Muthulekha Swamydas

Affiliations

Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892.

Publications (17)

Development of a novel β-1,6-glucan-specific detection system using functionally-modified recombinant endo-β-1,6-glucanase.

The Journal of biological chemistry

Avec: Daisuke Yamanaka , Kazushiro Takatsu , Masahiro Kimura , Muthulekha Swamydas , Hiroaki Ohnishi , Takashi Umeyama , Fumitaka Oyama , Michail S Lionakis , Naohito Ohno

Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma.

Journal of hematology & oncology

Avec: Muthulekha Swamydas , Elena V Murphy , James J Ignatz-Hoover , Ehsan Malek , James J Driscoll

Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".

Science (New York, N.Y.)

Avec: Timothy J Break , Vasileios Oikonomou , Nicolas Dutzan , Jigar V Desai , Marc Swidergall , Tilo Freiwald , Daniel Chauss , Oliver J Harrison , Julie Alejo , Drake W Williams , Stefania Pittaluga , Chyi-Chia R Lee , Nicolas Bouladoux , Muthulekha Swamydas , Kevin W Hoffman , Teresa Greenwell-Wild , Vincent M Bruno , Lindsey B Rosen , Wint Lwin , Andy Renteria , Sergio M Pontejo , John P Shannon , Ian A Myles , Peter Olbrich , Elise M N Ferré , Monica Schmitt , Daniel Martin , Auteur inconnu , Daniel L Barber , Norma V Solis , Luigi D Notarangelo , David V Serreze , Mitsuru Matsumoto , Heather D Hickman , Philip M Murphy , Mark S Anderson , Jean K Lim , Steven M Holland , Scott G Filler , Behdad Afzali , Yasmine Belkaid , Niki M Moutsopoulos , Michail S Lionakis

Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria.

Cell host & microbe

Avec: Rebecca A Drummond , Jigar V Desai , Emily E Ricotta , Muthulekha Swamydas , Clay Deming , Sean Conlan , Mariam Quinones , Veronika Matei-Rascu , Lozan Sherif , David Lecky , Chyi-Chia R Lee , Nathaniel M Green , Nicholas Collins , Adrian M Zelazny , D Rebecca Prevots , David Bending , David Withers , Yasmine Belkaid , Julia A Segre , Michail S Lionakis

Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome.

The Journal of allergy and clinical immunology

Avec: Rosita Rigoni , Elena Fontana , Kerry Dobbs , Veronica Marrella , Valentina Taverniti , Virginia Maina , Amanda Facoetti , Giovanna D'Amico , Waleed Al-Herz , Mario Ernesto Cruz-Munoz , Catharina Schuetz , Andrew R Gennery , Elizabeth K Garabedian , Silvia Giliani , Deborah Draper , Ghassan Dbaibo , Raif S Geha , Isabelle Meyts , Thomas Tousseyn , Benedicte Neven , Despina Moshous , Alain Fischer , Ansgar Schulz , Andrea Finocchi , Douglas B Kuhns , Danielle L Fink , Michail S Lionakis , Muthulekha Swamydas , Simone Guglielmetti , Julie Alejo , Ian A Myles , Stefania Pittaluga , Luigi D Notarangelo , Anna Villa , Barbara Cassani

Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis.

The Journal of clinical investigation

Avec: Rebecca A Drummond , Jigar V Desai , Amy P Hsu , Vasileios Oikonomou , Donald C Vinh , Joshua A Acklin , Michael S Abers , Magdalena A Walkiewicz , Sarah L Anzick , Muthulekha Swamydas , Simon Vautier , Mukil Natarajan , Andrew J Oler , Daisuke Yamanaka , Katrin D Mayer-Barber , Yoichiro Iwakura , David Bianchi , Brian Driscoll , Ken Hauck , Ahnika Kline , Nicholas Sp Viall , Christa S Zerbe , Elise Mn Ferré , Monica M Schmitt , Tom DiMaggio , Stefania Pittaluga , John A Butman , Adrian M Zelazny , Yvonne R Shea , Cesar A Arias , Cameron Ashbaugh , Maryam Mahmood , Zelalem Temesgen , Alexander G Theofiles , Masayuki Nigo , Varsha Moudgal , Karen C Bloch , Sean G Kelly , M Suzanne Whitworth , Ganesh Rao , Cindy J Whitener , Neema Mafi , Juan Gea-Banacloche , Lawrence C Kenyon , William R Miller , Katia Boggian , Andrea Gilbert , Matthew Sincock , Alexandra F Freeman , John E Bennett , Rodrigo Hasbun , Constantinos M Mikelis , Kyung J Kwon-Chung , Yasmine Belkaid , Gordon D Brown , Jean K Lim , Douglas B Kuhns , Steven M Holland , Michail S Lionakis

Therapeutic responses to

Science translational medicine

Avec: Ian A Myles , Carlo R Castillo , Kent D Barbian , Kishore Kanakabandi , Kimmo Virtaneva , Emily Fitzmeyer , Monica Paneru , Francisco Otaizo-Carrasquero , Timothy G Myers , Tovah E Markowitz , Ian N Moore , Xue Liu , Marc Ferrer , Yosuke Sakamachi , Stavros Garantziotis , Muthulekha Swamydas , Michail S Lionakis , Erik D Anderson , Noah J Earland , Sundar Ganesan , Ashleigh A Sun , Jenna R E Bergerson , Robert A Silverman , Maureen Petersen , Craig A Martens , Sandip K Datta

Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.

Blood

Avec: Amy P Hsu , Agnes Donkó , Megan E Arrington , Muthulekha Swamydas , Danielle Fink , Arundhoti Das , Omar Escobedo , Vincent Bonagura , Paul Szabolcs , Harry N Steinberg , Jenna Bergerson , Amanda Skoskiewicz , Melanie Makhija , Joie Davis , Ladan Foruraghi , Cindy Palmer , Ramsay L Fuleihan , Joseph A Church , Avinash Bhandoola , Michail S Lionakis , Sharon Campbell , Thomas L Leto , Douglas B Kuhns , Steven M Holland

Vactosertib, a novel TGF-β1 type I receptor kinase inhibitor, improves T-cell fitness: a single-arm, phase 1b trial in relapsed/refractory multiple myeloma.

Research square

Avec: Ehsan Malek , Priyanka S Rana , Muthulekha Swamydas , Michael Daunov , Masaru Miyagi , Elena Murphy , James J Ignatz-Hoover , Leland Metheny , Kim Seong Jin , James J Driscoll

The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial.

Nature communications

Avec: Ehsan Malek , Priyanka S Rana , Muthulekha Swamydas , Michael Daunov , Masaru Miyagi , Elena Murphy , James J Ignatz-Hoover , Leland Metheny , Seong Jin Kim , James J Driscoll

CARD9

Nature immunology

Avec: Rebecca A Drummond , Muthulekha Swamydas , Vasileios Oikonomou , Bing Zhai , Ivy M Dambuza , Brian C Schaefer , Andrea C Bohrer , Katrin D Mayer-Barber , Sergio A Lira , Yoichiro Iwakura , Scott G Filler , Gordon D Brown , Bernhard Hube , Julian R Naglik , Tobias M Hohl , Michail S Lionakis

Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance.

Science translational medicine

Avec: Elise M N Ferré , Timothy J Break , Peter D Burbelo , Michael Allgäuer , David E Kleiner , Dakai Jin , Ziyue Xu , Les R Folio , Daniel J Mollura , Muthulekha Swamydas , Wenjuan Gu , Sally Hunsberger , Chyi-Chia R Lee , Anamaria Bondici , Kevin W Hoffman , Jean K Lim , Kerry Dobbs , Julie E Niemela , Thomas A Fleisher , Amy P Hsu , Laquita N Snow , Dirk N Darnell , Samar Ojaimi , Megan A Cooper , Martin Bozzola , Gary I Kleiner , Juan C Martinez , Robin R Deterding , Douglas B Kuhns , Theo Heller , Karen K Winer , Arun Rajan , Steven M Holland , Luigi D Notarangelo , Kevin P Fennelly , Kenneth N Olivier , Michail S Lionakis

Protective Activity of Programmed Cell Death Protein 1 Blockade and Synergy With Caspofungin in a Murine Invasive Pulmonary Aspergillosis Model.

The Journal of infectious diseases

Avec: Sebastian Wurster , Prema Robinson , Nathaniel D Albert , Jeffrey J Tarrand , Marisa Goff , Muthulekha Swamydas , Jean K Lim , Michail S Lionakis , Dimitrios P Kontoyiannis

Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.

Science (New York, N.Y.)

Frontiers in cellular and infection microbiology

Avec: Caio C B Bomfim , Logan Fisher , Eduardo P Amaral , Lara Mittereder , Katelyn McCann , André A S Correa , Sivaranjani Namasivayam , Muthulekha Swamydas , Mahtab Moayeri , Jonathan M Weiss , Raj Chari , Daniel W McVicar , Diego L Costa , Maria R D'Império Lima , Alan Sher

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection.

Cell

Avec: Jigar V Desai , Dhaneshwar Kumar , Tilo Freiwald , Daniel Chauss , Melissa D Johnson , Michael S Abers , Julie M Steinbrink , John R Perfect , Barbara Alexander , Vasiliki Matzaraki , Brendan D Snarr , Marissa A Zarakas , Vasileios Oikonomou , Lakmali M Silva , Raju Shivarathri , Emily Beltran , Luciana Negro Demontel , Luopin Wang , Jean K Lim , Dylan Launder , Heather R Conti , Muthulekha Swamydas , Micah T McClain , Niki M Moutsopoulos , Majid Kazemian , Mihai G Netea , Vinod Kumar , Jörg Köhl , Claudia Kemper , Behdad Afzali , Michail S Lionakis

Isolation of Mouse Neutrophils.

Current protocols

Avec: Andrew L Wishart , Muthulekha Swamydas , Michail S Lionakis

Réseau de co-auteurs

Michail S Lionakis 13 collaborations

Jean K Lim 6 collaborations

Vasileios Oikonomou 5 collaborations

Jigar V Desai 5 collaborations

Steven M Holland 5 collaborations

Stefania Pittaluga 4 collaborations

Chyi-Chia R Lee 4 collaborations

Ian A Myles 4 collaborations

Luigi D Notarangelo 4 collaborations

Yasmine Belkaid 4 collaborations

Douglas B Kuhns 4 collaborations

James J Ignatz-Hoover 3 collaborations

Ehsan Malek 3 collaborations

James J Driscoll 3 collaborations

Timothy J Break 3 collaborations

Tilo Freiwald 3 collaborations

Daniel Chauss 3 collaborations

Julie Alejo 3 collaborations

Kevin W Hoffman 3 collaborations

Elise M N Ferré 3 collaborations

Scott G Filler 3 collaborations

Behdad Afzali 3 collaborations

Niki M Moutsopoulos 3 collaborations

Rebecca A Drummond 3 collaborations

Amy P Hsu 3 collaborations

Daisuke Yamanaka 2 collaborations

Nicolas Dutzan 2 collaborations

Marc Swidergall 2 collaborations

Oliver J Harrison 2 collaborations

Drake W Williams 2 collaborations

Nicolas Bouladoux 2 collaborations

Teresa Greenwell-Wild 2 collaborations

Vincent M Bruno 2 collaborations

Lindsey B Rosen 2 collaborations

Wint Lwin 2 collaborations

Andy Renteria 2 collaborations

Sergio M Pontejo 2 collaborations

John P Shannon 2 collaborations

Peter Olbrich 2 collaborations

Monica Schmitt 2 collaborations

Daniel Martin 2 collaborations

None None 2 collaborations

Daniel L Barber 2 collaborations

Norma V Solis 2 collaborations

David V Serreze 2 collaborations

Mitsuru Matsumoto 2 collaborations

Heather D Hickman 2 collaborations

Philip M Murphy 2 collaborations

Mark S Anderson 2 collaborations

Adrian M Zelazny 2 collaborations

Kerry Dobbs 2 collaborations

Michael S Abers 2 collaborations

Katrin D Mayer-Barber 2 collaborations

Yoichiro Iwakura 2 collaborations

Gordon D Brown 2 collaborations

Priyanka S Rana 2 collaborations

Michael Daunov 2 collaborations

Masaru Miyagi 2 collaborations

Elena Murphy 2 collaborations

Leland Metheny 2 collaborations

Kazushiro Takatsu 1 collaboration

Masahiro Kimura 1 collaboration

Hiroaki Ohnishi 1 collaboration

Takashi Umeyama 1 collaboration

Fumitaka Oyama 1 collaboration

Naohito Ohno 1 collaboration

Elena V Murphy 1 collaboration

Emily E Ricotta 1 collaboration

Clay Deming 1 collaboration

Sean Conlan 1 collaboration

Mariam Quinones 1 collaboration

Veronika Matei-Rascu 1 collaboration

Lozan Sherif 1 collaboration

David Lecky 1 collaboration

Nathaniel M Green 1 collaboration

Nicholas Collins 1 collaboration

D Rebecca Prevots 1 collaboration

David Bending 1 collaboration

David Withers 1 collaboration

Julia A Segre 1 collaboration

Rosita Rigoni 1 collaboration

Elena Fontana 1 collaboration

Veronica Marrella 1 collaboration

Valentina Taverniti 1 collaboration

Virginia Maina 1 collaboration

Amanda Facoetti 1 collaboration

Giovanna D'Amico 1 collaboration

Waleed Al-Herz 1 collaboration

Mario Ernesto Cruz-Munoz 1 collaboration

Catharina Schuetz 1 collaboration

Andrew R Gennery 1 collaboration

Elizabeth K Garabedian 1 collaboration

Silvia Giliani 1 collaboration

Deborah Draper 1 collaboration

Ghassan Dbaibo 1 collaboration

Raif S Geha 1 collaboration

Isabelle Meyts 1 collaboration

Thomas Tousseyn 1 collaboration

Benedicte Neven 1 collaboration

Despina Moshous 1 collaboration

Alain Fischer 1 collaboration

Ansgar Schulz 1 collaboration

Andrea Finocchi 1 collaboration

Danielle L Fink 1 collaboration

Simone Guglielmetti 1 collaboration

Anna Villa 1 collaboration

Barbara Cassani 1 collaboration

Donald C Vinh 1 collaboration

Joshua A Acklin 1 collaboration

Magdalena A Walkiewicz 1 collaboration

Sarah L Anzick 1 collaboration

Simon Vautier 1 collaboration

Mukil Natarajan 1 collaboration

Andrew J Oler 1 collaboration

David Bianchi 1 collaboration

Brian Driscoll 1 collaboration

Ken Hauck 1 collaboration

Ahnika Kline 1 collaboration

Nicholas Sp Viall 1 collaboration

Christa S Zerbe 1 collaboration

Elise Mn Ferré 1 collaboration

Monica M Schmitt 1 collaboration

Tom DiMaggio 1 collaboration

John A Butman 1 collaboration

Yvonne R Shea 1 collaboration

Cesar A Arias 1 collaboration

Cameron Ashbaugh 1 collaboration

Maryam Mahmood 1 collaboration

Zelalem Temesgen 1 collaboration

Alexander G Theofiles 1 collaboration

Masayuki Nigo 1 collaboration

Varsha Moudgal 1 collaboration

Karen C Bloch 1 collaboration

Sean G Kelly 1 collaboration

M Suzanne Whitworth 1 collaboration

Ganesh Rao 1 collaboration

Cindy J Whitener 1 collaboration

Neema Mafi 1 collaboration

Juan Gea-Banacloche 1 collaboration

Lawrence C Kenyon 1 collaboration

William R Miller 1 collaboration

Katia Boggian 1 collaboration

Andrea Gilbert 1 collaboration

Matthew Sincock 1 collaboration

Alexandra F Freeman 1 collaboration

John E Bennett 1 collaboration

Rodrigo Hasbun 1 collaboration

Constantinos M Mikelis 1 collaboration

Kyung J Kwon-Chung 1 collaboration

Carlo R Castillo 1 collaboration

Kent D Barbian 1 collaboration

Kishore Kanakabandi 1 collaboration

Kimmo Virtaneva 1 collaboration

Emily Fitzmeyer 1 collaboration

Monica Paneru 1 collaboration

Francisco Otaizo-Carrasquero 1 collaboration

Timothy G Myers 1 collaboration

Tovah E Markowitz 1 collaboration

Ian N Moore 1 collaboration

Xue Liu 1 collaboration

Marc Ferrer 1 collaboration

Yosuke Sakamachi 1 collaboration

Stavros Garantziotis 1 collaboration

Erik D Anderson 1 collaboration

Noah J Earland 1 collaboration

Sundar Ganesan 1 collaboration

Ashleigh A Sun 1 collaboration

Jenna R E Bergerson 1 collaboration

Robert A Silverman 1 collaboration

Maureen Petersen 1 collaboration

Craig A Martens 1 collaboration

Sandip K Datta 1 collaboration

Agnes Donkó 1 collaboration

Megan E Arrington 1 collaboration

Danielle Fink 1 collaboration

Arundhoti Das 1 collaboration

Omar Escobedo 1 collaboration

Vincent Bonagura 1 collaboration

Paul Szabolcs 1 collaboration

Harry N Steinberg 1 collaboration

Jenna Bergerson 1 collaboration

Amanda Skoskiewicz 1 collaboration

Melanie Makhija 1 collaboration

Joie Davis 1 collaboration

Ladan Foruraghi 1 collaboration

Cindy Palmer 1 collaboration

Ramsay L Fuleihan 1 collaboration

Joseph A Church 1 collaboration

Avinash Bhandoola 1 collaboration

Sharon Campbell 1 collaboration

Thomas L Leto 1 collaboration

Kim Seong Jin 1 collaboration

Seong Jin Kim 1 collaboration

Bing Zhai 1 collaboration

Ivy M Dambuza 1 collaboration

Brian C Schaefer 1 collaboration

Andrea C Bohrer 1 collaboration

Sergio A Lira 1 collaboration

Bernhard Hube 1 collaboration

Julian R Naglik 1 collaboration

Tobias M Hohl 1 collaboration

Peter D Burbelo 1 collaboration

Michael Allgäuer 1 collaboration

David E Kleiner 1 collaboration

Dakai Jin 1 collaboration

Ziyue Xu 1 collaboration

Les R Folio 1 collaboration

Daniel J Mollura 1 collaboration

Wenjuan Gu 1 collaboration

Sally Hunsberger 1 collaboration

Anamaria Bondici 1 collaboration

Julie E Niemela 1 collaboration

Thomas A Fleisher 1 collaboration

Laquita N Snow 1 collaboration

Dirk N Darnell 1 collaboration

Samar Ojaimi 1 collaboration

Megan A Cooper 1 collaboration

Martin Bozzola 1 collaboration

Gary I Kleiner 1 collaboration

Juan C Martinez 1 collaboration

Robin R Deterding 1 collaboration

Theo Heller 1 collaboration

Karen K Winer 1 collaboration

Arun Rajan 1 collaboration

Kevin P Fennelly 1 collaboration

Kenneth N Olivier 1 collaboration

Sebastian Wurster 1 collaboration

Prema Robinson 1 collaboration

Nathaniel D Albert 1 collaboration

Jeffrey J Tarrand 1 collaboration

Marisa Goff 1 collaboration

Dimitrios P Kontoyiannis 1 collaboration

Caio C B Bomfim 1 collaboration

Logan Fisher 1 collaboration

Eduardo P Amaral 1 collaboration

Lara Mittereder 1 collaboration

Katelyn McCann 1 collaboration

André A S Correa 1 collaboration

Sivaranjani Namasivayam 1 collaboration

Mahtab Moayeri 1 collaboration

Jonathan M Weiss 1 collaboration

Raj Chari 1 collaboration

Daniel W McVicar 1 collaboration

Diego L Costa 1 collaboration

Maria R D'Império Lima 1 collaboration

Alan Sher 1 collaboration

Dhaneshwar Kumar 1 collaboration

Melissa D Johnson 1 collaboration

Julie M Steinbrink 1 collaboration

John R Perfect 1 collaboration

Barbara Alexander 1 collaboration

Vasiliki Matzaraki 1 collaboration

Brendan D Snarr 1 collaboration

Marissa A Zarakas 1 collaboration

Lakmali M Silva 1 collaboration

Raju Shivarathri 1 collaboration

Emily Beltran 1 collaboration

Luciana Negro Demontel 1 collaboration

Luopin Wang 1 collaboration

Dylan Launder 1 collaboration

Heather R Conti 1 collaboration

Micah T McClain 1 collaboration

Majid Kazemian 1 collaboration

Mihai G Netea 1 collaboration

Vinod Kumar 1 collaboration

Jörg Köhl 1 collaboration

Claudia Kemper 1 collaboration

Andrew L Wishart 1 collaboration