , Matteo Pedrelli , Mirko E Minniti , Serge Luquet , Raphaël Gp Denis , Maria Olin , Jennifer Härdfeldt , Lise-Lotte Vedin , Knut R Steffensen , Mikael Rydén , Leanne Hodson , Mats Eriksson , Paolo Parini

Determining the temporal, dose, and composition effects of nutritional substrates in an in vitro model of intrahepatocellular triglyceride accumulation.

Physiological reports

Avec: Shilpa R Nagarajan , Eloise Cross , Elspeth Johnson , Fabio Sanna , Lorna J Daniels , David W Ray , Leanne Hodson

11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial.

Nature communications

Avec: Nantia Othonos , Riccardo Pofi , Anastasia Arvaniti , Sarah White , Ilaria Bonaventura , Nikolaos Nikolaou , Ahmad Moolla , Thomas Marjot , Roland H Stimson , André P van Beek , Martijn van Faassen , Andrea M Isidori , Elizabeth Bateman , Ross Sadler , Fredrik Karpe , Paul M Stewart , Craig Webster , Joanne Duffy , Richard Eastell , Fatma Gossiel , Thomas Cornfield , Leanne Hodson , K Jane Escott , Andrew Whittaker , Ufuk Kirik , Ruth L Coleman , Charles A B Scott , Joanne E Milton , Olorunsola Agbaje , Rury R Holman , Jeremy W Tomlinson

MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies.

Metabolism: clinical and experimental

Avec: Shilpa R Nagarajan , Eilidh J Livingstone , Thomas Monfeuga , Lara C Lewis , Shahul Hameed Liyakath Ali , Anandhakumar Chandran , David J Dearlove , Matt J Neville , Lingyan Chen , Cyrielle Maroteau , Maxwell A Ruby , Leanne Hodson

Hepatocyte mARC1 promotes fatty liver disease.

JHEP reports : innovation in hepatology

Avec: Lara C Lewis , Lingyan Chen , L Shahul Hameed , Robert R Kitchen , Cyrielle Maroteau , Shilpa R Nagarajan , Jenny Norlin , Charlotte E Daly , Iwona Szczerbinska , Sara Toftegaard Hjuler , Rahul Patel , Eilidh J Livingstone , Tom N Durrant , Elisabeth Wondimu , Soumik BasuRay , Anandhakumar Chandran , Wan-Hung Lee , Sile Hu , Barak Gilboa , Megan E Grandi , Enrique M Toledo , Abdullah H A Erikat , Leanne Hodson , William G Haynes , Natalie W Pursell , Ken Coppieters , Jan Fleckner , Joanna M M Howson , Birgitte Andersen , Maxwell A Ruby

The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans.

Cell metabolism

Avec: Panu K Luukkonen , Kimmo Porthan , Noora Ahlholm , Fredrik Rosqvist , Sylvie Dufour , Xian-Man Zhang , Tiina E Lehtimäki , Wenla Seppänen , Marju Orho-Melander , Leanne Hodson , Kitt Falk Petersen , Gerald I Shulman , Hannele Yki-Järvinen

Réseau de co-auteurs

Leanne Hodson 13 collaborations

Thomas Cornfield 5 collaborations

Camilla Pramfalk 4 collaborations

Shilpa R Nagarajan 4 collaborations

Charlotte J Green 3 collaborations

Jeremy W Tomlinson 3 collaborations

Pippa J Gunn 2 collaborations

Nikolaos Nikolaou 2 collaborations

Anastasia Arvaniti 2 collaborations

Fredrik Rosqvist 2 collaborations

Fredrik Karpe 2 collaborations

Thomas Marjot 2 collaborations

Ahmad Moolla 2 collaborations

David W Ray 2 collaborations

David J Dearlove 2 collaborations

Eilidh J Livingstone 2 collaborations

Lara C Lewis 2 collaborations

Anandhakumar Chandran 2 collaborations

Lingyan Chen 2 collaborations

Cyrielle Maroteau 2 collaborations

Maxwell A Ruby 2 collaborations

Val Millar 1 collaboration

Matthew Hutchinson 1 collaboration

Elspeth M Johnson 1 collaboration

Perla Troncoso-Rey 1 collaboration

Richard F Mithen 1 collaboration

Katherine E Pinnick 1 collaboration

Maria H Traka 1 collaboration

Jonas Lategahn 1 collaboration

Marina Keul 1 collaboration

Philip Klövekorn 1 collaboration

Hannah L Tumbrink 1 collaboration

Janina Niggenaber 1 collaboration

Matthias P Müller 1 collaboration

Maren Flaßhoff 1 collaboration

Julia Hardick 1 collaboration

Tobias Grabe 1 collaboration

Julian Engel 1 collaboration

Carsten Schultz-Fademrecht 1 collaboration

Matthias Baumann 1 collaboration

Julia Ketzer 1 collaboration

Thomas Mühlenberg 1 collaboration

Wolf Hiller 1 collaboration

Georgia Günther 1 collaboration

Anke Unger 1 collaboration

Heiko Müller 1 collaboration

Alena Heimsoeth 1 collaboration

Christopher Golz 1 collaboration

Bernhard Blank-Landeshammer 1 collaboration

Laxmikanth Kollipara 1 collaboration

René P Zahedi 1 collaboration

Carsten Strohmann 1 collaboration

Jan G Hengstler 1 collaboration

Willem A L van Otterlo 1 collaboration

Sebastian Bauer 1 collaboration

Daniel Rauh 1 collaboration

Laura L Gathercole 1 collaboration

Lea Marchand 1 collaboration

Sara Althari 1 collaboration

Niall J Dempster 1 collaboration

Martijn van de Bunt 1 collaboration

Catriona McNeil 1 collaboration

Beverly A Hughes 1 collaboration

Bruno Sgromo 1 collaboration

Richard S Gillies 1 collaboration

Hanns-Ulrich Marschall 1 collaboration

Trevor M Penning 1 collaboration

John Ryan 1 collaboration

Wiebke Arlt 1 collaboration

Catriona A McNeil 1 collaboration

Sion A Parry 1 collaboration

Wee Suan Low 1 collaboration

Barbara A Fielding 1 collaboration

Catriona A Charlton 1 collaboration

Michael Pavlides 1 collaboration

Jeremy F Cobbold 1 collaboration

Ann Louise Hunter 1 collaboration

Charlotte E Pelekanou 1 collaboration

Nichola J Barron 1 collaboration

Rebecca C Northeast 1 collaboration

Magdalena Grudzien 1 collaboration

Antony D Adamson 1 collaboration

Polly Downton 1 collaboration

Peter S Cunningham 1 collaboration

Jean-Noel Billaud 1 collaboration

Andrew Si Loudon 1 collaboration

Richard D Unwin 1 collaboration

Mudassar Iqbal 1 collaboration

David A Bechtold 1 collaboration

Adrian Soto Mota 1 collaboration

David Hauton 1 collaboration

Katherine Pinnick 1 collaboration

Rhys Evans 1 collaboration

Jack Miller 1 collaboration

Roman Fischer 1 collaboration

James S O Mccullagh 1 collaboration

Kieran Clarke 1 collaboration

Pete J Cox 1 collaboration

Osman Ahmed 1 collaboration

Matteo Pedrelli 1 collaboration

Mirko E Minniti 1 collaboration

Serge Luquet 1 collaboration

Raphaël Gp Denis 1 collaboration

Maria Olin 1 collaboration

Jennifer Härdfeldt 1 collaboration

Lise-Lotte Vedin 1 collaboration

Knut R Steffensen 1 collaboration

Mikael Rydén 1 collaboration

Mats Eriksson 1 collaboration

Paolo Parini 1 collaboration

Eloise Cross 1 collaboration

Elspeth Johnson 1 collaboration

Fabio Sanna 1 collaboration

Lorna J Daniels 1 collaboration

Nantia Othonos 1 collaboration

Riccardo Pofi 1 collaboration

Sarah White 1 collaboration

Ilaria Bonaventura 1 collaboration

Roland H Stimson 1 collaboration

André P van Beek 1 collaboration

Martijn van Faassen 1 collaboration

Andrea M Isidori 1 collaboration

Elizabeth Bateman 1 collaboration

Ross Sadler 1 collaboration

Paul M Stewart 1 collaboration

Craig Webster 1 collaboration

Joanne Duffy 1 collaboration

Richard Eastell 1 collaboration

Fatma Gossiel 1 collaboration

K Jane Escott 1 collaboration

Andrew Whittaker 1 collaboration

Ufuk Kirik 1 collaboration

Ruth L Coleman 1 collaboration

Charles A B Scott 1 collaboration

Joanne E Milton 1 collaboration

Olorunsola Agbaje 1 collaboration

Rury R Holman 1 collaboration

Thomas Monfeuga 1 collaboration

Shahul Hameed Liyakath Ali 1 collaboration

Matt J Neville 1 collaboration

L Shahul Hameed 1 collaboration

Robert R Kitchen 1 collaboration

Jenny Norlin 1 collaboration

Charlotte E Daly 1 collaboration

Iwona Szczerbinska 1 collaboration

Sara Toftegaard Hjuler 1 collaboration

Rahul Patel 1 collaboration

Tom N Durrant 1 collaboration

Elisabeth Wondimu 1 collaboration

Soumik BasuRay 1 collaboration

Wan-Hung Lee 1 collaboration

Sile Hu 1 collaboration

Barak Gilboa 1 collaboration

Megan E Grandi 1 collaboration

Enrique M Toledo 1 collaboration

Abdullah H A Erikat 1 collaboration

William G Haynes 1 collaboration

Natalie W Pursell 1 collaboration

Ken Coppieters 1 collaboration

Jan Fleckner 1 collaboration

Joanna M M Howson 1 collaboration

Birgitte Andersen 1 collaboration

Panu K Luukkonen 1 collaboration

Kimmo Porthan 1 collaboration

Noora Ahlholm 1 collaboration

Sylvie Dufour 1 collaboration

Xian-Man Zhang 1 collaboration

Tiina E Lehtimäki 1 collaboration

Wenla Seppänen 1 collaboration

Marju Orho-Melander 1 collaboration

Kitt Falk Petersen 1 collaboration

Gerald I Shulman 1 collaboration

Hannele Yki-Järvinen 1 collaboration