M Westhoff

Affiliations

Department of Pulmonology, Klinik für Pneumologie, Schlaf und Beatmungsmedizin, Lungenklinik Hemer, Zentrum für Pneumologie und Thoraxchirurgie, Hemer, Germany.
Universität Witten/Herdecke University, Witten, Germany.

Publications (18)

The limitations of targeting MEK signalling in Glioblastoma therapy.

Scientific reports

Avec: Karthika D Selvasaravanan , Nicole Wiederspohn , Amina Hadzalic , Hannah Strobel , Christel Payer , Andrea Schuster , Georg Karpel-Massler , Markus D Siegelin , Marc-Eric Halatsch , Klaus-Michael Debatin , Mike-Andrew Westhoff

Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems.

Cells

Avec: Trang T T Nguyen , Yiru Zhang , Enyuan Shang , Chang Shu , Catarina M Quinzii , Mike-Andrew Westhoff , Georg Karpel-Massler , Markus D Siegelin

Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma.

British journal of cancer

Avec: Maximilian Pruss , Annika Dwucet , Mine Tanriover , Michal Hlavac , Richard Eric Kast , Klaus-Michael Debatin , Christian Rainer Wirtz , Marc-Eric Halatsch , Markus David Siegelin , Mike-Andrew Westhoff , Georg Karpel-Massler

Difficult diagnosis and rare morphology of lymphangioleiomyomatosis with giant cysts.

Respiratory medicine case reports

Avec: Stefan Welter , Philipp Thrull , Michael Westhoff , Peter Bach , Helmut Popper , Hans-Jörg Maschek

Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide.

Cancers

Avec: Anna-Laura Potthoff , Dieter Henrik Heiland , Bernd O Evert , Filipe Rodrigues Almeida , Simon P Behringer , Andreas Dolf , Ági Güresir , Erdem Güresir , Kevin Joseph , Torsten Pietsch , Patrick Schuss , Ulrich Herrlinger , Mike-Andrew Westhoff , Hartmut Vatter , Andreas Waha , Matthias Schneider

Critical View of Novel Treatment Strategies for Glioblastoma: Failure and Success of Resistance Mechanisms by Glioblastoma Cells.

Frontiers in cell and developmental biology

Avec: Timo Burster , Rebecca Traut , Zhanerke Yermekkyzy , Katja Mayer , Mike-Andrew Westhoff , Joachim Bischof , Uwe Knippschild

[Weaning from invasive mechanical ventilation].

Medizinische Klinik, Intensivmedizin und Notfallmedizin

Avec: Jens Geiseler , Michael Westhoff

Unblinding the watchmaker: cancer treatment and drug design in the face of evolutionary pressure.

Expert opinion on drug discovery

Avec: Sophia Konig , Hannah Strobel , Michael Grunert , Marcin Lyszkiewicz , Oliver Brühl , Georg Karpel-Massler , Natalia Ziętara , Katia La Ferla-Brühl , Markus D Siegelin , Klaus-Michael Debatin , Mike-Andrew Westhoff

Successful simultaneous stenting of a pulmonary artery and vein in pulmonary vascular stenosis due to silicosis. Case report and literature review.

Frontiers in cardiovascular medicine

Avec: M Westhoff , T Hardebusch , P Litterst , A Breithecker , M Haas , M Kuniss , T Neumann , S Guth , C B Wiedenroth

The Alcatraz-Strategy: a roadmap to break the connectivity barrier in malignant brain tumours.

Molecular oncology

Avec: Matthias Schneider , Anna-Laura Potthoff , Georg Karpel-Massler , Patrick Schuss , Markus D Siegelin , Klaus-Michael Debatin , Hugues Duffau , Hartmut Vatter , Ulrich Herrlinger , Mike-Andrew Westhoff

BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts.

Nature communications

Avec: Maartje Westhoff , Silvia G Del Villar , Taylor L Voelker , Phung N Thai , Heather C Spooner , Alexandre D Costa , Padmini Sirish , Nipavan Chiamvimonvat , Eamonn J Dickson , Rose E Dixon

Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma.

NPJ precision oncology

Avec: Thomas Freitag , Philipp Kaps , Justus Ramtke , Sarah Bertels , Emily Zunke , Björn Schneider , Anne-Sophie Becker , Dirk Koczan , Daniel Dubinski , Thomas M Freiman , Felix Wittig , Burkhard Hinz , Mike-Andrew Westhoff , Hannah Strobel , Franziska Meiners , Daniel Wolter , Nadja Engel , Sascha Troschke-Meurer , Wendy Bergmann-Ewert , Susanne Staehlke , Annabell Wolff , Florian Gessler , Christian Junghanss , Claudia Maletzki

Current state and future perspective of drug repurposing in malignant glioma.

Seminars in cancer biology

Avec: Markus David Siegelin , Elisabeth Schneider , Mike-Andrew Westhoff , Christian Rainer Wirtz , Georg Karpel-Massler

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy.

Biomedicines

Avec: Hannah Strobel , Tim Baisch , Rahel Fitzel , Katharina Schilberg , Markus D Siegelin , Georg Karpel-Massler , Klaus-Michael Debatin , Mike-Andrew Westhoff

Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic activity of a low-dose CUSP9 repurposed drug regime against glioblastoma.

British journal of pharmacology

Avec: Marc-Eric Halatsch , Richard Eric Kast , Annika Dwucet , Michal Hlavac , Tim Heiland , Mike-Andrew Westhoff , Klaus-Michael Debatin , Christian Rainer Wirtz , Markus David Siegelin , Georg Karpel-Massler

Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis.

Cellular oncology (Dordrecht)

Avec: Michal Hlavac , Annika Dwucet , Richard Eric Kast , Jens Engelke , Mike-Andrew Westhoff , Markus D Siegelin , Klaus-Michael Debatin , Christian Rainer Wirtz , Marc-Eric Halatsch , Georg Karpel-Massler

HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models.

The Journal of clinical investigation

Avec: Trang Thi Thu Nguyen , Yiru Zhang , Enyuan Shang , Chang Shu , Consuelo Torrini , Junfei Zhao , Elena Bianchetti , Angeliki Mela , Nelson Humala , Aayushi Mahajan , Arif O Harmanci , Zhengdeng Lei , Mark Maienschein-Cline , Catarina M Quinzii , Mike-Andrew Westhoff , Georg Karpel-Massler , Jeffrey N Bruce , Peter Canoll , Markus D Siegelin

Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma.

Cancers

Avec: Enyuan Shang , Trang T T Nguyen , Chang Shu , Mike-Andrew Westhoff , Georg Karpel-Massler , Markus D Siegelin

Réseau de co-auteurs

Mike-Andrew Westhoff 14 collaborations

Georg Karpel-Massler 11 collaborations

Markus D Siegelin 8 collaborations

Klaus-Michael Debatin 7 collaborations

Hannah Strobel 4 collaborations

Marc-Eric Halatsch 4 collaborations

Christian Rainer Wirtz 4 collaborations

Enyuan Shang 3 collaborations

Chang Shu 3 collaborations

Annika Dwucet 3 collaborations

Michal Hlavac 3 collaborations

Richard Eric Kast 3 collaborations

Markus David Siegelin 3 collaborations

Trang T T Nguyen 2 collaborations

Yiru Zhang 2 collaborations

Catarina M Quinzii 2 collaborations

Michael Westhoff 2 collaborations

Anna-Laura Potthoff 2 collaborations

Patrick Schuss 2 collaborations

Ulrich Herrlinger 2 collaborations

Hartmut Vatter 2 collaborations

Matthias Schneider 2 collaborations

Karthika D Selvasaravanan 1 collaboration

Nicole Wiederspohn 1 collaboration

Amina Hadzalic 1 collaboration

Christel Payer 1 collaboration

Andrea Schuster 1 collaboration

Maximilian Pruss 1 collaboration

Mine Tanriover 1 collaboration

Stefan Welter 1 collaboration

Philipp Thrull 1 collaboration

Peter Bach 1 collaboration

Helmut Popper 1 collaboration

Hans-Jörg Maschek 1 collaboration

Dieter Henrik Heiland 1 collaboration

Bernd O Evert 1 collaboration

Filipe Rodrigues Almeida 1 collaboration

Simon P Behringer 1 collaboration

Andreas Dolf 1 collaboration

Ági Güresir 1 collaboration

Erdem Güresir 1 collaboration

Kevin Joseph 1 collaboration

Torsten Pietsch 1 collaboration

Andreas Waha 1 collaboration

Timo Burster 1 collaboration

Rebecca Traut 1 collaboration

Zhanerke Yermekkyzy 1 collaboration

Katja Mayer 1 collaboration

Joachim Bischof 1 collaboration

Uwe Knippschild 1 collaboration

Jens Geiseler 1 collaboration

Sophia Konig 1 collaboration

Michael Grunert 1 collaboration

Marcin Lyszkiewicz 1 collaboration

Oliver Brühl 1 collaboration

Natalia Ziętara 1 collaboration

Katia La Ferla-Brühl 1 collaboration

T Hardebusch 1 collaboration

P Litterst 1 collaboration

A Breithecker 1 collaboration

M Haas 1 collaboration

M Kuniss 1 collaboration

T Neumann 1 collaboration

S Guth 1 collaboration

C B Wiedenroth 1 collaboration

Hugues Duffau 1 collaboration

Maartje Westhoff 1 collaboration

Silvia G Del Villar 1 collaboration

Taylor L Voelker 1 collaboration

Phung N Thai 1 collaboration

Heather C Spooner 1 collaboration

Alexandre D Costa 1 collaboration

Padmini Sirish 1 collaboration

Nipavan Chiamvimonvat 1 collaboration

Eamonn J Dickson 1 collaboration

Rose E Dixon 1 collaboration

Thomas Freitag 1 collaboration

Philipp Kaps 1 collaboration

Justus Ramtke 1 collaboration

Sarah Bertels 1 collaboration

Emily Zunke 1 collaboration

Björn Schneider 1 collaboration

Anne-Sophie Becker 1 collaboration

Dirk Koczan 1 collaboration

Daniel Dubinski 1 collaboration

Thomas M Freiman 1 collaboration

Felix Wittig 1 collaboration

Burkhard Hinz 1 collaboration

Franziska Meiners 1 collaboration

Daniel Wolter 1 collaboration

Nadja Engel 1 collaboration

Sascha Troschke-Meurer 1 collaboration

Wendy Bergmann-Ewert 1 collaboration

Susanne Staehlke 1 collaboration

Annabell Wolff 1 collaboration

Florian Gessler 1 collaboration

Christian Junghanss 1 collaboration

Claudia Maletzki 1 collaboration

Elisabeth Schneider 1 collaboration

Tim Baisch 1 collaboration

Rahel Fitzel 1 collaboration

Katharina Schilberg 1 collaboration

Tim Heiland 1 collaboration

Jens Engelke 1 collaboration

Trang Thi Thu Nguyen 1 collaboration

Consuelo Torrini 1 collaboration

Junfei Zhao 1 collaboration

Elena Bianchetti 1 collaboration

Angeliki Mela 1 collaboration

Nelson Humala 1 collaboration

Aayushi Mahajan 1 collaboration

Arif O Harmanci 1 collaboration

Zhengdeng Lei 1 collaboration

Mark Maienschein-Cline 1 collaboration

Jeffrey N Bruce 1 collaboration

Peter Canoll 1 collaboration