Marc-David Ruepp

Affiliations

UK Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Strand, London, WC2R 2LS, UK.

Publications (21)

ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells.

Scientific reports

Avec: Ankur Gadgil , Agnieszka Walczak , Agata Stępień , Jonas Mechtersheimer , Agnes Lumi Nishimura , Christopher E Shaw , Marc-David Ruepp , Katarzyna Dorota Raczyńska

Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons.

Stem cell reports

Avec: Carole Shum , Erin C Hedges , Joseph Allison , Youn-Bok Lee , Natalia Arias , Graham Cocks , Siddharthan Chandran , Marc-David Ruepp , Christopher E Shaw , Agnes L Nishimura

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.

Nature communications

Avec: Ian Casci , Karthik Krishnamurthy , Sukhleen Kour , Vadreenath Tripathy , Nandini Ramesh , Eric N Anderson , Lara Marrone , Rogan A Grant , Stacie Oliver , Lauren Gochenaur , Krishani Patel , Jared Sterneckert , Amanda M Gleixner , Christopher J Donnelly , Marc-David Ruepp , Antonella M Sini , Emanuela Zuccaro , Maria Pennuto , Piera Pasinelli , Udai Bhan Pandey

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Nature communications

Avec: Daniel Jutzi , Sébastien Campagne , Ralf Schmidt , Stefan Reber , Jonas Mechtersheimer , Foivos Gypas , Christoph Schweingruber , Martino Colombo , Christine von Schroetter , Fionna E Loughlin , Anny Devoy , Eva Hedlund , Mihaela Zavolan , Frédéric H-T Allain , Marc-David Ruepp

G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes.

Nucleic acids research

Avec: Guillaume Giraud , Mélanie Rodà , Pélagie Huchon , Maud Michelet , Sarah Maadadi , Daniel Jutzi , Roland Montserret , Marc-David Ruepp , Romain Parent , Christophe Combet , Fabien Zoulim , Barbara Testoni

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

The EMBO journal

Avec: Julie Qiaojin Lin , Deepak Khuperkar , Sofia Pavlou , Stanislaw Makarchuk , Nikolaos Patikas , Flora Cy Lee , Julia M Zbiegly , Jianning Kang , Sarah F Field , David Md Bailey , Joshua L Freeman , Jernej Ule , Emmanouil Metzakopian , Marc-David Ruepp , Giovanna R Mallucci

Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria.

Cell chemical biology

Avec: François Halloy , Pavithra S Iyer , Alice Ghidini , Veronika Lysenko , Jasmin Barman-Aksözen , Chia-Pei Grubenmann , Jessica Jucker , Nicole Wildner-Verhey van Wijk , Marc-David Ruepp , Elisabeth I Minder , Anna-Elisabeth Minder , Xiaoye Schneider-Yin , Alexandre P A Theocharides , Daniel Schümperli , Jonathan Hall

Comparing modalities of conducting the six-minute walk test in healthy children and adolescents.

Minerva pediatrica

Avec: Markus Rauchenzauner , Johanna Schneider , Valeria Colleselli , Monika Ruepp , Gerard Cortina , Wolfgang Högler , Sabrina Neururer , Ralf Geiger

The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.

Molecular cell

Avec: Fionna E Loughlin , Peter J Lukavsky , Tamara Kazeeva , Stefan Reber , Eva-Maria Hock , Martino Colombo , Christine Von Schroetter , Phillip Pauli , Antoine Cléry , Oliver Mühlemann , Magdalini Polymenidou , Marc-David Ruepp , Frédéric H-T Allain

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Nucleic acids research

Avec: Stefan Reber , Daniel Jutzi , Helen Lindsay , Anny Devoy , Jonas Mechtersheimer , Brunno Rocha Levone , Michal Domanski , Eva Bentmann , Dorothee Dormann , Oliver Mühlemann , Silvia M L Barabino , Marc-David Ruepp

FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.

The Journal of cell biology

Avec: Brunno R Levone , Silvia C Lenzken , Marco Antonaci , Andreas Maiser , Alexander Rapp , Francesca Conte , Stefan Reber , Jonas Mechtersheimer , Antonella E Ronchi , Oliver Mühlemann , Heinrich Leonhardt , M Cristina Cardoso , Marc-David Ruepp , Silvia M L Barabino

Alternative Splicing in Human Biology and Disease.

Methods in molecular biology (Clifton, N.J.)

Avec: Daniel Jutzi , Marc-David Ruepp

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.

Nucleic acids research

Avec: Jack Humphrey , Nicol Birsa , Carmelo Milioto , Martha McLaughlin , Agnieszka M Ule , David Robaldo , Andrea B Eberle , Rahel Kräuchi , Matthew Bentham , Anna-Leigh Brown , Seth Jarvis , Cristian Bodo , Maria G Garone , Anny Devoy , Gianni Soraru , Alessandro Rosa , Irene Bozzoni , Elizabeth M C Fisher , Oliver Mühlemann , Giampietro Schiavo , Marc-David Ruepp , Adrian M Isaacs , Vincent Plagnol , Pietro Fratta

Mapping the Orthosteric Binding Site of the Human 5-HT

ACS chemical neuroscience

Avec: Thomas Jack , Michele Leuenberger , Marc-David Ruepp , Sanjeev Kumar V Vernekar , Andrew J Thompson , Sophie Braga-Lagache , Manfred Heller , Martin Lochner

Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.

Cellular and molecular life sciences : CMLS

Avec: Shiden Solomon , Nirmal Kumar Sampathkumar , Ivo Carre , Mrityunjoy Mondal , George Chennell , Anthony C Vernon , Marc-David Ruepp , Jacqueline C Mitchell

P2X

Brain, behavior, and immunity

Avec: Paula Beltran-Lobo , Martina M Hughes , Claire Troakes , Cara L Croft , Huzefa Rupawala , Daniel Jutzi , Marc-David Ruepp , Maria Jimenez-Sanchez , Michael S Perkinton , Michael Kassiou , Todd E Golde , Diane P Hanger , Alexei Verkhratsky , Beatriz G Perez-Nievas , Wendy Noble

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.

Nature communications

Avec: Sébastien Campagne , Daniel Jutzi , Florian Malard , Maja Matoga , Ksenija Romane , Miki Feldmuller , Martino Colombo , Marc-David Ruepp , Frédéric H-T Allain

Direct Measurement of Single-Molecule Ligand-Receptor Interactions.

The journal of physical chemistry. B

Avec: K-T Lam , E L Taylor , A J Thompson , M-D Ruepp , M Lochner , Michael J Martinez , J A Brozik

miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis.

Progress in neurobiology

Avec: Alessia Loffreda , Monica Nizzardo , Alessandro Arosio , Marc-David Ruepp , Raffaele A Calogero , Stefano Volinia , Marco Galasso , Caterina Bendotti , Carlo Ferrarese , Christian Lunetta , Mafalda Rizzuti , Antonella E Ronchi , Oliver Mühlemann , Lucio Tremolizzo , Stefania Corti , Silvia M L Barabino

Human vtRNA1-1 Levels Modulate Signaling Pathways and Regulate Apoptosis in Human Cancer Cells.

Biomolecules

Avec: Lisamaria Bracher , Iolanda Ferro , Carlos Pulido-Quetglas , Marc-David Ruepp , Rory Johnson , Norbert Polacek

Mimicking hypomethylation of FUS requires liquid-liquid phase separation to induce synaptic dysfunctions.

Acta neuropathologica communications

Avec: Seung Chan Kim , Scott J Mitchell , Seema Qamar , Daniel J Whitcomb , Marc-David Ruepp , Peter St George-Hyslop , Kwangwook Cho

Réseau de co-auteurs

Daniel Jutzi 6 collaborations

Oliver Mühlemann 5 collaborations

Jonas Mechtersheimer 4 collaborations

Stefan Reber 4 collaborations

Martino Colombo 3 collaborations

Anny Devoy 3 collaborations

Frédéric H-T Allain 3 collaborations

Silvia M L Barabino 3 collaborations

Christopher E Shaw 2 collaborations

Sébastien Campagne 2 collaborations

Fionna E Loughlin 2 collaborations

Antonella E Ronchi 2 collaborations

Ankur Gadgil 1 collaboration

Agnieszka Walczak 1 collaboration

Agata Stępień 1 collaboration

Agnes Lumi Nishimura 1 collaboration

Katarzyna Dorota Raczyńska 1 collaboration

Carole Shum 1 collaboration

Erin C Hedges 1 collaboration

Joseph Allison 1 collaboration

Youn-Bok Lee 1 collaboration

Natalia Arias 1 collaboration

Graham Cocks 1 collaboration

Siddharthan Chandran 1 collaboration

Agnes L Nishimura 1 collaboration

Ian Casci 1 collaboration

Karthik Krishnamurthy 1 collaboration

Sukhleen Kour 1 collaboration

Vadreenath Tripathy 1 collaboration

Nandini Ramesh 1 collaboration

Eric N Anderson 1 collaboration

Lara Marrone 1 collaboration

Rogan A Grant 1 collaboration

Stacie Oliver 1 collaboration

Lauren Gochenaur 1 collaboration

Krishani Patel 1 collaboration

Jared Sterneckert 1 collaboration

Amanda M Gleixner 1 collaboration

Christopher J Donnelly 1 collaboration

Antonella M Sini 1 collaboration

Emanuela Zuccaro 1 collaboration

Maria Pennuto 1 collaboration

Piera Pasinelli 1 collaboration

Udai Bhan Pandey 1 collaboration

Ralf Schmidt 1 collaboration

Foivos Gypas 1 collaboration

Christoph Schweingruber 1 collaboration

Christine von Schroetter 1 collaboration

Eva Hedlund 1 collaboration

Mihaela Zavolan 1 collaboration

Guillaume Giraud 1 collaboration

Mélanie Rodà 1 collaboration

Pélagie Huchon 1 collaboration

Maud Michelet 1 collaboration

Sarah Maadadi 1 collaboration

Roland Montserret 1 collaboration

Romain Parent 1 collaboration

Christophe Combet 1 collaboration

Fabien Zoulim 1 collaboration

Barbara Testoni 1 collaboration

Julie Qiaojin Lin 1 collaboration

Deepak Khuperkar 1 collaboration

Sofia Pavlou 1 collaboration

Stanislaw Makarchuk 1 collaboration

Nikolaos Patikas 1 collaboration

Flora Cy Lee 1 collaboration

Julia M Zbiegly 1 collaboration

Jianning Kang 1 collaboration

Sarah F Field 1 collaboration

David Md Bailey 1 collaboration

Joshua L Freeman 1 collaboration

Jernej Ule 1 collaboration

Emmanouil Metzakopian 1 collaboration

Giovanna R Mallucci 1 collaboration

François Halloy 1 collaboration

Pavithra S Iyer 1 collaboration

Alice Ghidini 1 collaboration

Veronika Lysenko 1 collaboration

Jasmin Barman-Aksözen 1 collaboration

Chia-Pei Grubenmann 1 collaboration

Jessica Jucker 1 collaboration

Nicole Wildner-Verhey van Wijk 1 collaboration

Elisabeth I Minder 1 collaboration

Anna-Elisabeth Minder 1 collaboration

Xiaoye Schneider-Yin 1 collaboration

Alexandre P A Theocharides 1 collaboration

Daniel Schümperli 1 collaboration

Jonathan Hall 1 collaboration

Markus Rauchenzauner 1 collaboration

Johanna Schneider 1 collaboration

Valeria Colleselli 1 collaboration

Monika Ruepp 1 collaboration

Gerard Cortina 1 collaboration

Wolfgang Högler 1 collaboration

Sabrina Neururer 1 collaboration

Ralf Geiger 1 collaboration

Peter J Lukavsky 1 collaboration

Tamara Kazeeva 1 collaboration

Eva-Maria Hock 1 collaboration

Christine Von Schroetter 1 collaboration

Phillip Pauli 1 collaboration

Antoine Cléry 1 collaboration

Magdalini Polymenidou 1 collaboration

Helen Lindsay 1 collaboration

Brunno Rocha Levone 1 collaboration

Michal Domanski 1 collaboration

Eva Bentmann 1 collaboration

Dorothee Dormann 1 collaboration

Brunno R Levone 1 collaboration

Silvia C Lenzken 1 collaboration

Marco Antonaci 1 collaboration

Andreas Maiser 1 collaboration

Alexander Rapp 1 collaboration

Francesca Conte 1 collaboration

Heinrich Leonhardt 1 collaboration

M Cristina Cardoso 1 collaboration

Jack Humphrey 1 collaboration

Nicol Birsa 1 collaboration

Carmelo Milioto 1 collaboration

Martha McLaughlin 1 collaboration

Agnieszka M Ule 1 collaboration

David Robaldo 1 collaboration

Andrea B Eberle 1 collaboration

Rahel Kräuchi 1 collaboration

Matthew Bentham 1 collaboration

Anna-Leigh Brown 1 collaboration

Seth Jarvis 1 collaboration

Cristian Bodo 1 collaboration

Maria G Garone 1 collaboration

Gianni Soraru 1 collaboration

Alessandro Rosa 1 collaboration

Irene Bozzoni 1 collaboration

Elizabeth M C Fisher 1 collaboration

Giampietro Schiavo 1 collaboration

Adrian M Isaacs 1 collaboration

Vincent Plagnol 1 collaboration

Pietro Fratta 1 collaboration

Thomas Jack 1 collaboration

Michele Leuenberger 1 collaboration

Sanjeev Kumar V Vernekar 1 collaboration

Andrew J Thompson 1 collaboration

Sophie Braga-Lagache 1 collaboration

Manfred Heller 1 collaboration

Martin Lochner 1 collaboration

Shiden Solomon 1 collaboration

Nirmal Kumar Sampathkumar 1 collaboration

Ivo Carre 1 collaboration

Mrityunjoy Mondal 1 collaboration

George Chennell 1 collaboration

Anthony C Vernon 1 collaboration

Jacqueline C Mitchell 1 collaboration

Paula Beltran-Lobo 1 collaboration

Martina M Hughes 1 collaboration

Claire Troakes 1 collaboration

Cara L Croft 1 collaboration

Huzefa Rupawala 1 collaboration

Maria Jimenez-Sanchez 1 collaboration

Michael S Perkinton 1 collaboration

Michael Kassiou 1 collaboration

Todd E Golde 1 collaboration

Diane P Hanger 1 collaboration

Alexei Verkhratsky 1 collaboration

Beatriz G Perez-Nievas 1 collaboration

Wendy Noble 1 collaboration

Florian Malard 1 collaboration

Maja Matoga 1 collaboration

Ksenija Romane 1 collaboration

Miki Feldmuller 1 collaboration

K-T Lam 1 collaboration

E L Taylor 1 collaboration

A J Thompson 1 collaboration

M-D Ruepp 1 collaboration

M Lochner 1 collaboration

Michael J Martinez 1 collaboration

J A Brozik 1 collaboration

Alessia Loffreda 1 collaboration

Monica Nizzardo 1 collaboration

Alessandro Arosio 1 collaboration

Raffaele A Calogero 1 collaboration

Stefano Volinia 1 collaboration

Marco Galasso 1 collaboration

Caterina Bendotti 1 collaboration

Carlo Ferrarese 1 collaboration

Christian Lunetta 1 collaboration

Mafalda Rizzuti 1 collaboration

Lucio Tremolizzo 1 collaboration

Stefania Corti 1 collaboration

Lisamaria Bracher 1 collaboration

Iolanda Ferro 1 collaboration

Carlos Pulido-Quetglas 1 collaboration

Rory Johnson 1 collaboration

Norbert Polacek 1 collaboration

Seung Chan Kim 1 collaboration

Scott J Mitchell 1 collaboration

Seema Qamar 1 collaboration

Daniel J Whitcomb 1 collaboration

Peter St George-Hyslop 1 collaboration

Kwangwook Cho 1 collaboration