M Lahn

Affiliations

Eli Lilly and Company, Indianapolis, Indiana, USA.

Publications (18)

Leveraging historical data into oncology development programs: Two case studies of phase 2 Bayesian augmented control trial designs.

Pharmaceutical statistics

Avec: Claire L Smith , Zachary Thomas , Nathan Enas , Katharine Thorn , Michael Lahn , Karim Benhadji , Ann Cleverly

Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy.

Cancer immunology, immunotherapy : CII

Avec: Michele Maio , George Coukos , Soldano Ferrone , Bernard A Fox , Wolf H Fridman , Patrick L Garcia , Michael Lahn , Olivier Provendier , Vincenzo Russo , Dominik Rüttinger , Aiman Shalabi , Zlatko Trajanoski , Jean Viallet , Jedd D Wolchok , Ramy Ibrahim

IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance.

Cancer research communications

Avec: Zoë Johnson , Chiara Tarantelli , Elisa Civanelli , Luciano Cascione , Filippo Spriano , Amy Fraser , Pritom Shah , Tyzoon Nomanbhoy , Sara Napoli , Andrea Rinaldi , Karolina Niewola-Staszkowska , Michael Lahn , Dominique Perrin , Mathias Wenes , Denis Migliorini , Francesco Bertoni , Lars van der Veen , Giusy Di Conza

Targeting T regulatory (T

Cancer drug resistance (Alhambra, Calif.)

Avec: Pavlina Spiliopoulou , Paramjit Kaur , Tracey Hammett , Giusy Di Conza , Michael Lahn

A Phase 2 Study of Galunisertib (TGF-β1 Receptor Type I Inhibitor) and Sorafenib in Patients With Advanced Hepatocellular Carcinoma.

Clinical and translational gastroenterology

Avec: R K Kelley , E Gane , E Assenat , J Siebler , P R Galle , P Merle , I O Hourmand , A Cleverly , Y Zhao , I Gueorguieva , M Lahn , S Faivre , K A Benhadji , G Giannelli

Validation of an LC-MS/MS method for the quantification IOA-289 in human plasma and its application in a first-in-human clinical trial.

Journal of pharmaceutical and biomedical analysis

Avec: M Mameli , J Franchi , G Calusi , M A Deken , Z Johnson , L van der Veen , M Lahn , A Vezzelli , R Cardin , A Greco , M Breda

Non-Clinical Toxicology Evaluation of the Novel Non-ATP Competitive Oral PI3 Kinase Delta Inhibitor Roginolisib.

International journal of toxicology

Avec: Lars van der Veen , Michael Schmitt , Marcel A Deken , Michael Lahn

Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors.

Immuno-oncology technology

Avec: M A Deken , K Niewola-Staszkowska , O Peyruchaud , N Mikulčić , M Antolić , P Shah , A Cheasty , A Tagliavini , A Nizzardo , M Pergher , L Ziviani , S Milleri , C Pickering , M Lahn , L van der Veen , G Di Conza , Z Johnson

The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition.

Translational oncology

Avec: Claudia Kalla , German Ott , Francesca Finotello , Karolina Niewola-Staszkowska , Giusy Di Conza , Michael Lahn , Lars van der Veen , Julia Schüler , Roger Falkenstern-Ge , Joanna Kopecka , Chiara Riganti

Phase 1b study of galunisertib and ramucirumab in patients with advanced hepatocellular carcinoma.

Cancer medicine

Avec: James J Harding , Richard K Do , Amin Yaqubie , Ann Cleverly , Yumin Zhao , Ivelina Gueorguieva , Michael Lahn , Karim A Benhadji , Robin K Kelley , Ghassan K Abou-Alfa

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models.

Journal of experimental & clinical cancer research : CR

Avec: Matteo Centonze , Giusy Di Conza , Michael Lahn , Isabel Fabregat , Francesco Dituri , Isabella Gigante , Grazia Serino , Rosanna Scialpi , Livianna Carrieri , Roberto Negro , Elena Pizzuto , Gianluigi Giannelli

Autotaxin secretion is a stromal mechanism of adaptive resistance to TGFβ inhibition in pancreatic ductal adenocarcinoma.

Cancer research

Avec: Silvia Pietrobono , Fabio Sabbadini , Monica Bertolini , Domenico Mangiameli , Veronica De Vita , Federica Fazzini , Giulia Lunardi , Simona Casalino , Enza Scarlato , Valeria Merz , Camilla Zecchetto , Alberto Quinzii , Giusy Di Conza , Michael Lahn , Davide Melisi

The future of targeting cytotoxic T-lymphocyte-associated protein-4: Is there a role?

European journal of cancer (Oxford, England : 1990)

Avec: Anna Maria Di Giacomo , Michael Lahn , Alexander Mm Eggermont , Bernard Fox , Ramy Ibrahim , Padmanee Sharma , James P Allison , Michele Maio

High levels of autotaxin and lysophosphatidic acid predict poor outcome in treatment of resectable gastric carcinoma.

European journal of cancer (Oxford, England : 1990)

Avec: Annalisa Schirizzi , Rossella Donghia , Valentina De Nunzio , Natasha Renna , Matteo Centonze , Giampiero De Leonardis , Vincenza Lorusso , Alessia Fantasia , Sergio Coletta , Dolores Stabile , Annalisa Ferro , Maria Notarnicola , Angela D Ricci , Claudio Lotesoriere , Michael Lahn , Rosalba D'Alessandro , Gianluigi Giannelli

A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia.

Drug design, development and therapy

Avec: Jason D Lickliter , Hui K Gan , Mark Voskoboynik , Surein Arulananda , Bo Gao , Adnan Nagrial , Peter Grimison , Michelle Harrison , Jianjun Zou , Lianshan Zhang , Stacey Luo , Michael Lahn , Howard Kallender , Andrea Mannucci , Catello Somma , Katherine Woods , Andreas Behren , Pablo Fernandez-Penas , Michael Millward , Tarek Meniawy

Neoadjuvant immunotherapy is reshaping cancer management across multiple tumour types: The future is now!

European journal of cancer (Oxford, England : 1990)

Avec: Michele Maio , Christian Blank , Andrea Necchi , Anna Maria Di Giacomo , Ramy Ibrahim , Michael Lahn , Bernard A Fox , R Bryan Bell , Giampaolo Tortora , Alexander M M Eggermont

A vision of immuno-oncology: the Siena think tank of the Italian network for tumor biotherapy (NIBIT) foundation.

Journal of experimental & clinical cancer research : CR

Avec: Michele Maio , Michael Lahn , Anna Maria Di Giacomo , Alessia Covre , Luana Calabrò , Ramy Ibrahim , Bernard Fox , Auteur inconnu

Immunotherapy for brain metastases and primary brain tumors.

European journal of cancer (Oxford, England : 1990)

Avec: Anna M Di Giacomo , Maximilian J Mair , Michele Ceccarelli , Andrea Anichini , Ramy Ibrahim , Michael Weller , Michael Lahn , Alexander M M Eggermont , Bernard Fox , Michele Maio

Réseau de co-auteurs

Michael Lahn 15 collaborations

Michele Maio 5 collaborations

Ramy Ibrahim 5 collaborations

Giusy Di Conza 5 collaborations

Lars van der Veen 3 collaborations

Anna Maria Di Giacomo 3 collaborations

Bernard Fox 3 collaborations

Ann Cleverly 2 collaborations

Bernard A Fox 2 collaborations

Karolina Niewola-Staszkowska 2 collaborations

M A Deken 2 collaborations

Z Johnson 2 collaborations

L van der Veen 2 collaborations

Matteo Centonze 2 collaborations

Gianluigi Giannelli 2 collaborations

Alexander M M Eggermont 2 collaborations

Claire L Smith 1 collaboration

Zachary Thomas 1 collaboration

Nathan Enas 1 collaboration

Katharine Thorn 1 collaboration

Karim Benhadji 1 collaboration

George Coukos 1 collaboration

Soldano Ferrone 1 collaboration

Wolf H Fridman 1 collaboration

Patrick L Garcia 1 collaboration

Olivier Provendier 1 collaboration

Vincenzo Russo 1 collaboration

Dominik Rüttinger 1 collaboration

Aiman Shalabi 1 collaboration

Zlatko Trajanoski 1 collaboration

Jean Viallet 1 collaboration

Jedd D Wolchok 1 collaboration

Zoë Johnson 1 collaboration

Chiara Tarantelli 1 collaboration

Elisa Civanelli 1 collaboration

Luciano Cascione 1 collaboration

Filippo Spriano 1 collaboration

Amy Fraser 1 collaboration

Pritom Shah 1 collaboration

Tyzoon Nomanbhoy 1 collaboration

Sara Napoli 1 collaboration

Andrea Rinaldi 1 collaboration

Dominique Perrin 1 collaboration

Mathias Wenes 1 collaboration

Denis Migliorini 1 collaboration

Francesco Bertoni 1 collaboration

Pavlina Spiliopoulou 1 collaboration

Paramjit Kaur 1 collaboration

Tracey Hammett 1 collaboration

R K Kelley 1 collaboration

E Gane 1 collaboration

E Assenat 1 collaboration

J Siebler 1 collaboration

P R Galle 1 collaboration

P Merle 1 collaboration

I O Hourmand 1 collaboration

A Cleverly 1 collaboration

Y Zhao 1 collaboration

I Gueorguieva 1 collaboration

S Faivre 1 collaboration

K A Benhadji 1 collaboration

G Giannelli 1 collaboration

M Mameli 1 collaboration

J Franchi 1 collaboration

G Calusi 1 collaboration

A Vezzelli 1 collaboration

R Cardin 1 collaboration

A Greco 1 collaboration

M Breda 1 collaboration

Michael Schmitt 1 collaboration

Marcel A Deken 1 collaboration

K Niewola-Staszkowska 1 collaboration

O Peyruchaud 1 collaboration

N Mikulčić 1 collaboration

M Antolić 1 collaboration

P Shah 1 collaboration

A Cheasty 1 collaboration

A Tagliavini 1 collaboration

A Nizzardo 1 collaboration

M Pergher 1 collaboration

L Ziviani 1 collaboration

S Milleri 1 collaboration

C Pickering 1 collaboration

G Di Conza 1 collaboration

Claudia Kalla 1 collaboration

German Ott 1 collaboration

Francesca Finotello 1 collaboration

Julia Schüler 1 collaboration

Roger Falkenstern-Ge 1 collaboration

Joanna Kopecka 1 collaboration

Chiara Riganti 1 collaboration

James J Harding 1 collaboration

Richard K Do 1 collaboration

Amin Yaqubie 1 collaboration

Yumin Zhao 1 collaboration

Ivelina Gueorguieva 1 collaboration

Karim A Benhadji 1 collaboration

Robin K Kelley 1 collaboration

Ghassan K Abou-Alfa 1 collaboration

Isabel Fabregat 1 collaboration

Francesco Dituri 1 collaboration

Isabella Gigante 1 collaboration

Grazia Serino 1 collaboration

Rosanna Scialpi 1 collaboration

Livianna Carrieri 1 collaboration

Roberto Negro 1 collaboration

Elena Pizzuto 1 collaboration

Silvia Pietrobono 1 collaboration

Fabio Sabbadini 1 collaboration

Monica Bertolini 1 collaboration

Domenico Mangiameli 1 collaboration

Veronica De Vita 1 collaboration

Federica Fazzini 1 collaboration

Giulia Lunardi 1 collaboration

Simona Casalino 1 collaboration

Enza Scarlato 1 collaboration

Valeria Merz 1 collaboration

Camilla Zecchetto 1 collaboration

Alberto Quinzii 1 collaboration

Davide Melisi 1 collaboration

Alexander Mm Eggermont 1 collaboration

Padmanee Sharma 1 collaboration

James P Allison 1 collaboration

Annalisa Schirizzi 1 collaboration

Rossella Donghia 1 collaboration

Valentina De Nunzio 1 collaboration

Natasha Renna 1 collaboration

Giampiero De Leonardis 1 collaboration

Vincenza Lorusso 1 collaboration

Alessia Fantasia 1 collaboration

Sergio Coletta 1 collaboration

Dolores Stabile 1 collaboration

Annalisa Ferro 1 collaboration

Maria Notarnicola 1 collaboration

Angela D Ricci 1 collaboration

Claudio Lotesoriere 1 collaboration

Rosalba D'Alessandro 1 collaboration

Jason D Lickliter 1 collaboration

Hui K Gan 1 collaboration

Mark Voskoboynik 1 collaboration

Surein Arulananda 1 collaboration

Bo Gao 1 collaboration

Adnan Nagrial 1 collaboration

Peter Grimison 1 collaboration

Michelle Harrison 1 collaboration

Jianjun Zou 1 collaboration

Lianshan Zhang 1 collaboration

Stacey Luo 1 collaboration

Howard Kallender 1 collaboration

Andrea Mannucci 1 collaboration

Catello Somma 1 collaboration

Katherine Woods 1 collaboration

Andreas Behren 1 collaboration

Pablo Fernandez-Penas 1 collaboration

Michael Millward 1 collaboration

Tarek Meniawy 1 collaboration

Christian Blank 1 collaboration

Andrea Necchi 1 collaboration

R Bryan Bell 1 collaboration

Giampaolo Tortora 1 collaboration

Alessia Covre 1 collaboration

Luana Calabrò 1 collaboration

None None 1 collaboration

Anna M Di Giacomo 1 collaboration

Maximilian J Mair 1 collaboration

Michele Ceccarelli 1 collaboration

Andrea Anichini 1 collaboration

Michael Weller 1 collaboration