M A Shulepko

Affiliations

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Biological Faculty, Moscow State University, 119234, Moscow, Russia.

Publications (23)

Water-soluble variant of human Lynx1 positively modulates synaptic plasticity and ameliorates cognitive impairment associated with α7-nAChR dysfunction.

Journal of neurochemistry

Avec: Zakhar O Shenkarev , Mikhail A Shulepko , Maxim L Bychkov , Dmitrii S Kulbatskii , Olga V Shlepova , Nathalia A Vasilyeva , Alexander A Andreev-Andrievskiy , Anfisa S Popova , Evgeniya A Lagereva , Eugene V Loktyushov , Sergey G Koshelev , Morten S Thomsen , Dmitry A Dolgikh , Sergey A Kozlov , Pavel M Balaban , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Recombinant Production and Structure-Function Study of the Ts1 Toxin from the Brazilian Scorpion Tityus serrulatus.

Doklady. Biochemistry and biophysics

Avec: Z O Shenkarev , M A Shulepko , S Peigneur , M Yu Myshkin , A A Berkut , A A Vassilevski , J Tytgat , E N Lyukmanova , M P Kirpichnikov

Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis.

The Journal of investigative dermatology

Avec: Mikhail A Shulepko , Maxim L Bychkov , Zakhar O Shenkarev , Dmitrii S Kulbatskii , Alexey M Makhonin , Alexander S Paramonov , Anton O Chugunov , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

New Three-Finger Protein from Starfish

Marine drugs

Avec: Alexander S Paramonov , Mikhail A Shulepko , Alexey M Makhonin , Maxim L Bychkov , Dmitrii S Kulbatskii , Andrey M Chernikov , Mikhail Yu Myshkin , Sergey V Shabelnikov , Zakhar O Shenkarev , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of Multicellular Spheroids Reconstructed from Carcinoma Cells.

Doklady. Biochemistry and biophysics

Avec: M L Bychkov , M A Shulepko , O V Shlepova , E N Lyukmanova , M P Kirpichnikov

Expression of Xanthorhodopsin in Escherichia coli.

The protein journal

Avec: Lada E Petrovskaya , Evgeniy P Lukashev , Ekaterina N Lyukmanova , Mikhail A Shulepko , Elena A Kryukova , Rustam H Ziganshin , Dmitriy A Dolgikh , Evgeniy G Maksimov , Andrei B Rubin , Mikhail P Kirpichnikov , Janos K Lanyi , Sergei P Balashov

Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider

Toxins

Avec: Ekaterina N Lyukmanova , Pavel A Mironov , Dmitrii S Kulbatskii , Mikhail A Shulepko , Alexander S Paramonov , Elizaveta M Chernaya , Yulia A Logashina , Yaroslav A Andreev , Mikhail P Kirpichnikov , Zakhar O Shenkarev

Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline.

Biomolecules

Avec: Dmitry I Osmakov , Sergey G Koshelev , Ekaterina N Lyukmanova , Mikhail A Shulepko , Yaroslav A Andreev , Peter Illes , Sergey A Kozlov

Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors.

International journal of molecular sciences

Avec: Alexander S Paramonov , Milita V Kocharovskaya , Andrey V Tsarev , Dmitrii S Kulbatskii , Eugene V Loktyushov , Mikhail A Shulepko , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova , Zakhar O Shenkarev

Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors.

Communications biology

Avec: Zakhar O Shenkarev , Yuri M Chesnokov , Maxim M Zaigraev , Anton O Chugunov , Dmitrii S Kulbatskii , Milita V Kocharovskaya , Alexander S Paramonov , Maxim L Bychkov , Mikhail A Shulepko , Dmitry E Nolde , Roman A Kamyshinsky , Evgeniy O Yablokov , Alexey S Ivanov , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.

Biochemical and biophysical research communications

Avec: Nikolai N Sluchanko , Anna A Kapitonova , Mikhail A Shulepko , Ilya D Kukushkin , Dmitrii S Kulbatskii , Kristina V Tugaeva , Larisa A Varfolomeeva , Mikhail E Minyaev , Konstantin M Boyko , Vladimir O Popov , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma

Frontiers in cell and developmental biology

Avec: O V Shlepova , M A Shulepko , V O Shipunova , M L Bychkov , I D Kukushkin , I A Chulina , V N Azev , E I Shramova , V A Kazakov , A M Ismailova , Y A Palikova , V A Palikov , E A Kalabina , E A Shaykhutdinova , G A Slashcheva , E A Tukhovskaya , I A Dyachenko , A N Murashev , S M Deyev , M P Kirpichnikov , Z O Shenkarev , E N Lyukmanova

ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest.

Acta naturae

Avec: M L Bychkov , M A Shulepko , V Y Vasileva , A V Sudarikova , M P Kirpichnikov , E N Lyukmanova

Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of U251 MG and A172 Glioma Cells.

Doklady. Biochemistry and biophysics

Avec: M A Shulepko , M L Bychkov , E N Lyukmanova , M P Kirpichnikov

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer.

Frontiers in cell and developmental biology

Avec: Maxim L Bychkov , Mikhail A Shulepko , Olga V Shlepova , Dmitrii S Kulbatskii , Irina A Chulina , Alexander S Paramonov , Ludmila K Baidakova , Viatcheslav N Azev , Sergey G Koshelev , Mikhail P Kirpichnikov , Zakhar O Shenkarev , Ekaterina N Lyukmanova

Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes.

Biomedicines

Avec: Maxim L Bychkov , Artem V Kirichenko , Irina N Mikhaylova , Alexander S Paramonov , Evgeny V Yastremsky , Mikhail P Kirpichnikov , Mikhail A Shulepko , Ekaterina N Lyukmanova

Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer.

Frontiers in oncology

Avec: Anastasia V Sudarikova , Maxim L Bychkov , Dmitrii S Kulbatskii , Vladislav I Chubinskiy-Nadezhdin , Olga V Shlepova , Mikhail A Shulepko , Sergey G Koshelev , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Na

Frontiers in pharmacology

Avec: Mikhail Yu Myshkin , Roope Männikkö , Olesya A Krumkacheva , Dmitrii S Kulbatskii , Anton O Chugunov , Antonina A Berkut , Alexander S Paramonov , Mikhail A Shulepko , Matvey V Fedin , Michael G Hanna , Dimitri M Kullmann , Elena G Bagryanskaya , Alexander S Arseniev , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova , Alexander A Vassilevski , Zakhar O Shenkarev

Efficient screening of ligand-receptor complex formation using fluorescence labeling and size-exclusion chromatography.

Biochemical and biophysical research communications

Avec: D S Kulbatskii , M A Shulepko , N N Sluchanko , E O Yablokov , R A Kamyshinsky , Y M Chesnokov , M P Kirpichnikov , E N Lyukmanova

Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells.

International immunopharmacology

Avec: Mikhail A Shulepko , Maxim L Bychkov , Olga V Shlepova , Zakhar O Shenkarev , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis.

Biomedicines

Avec: Maxim L Bychkov , Artem V Kirichenko , Mikhail A Shulepko , Irina N Mikhaylova , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells.

Toxins

Avec: Ekaterina N Lyukmanova , Maxim M Zaigraev , Dmitrii S Kulbatskii , Aizek B Isaev , Ilya D Kukushkin , Maxim L Bychkov , Mikhail A Shulepko , Anton O Chugunov , Mikhail P Kirpichnikov

Upregulation of cholinergic modulators Lypd6 and Lypd6b associated with autism drives anxiety and cognitive decline.

Cell death discovery

Avec: Aizek B Isaev , Maxim L Bychkov , Dmitrii S Kulbatskii , Alexander A Andreev-Andrievskiy , Mikhail A Mashkin , Mikhail A Shulepko , Olga V Shlepova , Eugene V Loktyushov , Alexander V Latanov , Mikhail P Kirpichnikov , Ekaterina N Lyukmanova

Réseau de co-auteurs

Mikhail A Shulepko 17 collaborations

Ekaterina N Lyukmanova 17 collaborations

Mikhail P Kirpichnikov 16 collaborations

Dmitrii S Kulbatskii 12 collaborations

Maxim L Bychkov 11 collaborations

Zakhar O Shenkarev 9 collaborations

Alexander S Paramonov 8 collaborations

E N Lyukmanova 6 collaborations

M P Kirpichnikov 6 collaborations

Olga V Shlepova 5 collaborations

Sergey G Koshelev 4 collaborations

Anton O Chugunov 4 collaborations

M L Bychkov 4 collaborations

Eugene V Loktyushov 3 collaborations

Alexander A Andreev-Andrievskiy 2 collaborations

Sergey A Kozlov 2 collaborations

Z O Shenkarev 2 collaborations

Alexey M Makhonin 2 collaborations

Mikhail Yu Myshkin 2 collaborations

O V Shlepova 2 collaborations

Yaroslav A Andreev 2 collaborations

Milita V Kocharovskaya 2 collaborations

Maxim M Zaigraev 2 collaborations

Ilya D Kukushkin 2 collaborations

Artem V Kirichenko 2 collaborations

Irina N Mikhaylova 2 collaborations

Aizek B Isaev 2 collaborations

Nathalia A Vasilyeva 1 collaboration

Anfisa S Popova 1 collaboration

Evgeniya A Lagereva 1 collaboration

Morten S Thomsen 1 collaboration

Dmitry A Dolgikh 1 collaboration

Pavel M Balaban 1 collaboration

S Peigneur 1 collaboration

M Yu Myshkin 1 collaboration

A A Berkut 1 collaboration

A A Vassilevski 1 collaboration

J Tytgat 1 collaboration

Andrey M Chernikov 1 collaboration

Sergey V Shabelnikov 1 collaboration

Lada E Petrovskaya 1 collaboration

Evgeniy P Lukashev 1 collaboration

Elena A Kryukova 1 collaboration

Rustam H Ziganshin 1 collaboration

Dmitriy A Dolgikh 1 collaboration

Evgeniy G Maksimov 1 collaboration

Andrei B Rubin 1 collaboration

Janos K Lanyi 1 collaboration

Sergei P Balashov 1 collaboration

Pavel A Mironov 1 collaboration

Elizaveta M Chernaya 1 collaboration

Yulia A Logashina 1 collaboration

Dmitry I Osmakov 1 collaboration

Peter Illes 1 collaboration

Andrey V Tsarev 1 collaboration

Yuri M Chesnokov 1 collaboration

Dmitry E Nolde 1 collaboration

Roman A Kamyshinsky 1 collaboration

Evgeniy O Yablokov 1 collaboration

Alexey S Ivanov 1 collaboration

Nikolai N Sluchanko 1 collaboration

Anna A Kapitonova 1 collaboration

Kristina V Tugaeva 1 collaboration

Larisa A Varfolomeeva 1 collaboration

Mikhail E Minyaev 1 collaboration

Konstantin M Boyko 1 collaboration

Vladimir O Popov 1 collaboration

V O Shipunova 1 collaboration

I D Kukushkin 1 collaboration

I A Chulina 1 collaboration

V N Azev 1 collaboration

E I Shramova 1 collaboration

V A Kazakov 1 collaboration

A M Ismailova 1 collaboration

Y A Palikova 1 collaboration

V A Palikov 1 collaboration

E A Kalabina 1 collaboration

E A Shaykhutdinova 1 collaboration

G A Slashcheva 1 collaboration

E A Tukhovskaya 1 collaboration

I A Dyachenko 1 collaboration

A N Murashev 1 collaboration

S M Deyev 1 collaboration

V Y Vasileva 1 collaboration

A V Sudarikova 1 collaboration

Irina A Chulina 1 collaboration

Ludmila K Baidakova 1 collaboration

Viatcheslav N Azev 1 collaboration

Evgeny V Yastremsky 1 collaboration

Anastasia V Sudarikova 1 collaboration

Vladislav I Chubinskiy-Nadezhdin 1 collaboration

Roope Männikkö 1 collaboration

Olesya A Krumkacheva 1 collaboration

Antonina A Berkut 1 collaboration

Matvey V Fedin 1 collaboration

Michael G Hanna 1 collaboration

Dimitri M Kullmann 1 collaboration

Elena G Bagryanskaya 1 collaboration

Alexander S Arseniev 1 collaboration

Alexander A Vassilevski 1 collaboration

D S Kulbatskii 1 collaboration

N N Sluchanko 1 collaboration

E O Yablokov 1 collaboration

R A Kamyshinsky 1 collaboration

Y M Chesnokov 1 collaboration

Mikhail A Mashkin 1 collaboration

Alexander V Latanov 1 collaboration