Luna Musib

Affiliations

Genentech, Inc., South San Francisco, California, USA.

Publications (15)

Exposure-Response-Based Product Profile-Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer.

CPT: pharmacometrics & systems pharmacology

Avec: Rui Zhu , Bill Poland , Russ Wada , Qi Liu , Luna Musib , Daniel Maslyar , Eunpi Cho , Wei Yu , Han Ma , Jin Yan Jin , Nageshwar Budha

Time to Rethink the Current Paradigm for Assessing Kidney Function in Drug Development and Beyond.

Clinical pharmacology and therapeutics

Avec: Ashish Sharma , Vaishali Sahasrabudhe , Luna Musib , Steven Zhang , Islam Younis , Jitendra Kanodia

A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors.

Investigational new drugs

Avec: Geoffrey I Shapiro , Patricia LoRusso , Daniel C Cho , Luna Musib , Yibing Yan , Matthew Wongchenko , Ilsung Chang , Premal Patel , Iris T Chan , Sandra Sanabria-Bohorquez , Raymond D Meng , Johanna C Bendell

Assessment of cytochrome P450 3A4-mediated drug-drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model.

Cancer chemotherapy and pharmacology

Avec: Jing Jing , Yuan Chen , Luna Musib , Jin Y Jin , Kit Wun Kathy Cheung , Kenta Yoshida , Rucha Sane

Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study.

Targeted oncology

Avec: Tanya Trippett , Helen Toledano , Quentin Campbell Hewson , Arnauld Verschuur , Anne-Marie Langevin , Isabelle Aerts , Lisa Howell , Soledad Gallego , Claudia Rossig , Amy Smith , Darshak Patel , Leonardo R Pereira , Sravanthi Cheeti , Luna Musib , Katherine E Hutchinson , Clare Devlin , Ronald Bernardi , Birgit Geoerger

Priority-Elastic net for binary disease outcome prediction based on multi-omics data.

BioData mining

Avec: Laila Musib , Roberta Coletti , Marta B Lopes , Helena Mouriño , Eunice Carrasquinha

Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors.

Annals of oncology : official journal of the European Society for Medical Oncology

Avec: S J Isakoff , J Tabernero , L R Molife , J-C Soria , A Cervantes , N J Vogelzang , M R Patel , M Hussain , A Baron , G Argilés , P R Conkling , D Sampath , D Maslyar , P Patel , W Chan , S Gendreau , L Musib , N Xu , H Ma , K Lin , J Bendell

Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function.

Journal of clinical pharmacology

Avec: Rucha Sane , Vikram Malhi , Dhruvitkumar S Sutaria , Eunpi Cho , Patrick Twomey , Christopher Craggs , Jianshuang Wang , Adam Harris , Luna Musib

The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Ryan H Takahashi , Vikram Malhi , Bianca M Liederer , Sungjoon Cho , Yuzhong Deng , Brian Dean , James Nugteren , Edward Yost , Mohammad A Al-Sayah , Rucha Sane , Smita Kshirsagar , Shuguang Ma , Luna Musib

Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Smita Kshirsagar , Ya-Chi Chen , Jiajie Yu , Mary R Gates , Sonoko Kawakatsu , S Cyrus Khojasteh , Shuguang Ma , Luna Musib , Vikram Malhi , Uyi Osaghae , Jing Wang , Sungjoon Cho , Yang Tang , Donglu Zhang , Weiping Zhao , Tom De Bruyn

Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics.

Clinical pharmacology in drug development

Avec: Sravanthi Cheeti , Yuzhong Deng , Ilsung Chang , Isabela Georgescu , Ian Templeton , Nicholas Choong , Kit Wun Kathy Cheung , Sandhya Girish , Luna Musib

Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors.

Investigational new drugs

Avec: Geoffrey I Shapiro , Patricia LoRusso , Eunice Kwak , Susan Pandya , Charles M Rudin , Carla Kurkjian , James M Cleary , Mary Jo Pilat , Suzanne Jones , Alex de Crespigny , Jill Fredrickson , Luna Musib , Yibing Yan , Matthew Wongchenko , Hsin-Ju Hsieh , Mary R Gates , Iris T Chan , Johanna Bendell

Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Rucha Sane , Kit Wun Kathy Cheung , Péter Kovács , Taleah Farasyn , Ruina Li , Annamaria Bui , Luna Musib , Emese Kis , Emile Plise , Zsuzsanna Gáborik

Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects.

The Journal of pharmacology and experimental therapeutics

Avec: Rucha S Sane , Kit Wun Kathy Cheung , Eunpi Cho , Bianca M Liederer , Justin Hanover , Vikram Malhi , Emile Plise , Susan Wong , Luna Musib

Single- and multiple-dose pharmacokinetics, potential for CYP3A inhibition, and food effect in patients with cancer and healthy subjects receiving ipatasertib.

Cancer chemotherapy and pharmacology

Avec: Vikram Malhi , Nageshwar Budha , Rucha Sane , Jian Huang , Bianca Liederer , Raymond Meng , Premal Patel , Yuzhong Deng , Andres Cervantes , Josep Tabernero , Luna Musib

Réseau de co-auteurs

Rucha Sane 5 collaborations

Vikram Malhi 5 collaborations

Kit Wun Kathy Cheung 4 collaborations

Eunpi Cho 3 collaborations

Yuzhong Deng 3 collaborations

Nageshwar Budha 2 collaborations

Geoffrey I Shapiro 2 collaborations

Patricia LoRusso 2 collaborations

Yibing Yan 2 collaborations

Matthew Wongchenko 2 collaborations

Ilsung Chang 2 collaborations

Premal Patel 2 collaborations

Iris T Chan 2 collaborations

Sravanthi Cheeti 2 collaborations

Bianca M Liederer 2 collaborations

Sungjoon Cho 2 collaborations

Smita Kshirsagar 2 collaborations

Shuguang Ma 2 collaborations

Mary R Gates 2 collaborations

Emile Plise 2 collaborations

Rui Zhu 1 collaboration

Bill Poland 1 collaboration

Russ Wada 1 collaboration

Qi Liu 1 collaboration

Daniel Maslyar 1 collaboration

Wei Yu 1 collaboration

Han Ma 1 collaboration

Jin Yan Jin 1 collaboration

Ashish Sharma 1 collaboration

Vaishali Sahasrabudhe 1 collaboration

Steven Zhang 1 collaboration

Islam Younis 1 collaboration

Jitendra Kanodia 1 collaboration

Daniel C Cho 1 collaboration

Sandra Sanabria-Bohorquez 1 collaboration

Raymond D Meng 1 collaboration

Johanna C Bendell 1 collaboration

Jing Jing 1 collaboration

Yuan Chen 1 collaboration

Jin Y Jin 1 collaboration

Kenta Yoshida 1 collaboration

Tanya Trippett 1 collaboration

Helen Toledano 1 collaboration

Quentin Campbell Hewson 1 collaboration

Arnauld Verschuur 1 collaboration

Anne-Marie Langevin 1 collaboration

Isabelle Aerts 1 collaboration

Lisa Howell 1 collaboration

Soledad Gallego 1 collaboration

Claudia Rossig 1 collaboration

Amy Smith 1 collaboration

Darshak Patel 1 collaboration

Leonardo R Pereira 1 collaboration

Katherine E Hutchinson 1 collaboration

Clare Devlin 1 collaboration

Ronald Bernardi 1 collaboration

Birgit Geoerger 1 collaboration

Laila Musib 1 collaboration

Roberta Coletti 1 collaboration

Marta B Lopes 1 collaboration

Helena Mouriño 1 collaboration

Eunice Carrasquinha 1 collaboration

S J Isakoff 1 collaboration

J Tabernero 1 collaboration

L R Molife 1 collaboration

J-C Soria 1 collaboration

A Cervantes 1 collaboration

N J Vogelzang 1 collaboration

M R Patel 1 collaboration

M Hussain 1 collaboration

A Baron 1 collaboration

G Argilés 1 collaboration

P R Conkling 1 collaboration

D Sampath 1 collaboration

D Maslyar 1 collaboration

P Patel 1 collaboration

W Chan 1 collaboration

S Gendreau 1 collaboration

L Musib 1 collaboration

N Xu 1 collaboration

H Ma 1 collaboration

K Lin 1 collaboration

J Bendell 1 collaboration

Dhruvitkumar S Sutaria 1 collaboration

Patrick Twomey 1 collaboration

Christopher Craggs 1 collaboration

Jianshuang Wang 1 collaboration

Adam Harris 1 collaboration

Ryan H Takahashi 1 collaboration

Brian Dean 1 collaboration

James Nugteren 1 collaboration

Edward Yost 1 collaboration

Mohammad A Al-Sayah 1 collaboration

Ya-Chi Chen 1 collaboration

Jiajie Yu 1 collaboration

Sonoko Kawakatsu 1 collaboration

S Cyrus Khojasteh 1 collaboration

Uyi Osaghae 1 collaboration

Jing Wang 1 collaboration

Yang Tang 1 collaboration

Donglu Zhang 1 collaboration

Weiping Zhao 1 collaboration

Tom De Bruyn 1 collaboration

Isabela Georgescu 1 collaboration

Ian Templeton 1 collaboration

Nicholas Choong 1 collaboration

Sandhya Girish 1 collaboration

Eunice Kwak 1 collaboration

Susan Pandya 1 collaboration

Charles M Rudin 1 collaboration

Carla Kurkjian 1 collaboration

James M Cleary 1 collaboration

Mary Jo Pilat 1 collaboration

Suzanne Jones 1 collaboration

Alex de Crespigny 1 collaboration

Jill Fredrickson 1 collaboration

Hsin-Ju Hsieh 1 collaboration

Johanna Bendell 1 collaboration

Péter Kovács 1 collaboration

Taleah Farasyn 1 collaboration

Ruina Li 1 collaboration

Annamaria Bui 1 collaboration

Emese Kis 1 collaboration

Zsuzsanna Gáborik 1 collaboration

Rucha S Sane 1 collaboration

Justin Hanover 1 collaboration

Susan Wong 1 collaboration

Jian Huang 1 collaboration

Bianca Liederer 1 collaboration

Raymond Meng 1 collaboration

Andres Cervantes 1 collaboration

Josep Tabernero 1 collaboration