Obdulia Rabal

Affiliations

Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain.

Publications (14)

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia.

Nature communications

Avec: Edurne San José-Enériz , Naroa Gimenez-Camino , Obdulia Rabal , Leire Garate , Estibaliz Miranda , Nahia Gómez-Echarte , Fernando García , Stella Charalampopoulou , Elena Sáez , Amaia Vilas-Zornoza , Patxi San Martín-Uriz , Luis V Valcárcel , Naroa Barrena , Diego Alignani , Luis Esteban Tamariz-Amador , Ana Pérez-Ruiz , Sebastian Hilscher , Mike Schutkowski , Ana Alfonso-Pierola , Nicolás Martinez-Calle , María José Larrayoz , Bruno Paiva , María José Calasanz , Javier Muñoz , Marta Isasa , José Ignacio Martin-Subero , Antonio Pineda-Lucena , Julen Oyarzabal , Xabier Agirre , Felipe Prósper

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with

Journal of medicinal chemistry

Avec: Obdulia Rabal , Edurne San José-Enériz , Xabier Agirre , Juan Antonio Sánchez-Arias , Irene de Miguel , Raquel Ordoñez , Leire Garate , Estíbaliz Miranda , Elena Sáez , Amaia Vilas-Zornoza , Antonio Pineda-Lucena , Ander Estella , Feifei Zhang , Wei Wu , Musheng Xu , Felipe Prosper , Julen Oyarzabal

A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity.

Cancer letters

Avec: Carmen Vicente , Elena Arriazu , Elena Martínez-Balsalobre , Irene Peris , Nerea Marcotegui , Patricia García-Ramírez , Raffaella Pippa , Obdulia Rabal , Julen Oyarzábal , Elizabeth Guruceaga , Felipe Prósper , María C Mateos , María L Cayuela , María D Odero

Fine tuning for success in structure-based virtual screening.

Journal of computer-aided molecular design

Avec: Emilie Pihan , Martin Kotev , Obdulia Rabal , Claudia Beato , Constantino Diaz Gonzalez

Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.

ACS chemical neuroscience

Avec: Obdulia Rabal , Juan A Sánchez-Arias , Mar Cuadrado-Tejedor , Irene de Miguel , Marta Pérez-González , Carolina García-Barroso , Ana Ugarte , Ander Estella-Hermoso de Mendoza , Elena Sáez , Maria Espelosin , Susana Ursua , Tan Haizhong , Wu Wei , Xu Musheng , Ana Garcia-Osta , Julen Oyarzabal

Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles.

ACS chemical neuroscience

Avec: Obdulia Rabal , Juan A Sánchez-Arias , Mar Cuadrado-Tejedor , Irene de Miguel , Marta Pérez-González , Carolina García-Barroso , Ana Ugarte , Ander Estella-Hermoso de Mendoza , Elena Sáez , Maria Espelosin , Susana Ursua , Haizhong Tan , Wei Wu , Musheng Xu , Antonio Pineda-Lucena , Ana Garcia-Osta , Julen Oyarzabal

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors.

European journal of medicinal chemistry

Avec: Sonia Martínez-González , Sonsoles Rodríguez-Arístegui , Cristina Ana Gómez de la Oliva , Ana Isabel Hernández , Esther González Cantalapiedra , Carmen Varela , Ana Belén García , Obdulia Rabal , Julen Oyarzabal , James R Bischoff , Javier Klett , María Isabel Albarrán , Antonio Cebriá , Nuria Ajenjo , Beatriz García-Serelde , Elena Gómez-Casero , Manuel Cuadrado-Urbano , David Cebrián , Carmen Blanco-Aparicio , Joaquín Pastor

Towards the understanding of the activity of G9a inhibitors: an activity landscape and molecular modeling approach.

Journal of computer-aided molecular design

Avec: Edgar López-López , Obdulia Rabal , Julen Oyarzabal , José L Medina-Franco

MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes.

Translational stroke research

Avec: Manuel Navarro-Oviedo , Carmen Roncal , Agustina Salicio , Miriam Belzunce , Obdulia Rabal , Estefanía Toledo , Beatriz Zandio , Jose A Rodríguez , Jose A Páramo , Roberto Muñoz , Josune Orbe

Artificial Intelligence, Machine Learning, and Deep Learning in Real-Life Drug Design Cases.

Methods in molecular biology (Clifton, N.J.)

Avec: Christophe Muller , Obdulia Rabal , Constantino Diaz Gonzalez

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease.

Frontiers in aging neuroscience

Avec: Mar Cuadrado-Tejedor , Marta Pérez-González , Cristina García-Muñoz , Damián Muruzabal , Carolina García-Barroso , Obdulia Rabal , Víctor Segura , Juan A Sánchez-Arias , Julen Oyarzabal , Ana Garcia-Osta

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.

Nature medicine

Avec: Cristina Segovia , Edurne San José-Enériz , Ester Munera-Maravilla , Mónica Martínez-Fernández , Leire Garate , Estíbaliz Miranda , Amaia Vilas-Zornoza , Iris Lodewijk , Carolina Rubio , Carmen Segrelles , Luis Vitores Valcárcel , Obdulia Rabal , Noelia Casares , Alejandra Bernardini , Cristian Suarez-Cabrera , Fernando F López-Calderón , Puri Fortes , José A Casado , Marta Dueñas , Felipe Villacampa , Juan José Lasarte , Félix Guerrero-Ramos , Guillermo de Velasco , Julen Oyarzabal , Daniel Castellano , Xabier Agirre , Felipe Prósper , Jesús M Paramio

Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma.

Hepatology (Baltimore, Md.)

Avec: Marina Bárcena-Varela , Stefano Caruso , Susana Llerena , Gloria Álvarez-Sola , Iker Uriarte , M Ujue Latasa , Raquel Urtasun , Sandra Rebouissou , Laura Alvarez , Maddalen Jimenez , Eva Santamaría , Carlos Rodriguez-Ortigosa , Giuseppe Mazza , Krista Rombouts , Edurne San José-Eneriz , Obdulia Rabal , Xabier Agirre , Maria Iraburu , Alvaro Santos-Laso , Jesus M Banales , Jessica Zucman-Rossi , Felipe Prósper , Julen Oyarzabal , Carmen Berasain , Matías A Ávila , Maite G Fernández-Barrena

A toolkit for covalent docking with GOLD: from automated ligand preparation with KNIME to bound protein-ligand complexes.

Bioinformatics advances

Avec: Laurianne David , Anissa Mdahoma , Natesh Singh , Sébastien Buchoux , Emilie Pihan , Constantino Diaz , Obdulia Rabal

Réseau de co-auteurs

Julen Oyarzabal 9 collaborations

Elena Sáez 4 collaborations

Xabier Agirre 4 collaborations

Felipe Prósper 4 collaborations

Edurne San José-Enériz 3 collaborations

Leire Garate 3 collaborations

Amaia Vilas-Zornoza 3 collaborations

Antonio Pineda-Lucena 3 collaborations

Irene de Miguel 3 collaborations

Juan A Sánchez-Arias 3 collaborations

Mar Cuadrado-Tejedor 3 collaborations

Marta Pérez-González 3 collaborations

Carolina García-Barroso 3 collaborations

Ana Garcia-Osta 3 collaborations

Estíbaliz Miranda 2 collaborations

Wei Wu 2 collaborations

Musheng Xu 2 collaborations

Emilie Pihan 2 collaborations

Constantino Diaz Gonzalez 2 collaborations

Ana Ugarte 2 collaborations

Ander Estella-Hermoso de Mendoza 2 collaborations

Maria Espelosin 2 collaborations

Susana Ursua 2 collaborations

Naroa Gimenez-Camino 1 collaboration

Estibaliz Miranda 1 collaboration

Nahia Gómez-Echarte 1 collaboration

Fernando García 1 collaboration

Stella Charalampopoulou 1 collaboration

Patxi San Martín-Uriz 1 collaboration

Luis V Valcárcel 1 collaboration

Naroa Barrena 1 collaboration

Diego Alignani 1 collaboration

Luis Esteban Tamariz-Amador 1 collaboration

Ana Pérez-Ruiz 1 collaboration

Sebastian Hilscher 1 collaboration

Mike Schutkowski 1 collaboration

Ana Alfonso-Pierola 1 collaboration

Nicolás Martinez-Calle 1 collaboration

María José Larrayoz 1 collaboration

Bruno Paiva 1 collaboration

María José Calasanz 1 collaboration

Javier Muñoz 1 collaboration

Marta Isasa 1 collaboration

José Ignacio Martin-Subero 1 collaboration

Juan Antonio Sánchez-Arias 1 collaboration

Raquel Ordoñez 1 collaboration

Ander Estella 1 collaboration

Feifei Zhang 1 collaboration

Felipe Prosper 1 collaboration

Carmen Vicente 1 collaboration

Elena Arriazu 1 collaboration

Elena Martínez-Balsalobre 1 collaboration

Irene Peris 1 collaboration

Nerea Marcotegui 1 collaboration

Patricia García-Ramírez 1 collaboration

Raffaella Pippa 1 collaboration

Julen Oyarzábal 1 collaboration

Elizabeth Guruceaga 1 collaboration

María C Mateos 1 collaboration

María L Cayuela 1 collaboration

María D Odero 1 collaboration

Martin Kotev 1 collaboration

Claudia Beato 1 collaboration

Tan Haizhong 1 collaboration

Wu Wei 1 collaboration

Xu Musheng 1 collaboration

Haizhong Tan 1 collaboration

Sonia Martínez-González 1 collaboration

Sonsoles Rodríguez-Arístegui 1 collaboration

Cristina Ana Gómez de la Oliva 1 collaboration

Ana Isabel Hernández 1 collaboration

Esther González Cantalapiedra 1 collaboration

Carmen Varela 1 collaboration

Ana Belén García 1 collaboration

James R Bischoff 1 collaboration

Javier Klett 1 collaboration

María Isabel Albarrán 1 collaboration

Antonio Cebriá 1 collaboration

Nuria Ajenjo 1 collaboration

Beatriz García-Serelde 1 collaboration

Elena Gómez-Casero 1 collaboration

Manuel Cuadrado-Urbano 1 collaboration

David Cebrián 1 collaboration

Carmen Blanco-Aparicio 1 collaboration

Joaquín Pastor 1 collaboration

Edgar López-López 1 collaboration

José L Medina-Franco 1 collaboration

Manuel Navarro-Oviedo 1 collaboration

Carmen Roncal 1 collaboration

Agustina Salicio 1 collaboration

Miriam Belzunce 1 collaboration

Estefanía Toledo 1 collaboration

Beatriz Zandio 1 collaboration

Jose A Rodríguez 1 collaboration

Jose A Páramo 1 collaboration

Roberto Muñoz 1 collaboration

Josune Orbe 1 collaboration

Christophe Muller 1 collaboration

Cristina García-Muñoz 1 collaboration

Damián Muruzabal 1 collaboration

Víctor Segura 1 collaboration

Cristina Segovia 1 collaboration

Ester Munera-Maravilla 1 collaboration

Mónica Martínez-Fernández 1 collaboration

Iris Lodewijk 1 collaboration

Carolina Rubio 1 collaboration

Carmen Segrelles 1 collaboration

Luis Vitores Valcárcel 1 collaboration

Noelia Casares 1 collaboration

Alejandra Bernardini 1 collaboration

Cristian Suarez-Cabrera 1 collaboration

Fernando F López-Calderón 1 collaboration

Puri Fortes 1 collaboration

José A Casado 1 collaboration

Marta Dueñas 1 collaboration

Felipe Villacampa 1 collaboration

Juan José Lasarte 1 collaboration

Félix Guerrero-Ramos 1 collaboration

Guillermo de Velasco 1 collaboration

Daniel Castellano 1 collaboration

Jesús M Paramio 1 collaboration

Marina Bárcena-Varela 1 collaboration

Stefano Caruso 1 collaboration

Susana Llerena 1 collaboration

Gloria Álvarez-Sola 1 collaboration

Iker Uriarte 1 collaboration

M Ujue Latasa 1 collaboration

Raquel Urtasun 1 collaboration

Sandra Rebouissou 1 collaboration

Laura Alvarez 1 collaboration

Maddalen Jimenez 1 collaboration

Eva Santamaría 1 collaboration

Carlos Rodriguez-Ortigosa 1 collaboration

Giuseppe Mazza 1 collaboration

Krista Rombouts 1 collaboration

Edurne San José-Eneriz 1 collaboration

Maria Iraburu 1 collaboration

Alvaro Santos-Laso 1 collaboration

Jesus M Banales 1 collaboration

Jessica Zucman-Rossi 1 collaboration

Carmen Berasain 1 collaboration

Matías A Ávila 1 collaboration

Maite G Fernández-Barrena 1 collaboration

Laurianne David 1 collaboration

Anissa Mdahoma 1 collaboration

Natesh Singh 1 collaboration

Sébastien Buchoux 1 collaboration

Constantino Diaz 1 collaboration