Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.

Mice Animals Histone Deacetylase Inhibitors / pharmacology Repressor Proteins Mice, Inbred C57BL Histone Deacetylases / metabolism Hydrazines

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 12 2022
Historique:
pubmed: 1 12 2022
medline: 24 12 2022
entrez: 30 11 2022
Statut: ppublish

Résumé

Histone deacetylases (HDACs) are epigenetic regulators and additionally control the activity of non-histone substrates. We recently demonstrated that inhibition of HDAC8 overexpressed in various of cancers reduces hepatocellular carcinoma tumorigenicity in a T cell-dependent manner. Here, we present alkylated hydrazide-based class I HDAC inhibitors in which the

Identifiants

DOI: 10.1021/acs.jmedchem.2c01132 PMID: 36449385
pubmed: 36449385
doi: 10.1021/acs.jmedchem.2c01132
doi:

Substances chimiques

Histone Deacetylase Inhibitors 0
Repressor Proteins 0
Histone Deacetylases EC 3.5.1.98
Hydrazines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16313-16337

Auteurs

Ping Sun (P)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.

Jing Wang (J)

School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.

Khadija S Khan (KS)

School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
School of Pharmacy, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.

Weiqin Yang (W)

School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.

Billy Wai-Lung Ng (BW)

School of Pharmacy, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
ORCID: 0000-0003-2892-6318

Nikita Ilment (N)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
ORCID: 0000-0003-0675-8536

Matthes Zessin (M)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.

Emre F Bülbül (EF)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.

Dina Robaa (D)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.

Frank Erdmann (F)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.

Matthias Schmidt (M)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.

Christophe Romier (C)

Département de Biologie Structurale Intégrative, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS, INSERM, 67404 Illkirch Cedex, France.
ORCID: 0000-0002-3680-935X

Mike Schutkowski (M)

Department of Enzymology, Institute of Biotechnology, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
ORCID: 0000-0003-0919-7076

Alfred Sze-Lok Cheng (AS)

School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.

Wolfgang Sippl (W)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
ORCID: 0000-0002-5985-9261

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Development of Alkylated Hydrazides as Highly...
questionsmedicales.fr › Eucaryotes › Animaux › Development of Alkylated Hydrazides as Highly...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › Development of Alkylated Hydrazides as Highly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Development of Alkylated Hydrazides as Highly...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Development of Alkylated Hydrazides as Highly...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Histone deacetylases › Development of Alkylated Hydrazides as Highly...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › Development of Alkylated Hydrazides as Highly...