Marina Kleanthous

Affiliations

a Molecular Genetics Thalassaemia Department , The Cyprus Institute of Neurology and Genetics , Nicosia , Cyprus.

Publications (29)

MS-275 Chemical Analogues Promote Hemoglobin Production and Erythroid Differentiation of K562 Cells.

Hemoglobin

Avec: Stella Voskou , Marios Phylactides , Andreas Afantitis , Georgia Melagraki , Andreas Tsoumanis , Panayotis A Koutentis , Tina Mitsidi , Styliana I Mirallai , Marina Kleanthous

Distinct miRNA Signatures and Networks Discern Fetal from Adult Erythroid Differentiation and Primary from Immortalized Erythroid Cells.

International journal of molecular sciences

Avec: Panayiota L Papasavva , Nikoletta Y Papaioannou , Petros Patsali , Ryo Kurita , Yukio Nakamura , Maria Sitarou , Soteroulla Christou , Marina Kleanthous , Carsten W Lederer

CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation.

International journal of molecular sciences

Avec: Panayiota L Papasavva , Petros Patsali , Constantinos C Loucari , Ryo Kurita , Yukio Nakamura , Marina Kleanthous , Carsten W Lederer

Optimized Droplet Digital PCR Assay on Cell-Free DNA Samples for Non-Invasive Prenatal Diagnosis: Application to Beta-Thalassemia.

Clinical chemistry

Avec: Constantina G Constantinou , Eleni Karitzi , Stefania Byrou , Coralea Stephanou , Kyriaki Michailidou , Christiana Makariou , Georgia Hadjilambi , Agathoklis Christofides , Marina Kleanthous , Thessalia Papasavva

The Optimized γ-Globin Lentiviral Vector GGHI-mB-3D Leads to Nearly Therapeutic HbF Levels In Vitro in CD34

Viruses

Avec: Ekati Drakopoulou , Maria Georgomanoli , Carsten W Lederer , Fottes Panetsos , Marina Kleanthous , Ersi Voskaridou , Dimitrios Valakos , Eleni Papanikolaou , Nicholas P Anagnou

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance.

Haematologica

Avec: Alisa Dong , Valentina Ghiaccio , Irene Motta , Shuling Guo , Raechel Peralta , Susan M Freier , Andy Watt , Sagar Damle , Yasuhiro Ikawa , Danuta Jarocha , Maxwell Chappell , Coralea Stephanou , Paola Delbini , Connie Chen , Soteroula Christou , Marina Kleanthous , Kim Smith-Whitley , Deepa Manwani , Carla Casu , Osheiza Abdulmalik , Maria Domenica Cappellini , Stefano Rivella , Laura Breda

European biophysics journal : EBJ

Avec: George Charitou , Charalambos Tsertos , Yannis Parpottas , Marina Kleanthous , Carsten W Lederer , Marios Phylactides

Relative and Absolute Quantification of Aberrant and Normal Splice Variants in

International journal of molecular sciences

Avec: Petros Patsali , Panayiota Papasavva , Soteroulla Christou , Maria Sitarou , Michael N Antoniou , Carsten W Lederer , Marina Kleanthous

Global Globin Network Consensus Paper: Classification and Stratified Roadmaps for Improved Thalassaemia Care and Prevention in 32 Countries.

Journal of personalized medicine

Avec: Bin Hashim Halim-Fikri , Carsten W Lederer , Atif Amin Baig , Siti Nor Assyuhada Mat-Ghani , Sharifah-Nany Rahayu-Karmilla Syed-Hassan , Wardah Yusof , Diana Abdul Rashid , Nurul Fatihah Azman , Suthat Fucharoen , Ramdan Panigoro , Catherine Lynn T Silao , Vip Viprakasit , Norunaluwar Jalil , Norafiza Mohd Yasin , Rosnah Bahar , Veena Selvaratnam , Norsarwany Mohamad , Nik Norliza Nik Hassan , Ezalia Esa , Amanda Krause , Helen Robinson , Julia Hasler , Coralea Stephanou , Raja-Zahratul-Azma Raja-Sabudin , Jacques Elion , Ghada El-Kamah , Domenico Coviello , Narazah Yusoff , Zarina Abdul Latiff , Chris Arnold , John Burn , Petros Kountouris , Marina Kleanthous , Raj Ramesar , Bin Alwi Zilfalil , On Behalf Of The Global Globin Network Ggn

Catching Them Early: Framework Parameters and Progress for Prenatal and Childhood Application of Advanced Therapies.

Pharmaceutics

Avec: Carsten W Lederer , Lola Koniali , Tina Buerki-Thurnherr , Panayiota L Papasavva , Stefania La Grutta , Amelia Licari , Frantisek Staud , Donato Bonifazi , Marina Kleanthous

Evaluation of Mono- and Bi-Functional GLOBE-Based Vectors for Therapy of β-Thalassemia by

Cells

Avec: Lola Koniali , Christina Flouri , Markela I Kostopoulou , Nikoletta Y Papaioannou , Panayiota L Papasavva , Basma Naiisseh , Coralea Stephanou , Anthi Demetriadou , Maria Sitarou , Soteroula Christou , Michael N Antoniou , Marina Kleanthous , Petros Patsali , Carsten W Lederer

Proteomic Studies for the Investigation of γ-Globin Induction by Decitabine in Human Primary Erythroid Progenitor Cultures.

Journal of clinical medicine

Avec: Andria Theodorou , Marios Phylactides , Eleni Katsantoni , Kostas Vougas , Spyros D Garbis , Pavlos Fanis , Maria Sitarou , Swee Lay Thein , Marina Kleanthous

Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.

International journal of molecular sciences

Avec: Kalia Kyriakou , Carsten W Lederer , Marina Kleanthous , Anthi Drousiotou , Anna Malekkou

Genetic Modifiers at the Crossroads of Personalised Medicine for Haemoglobinopathies.

Journal of clinical medicine

Avec: Coralea Stephanou , Stella Tamana , Anna Minaidou , Panayiota Papasavva , Marina Kleanthous , Petros Kountouris

A Novel BaEVRless-Pseudotyped γ-Globin Lentiviral Vector Drives High and Stable Fetal Hemoglobin Expression and Improves Thalassemic Erythropoiesis

Human gene therapy

Avec: Ekati Drakopoulou , Maria Georgomanoli , Carsten W Lederer , Marina Kleanthous , Caroline Costa , Ornellie Bernadin , François-Loïc Cosset , Ersi Voskaridou , Els Verhoeyen , Eleni Papanikolaou , Nicholas P Anagnou

Disruptive Technology: CRISPR/Cas-Based Tools and Approaches.

Molecular diagnosis & therapy

Avec: Petros Patsali , Marina Kleanthous , Carsten W Lederer

Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus.

Haematologica

Avec: Petros Kountouris , Kyriaki Michailidou , Soteroula Christou , Michael Hadjigavriel , Maria Sitarou , Anita Kolnagou , Marina Kleanthous , Paul Telfer

Adapting the ACMG/AMP variant classification framework: A perspective from the ClinGen Hemoglobinopathy Variant Curation Expert Panel.

Human mutation

Avec: Petros Kountouris , Coralea Stephanou , Carsten W Lederer , Joanne Traeger-Synodinos , Celeste Bento , Cornelis L Harteveld , Eirini Fylaktou , Tamara T Koopmann , Hashim Halim-Fikri , Kyriaki Michailidou , Landry E Nfonsam , John S Waye , Bin A Zilfalil , Marina Kleanthous , Auteur inconnu

Evaluation of in silico predictors on short nucleotide variants in

eLife

Avec: Stella Tamana , Maria Xenophontos , Anna Minaidou , Coralea Stephanou , Cornelis L Harteveld , Celeste Bento , Joanne Traeger-Synodinos , Irene Fylaktou , Norafiza Mohd Yasin , Faidatul Syazlin Abdul Hamid , Ezalia Esa , Hashim Halim-Fikri , Bin Alwi Zilfalil , Andrea C Kakouri , Auteur inconnu , Marina Kleanthous , Petros Kountouris

A novel mutation in the erythroid transcription factor KLF1 is likely responsible for ameliorating β-thalassemia major.

Human mutation

Avec: Pavlos Fanis , Ioanna Kousiappa , Marios Phylactides , Andreani Kyrri , Michael Hadjigavriel , Soteroula Christou , Maria Sitarou , Marina Kleanthous

The Scope for Thalassemia Gene Therapy by Disruption of Aberrant Regulatory Elements.

Journal of clinical medicine

Avec: Petros Patsali , Claudio Mussolino , Petros Ladas , Argyro Floga , Annita Kolnagou , Soteroula Christou , Maria Sitarou , Michael N Antoniou , Toni Cathomen , Carsten Werner Lederer , Marina Kleanthous

Therapy Development by Genome Editing of Hematopoietic Stem Cells.

Cells

Avec: Lola Koniali , Carsten W Lederer , Marina Kleanthous

Global Globin Network and adopting genomic variant database requirements for thalassemia.

Database : the journal of biological databases and curation

Avec: Hashim Halim-Fikri , Ninie Nadia Zulkipli , Hafiza Alauddin , Celeste Bento , Carsten W Lederer , Petros Kountouris , Marina Kleanthous , Yetti Hernaningsih , Meow-Keong Thong , Muhammad Hamdi Mahmood , Norafiza Mohd Yasin , Ezalia Esa , Jacques Elion , Domenico Coviello , Raja-Zahratul-Azma Raja-Sabudin , Ghada El-Kamah , John Burn , Narazah Mohd Yusoff , Raj Ramesar , Bin Alwi Zilfalil

Rare Opportunities: CRISPR/Cas-Based Therapy Development for Rare Genetic Diseases.

Molecular diagnosis & therapy

Avec: Panayiota Papasavva , Marina Kleanthous , Carsten W Lederer

The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia.

Mediterranean journal of hematology and infectious diseases

Avec: George J Kontoghiorghes , Marios Kleanthous , Christina N Kontoghiorghe

Unravelling the Complexity of the +33 C>G [HBB:c.-18C>G] Variant in Beta Thalassemia.

Biomedicines

Avec: Coralea Stephanou , Miranda Petrou , Petros Kountouris , Christiana Makariou , Soteroula Christou , Michael Hadjigavriel , Marina Kleanthous , Thessalia Papasavva

Context base editing for splice correction of IVSI-110 β-thalassemia.

Molecular therapy. Nucleic acids

Avec: Basma Naiisseh , Panayiota L Papasavva , Nikoletta Y Papaioannou , Marios Tomazou , Lola Koniali , Xenia Felekis , Constantina G Constantinou , Maria Sitarou , Soteroula Christou , Marina Kleanthous , Carsten W Lederer , Petros Patsali

Benefits and Risks in Polypathology and Polypharmacotherapy Challenges in the Era of the Transition of Thalassaemia from a Fatal to a Chronic or Curable Disease.

Frontiers in bioscience (Elite edition)

Avec: Annita Kolnagou , Marios Kleanthous , George J Kontoghiorghes

A Novel Tool for the Analysis and Detection of Copy Number Variants Associated with Haemoglobinopathies.

International journal of molecular sciences

Avec: Anna Minaidou , Stella Tamana , Coralea Stephanou , Maria Xenophontos , Cornelis L Harteveld , Celeste Bento , Marina Kleanthous , Petros Kountouris

Réseau de co-auteurs

Carsten W Lederer 16 collaborations

Coralea Stephanou 9 collaborations

Maria Sitarou 8 collaborations

Petros Kountouris 8 collaborations

Petros Patsali 7 collaborations

Soteroula Christou 7 collaborations

Panayiota L Papasavva 5 collaborations

Marios Phylactides 4 collaborations

Lola Koniali 4 collaborations

Celeste Bento 4 collaborations

Nikoletta Y Papaioannou 3 collaborations

Kyriaki Michailidou 3 collaborations

Panayiota Papasavva 3 collaborations

Michael N Antoniou 3 collaborations

Norafiza Mohd Yasin 3 collaborations

Ezalia Esa 3 collaborations

Bin Alwi Zilfalil 3 collaborations

Stella Tamana 3 collaborations

Anna Minaidou 3 collaborations

Michael Hadjigavriel 3 collaborations

Cornelis L Harteveld 3 collaborations

Hashim Halim-Fikri 3 collaborations

Ryo Kurita 2 collaborations

Yukio Nakamura 2 collaborations

Soteroulla Christou 2 collaborations

Constantina G Constantinou 2 collaborations

Christiana Makariou 2 collaborations

Thessalia Papasavva 2 collaborations

Ekati Drakopoulou 2 collaborations

Maria Georgomanoli 2 collaborations

Ersi Voskaridou 2 collaborations

Eleni Papanikolaou 2 collaborations

Nicholas P Anagnou 2 collaborations

Raja-Zahratul-Azma Raja-Sabudin 2 collaborations

Jacques Elion 2 collaborations

Ghada El-Kamah 2 collaborations

Domenico Coviello 2 collaborations

John Burn 2 collaborations

Raj Ramesar 2 collaborations

Basma Naiisseh 2 collaborations

Pavlos Fanis 2 collaborations

Joanne Traeger-Synodinos 2 collaborations

None None 2 collaborations

Maria Xenophontos 2 collaborations

Annita Kolnagou 2 collaborations

George J Kontoghiorghes 2 collaborations

Marios Kleanthous 2 collaborations

Stella Voskou 1 collaboration

Andreas Afantitis 1 collaboration

Georgia Melagraki 1 collaboration

Andreas Tsoumanis 1 collaboration

Panayotis A Koutentis 1 collaboration

Tina Mitsidi 1 collaboration

Styliana I Mirallai 1 collaboration

Constantinos C Loucari 1 collaboration

Eleni Karitzi 1 collaboration

Stefania Byrou 1 collaboration

Georgia Hadjilambi 1 collaboration

Agathoklis Christofides 1 collaboration

Fottes Panetsos 1 collaboration

Dimitrios Valakos 1 collaboration

Alisa Dong 1 collaboration

Valentina Ghiaccio 1 collaboration

Irene Motta 1 collaboration

Shuling Guo 1 collaboration

Raechel Peralta 1 collaboration

Susan M Freier 1 collaboration

Andy Watt 1 collaboration

Sagar Damle 1 collaboration

Yasuhiro Ikawa 1 collaboration

Danuta Jarocha 1 collaboration

Maxwell Chappell 1 collaboration

Paola Delbini 1 collaboration

Connie Chen 1 collaboration

Kim Smith-Whitley 1 collaboration

Deepa Manwani 1 collaboration

Carla Casu 1 collaboration

Osheiza Abdulmalik 1 collaboration

Maria Domenica Cappellini 1 collaboration

Stefano Rivella 1 collaboration

Laura Breda 1 collaboration

George Charitou 1 collaboration

Charalambos Tsertos 1 collaboration

Yannis Parpottas 1 collaboration

Bin Hashim Halim-Fikri 1 collaboration

Atif Amin Baig 1 collaboration

Siti Nor Assyuhada Mat-Ghani 1 collaboration

Sharifah-Nany Rahayu-Karmilla Syed-Hassan 1 collaboration

Wardah Yusof 1 collaboration

Diana Abdul Rashid 1 collaboration

Nurul Fatihah Azman 1 collaboration

Suthat Fucharoen 1 collaboration

Ramdan Panigoro 1 collaboration

Catherine Lynn T Silao 1 collaboration

Vip Viprakasit 1 collaboration

Norunaluwar Jalil 1 collaboration

Rosnah Bahar 1 collaboration

Veena Selvaratnam 1 collaboration

Norsarwany Mohamad 1 collaboration

Nik Norliza Nik Hassan 1 collaboration

Amanda Krause 1 collaboration

Helen Robinson 1 collaboration

Julia Hasler 1 collaboration

Narazah Yusoff 1 collaboration

Zarina Abdul Latiff 1 collaboration

Chris Arnold 1 collaboration

None On Behalf Of The Global Globin Network Ggn 1 collaboration

Tina Buerki-Thurnherr 1 collaboration

Stefania La Grutta 1 collaboration

Amelia Licari 1 collaboration

Frantisek Staud 1 collaboration

Donato Bonifazi 1 collaboration

Christina Flouri 1 collaboration

Markela I Kostopoulou 1 collaboration

Anthi Demetriadou 1 collaboration

Andria Theodorou 1 collaboration

Eleni Katsantoni 1 collaboration

Kostas Vougas 1 collaboration

Spyros D Garbis 1 collaboration

Swee Lay Thein 1 collaboration

Kalia Kyriakou 1 collaboration

Anthi Drousiotou 1 collaboration

Anna Malekkou 1 collaboration

Caroline Costa 1 collaboration

Ornellie Bernadin 1 collaboration

François-Loïc Cosset 1 collaboration

Els Verhoeyen 1 collaboration

Anita Kolnagou 1 collaboration

Paul Telfer 1 collaboration

Eirini Fylaktou 1 collaboration

Tamara T Koopmann 1 collaboration

Landry E Nfonsam 1 collaboration

John S Waye 1 collaboration

Bin A Zilfalil 1 collaboration

Irene Fylaktou 1 collaboration

Faidatul Syazlin Abdul Hamid 1 collaboration

Andrea C Kakouri 1 collaboration

Ioanna Kousiappa 1 collaboration

Andreani Kyrri 1 collaboration

Claudio Mussolino 1 collaboration

Petros Ladas 1 collaboration

Argyro Floga 1 collaboration

Toni Cathomen 1 collaboration

Carsten Werner Lederer 1 collaboration

Ninie Nadia Zulkipli 1 collaboration

Hafiza Alauddin 1 collaboration

Yetti Hernaningsih 1 collaboration

Meow-Keong Thong 1 collaboration

Muhammad Hamdi Mahmood 1 collaboration

Narazah Mohd Yusoff 1 collaboration

Christina N Kontoghiorghe 1 collaboration

Miranda Petrou 1 collaboration

Marios Tomazou 1 collaboration

Xenia Felekis 1 collaboration