Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma.
CAR T cells
Cytotoxic T cell
Drug resistance
Immune escape
Immunotherapy
Multiple myeloma
NK cell
Proteasome
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
16 02 2022
16 02 2022
Historique:
received:
20
12
2021
accepted:
03
02
2022
entrez:
17
2
2022
pubmed:
18
2
2022
medline:
17
3
2022
Statut:
epublish
Résumé
Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of malignant plasma cells nurtured within a permissive bone marrow microenvironment. While patients mount numerous adaptive immune responses directed against their disease, emerging data demonstrate that tumor intrinsic and extrinsic mechanisms allow myeloma cells to subvert host immunosurveillance and resist current therapeutic strategies. Myeloma downregulates antigens recognized by cellular immunity and modulates the bone marrow microenvironment to promote uncontrolled tumor proliferation, apoptotic resistance, and further hamper anti-tumor immunity. Additional resistance often develops after an initial clinical response to small molecules, immune-targeting antibodies, immune checkpoint blockade or cellular immunotherapy. Profound quantitative and qualitative dysfunction of numerous immune effector cell types that confer anti-myeloma immunity further supports myelomagenesis, disease progression and the emergence of drug resistance. Identification of tumor intrinsic and extrinsic resistance mechanisms may direct the design of rationally-designed drug combinations that prevent or overcome drug resistance to improve patient survival. Here, we summarize various mechanisms of immune escape as a means to inform novel strategies that may restore and improve host anti-myeloma immunity.
Identifiants
pubmed: 35172851
doi: 10.1186/s13045-022-01234-2
pii: 10.1186/s13045-022-01234-2
pmc: PMC8848665
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17Subventions
Organisme : NIAID NIH HHS
ID : R01 AI139141
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Blood. 2014 Dec 11;124(25):3748-57
pubmed: 25320245
Cells. 2021 Feb 16;10(2):
pubmed: 33669402
Immunology. 2013 Jul;139(3):338-41
pubmed: 23360454
Blood Adv. 2021 Dec 14;5(23):5128-5139
pubmed: 34625791
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
Cancers (Basel). 2021 Jun 28;13(13):
pubmed: 34203150
Science. 2011 Mar 25;331(6024):1565-70
pubmed: 21436444
Front Immunol. 2020 Jun 05;11:1128
pubmed: 32582204
Nat Med. 2007 Jan;13(1):54-61
pubmed: 17187072
J Immunol. 2004 Jun 15;172(12):7335-40
pubmed: 15187109
Cancers (Basel). 2020 Nov 04;12(11):
pubmed: 33158030
Semin Cancer Biol. 2012 Aug;22(4):275-81
pubmed: 22313874
Clin Lymphoma Myeloma Leuk. 2016 May;16(5):e59-64
pubmed: 26997107
Clin Cancer Res. 2020 Apr 1;26(7):1541-1554
pubmed: 31672768
Nat Immunol. 2011 Jun;12(6):492-9
pubmed: 21739672
Clin Exp Immunol. 2001 Aug;125(2):190-7
pubmed: 11529908
Genes Immun. 2020 Nov;21(5):273-287
pubmed: 32839530
Blood. 2006 Jan 1;107(1):301-4
pubmed: 16150935
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
FEBS Lett. 1999 Dec 31;464(3):108-12
pubmed: 10618487
JCI Insight. 2019 Nov 1;4(21):
pubmed: 31593552
Immunol Res. 2014 Aug;59(1-3):188-202
pubmed: 24845460
Br J Haematol. 1983 Feb;53(2):271-5
pubmed: 6217831
Leukemia. 2022 Jan;36(1):138-154
pubmed: 34290359
Cell Mol Immunol. 2012 Mar;9(2):136-46
pubmed: 22307040
Nat Cancer. 2020 May;1(5):493-506
pubmed: 33409501
Pharmacotherapy. 2017 Jan;37(1):129-143
pubmed: 27870103
Cancer Cell Int. 2018 Aug 22;18:119
pubmed: 30166942
Int Immunol. 2015 Oct;27(10):479-86
pubmed: 26071023
Hum Immunol. 2009 Oct;70(10):854-7
pubmed: 19580833
Nat Immunol. 2002 Nov;3(11):991-8
pubmed: 12407406
Cancer Immunol Immunother. 2022 Jan;71(1):177-187
pubmed: 34061243
Blood. 2020 Dec 10;136(24):2731-2740
pubmed: 32645135
Cells. 2020 May 24;9(5):
pubmed: 32456301
Blood Cancer J. 2015 Jul 03;5:e321
pubmed: 26140429
Immunol Rev. 2015 Jan;263(1):160-72
pubmed: 25510276
Blood Adv. 2021 Apr 27;5(8):2196-2215
pubmed: 33890981
Oncol Res Treat. 2021;44(12):690-699
pubmed: 34784608
Ann Lab Med. 2016 Nov;36(6):573-82
pubmed: 27578511
Blood. 2002 Aug 15;100(4):1417-24
pubmed: 12149226
J Immunol. 2002 Jan 15;168(2):689-95
pubmed: 11777962
Blood. 2013 Apr 11;121(15):2975-87
pubmed: 23321256
Blood Cancer Discov. 2021 Aug 17;2(5):423-433
pubmed: 34661161
Clin Cancer Res. 2021 Jul 1;27(13):3793-3803
pubmed: 33883175
Cell Mol Immunol. 2017 Aug;14(8):662-674
pubmed: 28626234
Br J Cancer. 2012 Jan 31;106(3):546-52
pubmed: 22223085
J Biomed Biotechnol. 2012;2012:157496
pubmed: 23093834
Eur J Cancer. 2006 Jul;42(11):1564-73
pubmed: 16765041
Am J Transplant. 2004 Oct;4(10):1614-27
pubmed: 15367216
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Nat Rev Immunol. 2012 Mar 22;12(4):239-52
pubmed: 22437937
Br J Haematol. 1998 Dec;103(4):1152-60
pubmed: 9886334
Immunity. 2010 Jan 29;32(1):129-40
pubmed: 20079667
N Engl J Med. 2004 Oct 28;351(18):1860-73
pubmed: 15509819
Cancers (Basel). 2021 Jan 09;13(2):
pubmed: 33435306
Nat Rev Immunol. 2021 Aug;21(8):485-498
pubmed: 33526920
Leuk Lymphoma. 2002 May;43(5):969-74
pubmed: 12148907
Leuk Lymphoma. 2020 Aug;61(8):1869-1876
pubmed: 32324088
Cancers (Basel). 2021 May 31;13(11):
pubmed: 34072645
Nat Rev Immunol. 2007 Mar;7(3):238-43
pubmed: 17290299
Nat Rev Cancer. 2017 Aug 24;17(9):543-556
pubmed: 28835722
Immunity. 2015 Apr 21;42(4):607-12
pubmed: 25902480
J Hematol Oncol. 2020 Jun 9;13(1):74
pubmed: 32517713
Blood. 2014 May 22;123(21):3305-15
pubmed: 24723682
Front Immunol. 2017 Feb 24;8:175
pubmed: 28286501
Leukemia. 2020 Dec;34(12):3111-3125
pubmed: 33046818
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4120-5
pubmed: 12646700
Leukemia. 2006 Apr;20(4):732-3
pubmed: 16437151
J Exp Med. 2007 Apr 16;204(4):831-40
pubmed: 17389240
Int Immunopharmacol. 2019 Feb;67:281-286
pubmed: 30572252
Cancer Immunol Immunother. 2015 Mar;64(3):389-99
pubmed: 25548095
Leuk Lymphoma. 2014 Dec;55(12):2893-900
pubmed: 24625328
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1285-90
pubmed: 18202175
Oncotarget. 2018 Sep 14;9(72):33621-33622
pubmed: 30263089
Curr Opin Pharmacol. 2013 Aug;13(4):595-601
pubmed: 23773801
Oncologist. 2020 Sep;25(9):e1406-e1413
pubmed: 32335971
Blood. 1996 Apr 15;87(8):3297-306
pubmed: 8605346
Cell Mol Immunol. 2020 Apr;17(4):323-334
pubmed: 32203193
Curr Opin Immunol. 2014 Apr;27:16-25
pubmed: 24531241
Scand J Haematol. 1976 Jul;17(1):62-70
pubmed: 959776
J Immunol. 2018 Apr 15;200(8):2581-2591
pubmed: 29531171
Immunity. 2001 Mar;14(3):303-13
pubmed: 11290339
Blood. 2014 Jul 24;124(4):555-66
pubmed: 24928860
Blood Adv. 2021 Oct 12;5(19):3794-3798
pubmed: 34471932
Blood. 2010 Jul 1;115(26):5385-92
pubmed: 20395418
Nat Commun. 2021 Feb 8;12(1):868
pubmed: 33558511
Cancer Immunol Immunother. 2009 Jan;58(1):49-59
pubmed: 18446337
Blood. 2013 Aug 1;122(5):684-93
pubmed: 23801635
Best Pract Res Clin Haematol. 2010 Sep;23(3):433-51
pubmed: 21112041
Blood. 2005 Jan 1;105(1):251-8
pubmed: 15328155
J Clin Invest. 2015 Jul 1;125(7):2904
pubmed: 26075821
Sci Rep. 2019 Feb 27;9(1):2855
pubmed: 30814560
Blood. 2002 Jul 1;100(1):230-7
pubmed: 12070032
Cancer Discov. 2016 May;6(5):546-59
pubmed: 26928313
Front Immunol. 2014 Jul 02;5:303
pubmed: 25071764
Front Immunol. 2020 Jun 19;11:1155
pubmed: 32636838
Sci Rep. 2020 Feb 6;10(1):1983
pubmed: 32029833
J Immunol. 2009 Jul 15;183(2):937-44
pubmed: 19553533
Oncoimmunology. 2012 Dec 1;1(9):1658-1660
pubmed: 23264928
Oncogene. 2006 Jul 20;25(31):4257-66
pubmed: 16518413
Nat Rev Cancer. 2013 Oct;13(10):739-52
pubmed: 24060865
Immunology. 2018 Sep;155(1):24-35
pubmed: 29682722
Haematologica. 2017 Mar;102(3):423-432
pubmed: 28082344
Cell Mol Life Sci. 2016 Apr;73(8):1569-89
pubmed: 26801219
Br J Haematol. 2001 Jun;113(4):1051-9
pubmed: 11442502
Blood Cancer J. 2017 Mar 24;7(3):e547
pubmed: 28338671
J Oncol. 2021 Feb 27;2021:6630295
pubmed: 33727923
Front Immunol. 2020 Apr 24;11:501
pubmed: 32391000
Blood. 2012 Sep 6;120(10):2055-63
pubmed: 22705596
Acta Haematol. 1997;98(3):150-4
pubmed: 9352746
Nat Med. 2021 Apr;27(4):616-619
pubmed: 33619368
Am J Pathol. 2016 Mar;186(3):678-90
pubmed: 26801735
Cancers (Basel). 2021 Oct 09;13(20):
pubmed: 34680184
Blood. 2004 Apr 15;103(8):3148-57
pubmed: 15070697
Lancet. 2009 Jul 25;374(9686):324-39
pubmed: 19541364
J Leukoc Biol. 2018 May;103(5):821-828
pubmed: 29733502
Curr Biol. 2020 Aug 17;30(16):R921-R925
pubmed: 32810447
Nature. 2011 Jun 08;475(7355):222-5
pubmed: 21654748
Eur J Immunol. 2010 Dec;40(12):3347-57
pubmed: 21110318
Nat Immunol. 2021 Jun;22(6):769-780
pubmed: 34017122
Front Immunol. 2017 Nov 07;8:1444
pubmed: 29163516
Int J Cancer. 2021 Dec 15;149(12):1980-1996
pubmed: 34398972
Blood. 2010 Feb 11;115(6):1185-93
pubmed: 20008301
Front Oncol. 2020 Nov 20;10:587237
pubmed: 33330069
Front Immunol. 2018 Sep 26;9:2204
pubmed: 30319648
Front Oncol. 2021 Jul 08;11:684561
pubmed: 34307150
J Hematol Oncol. 2021 Apr 6;14(1):55
pubmed: 33823905
Leukemia. 2014 Feb;28(2):384-390
pubmed: 23817176
Blood. 2009 Oct 22;114(17):3625-8
pubmed: 19710503
J Hematol Oncol. 2019 Aug 22;12(1):84
pubmed: 31438991
J Immunol Res. 2021 Aug 6;2021:6344344
pubmed: 34414242
Blood. 2004 Jan 15;103(2):689-94
pubmed: 14512299
Leukemia. 2005 Mar;19(3):449-55
pubmed: 15674420
Blood. 2006 May 15;107(10):3940-9
pubmed: 16410445
J Natl Cancer Inst. 2013 Aug 21;105(16):1172-87
pubmed: 23852952
Curr Opin Pharmacol. 2009 Aug;9(4):447-53
pubmed: 19481975
Nat Immunol. 2003 Sep;4(9):815
pubmed: 12942076
Cancer Immunol Immunother. 2010 Jun;59(6):829-39
pubmed: 20024547
Expert Opin Biol Ther. 2013 Jun;13 Suppl 1:S83-93
pubmed: 23692463
Blood. 2015 Sep 17;126(12):1443-51
pubmed: 26185130
Immunol Today. 2000 Sep;21(9):455-64
pubmed: 10953098
Scand J Immunol. 2010 Dec;72(6):540-7
pubmed: 21044128
Nat Commun. 2016 Jul 06;7:12150
pubmed: 27381735
Drugs Context. 2021 Sep 21;10:
pubmed: 34603459
J Immunol. 2012 Apr 1;188(7):3188-98
pubmed: 22368274
J Clin Invest. 2012 Mar;122(3):787-95
pubmed: 22378047
Ther Adv Hematol. 2019 Jan 18;10:2040620718822660
pubmed: 30719268
Leukemia. 2013 Mar;27(3):702-10
pubmed: 22996336
Clin Lymphoma Myeloma Leuk. 2021 Nov;21(11):741-751
pubmed: 34253497
Eur J Immunol. 2010 Jul;40(7):1830-5
pubmed: 20583029
J Immunol. 2001 Jan 1;166(1):678-89
pubmed: 11123353
Ther Adv Hematol. 2019 Jun 18;10:2040620719854171
pubmed: 31244984
J Immunol. 2007 Jul 15;179(2):977-83
pubmed: 17617589
Semin Oncol Nurs. 2017 Aug;33(3):225-236
pubmed: 28688533
Cancer Discov. 2020 Apr;10(4):552-567
pubmed: 32001516
Blood. 2010 Sep 30;116(13):2286-94
pubmed: 20460501
Sci Transl Med. 2013 Feb 20;5(173):173ra23
pubmed: 23427243
PLoS One. 2017 Jan 20;12(1):e0169932
pubmed: 28107450
Immunity. 2014 Jul 17;41(1):49-61
pubmed: 25035953
N Engl J Med. 2011 Mar 17;364(11):1046-60
pubmed: 21410373
Annu Rev Immunol. 2004;22:329-60
pubmed: 15032581
Mol Med. 2001 Mar;7(3):149-58
pubmed: 11471551
Blood. 2001 Nov 15;98(10):2992-8
pubmed: 11698282
J Exp Med. 2012 Sep 24;209(10):1869-82
pubmed: 22927549
BMJ. 2020 Sep 21;370:m3176
pubmed: 32958461
J Immunother. 2020 Jul/Aug;43(6):175-188
pubmed: 32349046
Trends Mol Med. 2019 May;25(5):382-394
pubmed: 30853173
Cancers (Basel). 2021 Oct 18;13(20):
pubmed: 34680358
Blood. 2006 Oct 15;108(8):2655-61
pubmed: 16763205
Eur J Immunol. 1997 Sep;27(9):2245-52
pubmed: 9341766
Blood. 2006 Sep 1;108(5):1724-32
pubmed: 16705089
Leukemia. 2017 Oct;31(10):2181-2190
pubmed: 28119525
Clin Cancer Res. 2015 Feb 15;21(4):687-92
pubmed: 25501578
Front Oncol. 2021 Jun 09;11:670673
pubmed: 34178656
Leukemia. 2016 Aug;30(8):1716-24
pubmed: 27102208
Br J Haematol. 1992 Mar;80(3):305-9
pubmed: 1581210
Clin Dev Immunol. 2012;2012:293479
pubmed: 22489248
Blood. 2006 Mar 15;107(6):2432-9
pubmed: 16291589
Front Immunol. 2014 Jul 29;5:360
pubmed: 25120546
Leuk Res. 2005 Feb;29(2):135-40
pubmed: 15607360
Int J Mol Sci. 2019 Jul 19;20(14):
pubmed: 32565533
Leuk Lymphoma. 2010 May;51(5):920-7
pubmed: 20367137
J Immunol. 2009 Jan 1;182(1):240-9
pubmed: 19109155
Oncogene. 2008 Jan 24;27(5):663-74
pubmed: 17667938
Nat Rev Immunol. 2012 Mar 22;12(4):253-68
pubmed: 22437938
Clin Cancer Res. 2020 Feb 15;26(4):935-944
pubmed: 31558476
Front Immunol. 2021 Mar 09;12:636568
pubmed: 33767702