Dina Robaa

Affiliations

Institute of Pharmacy , Martin-Luther-University Halle-Wittenberg , Wolfgang-Langenbeck-Straße 4 , 06120 Halle (Saale) , Germany.

Publications (32)

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.

ACS chemical biology

Avec: Martin Roatsch , Inga Hoffmann , Martine I Abboud , Rebecca L Hancock , Hanna Tarhonskaya , Kuo-Feng Hsu , Sarah E Wilkins , Tzu-Lan Yeh , Kerstin Lippl , Kerstin Serrer , Isabelle Moneke , Theresa D Ahrens , Dina Robaa , Sandra Wenzler , Nicolas P F Barthes , Henriette Franz , Wolfgang Sippl , Silke Lassmann , Sven Diederichs , Erik Schleicher , Christopher J Schofield , Akane Kawamura , Roland Schüle , Manfred Jung

HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*.

Chembiochem : a European journal of chemical biology

Avec: Matthias Schiedel , Attila Lehotzky , Sandor Szunyogh , Judit Oláh , Sören Hammelmann , Nathalie Wössner , Dina Robaa , Oliver Einsle , Wolfgang Sippl , Judit Ovádi , Manfred Jung

Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.

European journal of medicinal chemistry

Avec: Ehab Ghazy , Tino Heimburg , Julien Lancelot , Patrik Zeyen , Karin Schmidtkunz , Anne Truhn , Salma Darwish , Conrad V Simoben , Tajith B Shaik , Frank Erdmann , Matthias Schmidt , Dina Robaa , Christophe Romier , Manfred Jung , Raymond Pierce , Wolfgang Sippl

Strategies To Design Selective Histone Deacetylase Inhibitors.

ChemMedChem

Avec: Jelena Melesina , Conrad V Simoben , Lucas Praetorius , Emre F Bülbül , Dina Robaa , Wolfgang Sippl

Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors.

International journal of molecular sciences

Avec: Chiara Luise , Dina Robaa , Pierre Regenass , David Maurer , Dmytro Ostrovskyi , Ludwig Seifert , Johannes Bacher , Teresa Burgahn , Tobias Wagner , Johannes Seitz , Holger Greschik , Kwang-Su Park , Yan Xiong , Jian Jin , Roland Schüle , Bernhard Breit , Manfred Jung , Wolfgang Sippl

Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of

Molecules (Basel, Switzerland)

Avec: Conrad V Simoben , Ehab Ghazy , Patrik Zeyen , Salma Darwish , Matthias Schmidt , Christophe Romier , Dina Robaa , Wolfgang Sippl

Preclinical Evaluation of Benzazepine-Based PET Radioligands (

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Avec: Ahmed Haider , Adrienne Müller Herde , Stefanie D Krämer , Jasmine Varisco , Claudia Keller , Katrin Frauenknecht , Yves P Auberson , Louisa Temme , Dina Robaa , Wolfgang Sippl , Roger Schibli , Bernhard Wünsch , Linjing Mu , Simon M Ametamey

Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.

Bioorganic & medicinal chemistry

Avec: Sigrid Schwarthoff , Nicolas Tischer , Henrike Sager , Bianca Schätz , Marius M Rohrbach , Ihar Raztsou , Dina Robaa , Friedemann Gaube , Hans-Dieter Arndt , Thomas Winckler

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.

International journal of molecular sciences

Avec: Salma Darwish , Ehab Ghazy , Tino Heimburg , Daniel Herp , Patrik Zeyen , Rabia Salem-Altintas , Johannes Ridinger , Dina Robaa , Karin Schmidtkunz , Frank Erdmann , Matthias Schmidt , Christophe Romier , Manfred Jung , Ina Oehme , Wolfgang Sippl

Fatty Acid Binding to the Human Transport Proteins FABP3, FABP4, and FABP5 from a Ligand's Perspective.

The Journal of biological chemistry

Avec: Sebastian Michler , Florian Arndt Schöffmann , Dina Robaa , Jonas Volmer , Dariush Hinderberger

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.

PLoS neglected tropical diseases

Avec: Vitor Coutinho Carneiro , Isabel Caetano de Abreu da Silva , Murilo Sena Amaral , Adriana S A Pereira , Gilbert Oliveira Silveira , David da Silva Pires , Sergio Verjovski-Almeida , Frank J Dekker , Dante Rotili , Antonello Mai , Eduardo José Lopes-Torres , Dina Robaa , Wolfgang Sippl , Raymond J Pierce , M Teresa Borrello , A Ganesan , Julien Lancelot , Silvana Thiengo , Monica Ammon Fernandez , Amanda Roberta Revoredo Vicentino , Marina Moraes Mourão , Fernanda Sales Coelho , Marcelo Rosado Fantappié

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

Journal of medicinal chemistry

Avec: Katharina Vögerl , Nghia Ong , Johanna Senger , Daniel Herp , Karin Schmidtkunz , Martin Marek , Martin Müller , Karin Bartel , Tajith B Shaik , Nicholas J Porter , Dina Robaa , David W Christianson , Christophe Romier , Wolfgang Sippl , Manfred Jung , Franz Bracher

Exploring aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction: an in silico study.

Journal of computer-aided molecular design

Avec: Chiara Luise , Dina Robaa , Wolfgang Sippl

Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds.

Pharmaceuticals (Basel, Switzerland)

Avec: Emre F Bülbül , Dina Robaa , Ping Sun , Fereshteh Mahmoudi , Jelena Melesina , Matthes Zessin , Mike Schutkowski , Wolfgang Sippl

Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.

Journal of medicinal chemistry

Avec: Ping Sun , Jing Wang , Khadija S Khan , Weiqin Yang , Billy Wai-Lung Ng , Nikita Ilment , Matthes Zessin , Emre F Bülbül , Dina Robaa , Frank Erdmann , Matthias Schmidt , Christophe Romier , Mike Schutkowski , Alfred Sze-Lok Cheng , Wolfgang Sippl

Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.

Archiv der Pharmazie

Avec: Fady Baselious , Sebastian Hilscher , Sven Hagemann , Sunita Tripathee , Dina Robaa , Cyril Barinka , Stefan Hüttelmaier , Mike Schutkowski , Wolfgang Sippl

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.

European journal of medicinal chemistry

Avec: Ehab Ghazy , Patrik Zeyen , Daniel Herp , Martin Hügle , Karin Schmidtkunz , Frank Erdmann , Dina Robaa , Matthias Schmidt , Elizabeth R Morales , Christophe Romier , Stefan Günther , Manfred Jung , Wolfgang Sippl

Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.

Bioorganic & medicinal chemistry

Avec: Louisa Temme , Frederik Börgel , Dirk Schepmann , Dina Robaa , Wolfgang Sippl , Constantin Daniliuc , Bernhard Wünsch

Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors.

Molecules (Basel, Switzerland)

Avec: Emre F Bülbül , Jelena Melesina , Hany S Ibrahim , Mohamed Abdelsalam , Anita Vecchio , Dina Robaa , Matthes Zessin , Mike Schutkowski , Wolfgang Sippl

Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.

Journal of medicinal chemistry

Avec: Martin Pannek , Zayan Alhalabi , Daniela Tomaselli , Martina Menna , Francesco Fiorentino , Dina Robaa , Michael Weyand , Maximilian Puhlmann , Stefano Tomassi , Federica Barreca , Marco Tafani , Elma Zaganjor , Marcia C Haigis , Wolfgang Sippl , Dante Rotili , Antonello Mai , Clemens Steegborn

Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.

ChemMedChem

Avec: Beatrice Noce , Elisabetta Di Bello , Clemens Zwergel , Rossella Fioravanti , Sergio Valente , Dante Rotili , Andrea Masotti , Mohammad Salik Zeya Ansari , Daniela Trisciuoglio , Alokta Chakrabarti , Christophe Romier , Dina Robaa , Wolfgang Sippl , Manfred Jung , Cécile Häberli , Jennifer Keiser , Antonello Mai

Exploring Aromatic Cage Flexibility Using Cosolvent Molecular Dynamics Simulations─An In-Silico Case Study of Tudor Domains.

Journal of chemical information and modeling

Avec: Christopher Vorreiter , Dina Robaa , Wolfgang Sippl

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

International journal of molecular sciences

Avec: Fady Baselious , Sebastian Hilscher , Dina Robaa , Cyril Barinka , Mike Schutkowski , Wolfgang Sippl

Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds.

European journal of medicinal chemistry

Avec: Louisa Temme , Elena Bechthold , Julian A Schreiber , Sandeep Gawaskar , Dirk Schepmann , Dina Robaa , Wolfgang Sippl , Guiscard Seebohm , Bernhard Wünsch

Proteolysis targeting chimeras (PROTACs) for epigenetics research.

Current opinion in chemical biology

Avec: Anja Vogelmann , Dina Robaa , Wolfgang Sippl , Manfred Jung

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.

European journal of medicinal chemistry

Avec: Patrik Zeyen , Yanira Zeyn , Daniel Herp , Fereshteh Mahmoudi , Talha Z Yesiloglu , Frank Erdmann , Matthias Schmidt , Dina Robaa , Christophe Romier , Johannes Ridinger , Corey J Herbst-Gervasoni , David W Christianson , Ina Oehme , Manfred Jung , Oliver H Krämer , Wolfgang Sippl

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.

Chembiochem : a European journal of chemical biology

Avec: Daniel Herp , Johannes Ridinger , Dina Robaa , Stephen A Shinsky , Karin Schmidtkunz , Talha Z Yesiloglu , Theresa Bayer , Raphael R Steimbach , Corey J Herbst-Gervasoni , Annika Merz , Christophe Romier , Peter Sehr , Nikolas Gunkel , Aubry K Miller , David W Christianson , Ina Oehme , Wolfgang Sippl , Manfred Jung

Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.

International journal of molecular sciences

Avec: Hany S Ibrahim , Mohamed Abdelsalam , Yanira Zeyn , Matthes Zessin , Al-Hassan M Mustafa , Marten A Fischer , Patrik Zeyen , Ping Sun , Emre F Bülbül , Anita Vecchio , Frank Erdmann , Matthias Schmidt , Dina Robaa , Cyril Barinka , Christophe Romier , Mike Schutkowski , Oliver H Krämer , Wolfgang Sippl

Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis.

Pharmaceuticals (Basel, Switzerland)

Avec: Ehab Ghazy , Mohamed Abdelsalam , Dina Robaa , Raymond J Pierce , Wolfgang Sippl

Utilization of AlphaFold models for drug discovery: Feasibility and challenges. Histone deacetylase 11 as a case study.

Computers in biology and medicine

Avec: Fady Baselious , Dina Robaa , Wolfgang Sippl

Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD

Journal of medicinal chemistry

Avec: Arianna Colcerasa , Florian Friedrich , Jelena Melesina , Patrick Moser , Anja Vogelmann , Pavlos Tzortzoglou , Emilia Neuwirt , Manuela Sum , Dina Robaa , Lin Zhang , Elizabeth Ramos-Morales , Christophe Romier , Oliver Einsle , Eric Metzger , Roland Schüle , Olaf Groß , Wolfgang Sippl , Manfred Jung

Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer.

Cellular and molecular life sciences : CMLS

Avec: Michael Gekle , Robert Eckenstaler , Heike Braun , Abdurrahman Olgac , Dina Robaa , Sigrid Mildenberger , Virginie Dubourg , Barbara Schreier , Wolfgang Sippl , Ralf Benndorf

Réseau de co-auteurs

Wolfgang Sippl 30 collaborations

Manfred Jung 12 collaborations

Christophe Romier 11 collaborations

Matthias Schmidt 7 collaborations

Patrik Zeyen 6 collaborations

Frank Erdmann 6 collaborations

Mike Schutkowski 6 collaborations

Ehab Ghazy 5 collaborations

Karin Schmidtkunz 5 collaborations

Emre F Bülbül 5 collaborations

Daniel Herp 5 collaborations

Jelena Melesina 4 collaborations

Matthes Zessin 4 collaborations

Roland Schüle 3 collaborations

Salma Darwish 3 collaborations

Conrad V Simoben 3 collaborations

Louisa Temme 3 collaborations

Bernhard Wünsch 3 collaborations

Johannes Ridinger 3 collaborations

Ina Oehme 3 collaborations

Dante Rotili 3 collaborations

Antonello Mai 3 collaborations

David W Christianson 3 collaborations

Ping Sun 3 collaborations

Fady Baselious 3 collaborations

Cyril Barinka 3 collaborations

Mohamed Abdelsalam 3 collaborations

Oliver Einsle 2 collaborations

Tino Heimburg 2 collaborations

Julien Lancelot 2 collaborations

Tajith B Shaik 2 collaborations

Chiara Luise 2 collaborations

Raymond J Pierce 2 collaborations

Fereshteh Mahmoudi 2 collaborations

Sebastian Hilscher 2 collaborations

Dirk Schepmann 2 collaborations

Hany S Ibrahim 2 collaborations

Anita Vecchio 2 collaborations

Anja Vogelmann 2 collaborations

Yanira Zeyn 2 collaborations

Talha Z Yesiloglu 2 collaborations

Corey J Herbst-Gervasoni 2 collaborations

Oliver H Krämer 2 collaborations

Martin Roatsch 1 collaboration

Inga Hoffmann 1 collaboration

Martine I Abboud 1 collaboration

Rebecca L Hancock 1 collaboration

Hanna Tarhonskaya 1 collaboration

Kuo-Feng Hsu 1 collaboration

Sarah E Wilkins 1 collaboration

Tzu-Lan Yeh 1 collaboration

Kerstin Lippl 1 collaboration

Kerstin Serrer 1 collaboration

Isabelle Moneke 1 collaboration

Theresa D Ahrens 1 collaboration

Sandra Wenzler 1 collaboration

Nicolas P F Barthes 1 collaboration

Henriette Franz 1 collaboration

Silke Lassmann 1 collaboration

Sven Diederichs 1 collaboration

Erik Schleicher 1 collaboration

Christopher J Schofield 1 collaboration

Akane Kawamura 1 collaboration

Matthias Schiedel 1 collaboration

Attila Lehotzky 1 collaboration

Sandor Szunyogh 1 collaboration

Judit Oláh 1 collaboration

Sören Hammelmann 1 collaboration

Nathalie Wössner 1 collaboration

Judit Ovádi 1 collaboration

Anne Truhn 1 collaboration

Raymond Pierce 1 collaboration

Lucas Praetorius 1 collaboration

Pierre Regenass 1 collaboration

David Maurer 1 collaboration

Dmytro Ostrovskyi 1 collaboration

Ludwig Seifert 1 collaboration

Johannes Bacher 1 collaboration

Teresa Burgahn 1 collaboration

Tobias Wagner 1 collaboration

Johannes Seitz 1 collaboration

Holger Greschik 1 collaboration

Kwang-Su Park 1 collaboration

Yan Xiong 1 collaboration

Jian Jin 1 collaboration

Bernhard Breit 1 collaboration

Ahmed Haider 1 collaboration

Adrienne Müller Herde 1 collaboration

Stefanie D Krämer 1 collaboration

Jasmine Varisco 1 collaboration

Claudia Keller 1 collaboration

Katrin Frauenknecht 1 collaboration

Yves P Auberson 1 collaboration

Roger Schibli 1 collaboration

Linjing Mu 1 collaboration

Simon M Ametamey 1 collaboration

Sigrid Schwarthoff 1 collaboration

Nicolas Tischer 1 collaboration

Henrike Sager 1 collaboration

Bianca Schätz 1 collaboration

Marius M Rohrbach 1 collaboration

Ihar Raztsou 1 collaboration

Friedemann Gaube 1 collaboration

Hans-Dieter Arndt 1 collaboration

Thomas Winckler 1 collaboration

Rabia Salem-Altintas 1 collaboration

Sebastian Michler 1 collaboration

Florian Arndt Schöffmann 1 collaboration

Jonas Volmer 1 collaboration

Dariush Hinderberger 1 collaboration

Vitor Coutinho Carneiro 1 collaboration

Isabel Caetano de Abreu da Silva 1 collaboration

Murilo Sena Amaral 1 collaboration

Adriana S A Pereira 1 collaboration

Gilbert Oliveira Silveira 1 collaboration

David da Silva Pires 1 collaboration

Sergio Verjovski-Almeida 1 collaboration

Frank J Dekker 1 collaboration

Eduardo José Lopes-Torres 1 collaboration

M Teresa Borrello 1 collaboration

A Ganesan 1 collaboration

Silvana Thiengo 1 collaboration

Monica Ammon Fernandez 1 collaboration

Amanda Roberta Revoredo Vicentino 1 collaboration

Marina Moraes Mourão 1 collaboration

Fernanda Sales Coelho 1 collaboration

Marcelo Rosado Fantappié 1 collaboration

Katharina Vögerl 1 collaboration

Nghia Ong 1 collaboration

Johanna Senger 1 collaboration

Martin Marek 1 collaboration

Martin Müller 1 collaboration

Karin Bartel 1 collaboration

Nicholas J Porter 1 collaboration

Franz Bracher 1 collaboration

Jing Wang 1 collaboration

Khadija S Khan 1 collaboration

Weiqin Yang 1 collaboration

Billy Wai-Lung Ng 1 collaboration

Nikita Ilment 1 collaboration

Alfred Sze-Lok Cheng 1 collaboration

Sven Hagemann 1 collaboration

Sunita Tripathee 1 collaboration

Stefan Hüttelmaier 1 collaboration

Martin Hügle 1 collaboration

Elizabeth R Morales 1 collaboration

Stefan Günther 1 collaboration

Frederik Börgel 1 collaboration

Constantin Daniliuc 1 collaboration

Martin Pannek 1 collaboration

Zayan Alhalabi 1 collaboration

Daniela Tomaselli 1 collaboration

Martina Menna 1 collaboration

Francesco Fiorentino 1 collaboration

Michael Weyand 1 collaboration

Maximilian Puhlmann 1 collaboration

Stefano Tomassi 1 collaboration

Federica Barreca 1 collaboration

Marco Tafani 1 collaboration

Elma Zaganjor 1 collaboration

Marcia C Haigis 1 collaboration

Clemens Steegborn 1 collaboration

Beatrice Noce 1 collaboration

Elisabetta Di Bello 1 collaboration

Clemens Zwergel 1 collaboration

Rossella Fioravanti 1 collaboration

Sergio Valente 1 collaboration

Andrea Masotti 1 collaboration

Mohammad Salik Zeya Ansari 1 collaboration

Daniela Trisciuoglio 1 collaboration

Alokta Chakrabarti 1 collaboration

Cécile Häberli 1 collaboration

Jennifer Keiser 1 collaboration

Christopher Vorreiter 1 collaboration

Elena Bechthold 1 collaboration

Julian A Schreiber 1 collaboration

Sandeep Gawaskar 1 collaboration

Guiscard Seebohm 1 collaboration

Stephen A Shinsky 1 collaboration

Theresa Bayer 1 collaboration

Raphael R Steimbach 1 collaboration

Annika Merz 1 collaboration

Peter Sehr 1 collaboration

Nikolas Gunkel 1 collaboration

Aubry K Miller 1 collaboration

Al-Hassan M Mustafa 1 collaboration

Marten A Fischer 1 collaboration

Arianna Colcerasa 1 collaboration

Florian Friedrich 1 collaboration

Patrick Moser 1 collaboration

Pavlos Tzortzoglou 1 collaboration

Emilia Neuwirt 1 collaboration

Manuela Sum 1 collaboration

Lin Zhang 1 collaboration

Elizabeth Ramos-Morales 1 collaboration

Eric Metzger 1 collaboration

Olaf Groß 1 collaboration

Michael Gekle 1 collaboration

Robert Eckenstaler 1 collaboration

Heike Braun 1 collaboration

Abdurrahman Olgac 1 collaboration

Sigrid Mildenberger 1 collaboration

Virginie Dubourg 1 collaboration

Barbara Schreier 1 collaboration

Ralf Benndorf 1 collaboration