Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models.
ATP Binding Cassette Transporter, Subfamily G, Member 2
/ antagonists & inhibitors
Area Under Curve
Cholecystokinin
/ pharmacokinetics
Drug Evaluation, Preclinical
Drug Interactions
Estradiol
/ analogs & derivatives
HEK293 Cells
Humans
Liver-Specific Organic Anion Transporter 1
/ antagonists & inhibitors
Models, Biological
Neoplasm Proteins
/ antagonists & inhibitors
Peptide Fragments
/ pharmacokinetics
Rosuvastatin Calcium
/ pharmacokinetics
Solute Carrier Organic Anion Transporter Family Member 1B3
/ antagonists & inhibitors
Journal
Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
15
06
2020
accepted:
28
09
2020
pubmed:
11
10
2020
medline:
14
9
2021
entrez:
10
10
2020
Statut:
ppublish
Résumé
Organic anion-transporting polypeptide (OATP) 1B1/3-mediated drug-drug interaction (DDI) potential is evaluated in vivo with rosuvastatin (RST) as a probe substrate in clinical studies. We calibrated our assay with RST and estradiol 17-
Identifiants
pubmed: 33037044
pii: dmd.120.000149
doi: 10.1124/dmd.120.000149
doi:
Substances chimiques
ABCG2 protein, human
0
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
Liver-Specific Organic Anion Transporter 1
0
Neoplasm Proteins
0
Peptide Fragments
0
SLCO1B1 protein, human
0
SLCO1B3 protein, human
0
Solute Carrier Organic Anion Transporter Family Member 1B3
0
cholecystokinin 8
0
estradiol-17 beta-glucuronide
1806-98-0
Estradiol
4TI98Z838E
Rosuvastatin Calcium
83MVU38M7Q
Cholecystokinin
9011-97-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1264-1270Informations de copyright
Copyright © 2020 The Author(s).
Déclaration de conflit d'intérêts
Financial disclosure: R.S., K.W.K.C., R.L., L.M., T.F., and E.P. were employees of Genentech, a member of the Roche Group, when the work was performed. The employees are also holders of Roche Holding Ltd. stock. P.K., A.B., E.K., and Z.G. were employees of SOLVO Biotechnology, a Charles River Company, when the work was performed.