Melissa M Schutten

Affiliations

Department of Safety Assessment, Genentech, Inc., South San Francisco, CA, United States.

Publications (10)

Safety Considerations in the Development of Hippo Pathway Inhibitors in Cancers.

Frontiers in cell and developmental biology

Avec: Satoko Kakiuchi-Kiyota , Melissa M Schutten , Yu Zhong , James J Crawford , Anwesha Dey

Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma.

The AAPS journal

Avec: Hao Cai , Satoko Kakiuchi-Kiyota , Robert Hendricks , Shelly Zhong , Luna Liu , Adeyemi O Adedeji , Pamela Chan , Melissa M Schutten , Amrita V Kamath , Meric A Ovacik

The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results.

Nature communications

Avec: Gail D Lewis , Guangmin Li , Jun Guo , Shang-Fan Yu , Carter T Fields , Genee Lee , Donglu Zhang , Peter S Dragovich , Thomas Pillow , BinQing Wei , Jack Sadowsky , Douglas Leipold , Tim Wilson , Amrita Kamath , Michael Mamounas , M Violet Lee , Ola Saad , Voleak Choeurng , Alexander Ungewickell , Sharareh Monemi , Lisa Crocker , Kevin Kalinsky , Shanu Modi , Kyung Hae Jung , Erika Hamilton , Patricia LoRusso , Ian Krop , Melissa M Schutten , Renee Commerford , Mark X Sliwkowski , Eunpi Cho

The vedotin antibody-drug conjugate payload drives platform-based nonclinical safety and pharmacokinetic profiles.

Molecular cancer therapeutics

Avec: Haley D Neff-LaFord , Sarah A Carratt , Christopher Carosino , Nancy Everds , Kristen A Cardinal , Steven Duniho , Melissa M Schutten , Christopher Frantz , Christina Zuch de Zafra , Eric B Harstad

A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Mayur S Mitra , Karla Lancaster , Adeyemi O Adedeji , Gopinath S Palanisamy , Rutwij A Dave , Fiona Zhong , Matthew S Holdren , Shannon J Turley , Wei-Ching Liang , Yan Wu , Y Gloria Meng , Jean-Michel Vernes , Melissa M Schutten

An Anti-CD22-

Molecular cancer therapeutics

Avec: Shang-Fan Yu , Donna W Lee , Bing Zheng , Geoffrey Del Rosario , Douglas Leipold , Helen Booler , Fiona Zhong , Montserrat Carrasco-Triguero , Kyu Hong , Peter Yan , Rebecca K Rowntree , Melissa M Schutten , Thomas Pillow , Jack D Sadowsky , Peter S Dragovich , Andrew G Polson

A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.

Leukemia

Avec: Satoko Kakiuchi-Kiyota , Thorsten Ross , Heidi Ackerly Wallweber , James R Kiefer , Melissa M Schutten , Adeyemi O Adedeji , Hao Cai , Robert Hendricks , Sivan Cohen , Srividya Myneni , Luna Liu , Aaron Fullerton , Nicholas Corr , Lanlan Yu , Denise de Almeida Nagata , Shelly Zhong , Steven R Leong , Ji Li , Rin Nakamura , Teiko Sumiyoshi , Jinze Li , Ayse Meric Ovacik , Bing Zheng , Mike Dillon , Christoph Spiess , Susanne Wingert , Erich Rajkovic , Kristina Ellwanger , Uwe Reusch , Andrew G Polson

Ovarian Toxicity Assessment in Histopathological Images Using Deep Learning.

Toxicologic pathology

Avec: Fangyao Hu , Leah Schutt , Cleopatra Kozlowski , Karen Regan , Noel Dybdal , Melissa M Schutten

An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Bing Zheng , Shang-Fan Yu , Geoffrey Del Rosario , Steven R Leong , Genee Y Lee , Rajesh Vij , Cecilia Chiu , Wei-Ching Liang , Yan Wu , Cecile Chalouni , Jack Sadowsky , Vanessa Clark , Angela Hendricks , Kirsten Achilles Poon , Wayne Chu , Thomas Pillow , Melissa M Schutten , John Flygare , Andrew G Polson

Calicheamicin Antibody-Drug Conjugates with Improved Properties.

Molecular cancer therapeutics

Avec: Breanna S Vollmar , Chris Frantz , Melissa M Schutten , Fiona Zhong , Geoffrey Del Rosario , Mary Ann T Go , Shang-Fan Yu , Douglas D Leipold , Amrita V Kamath , Carl Ng , Keyang Xu , Josefa Dela Cruz-Chuh , Katherine R Kozak , Jinhua Chen , Zijin Xu , John Wai , Pragya Adhikari , Hans K Erickson , Peter S Dragovich , Andrew G Polson , Thomas H Pillow

Réseau de co-auteurs

Shang-Fan Yu 4 collaborations

Andrew G Polson 4 collaborations

Satoko Kakiuchi-Kiyota 3 collaborations

Adeyemi O Adedeji 3 collaborations

Peter S Dragovich 3 collaborations

Thomas Pillow 3 collaborations

Fiona Zhong 3 collaborations

Bing Zheng 3 collaborations

Geoffrey Del Rosario 3 collaborations

Hao Cai 2 collaborations

Robert Hendricks 2 collaborations

Shelly Zhong 2 collaborations

Luna Liu 2 collaborations

Amrita V Kamath 2 collaborations

Jack Sadowsky 2 collaborations

Douglas Leipold 2 collaborations

Wei-Ching Liang 2 collaborations

Yan Wu 2 collaborations

Steven R Leong 2 collaborations

Yu Zhong 1 collaboration

James J Crawford 1 collaboration

Anwesha Dey 1 collaboration

Pamela Chan 1 collaboration

Meric A Ovacik 1 collaboration

Gail D Lewis 1 collaboration

Guangmin Li 1 collaboration

Jun Guo 1 collaboration

Carter T Fields 1 collaboration

Genee Lee 1 collaboration

Donglu Zhang 1 collaboration

BinQing Wei 1 collaboration

Tim Wilson 1 collaboration

Amrita Kamath 1 collaboration

Michael Mamounas 1 collaboration

M Violet Lee 1 collaboration

Ola Saad 1 collaboration

Voleak Choeurng 1 collaboration

Alexander Ungewickell 1 collaboration

Sharareh Monemi 1 collaboration

Lisa Crocker 1 collaboration

Kevin Kalinsky 1 collaboration

Shanu Modi 1 collaboration

Kyung Hae Jung 1 collaboration

Erika Hamilton 1 collaboration

Patricia LoRusso 1 collaboration

Ian Krop 1 collaboration

Renee Commerford 1 collaboration

Mark X Sliwkowski 1 collaboration

Eunpi Cho 1 collaboration

Haley D Neff-LaFord 1 collaboration

Sarah A Carratt 1 collaboration

Christopher Carosino 1 collaboration

Nancy Everds 1 collaboration

Kristen A Cardinal 1 collaboration

Steven Duniho 1 collaboration

Christopher Frantz 1 collaboration

Christina Zuch de Zafra 1 collaboration

Eric B Harstad 1 collaboration

Mayur S Mitra 1 collaboration

Karla Lancaster 1 collaboration

Gopinath S Palanisamy 1 collaboration

Rutwij A Dave 1 collaboration

Matthew S Holdren 1 collaboration

Shannon J Turley 1 collaboration

Y Gloria Meng 1 collaboration

Jean-Michel Vernes 1 collaboration

Donna W Lee 1 collaboration

Helen Booler 1 collaboration

Montserrat Carrasco-Triguero 1 collaboration

Kyu Hong 1 collaboration

Peter Yan 1 collaboration

Rebecca K Rowntree 1 collaboration

Jack D Sadowsky 1 collaboration

Thorsten Ross 1 collaboration

Heidi Ackerly Wallweber 1 collaboration

James R Kiefer 1 collaboration

Sivan Cohen 1 collaboration

Srividya Myneni 1 collaboration

Aaron Fullerton 1 collaboration

Nicholas Corr 1 collaboration

Lanlan Yu 1 collaboration

Denise de Almeida Nagata 1 collaboration

Ji Li 1 collaboration

Rin Nakamura 1 collaboration

Teiko Sumiyoshi 1 collaboration

Jinze Li 1 collaboration

Ayse Meric Ovacik 1 collaboration

Mike Dillon 1 collaboration

Christoph Spiess 1 collaboration

Susanne Wingert 1 collaboration

Erich Rajkovic 1 collaboration

Kristina Ellwanger 1 collaboration

Uwe Reusch 1 collaboration

Fangyao Hu 1 collaboration

Leah Schutt 1 collaboration

Cleopatra Kozlowski 1 collaboration

Karen Regan 1 collaboration

Noel Dybdal 1 collaboration

Genee Y Lee 1 collaboration

Rajesh Vij 1 collaboration

Cecilia Chiu 1 collaboration

Cecile Chalouni 1 collaboration

Vanessa Clark 1 collaboration

Angela Hendricks 1 collaboration

Kirsten Achilles Poon 1 collaboration

Wayne Chu 1 collaboration

John Flygare 1 collaboration

Breanna S Vollmar 1 collaboration

Chris Frantz 1 collaboration

Mary Ann T Go 1 collaboration

Douglas D Leipold 1 collaboration

Carl Ng 1 collaboration

Keyang Xu 1 collaboration

Josefa Dela Cruz-Chuh 1 collaboration

Katherine R Kozak 1 collaboration

Jinhua Chen 1 collaboration

Zijin Xu 1 collaboration

John Wai 1 collaboration

Pragya Adhikari 1 collaboration

Hans K Erickson 1 collaboration

Thomas H Pillow 1 collaboration