Sebastian Hilscher

Affiliations

Faculty of Biosciences, Martin-Luther-University of Halle-Wittenberg, 06120, Halle/Saale, Germany.

Publications (9)

1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors.

Scientific reports

Avec: Maurício T Tavares , Arne Krüger , Sun L Rei Yan , Karoline B Waitman , Vinícius M Gomes , Daffiny Sumam de Oliveira , Franciarli Paz , Sebastian Hilscher , Mike Schutkowski , Wolfgang Sippl , Claudia Ruiz , Mônica F Z J Toledo , Neuza M A Hassimotto , João A Machado-Neto , Antti Poso , Michael D Cameron , Thomas D Bannister , Giuseppe Palmisano , Carsten Wrenger , Thales Kronenberger , Roberto Parise-Filho

Probing class I histone deacetylases (HDAC) with proteolysis targeting chimera (PROTAC) for the development of highly potent and selective degraders.

Bioorganic chemistry

Avec: Hany S Ibrahim , Menglu Guo , Sebatian Hilscher , Frank Erdmann , Matthias Schmidt , Mike Schutkowski , Chunquan Sheng , Wolfgang Sippl

Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.

Archiv der Pharmazie

Avec: Fady Baselious , Sebastian Hilscher , Sven Hagemann , Sunita Tripathee , Dina Robaa , Cyril Barinka , Stefan Hüttelmaier , Mike Schutkowski , Wolfgang Sippl

Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells.

Archiv der Pharmazie

Avec: Mohamed Abdelsalam , Mariia Zmyslia , Karin Schmidtkunz , Anita Vecchio , Sebastian Hilscher , Hany S Ibrahim , Mike Schutkowski , Manfred Jung , Claudia Jessen-Trefzer , Wolfgang Sippl

Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.

Journal of medicinal chemistry

Avec: Laura Sinatra , Anja Vogelmann , Florian Friedrich , Margarita A Tararina , Emilia Neuwirt , Arianna Colcerasa , Philipp König , Lara Toy , Talha Z Yesiloglu , Sebastian Hilscher , Lena Gaitzsch , Niklas Papenkordt , Shiyang Zhai , Lin Zhang , Christophe Romier , Oliver Einsle , Wolfgang Sippl , Mike Schutkowski , Olaf Gross , Gerd Bendas , David W Christianson , Finn K Hansen , Manfred Jung , Matthias Schiedel

Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines.

International journal of molecular sciences

Avec: Matthes Zessin , Marat Meleshin , Sebastian Hilscher , Cordelia Schiene-Fischer , Cyril Barinka , Manfred Jung , Mike Schutkowski

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

International journal of molecular sciences

Avec: Fady Baselious , Sebastian Hilscher , Dina Robaa , Cyril Barinka , Mike Schutkowski , Wolfgang Sippl

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia.

Nature communications

Avec: Edurne San José-Enériz , Naroa Gimenez-Camino , Obdulia Rabal , Leire Garate , Estibaliz Miranda , Nahia Gómez-Echarte , Fernando García , Stella Charalampopoulou , Elena Sáez , Amaia Vilas-Zornoza , Patxi San Martín-Uriz , Luis V Valcárcel , Naroa Barrena , Diego Alignani , Luis Esteban Tamariz-Amador , Ana Pérez-Ruiz , Sebastian Hilscher , Mike Schutkowski , Ana Alfonso-Pierola , Nicolás Martinez-Calle , María José Larrayoz , Bruno Paiva , María José Calasanz , Javier Muñoz , Marta Isasa , José Ignacio Martin-Subero , Antonio Pineda-Lucena , Julen Oyarzabal , Xabier Agirre , Felipe Prósper

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells.

Archiv der Pharmazie

Avec: Francesco Berluti , Fady Baselious , Sven Hagemann , Sebastian Hilscher , Matthias Schmidt , Stefan Hüttelmaier , Mike Schutkowski , Wolfgang Sippl , Hany S Ibrahim

Réseau de co-auteurs

Mike Schutkowski 9 collaborations

Wolfgang Sippl 7 collaborations

Hany S Ibrahim 3 collaborations

Fady Baselious 3 collaborations

Cyril Barinka 3 collaborations

Manfred Jung 3 collaborations

Matthias Schmidt 2 collaborations

Sven Hagemann 2 collaborations

Dina Robaa 2 collaborations

Stefan Hüttelmaier 2 collaborations

Maurício T Tavares 1 collaboration

Arne Krüger 1 collaboration

Sun L Rei Yan 1 collaboration

Karoline B Waitman 1 collaboration

Vinícius M Gomes 1 collaboration

Daffiny Sumam de Oliveira 1 collaboration

Franciarli Paz 1 collaboration

Claudia Ruiz 1 collaboration

Mônica F Z J Toledo 1 collaboration

Neuza M A Hassimotto 1 collaboration

João A Machado-Neto 1 collaboration

Antti Poso 1 collaboration

Michael D Cameron 1 collaboration

Thomas D Bannister 1 collaboration

Giuseppe Palmisano 1 collaboration

Carsten Wrenger 1 collaboration

Thales Kronenberger 1 collaboration

Roberto Parise-Filho 1 collaboration

Menglu Guo 1 collaboration

Sebatian Hilscher 1 collaboration

Frank Erdmann 1 collaboration

Chunquan Sheng 1 collaboration

Sunita Tripathee 1 collaboration

Mohamed Abdelsalam 1 collaboration

Mariia Zmyslia 1 collaboration

Karin Schmidtkunz 1 collaboration

Anita Vecchio 1 collaboration

Claudia Jessen-Trefzer 1 collaboration

Laura Sinatra 1 collaboration

Anja Vogelmann 1 collaboration

Florian Friedrich 1 collaboration

Margarita A Tararina 1 collaboration

Emilia Neuwirt 1 collaboration

Arianna Colcerasa 1 collaboration

Philipp König 1 collaboration

Lara Toy 1 collaboration

Talha Z Yesiloglu 1 collaboration

Lena Gaitzsch 1 collaboration

Niklas Papenkordt 1 collaboration

Shiyang Zhai 1 collaboration

Lin Zhang 1 collaboration

Christophe Romier 1 collaboration

Oliver Einsle 1 collaboration

Olaf Gross 1 collaboration

Gerd Bendas 1 collaboration

David W Christianson 1 collaboration

Finn K Hansen 1 collaboration

Matthias Schiedel 1 collaboration

Matthes Zessin 1 collaboration

Marat Meleshin 1 collaboration

Cordelia Schiene-Fischer 1 collaboration

Edurne San José-Enériz 1 collaboration

Naroa Gimenez-Camino 1 collaboration

Obdulia Rabal 1 collaboration

Leire Garate 1 collaboration

Estibaliz Miranda 1 collaboration

Nahia Gómez-Echarte 1 collaboration

Fernando García 1 collaboration

Stella Charalampopoulou 1 collaboration

Elena Sáez 1 collaboration

Amaia Vilas-Zornoza 1 collaboration

Patxi San Martín-Uriz 1 collaboration

Luis V Valcárcel 1 collaboration

Naroa Barrena 1 collaboration

Diego Alignani 1 collaboration

Luis Esteban Tamariz-Amador 1 collaboration

Ana Pérez-Ruiz 1 collaboration

Ana Alfonso-Pierola 1 collaboration

Nicolás Martinez-Calle 1 collaboration

María José Larrayoz 1 collaboration

Bruno Paiva 1 collaboration

María José Calasanz 1 collaboration

Javier Muñoz 1 collaboration

Marta Isasa 1 collaboration

José Ignacio Martin-Subero 1 collaboration

Antonio Pineda-Lucena 1 collaboration

Julen Oyarzabal 1 collaboration

Xabier Agirre 1 collaboration

Felipe Prósper 1 collaboration

Francesco Berluti 1 collaboration