Christophe Romier

Affiliations

Département de Biologie Structurale Intégrative Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS, INSERM, 1 rue Laurent Fries, 67404, Illkirch Cedex, France.

Publications (25)

Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.

ChemMedChem

Avec: Dmitrii V Kalinin , Sunit K Jana , Maxim Pfafenrot , Alokta Chakrabarti , Jelena Melesina , Tajith B Shaik , Julien Lancelot , Raymond J Pierce , Wolfgang Sippl , Christophe Romier , Manfred Jung , Ralph Holl

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.

European journal of medicinal chemistry

Avec: Ehab Ghazy , Patrik Zeyen , Daniel Herp , Martin Hügle , Karin Schmidtkunz , Frank Erdmann , Dina Robaa , Matthias Schmidt , Elizabeth R Morales , Christophe Romier , Stefan Günther , Manfred Jung , Wolfgang Sippl

Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.

Journal of medicinal chemistry

Avec: Laura Sinatra , Anja Vogelmann , Florian Friedrich , Margarita A Tararina , Emilia Neuwirt , Arianna Colcerasa , Philipp König , Lara Toy , Talha Z Yesiloglu , Sebastian Hilscher , Lena Gaitzsch , Niklas Papenkordt , Shiyang Zhai , Lin Zhang , Christophe Romier , Oliver Einsle , Wolfgang Sippl , Mike Schutkowski , Olaf Gross , Gerd Bendas , David W Christianson , Finn K Hansen , Manfred Jung , Matthias Schiedel

Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.

ChemMedChem

Avec: Beatrice Noce , Elisabetta Di Bello , Clemens Zwergel , Rossella Fioravanti , Sergio Valente , Dante Rotili , Andrea Masotti , Mohammad Salik Zeya Ansari , Daniela Trisciuoglio , Alokta Chakrabarti , Christophe Romier , Dina Robaa , Wolfgang Sippl , Manfred Jung , Cécile Häberli , Jennifer Keiser , Antonello Mai

The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains.

Cell reports

Avec: Marina Vitoria Gomes , Pauline Landwerlin , Marie-Laure Diebold-Durand , Tajith B Shaik , Alexandre Durand , Edouard Troesch , Chantal Weber , Karl Brillet , Marianne Victoria Lemée , Christophe Decroos , Ludivine Dulac , Pierre Antony , Erwan Watrin , Eric Ennifar , Christelle Golzio , Christophe Romier

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

Journal of medicinal chemistry

Avec: Katharina Vögerl , Nghia Ong , Johanna Senger , Daniel Herp , Karin Schmidtkunz , Martin Marek , Martin Müller , Karin Bartel , Tajith B Shaik , Nicholas J Porter , Dina Robaa , David W Christianson , Christophe Romier , Wolfgang Sippl , Manfred Jung , Franz Bracher

Biologie aujourd'hui

Avec: Pierre Antony , Sylvie Fournel , Joffrey Zoll , Jean-Marie Mantz , Katia Befort , Dominique Massotte , Philippe Giégé , Jocelyn Céraline , Daniel Metzger , Hubert Becker , Laurence Drouard , Catherine Florentz , Robert Martin , Canan Nébigil , Serge Potier , Adrien Schaefer , Evelyne Schaeffer , Catherine Schuster , Anne Bresson , Eric Quéméneur , Laurence Choulier , Nicolas Matt , Laurent Monassier , Claire Lugnier , Louis Freysz , Jules Hoffmann , Henri Dreyfus , Christophe Romier

In cellulo and in vivo assays for compound testing against Trypanosoma cruzi.

STAR protocols

Avec: Eloise Pavão Guerra-Slompo , Gisele Fernanda Assine Picchi-Constante , Martin Marek , Christophe Romier , Wolfgang Sippl , Nilson Ivo Tonin Zanchin

Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.

Journal of medicinal chemistry

Avec: Ping Sun , Jing Wang , Khadija S Khan , Weiqin Yang , Billy Wai-Lung Ng , Nikita Ilment , Matthes Zessin , Emre F Bülbül , Dina Robaa , Frank Erdmann , Matthias Schmidt , Christophe Romier , Mike Schutkowski , Alfred Sze-Lok Cheng , Wolfgang Sippl

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.

European journal of medicinal chemistry

Avec: Patrik Zeyen , Yanira Zeyn , Daniel Herp , Fereshteh Mahmoudi , Talha Z Yesiloglu , Frank Erdmann , Matthias Schmidt , Dina Robaa , Christophe Romier , Johannes Ridinger , Corey J Herbst-Gervasoni , David W Christianson , Ina Oehme , Manfred Jung , Oliver H Krämer , Wolfgang Sippl

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.

Chembiochem : a European journal of chemical biology

Avec: Daniel Herp , Johannes Ridinger , Dina Robaa , Stephen A Shinsky , Karin Schmidtkunz , Talha Z Yesiloglu , Theresa Bayer , Raphael R Steimbach , Corey J Herbst-Gervasoni , Annika Merz , Christophe Romier , Peter Sehr , Nikolas Gunkel , Aubry K Miller , David W Christianson , Ina Oehme , Wolfgang Sippl , Manfred Jung

Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in

STAR protocols

Avec: Gisele Fernanda Assine Picchi-Constante , Priscila Mazzocchi Hiraiwa , Martin Marek , Vanessa Zulkievicz Rogerio , Eloise Pavão Guerra-Slompo , Christophe Romier , Nilson Ivo Tonin Zanchin

Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.

International journal of molecular sciences

Avec: Hany S Ibrahim , Mohamed Abdelsalam , Yanira Zeyn , Matthes Zessin , Al-Hassan M Mustafa , Marten A Fischer , Patrik Zeyen , Ping Sun , Emre F Bülbül , Anita Vecchio , Frank Erdmann , Matthias Schmidt , Dina Robaa , Cyril Barinka , Christophe Romier , Mike Schutkowski , Oliver H Krämer , Wolfgang Sippl

Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD

Journal of medicinal chemistry

Avec: Arianna Colcerasa , Florian Friedrich , Jelena Melesina , Patrick Moser , Anja Vogelmann , Pavlos Tzortzoglou , Emilia Neuwirt , Manuela Sum , Dina Robaa , Lin Zhang , Elizabeth Ramos-Morales , Christophe Romier , Oliver Einsle , Eric Metzger , Roland Schüle , Olaf Groß , Wolfgang Sippl , Manfred Jung

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from

Journal of medicinal chemistry

Avec: Daria Monaldi , Dante Rotili , Julien Lancelot , Martin Marek , Nathalie Wössner , Alessia Lucidi , Daniela Tomaselli , Elizabeth Ramos-Morales , Christophe Romier , Raymond J Pierce , Antonello Mai , Manfred Jung

Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.

European journal of medicinal chemistry

Avec: Ehab Ghazy , Tino Heimburg , Julien Lancelot , Patrik Zeyen , Karin Schmidtkunz , Anne Truhn , Salma Darwish , Conrad V Simoben , Tajith B Shaik , Frank Erdmann , Matthias Schmidt , Dina Robaa , Christophe Romier , Manfred Jung , Raymond Pierce , Wolfgang Sippl

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.

Nucleic acids research

Avec: Elizabeth Ramos-Morales , Efil Bayam , Jordi Del-Pozo-Rodríguez , Thalia Salinas-Giegé , Martin Marek , Peggy Tilly , Philippe Wolff , Edouard Troesch , Eric Ennifar , Laurence Drouard , Juliette D Godin , Christophe Romier

Neurodevelopmental disorders associated variants in

medRxiv : the preprint server for health sciences

Avec: Jordi Del-Pozo-Rodriguez , Peggy Tilly , Romain Lecat , Hugo Rolando Vaca , Laureline Mosser , Till Balla , Marina Vitoria Gomes , Elizabeth Ramos-Morales , Elena Brivio , Thalia Salinas-Giégé , Grace VanNoy , Eleina M England , Alysia Kern Lovgren , Melanie O'Leary , Maya Chopra , Dustin Gable , Aisha Alnuzha , Mona Kamel , Nihal Almenabawy , Anne O'Donnell-Luria , Jennifer E Neil , Joseph G Gleeson , Christopher A Walsh , Nour Elkhateeb , Laila Selim , Siddharth Srivastava , Danny D Nedialkova , Laurence Drouard , Christophe Romier , Efil Bayam , Juliette D Godin

Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras.

Methods in molecular biology (Clifton, N.J.)

Avec: Salma Darwish , Tino Heimburg , Johannes Ridinger , Daniel Herp , Matthias Schmidt , Christophe Romier , Manfred Jung , Ina Oehme , Wolfgang Sippl

Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of

Molecules (Basel, Switzerland)

Avec: Conrad V Simoben , Ehab Ghazy , Patrik Zeyen , Salma Darwish , Matthias Schmidt , Christophe Romier , Dina Robaa , Wolfgang Sippl

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.

Nature communications

Avec: Sébastien Coassolo , Guillaume Davidson , Luc Negroni , Giovanni Gambi , Sylvain Daujat , Christophe Romier , Irwin Davidson

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.

Biochemistry

Avec: Matthes Zessin , Zsófia Kutil , Marat Meleshin , Zora Nováková , Ehab Ghazy , Diana Kalbas , Martin Marek , Christophe Romier , Wolfgang Sippl , Cyril Bařinka , Mike Schutkowski

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.

Cell reports

Avec: Martin Marek , Elizabeth Ramos-Morales , Gisele F A Picchi-Constante , Theresa Bayer , Carina Norström , Daniel Herp , Policarpo A Sales-Junior , Eloise P Guerra-Slompo , Kristin Hausmann , Alokta Chakrabarti , Tajith B Shaik , Annika Merz , Edouard Troesch , Karin Schmidtkunz , Samuel Goldenberg , Raymond J Pierce , Marina M Mourão , Manfred Jung , Johan Schultz , Wolfgang Sippl , Nilson I T Zanchin , Christophe Romier

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.

International journal of molecular sciences

Avec: Salma Darwish , Ehab Ghazy , Tino Heimburg , Daniel Herp , Patrik Zeyen , Rabia Salem-Altintas , Johannes Ridinger , Dina Robaa , Karin Schmidtkunz , Frank Erdmann , Matthias Schmidt , Christophe Romier , Manfred Jung , Ina Oehme , Wolfgang Sippl

Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni.

ChemMedChem

Avec: Muhammad Murtaza Hassan , Abootaleb Sedighi , Olasunkanmi O Olaoye , Cécile Häberli , Annika Merz , Elizabeth Ramos-Morales , Elvin D de Araujo , Christophe Romier , Manfred Jung , Jennifer Keiser , Patrick T Gunning

Réseau de co-auteurs

Wolfgang Sippl 17 collaborations

Manfred Jung 14 collaborations

Dina Robaa 11 collaborations

Matthias Schmidt 8 collaborations

Daniel Herp 7 collaborations

Martin Marek 7 collaborations

Patrik Zeyen 6 collaborations

Karin Schmidtkunz 6 collaborations

Frank Erdmann 6 collaborations

Elizabeth Ramos-Morales 6 collaborations

Tajith B Shaik 5 collaborations

Ehab Ghazy 5 collaborations

Mike Schutkowski 4 collaborations

David W Christianson 4 collaborations

Johannes Ridinger 4 collaborations

Ina Oehme 4 collaborations

Salma Darwish 4 collaborations

Alokta Chakrabarti 3 collaborations

Julien Lancelot 3 collaborations

Raymond J Pierce 3 collaborations

Talha Z Yesiloglu 3 collaborations

Edouard Troesch 3 collaborations

Laurence Drouard 3 collaborations

Matthes Zessin 3 collaborations

Annika Merz 3 collaborations

Tino Heimburg 3 collaborations

Jelena Melesina 2 collaborations

Anja Vogelmann 2 collaborations

Florian Friedrich 2 collaborations

Emilia Neuwirt 2 collaborations

Arianna Colcerasa 2 collaborations

Lin Zhang 2 collaborations

Oliver Einsle 2 collaborations

Dante Rotili 2 collaborations

Cécile Häberli 2 collaborations

Jennifer Keiser 2 collaborations

Antonello Mai 2 collaborations

Marina Vitoria Gomes 2 collaborations

Pierre Antony 2 collaborations

Eric Ennifar 2 collaborations

Eloise Pavão Guerra-Slompo 2 collaborations

Gisele Fernanda Assine Picchi-Constante 2 collaborations

Nilson Ivo Tonin Zanchin 2 collaborations

Ping Sun 2 collaborations

Emre F Bülbül 2 collaborations

Yanira Zeyn 2 collaborations

Corey J Herbst-Gervasoni 2 collaborations

Oliver H Krämer 2 collaborations

Theresa Bayer 2 collaborations

Conrad V Simoben 2 collaborations

Efil Bayam 2 collaborations

Peggy Tilly 2 collaborations

Juliette D Godin 2 collaborations

Dmitrii V Kalinin 1 collaboration

Sunit K Jana 1 collaboration

Maxim Pfafenrot 1 collaboration

Ralph Holl 1 collaboration

Martin Hügle 1 collaboration

Elizabeth R Morales 1 collaboration

Stefan Günther 1 collaboration

Laura Sinatra 1 collaboration

Margarita A Tararina 1 collaboration

Philipp König 1 collaboration

Lara Toy 1 collaboration

Sebastian Hilscher 1 collaboration

Lena Gaitzsch 1 collaboration

Niklas Papenkordt 1 collaboration

Shiyang Zhai 1 collaboration

Olaf Gross 1 collaboration

Gerd Bendas 1 collaboration

Finn K Hansen 1 collaboration

Matthias Schiedel 1 collaboration

Beatrice Noce 1 collaboration

Elisabetta Di Bello 1 collaboration

Clemens Zwergel 1 collaboration

Rossella Fioravanti 1 collaboration

Sergio Valente 1 collaboration

Andrea Masotti 1 collaboration

Mohammad Salik Zeya Ansari 1 collaboration

Daniela Trisciuoglio 1 collaboration

Pauline Landwerlin 1 collaboration

Marie-Laure Diebold-Durand 1 collaboration

Alexandre Durand 1 collaboration

Chantal Weber 1 collaboration

Karl Brillet 1 collaboration

Marianne Victoria Lemée 1 collaboration

Christophe Decroos 1 collaboration

Ludivine Dulac 1 collaboration

Erwan Watrin 1 collaboration

Christelle Golzio 1 collaboration

Katharina Vögerl 1 collaboration

Nghia Ong 1 collaboration

Johanna Senger 1 collaboration

Martin Müller 1 collaboration

Karin Bartel 1 collaboration

Nicholas J Porter 1 collaboration

Franz Bracher 1 collaboration

Sylvie Fournel 1 collaboration

Joffrey Zoll 1 collaboration

Jean-Marie Mantz 1 collaboration

Katia Befort 1 collaboration

Dominique Massotte 1 collaboration

Philippe Giégé 1 collaboration

Jocelyn Céraline 1 collaboration

Daniel Metzger 1 collaboration

Hubert Becker 1 collaboration

Catherine Florentz 1 collaboration

Robert Martin 1 collaboration

Canan Nébigil 1 collaboration

Serge Potier 1 collaboration

Adrien Schaefer 1 collaboration

Evelyne Schaeffer 1 collaboration

Catherine Schuster 1 collaboration

Anne Bresson 1 collaboration

Eric Quéméneur 1 collaboration

Laurence Choulier 1 collaboration

Nicolas Matt 1 collaboration

Laurent Monassier 1 collaboration

Claire Lugnier 1 collaboration

Louis Freysz 1 collaboration

Jules Hoffmann 1 collaboration

Henri Dreyfus 1 collaboration

Jing Wang 1 collaboration

Khadija S Khan 1 collaboration

Weiqin Yang 1 collaboration

Billy Wai-Lung Ng 1 collaboration

Nikita Ilment 1 collaboration

Alfred Sze-Lok Cheng 1 collaboration

Fereshteh Mahmoudi 1 collaboration

Stephen A Shinsky 1 collaboration

Raphael R Steimbach 1 collaboration

Peter Sehr 1 collaboration

Nikolas Gunkel 1 collaboration

Aubry K Miller 1 collaboration

Priscila Mazzocchi Hiraiwa 1 collaboration

Vanessa Zulkievicz Rogerio 1 collaboration

Hany S Ibrahim 1 collaboration

Mohamed Abdelsalam 1 collaboration

Al-Hassan M Mustafa 1 collaboration

Marten A Fischer 1 collaboration

Anita Vecchio 1 collaboration

Cyril Barinka 1 collaboration

Patrick Moser 1 collaboration

Pavlos Tzortzoglou 1 collaboration

Manuela Sum 1 collaboration

Eric Metzger 1 collaboration

Roland Schüle 1 collaboration

Olaf Groß 1 collaboration

Daria Monaldi 1 collaboration

Nathalie Wössner 1 collaboration

Alessia Lucidi 1 collaboration

Daniela Tomaselli 1 collaboration

Anne Truhn 1 collaboration

Raymond Pierce 1 collaboration

Jordi Del-Pozo-Rodríguez 1 collaboration

Thalia Salinas-Giegé 1 collaboration

Philippe Wolff 1 collaboration

Jordi Del-Pozo-Rodriguez 1 collaboration

Romain Lecat 1 collaboration

Hugo Rolando Vaca 1 collaboration

Laureline Mosser 1 collaboration

Till Balla 1 collaboration

Elena Brivio 1 collaboration

Thalia Salinas-Giégé 1 collaboration

Grace VanNoy 1 collaboration

Eleina M England 1 collaboration

Alysia Kern Lovgren 1 collaboration

Melanie O'Leary 1 collaboration

Maya Chopra 1 collaboration

Dustin Gable 1 collaboration

Aisha Alnuzha 1 collaboration

Mona Kamel 1 collaboration

Nihal Almenabawy 1 collaboration

Anne O'Donnell-Luria 1 collaboration

Jennifer E Neil 1 collaboration

Joseph G Gleeson 1 collaboration

Christopher A Walsh 1 collaboration

Nour Elkhateeb 1 collaboration

Laila Selim 1 collaboration

Siddharth Srivastava 1 collaboration

Danny D Nedialkova 1 collaboration

Sébastien Coassolo 1 collaboration

Guillaume Davidson 1 collaboration

Luc Negroni 1 collaboration

Giovanni Gambi 1 collaboration

Sylvain Daujat 1 collaboration

Irwin Davidson 1 collaboration

Zsófia Kutil 1 collaboration

Marat Meleshin 1 collaboration

Zora Nováková 1 collaboration

Diana Kalbas 1 collaboration

Cyril Bařinka 1 collaboration

Gisele F A Picchi-Constante 1 collaboration

Carina Norström 1 collaboration

Policarpo A Sales-Junior 1 collaboration

Eloise P Guerra-Slompo 1 collaboration

Kristin Hausmann 1 collaboration

Samuel Goldenberg 1 collaboration

Marina M Mourão 1 collaboration

Johan Schultz 1 collaboration

Nilson I T Zanchin 1 collaboration

Rabia Salem-Altintas 1 collaboration

Muhammad Murtaza Hassan 1 collaboration

Abootaleb Sedighi 1 collaboration

Olasunkanmi O Olaoye 1 collaboration

Elvin D de Araujo 1 collaboration

Patrick T Gunning 1 collaboration